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Philadelphia chromosome positive B cell acute lymphoblastic leukemia (Ph+ ALL) is an aggressive cancer of the bone marrow. The addition of tyrosine kinase inhibitors (TKIs) has improved outcomes but many patients still suffer relapse and novel therapeutic agents are needed. KPC34 is an orally available, novel phospholipid conjugate of gemcitabine, rationally designed to overcome multiple mechanisms of resistance, inhibit the classical and novel isoforms of protein kinase C, is able to cross the blood brain barrier and is orally bioavailable. KPC34 had an IC50 in the nanomolar range against multiple ALL cell lines tested but was lowest for Ph+ lines. In mice bearing either naïve or resistant Ph+ ALL, KPC34 treatment resulted in significantly improved survival compared to cytarabine and gemcitabine. Treatment with KPC34 and doxorubicin was more effective than doxorubicin and cytarabine. Mice with recurrence of their ALL after initial treatment with cytarabine and doxorubicin saw dramatic improvements in hind limb paralysis after treatment with KPC34 demonstrating activity against established CNS disease. Consistent with this KPC34 was better than gemcitabine at reducing CNS leukemic burden. These promising pre-clinical results justify the continued development of KPC34 for the treatment of Ph+ALL.

Covalent functionalization of graphene offers opportunities for tailoring its properties and is an unavoidable consequence of some graphene synthesis techniques. However, the changes induced by the functionalization are not well understood. By using atomic sources to control the extent of the oxygen and nitrogen functionalization, we studied the evolution in the structure and properties at the atomic scale. Atomic oxygen reversibly introduces epoxide groups whilst, under similar conditions, atomic nitrogen irreversibly creates diverse functionalities including substitutional, pyridinic, and pyrrolic nitrogen. Atomic oxygen leaves the Fermi energy at the Dirac point （i.e., undoped）, whilst atomic nitrogen results in a net n-doping; however, the experimental results are consistent with the dominant electronic effect for both being a transition from delocalized to localized states, and hence the loss of the signature electronic structure of graphene.

[...]Leopold was not only Wolfgang's father; he was a musician of talent, an accomplished teacher, and the author of one of the most important pedagogical treatises of the eighteenth century, the Versuch einer gründlichen Violinschule. [...]it is a welcome development that more scholarship has been devoted to Leopold himself in recent decades, and it may not be a coincidence that a more balanced appraisal of his character has emerged at the same time, notably in Ruth Halliwell's The Mozart Family: Four Lives in a Social Context (Oxford: Clarendon Press, 1998). [...]Leopold was far more than the composer of amusing trifles, as the listing of catalog sections reveals: I Masses and mass movements II Litanies III Smaller sacred works IV Oratorios, sacred cantatas, applausus, singspiele and school dramas V Sacred arias VI Secular songs VII Symphonies VIII Divertimenti, partitas, serenades, and other orchestral works IX Solo concertos X Dances XI Chamber music with keyboard XII Chamber music for strings or strings and winds XIII Music for keyboard XIV Miscellaneous XV Fragments, sketches, figured bass exercises XVI Copies and arrangements of works by other composers XVII Teaching works [in fact one work, the Versuch] The listing of works within each category is straightforward and easy to follow: works in most categories are numbered consecutively through the group, as in the secular songs VI:1-7.

[...] she was deeply involved in the musical life of the imperial capital, and because she entered that life as a woman, her career provides unique insights into Viennese society. (p. 153) There are similar insights into musical and social realities of the times throughout the book, making it a valuable addition to the extensive literature on music in lateeighteenth- century Vienna.

On this edition of Meet the Press: meteorologists Bill Karins and Al Roker, FEMA director, Chris Fugate, correspondent Peter Alexander, governors, Chris Christie, Martin O'Malley, and Bob McDonnell and Mayors Michael Nutter and Cory Booker discuss Hurricane Irene; insights and analysis from David Brooks, Jamie Gangel, Katty Kay, and Michael Eric Dyson.

Alexander reviews \"Franz Danzi: Briefwechsel (1785-1826)\" edited by Volkmar von Pechstaedt.

Alexander reviews \"The Music of Antonio Rosetti (Anton Rosler) ca. 1750-1792: A Thematic Catalog\" by Sterling E. Murray.

Eisen's well-grounded and thorough thematic catalog of Leopold Mozart's compositions is reviewed (Wißner, 2010).