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Traditional patches, such as sticking plaster or acrylic adhesives used for over a hundred years, lack functionality. To address this issue of poor functionality, adhesive hydrogel patches have emerged as an efficient bioactive multifunctional alternative. Hydrogels are three‐dimensional, water‐swellable, and polymeric materials closely resembling the native tissue architecture. The physicochemical properties of hydrogels can be modified easily, allowing them to be suitable for various biomedical applications. Moreover, adhesive properties can be imparted to hydrogels through physicochemical manipulations, making them ideal candidates for supplementing or replacing traditional sticking plaster. As a result, sticky hydrogel patches are widely used for transdermal drug delivery and have even found commercial purposes. Beyond transdermal delivery, such hydrogel patches have also found applications in cardiac therapy, cancer research, and biosensing, among other applications. In this mini‐review, we critically discuss the challenges of fabricating multifunctional adhesive hydrogel patches. Furthermore, we introduce some of the chemical strategies involved with fabricating the patches. We also review their emerging biomedical applications. Finally, we explore their potential future in the flourishing field of tissue engineering and drug delivery.

Structural DNA nanotechnology enables custom fabrication of nanoscale devices and promises diverse biological applications. However, the effects of design on DNA nanostructure (DN)-cell interactions in vitro and in vivo are not yet well-characterized. origamiFISH is a recently developed technique for imaging DNs in cells and tissues. Compared to the use of fluorescent tags, origamiFISH offers label-free and structure-agnostic detection of DNs with significantly improved sensitivity. Here, we extend the origamiFISH technique to quantifying DNs in single-cell suspensions, including nonadherent cells such as subsets of immune cells, via readout by flow cytometry. This method, referred to as origamiFISH-Flow, is high-throughput (e.g., 10,000 cells per second) and compatible with immunostaining for concurrent cell-type and -state characterization. We demonstrate that origamiFISH-Flow enhances signal-to-noise ratio by up to 20-fold compared to dye labeling approaches, leading to the capture of >25-fold more DN+ cells at low, single-picomolar DN uptake concentrations. We additionally show the use of origamiFISH-Flow to profile cell-type and shape-specific DN uptake patterns across cell lines and splenocytes and quantify in vivo DN accumulation in lymphoid organs. Together, origamiFISH-Flow offers a new tool to interrogate DN interactions with cells and tissues, while providing insights for tailoring their designs in bio-applications.

The matters mat I imagine you'll be talking about in diese next couple of days are where the cutting edge is today. Because of the technology today we have doctors who in effect say to patients:

I heard about it first on the radio, listening to the 24- hours-a-day news broadcasts to which I had by then become addicted. An elephant in Portland, Oregon, was 1,000 pounds overweight and believed soon to give birth, Very likely the zoo's three...

By January 1987, Capasso had pleaded guilty to income tax evasion charges and was sentenced to four years in prison. That month [Ed Koch] ordered a confidential investigation into the [Bess Myerson]-Capasso affair; meanwhile, Myerson took a leave of absence. When the confidential report came in alleging \"serious misconduct\" and confirming the \"secret understanding\" between the judge and Myerson, she resigned.

[Betty Bienen] is the woman who succeeded [BESS MYERSON]. When [Nancy Capasso] saw her on Madison Avenue, Betty was wearing Nancy's diamond bracelet! The Cartier circlet Nancy says [Andy Capasso] had given her, and then stole back when he stole the bulk of Nancy's jewelry, now twinkled on Betty's wrist. When Nancy saw it, she just closed her eyes, clenched her teeth, said her mantra -- [Jean Harris], Jean Harris! -- and kept going.

Bess Myerson was no bubblehead Miss America. She was smart, talented - a graduate of Hunter College, an accomplished pianist and flutist - and she was Jewish. She won her titles in 1945, first Miss New York, then Miss America - the same year that the shocking facts and sights of the Nazis' concentration camps and their extermination of 6-million Jews became known to the world. At that ghastly moment in human history, it seemed somehow redemptive that here in America a Jewish girl should be chosen fairest in all the land. People, especially Jewish people, took Myerson into their hearts in a very special way. In 1977 Myerson's good friend, Ed Koch, then a little-known unmarried New York congressman, decided to run for mayor. Throughout his campaign, New York's beloved Bess Myerson was ever by his side. Together they rode the subways and mounted the soapboxes. They hinted at wedding bells to come - after his election, of course. Some said that Myerson had made Koch a mayor by first making him a man. Certainly the constant presence on his arm of this vibrant woman did much to cancel out the hisses of the opposition: ``Vote for Cuomo, Not the Homo.`` By fall, an item appeared in one of the city's tabloids questioning Myerson's employment of Sukhreet Gabel, given that her mother was the judge in the Capasso case. Then rumors began to surface that Myerson had induced Judge Gabel to cut the size of Capasso's temporary alimony and support payments from $1,850 to $680 a week, in return for giving Sukhreet Gabel a $19,000 city job as Myerson's personal assistant. When Koch asked Myerson for an explanation, she sent him a letter of formal assurance that Sukhreet Gabel had been hired according to normal employment guidelines. The next spring, Myerson forced Sukhreet Gabel to resign.

By fall, an item appeared in one of the city's tabloids questioning [BESS MYERSON]' employment of [Sukhreet Gabel], given that her mother was the judge in the Capasso case. Then rumors began to surface that Bess had induced Judge Gabel to cut the size of Capasso's temporary alimony and support payments from $1,850 to $680 a week, in return for giving Sukhreet a $19,000 city job as Bess' personal assistant. When Mayor [Ed Koch] asked Bess for an explanation, she sent him a letter of formal assurance that Sukhreet had been hired according to normal employment guidelines. The following spring, Bess forced Sukhreet to resign.