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The use of convalescent plasma to treat Ebola virus disease has been a focus of interest since Ebola virus was first identified in the 1970s. However, in this report from Guinea, the use of convalescent plasma did not significantly improve survival. The recent outbreak of Ebola virus disease (EVD) in West Africa has been the worst ever witnessed. By September 9, 2015, a total of 28,183 cases and 11,306 deaths had been reported. 1 The high case fatality rate (40 to 60%) 2 , 3 highlights the need for effective EVD-specific treatments, which would also provide an incentive for patients to present to treatment centers early. Such interventions would facilitate the rapid tracing of contacts of patients and the implementation of measures to control the spread of an outbreak. The World Health Organization (WHO) has prioritized the evaluation of treatment with convalescent whole blood . . .

IntroductionThe COVID-19 pandemic has substantially impacted maternity care provision worldwide. Studies based on modelling estimated large indirect effects of the pandemic on services and health outcomes. The objective of this study was to prospectively document experiences of frontline maternal and newborn healthcare providers.MethodsWe conducted a global, cross-sectional study of maternal and newborn health professionals via an online survey disseminated through professional networks and social media in 12 languages. Information was collected between 24 March and 10 April 2020 on respondents’ background, preparedness for and response to COVID-19 and their experience during the pandemic. An optional module sought information on adaptations to 17 care processes. Descriptive statistics and qualitative thematic analysis were used to analyse responses, disaggregating by low-income and middle-income countries (LMICs) and high-income countries (HICs).ResultsWe analysed responses from 714 maternal and newborn health professionals. Only one-third received training on COVID-19 from their health facility and nearly all searched for information themselves. Half of respondents in LMICs received updated guidelines for care provision compared with 82% in HICs. Overall, 47% of participants in LMICs and 69% in HICs felt mostly or completely knowledgeable in how to care for COVID-19 maternity patients. Facility-level responses to COVID-19 (signage, screening, testing and isolation rooms) were more common in HICs than LMICs. Globally, 90% of respondents reported somewhat or substantially higher levels of stress. There was a widespread perception of reduced use of routine maternity care services, and of modification in care processes, some of which were not evidence-based practices.ConclusionsSubstantial knowledge gaps exist in guidance on management of maternity cases with or without COVID-19. Formal information-sharing channels for providers must be established and mental health support provided. Surveys of maternity care providers can help track the situation, capture innovations and support rapid development of effective responses.

Introduction Chronic viral hepatitis B constitutes a public health problem due to its morbidity, mortality and economic consequences. To date, the direct costs incurred by patients for the treatment of this condition are not well documented. Our study aims to provide evidence on this cost in order to help facilitate patient care and optimize national hepatitis control policies. Methodology This is a cross-sectional study with analytical aims lasting one month. The study population consisted of patients followed in outpatient consultation in the hepato-gastroenterology department of the Yalgado OUEDRAOGO University Hospital Center (CHU-YO). We conducted a census of patients seen in consultation and meeting the inclusion criteria. Data were collected following direct interviews with patients and review of medical records. The determinants of the direct cost of chronic viral hepatitis B management were identified using linear regression. Results The mean direct cost incurred by patients on tenofovir treatment during the first three years of follow-up was 538,293 XOF with a 95% CI [466,005–610,581] and a standard deviation of 35,739 XOF. The mean direct cost incurred by patients without tenofovir treatment during the first three years of follow-up was 359,664 XOF (≈ 611.4 USD) with a 95% CI [331,276–388,052] XOF and a standard deviation of 14,323 XOF . The mean non-medical direct cost during the first three years of follow-up was 30,037 XOF (≈ 52.14 USD) with a 95% CI [22,498–37,575] XOF and a standard deviation of 3,815 XOF. Conclusion The cost of chronic viral hepatitis B treatment at CHU-YO is very high compared to patients’ income. Laboratory and imaging tests constitute the bulk of patient care expenses. To facilitate patient monitoring in order to avoid or delay the occurrence of complications, it is necessary to implement financial protection mechanisms in health.

To assess training needs of healthcare workers (HCWs) on pulmonary plague (PP) control after the large PP outbreak in Madagascar 2017. In 2018, we conducted a knowledge, attitudes and practices (KAP) survey among HCWs (PP cases and comparison group) in Antananarivo and Toamasina. Proportions were calculated, differences between groups were tested for significance. Knowledge levels were similar for HCW PP cases and the HCW comparison group. Among 59 HCW over 90% named the distinctive disease forms of plague (bubonic (93%), pulmonary (98%)), and 72% the causative agent. Washing hands was mentioned as protective measure by 56%, while 93% reported to have always washed hands after performing medical procedures. Only 3.5% reported managed PP cases before the outbreak; 38% reported to have felt confident performing invasive procedures while caring for PP cases at the beginning versus 62% at the end of the outbreak. HCW who remained uninfected reported more often than PP cases to have worn multiple or single use medical coats ((93% vs. 53%, p = 0.001; 60% vs. 20%, p = 0.028), and less frequently to have paid for chemoprophylaxis out of pocket (11% versus 50%; p = 0.008). Despite the good overall knowledge, specific knowledge gaps and the mismatch between knowledge and practice of basic hygiene measures and low confidence in providing care for PP cases after the outbreak indicate a persisting need for training.

Background The 2013–2015 Ebola Virus Disease (EVD) outbreak in Guinea resulted in community mistrust that influenced health care service utilization. This study aimed to assess whether EVD-related memories affect post-outbreak health-seeking behaviours for children under 5 years of age with febrile illnesses in Guéckédou district, Guinea. Methods This cross-sectional study was conducted by surveying caregivers of children under 5 years of age in the sub-district most affected by the EVD outbreak (Guèndembou) and the least affected sub-district (Bolodou) in Guéckédou district. Memories of the outbreak were referred to as EVD-related fears in the post-EVD period, which was based on a series of questions regarding current feelings. Results While the majority of caregivers sought care for their children with febrile illness in both districts, a statistically significantly higher proportion of caregivers in Guèndembou sought care, compared to caregivers in Bolodou.. More caregivers in Guèndembou (19.9%; n  = 39) reported the death of family members or friends due to EVD compared to Bolodou (6.9%; n  = 14; P  < 0.001). The mean EVD fear score of caregivers was significantly higher in Guèndembou (3.0; SD: 3.0) than in Bolodou (2.0; SD: 1.1) ( p  < 0.001). Caregivers with a fear score above the median were 1.68 times more likely to seek care than those whose fear score was equal to or below the median; however, this difference was not statistically significant. Caregivers who reported family members’ or friends’ death due to EVD were also more likely to seek care (AOR = 2.12; 95%CI: 0.91–4.91), however, with no statistical significance. Only residing in the EVD-most affected sub-district of Guèndembou (AOR = 1.74; 95%CI: 1·09–2.79) was positively associated with seeking care. Conclusions This study reveals that community members in the rural district of Guéckédou still live with fear related to EVD nearly 2 years after the outbreak. It calls for more efforts in the health domain to preserve communities’ key values and address the psychosocial effect of EVD in rural Guinea.

In Morocco, there is little information on the circumstances surrounding maternal near misses. This study aimed to determine the incidence, characteristics, and determinants of maternal near misses in Morocco. A prospective case-control study was conducted at 3 referral maternity hospitals in the Marrakech region of Morocco between February and July 2012. Near-miss cases included severe hemorrhage, hypertensive disorders, and prolonged obstructed labor. Three unmatched controls were selected for each near-miss case. Three categories of risk factors (sociodemographics, reproductive history, and delays), as well as perinatal outcomes, were assessed, and bivariate and multivariate analyses of the determinants were performed. A sample of 30 near misses and 30 non-near misses was interviewed. The incidence of near misses was 12‰ of births. Hypertensive disorders during pregnancy (45%) and severe hemorrhage (39%) were the most frequent direct causes of near miss. The main risk factors were illiteracy [OR = 2.35; 95% CI: (1.07-5.15)], lack of antenatal care [OR = 3.97; 95% CI: (1.42-11.09)], complications during pregnancy [OR = 2.81; 95% CI:(1.26-6.29)], and having experienced a first phase delay [OR = 8.71; 95% CI: (3.97-19.12)] and a first phase of third delay [OR = 4.03; 95% CI: (1.75-9.25)]. The main reasons for the first delay were lack of a family authority figure who could make a decision, lack of sufficient financial resources, lack of a vehicle, and fear of health facilities. The majority of near misses demonstrated a third delay with many referrals. The women's perceptions of the quality of their care highlighted the importance of information, good communication, and attitude. Women and newborns with serious obstetric complications have a greater chance of successful outcomes if they are immediately directed to a functioning referral hospital and if the providers are responsive.

Background Malaria is a major public health issue in Guinea and care-seeking behaviour is dominated by self-medication and delayed access to appropriate care. However early and appropriate care-seeking are essential to control and reduce complicate forms and mortality, particularly for the most vulnerable. This study was conducted to analyse the diagnostic pathway, and the factors associated with early and appropriate care-seeking for malaria patients in the Republic of Guinea. Methods A cross-sectional study was carried out between December 2022 to March 2023 in nine health districts within health facilities and at community level. The study population was confirmed malaria patients with RDT or microscopy. Kroeger’s conceptual framework was used to design the questionnaire. Conventional recourse was defined as using a healthcare facility or community services, early and appropriate care-seeking was defined as within 24 h of symptom onset in a conventional recourse, and care pathway as the sequence of recourses followed by each patient. Sankey alluvial plots were used to represent patients' diagnostic pathways, and logistic regression to identify factors associated with early and appropriate care-seeking. Results A total of 3300 malaria patients were studied, of which 1632 (49.45%) were female and 1132 (34.30%) were under 5 years of age, with a median age of 23 months. At the time of the survey, 1337 (40.52%), 1423 (43.12%), and 437 (13.85%) of patients were respectively in their first, second and third recourse. A total of 2002 (60.67%) patients had sought care from a conventional recourse as a first line. Of all patients, 1757 (53.25%) had sought care within 24 h, while 28.55% had sought early and appropriate care. In the initial stages of treatment, self-medication was the most common approach, used by 1214 (37.30%). Patients from the health districts of Boffa (Lower Guinea, coastal region) OR = 0.48 95% CI 0.33–0.70, Dabola (Upper Guinea, savanna region) OR = 0.43 95% CI 0.30–0.63 and Labe (Middle Guinea, mountain region) OR = 0.63 CI 95% 0.43–0.91 (p < 0.05) were more likely to delay appropriate care-seeking, when compared to those in Dixinn, (Conakry). However, the under 5-year-old group OR = 1.55 95% CI 1.30–1.85 (p < 0.001) and the availability of a stable monthly household income OR = 4.98 95% CI 3.03, 8.27 (p < 0.001) were positively associated with early and appropriate care seeking. Conclusion A low rate of early and appropriate care-seeking was observed. Patients sought care through multiple means, often resulting in a delay in adequate management. The results show the need to deploy strategies adapted to the needs of communities.

The huge proportion of child marriage contributes to high rates of pregnancies among adolescent girls in Bangladesh. Despite substantial progress in reducing maternal mortality in the last two decades, the rate of adolescent pregnancy remains high. The use of skilled maternal health services is still low in Bangladesh. Several quantitative studies described the use of skilled maternal health services among adolescent girls. So far, very little qualitative evidence exists about attitudes and practices related to maternal health. To fill this gap, we aimed at exploring maternal health care-seeking behavior of adolescent girls and their experiences related to pregnancy and delivery in Bangladesh. A prospective qualitative study was conducted among thirty married adolescent girls from three Upazilas (sub-districts) of Rangpur district. They were interviewed in two subsequent phases (2014 and 2015). To triangulate and validate the data collected from these married adolescent girls, key informant interviews (KIIs) and focus group discussions (FGDs) were conducted with different stakeholders. Data analysis was guided by the Social-Ecological Model (SEM) including four levels of factors (individual, interpersonal and family, community and social, and organizational and health systems level) which influenced the maternal health care-seeking behavior of adolescent girls. While adolescent girls showed little decision making-autonomy, interpersonal and family level factors played an important role in their use of skilled maternal health services. In addition, community and social factors and as well as organizational and health systems factors shaped adolescent girls' maternal health care-seeking behavior. In order to improve the maternal health of adolescent girls, all four levels of factors of SEM should be taken into account while developing health interventions targeting adolescent girls.

Arboviruses represent a major cause of illness in Africa and have the potential to trigger widespread epidemics. We present data on arbovirus epidemics in Africa in 2023 and demonstrate the need for global public health authorities to intensify efforts in the surveillance and control of arbovirus diseases. Data were collected from the World Health Organization Weekly Bulletin on Outbreaks and Other Emergencies, Africa Centers for Disease Control and Prevention Weekly Event Based Surveillance Report, and other online sources. In 2023, a total of 7 arboviruses were responsible for 29 outbreaks across 25 countries in Africa, 22 of which occurred in West Africa; the outbreaks resulted in 19,569 confirmed cases and 820 deaths. Arbovirus epidemics in Africa pose a threat not only to public health within the continent but also globally, underscoring the urgent need for substantial investment in arbovirus surveillance, research, and preparedness capacities in Africa to prevent and respond to health crises effectively.

Background The state of the Guinean health workforce is one of the country’s bottlenecks in advancing health outcomes. The impact of the 2014–2015 Ebola virus disease outbreak and resulting international attention has provided a policy window to invest in the workforce and reform the health system. This research constitutes a baseline study on the health workforce situation, professional education, and retention policies in Guinea. The study was conducted to inform capacity development as part of a scientific collaboration between Belgian and Guinean health institutes aiming to strengthen public health systems and health workforce development. It provides initial recommendations to the Guinean government and key actors. Methodology The conceptual framework for this study is inspired by Gilson and Walt’s health policy triangle. The research consists of a mixed-methods approach with documents and data collected at the national, regional, and district levels between October 2016 and March 2017. Interviews were conducted with 57 resource persons from the Ministry of Health, other ministries, district health authorities, health centers and hospitals, health training institutions, health workers, community leaders, NGO representatives, and development partners. Quantitative data included figures obtained from seven health professionals’ schools in each administrative region of Guinea. A quantitative analysis was conducted to determine the professional graduate trends by year and type of personnel. This provided for a picture of the pool of professional graduates available in the regions in relation to the actual employment possibilities in rural areas. The districts of Forecariah and Yomou were chosen as the main study sites. Results Limited recruitment and a relative overproduction of medical doctors and nurse assistants have led to unemployment of health personnel. There was a mismatch between the number of civil servants administratively deployed and those actually present at their health posts. Participants argued for decentralization of health workforce management and financing. Collaboration between government actors and development partners is required to anticipate problems with the policy implementation of new health workers’ deployment in rural areas. Further privatization of health education has to meet health needs and labor market dynamics.