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2,764 result(s) for "Ali, Asad"
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The C# programmer's study guide (MCSD) : Exam 70-483
Prepare for Microsoft certification exam: 70-483: Programming in C#. The \"what, why, and how\" of each concept is presented along with quick summaries, code challenges, and exam questions to review and practice key concepts.
Nonprecious metal's graphene‐supported electrocatalysts for hydrogen evolution reaction: Fundamentals to applications
Sustainable production of hydrogen is a hopeful requirement of a strategic future economy and development. Water splitting driven by electricity is a favorable pathway for renewable hydrogen production. This critical review highlighted recent efforts toward the development of the nanoscale synthesis of nonprecious metal's graphene‐supported electrocatalysts and their electrocatalytic features for remarkable hydrogen evolution reaction (HER). Different essential nonprecious metal's graphene‐supported electrocatalysts, including metal carbides, sulfides, phosphides, selenides, oxides, and nitrides are reviewed. In the exploration, attention is given to the strategies of activity enhancement, the synthetic approach, and the composition/structure electrocatalytic‐performance relationship of these HER electrocatalysts. We are hopeful that this review confers a new momentum to the rational design of remarkable performance nonprecious metal's graphene‐supported electrocatalysts and comprehensive guide for researchers to utilize the subject catalysts in regular water splitting. Sustainable production of hydrogen is a hopeful requirement of a strategic future economy and development. Water splitting driven by electricity is a favorable pathway for renewable hydrogen production. This critical review highlighted recent efforts toward the development of the nanoscale synthesis of nonprecious metal's graphene‐supported electrocatalysts and their electrocatalytic features for remarkable hydrogen evolution reaction (HER). Different essential nonprecious metal's graphene‐supported electrocatalysts, including metal carbides, sulfides, phosphides, selenides, oxides, and nitrides are reviewed. In the exploration, attention is given to the strategies of activity enhancement, the synthetic approach, and the composition/structure electrocatalytic‐performance relationship of these HER electrocatalysts. We are hopeful that this review confers a new momentum to the rational design of remarkable performance nonprecious metal's graphene‐supported electrocatalysts and comprehensive guide for researchers to utilize the subject catalysts in regular water splitting.
AutoMap is a high performance homozygosity mapping tool using next-generation sequencing data
Homozygosity mapping is a powerful method for identifying mutations in patients with recessive conditions, especially in consanguineous families or isolated populations. Historically, it has been used in conjunction with genotypes from highly polymorphic markers, such as DNA microsatellites or common SNPs. Traditional software performs rather poorly with data from Whole Exome Sequencing (WES) and Whole Genome Sequencing (WGS), which are now extensively used in medical genetics. We develop AutoMap, a tool that is both web-based or downloadable, to allow performing homozygosity mapping directly on VCF (Variant Call Format) calls from WES or WGS projects. Following a training step on WES data from 26 consanguineous families and a validation procedure on a matched cohort, our method shows higher overall performances when compared with eight existing tools. Most importantly, when tested on real cases with negative molecular diagnosis from an internal set, AutoMap detects three gene-disease and multiple variant-disease associations that were previously unrecognized, projecting clear benefits for both molecular diagnosis and research activities in medical genetics. Homozygosity mapping is a useful tool for identifying candidate mutations in recessive conditions, however application to next generation sequencing data has been sub-optimal. Here, the authors present AutoMap, which efficiently identifies runs of homozygosity in whole exome/genome sequencing data.
Applications of Blockchain Technology in Medicine and Healthcare: Challenges and Future Perspectives
Blockchain technology has gained considerable attention, with an escalating interest in a plethora of numerous applications, ranging from data management, financial services, cyber security, IoT, and food science to healthcare industry and brain research. There has been a remarkable interest witnessed in utilizing applications of blockchain for the delivery of safe and secure healthcare data management. Also, blockchain is reforming the traditional healthcare practices to a more reliable means, in terms of effective diagnosis and treatment through safe and secure data sharing. In the future, blockchain could be a technology that may potentially help in personalized, authentic, and secure healthcare by merging the entire real-time clinical data of a patient’s health and presenting it in an up-to-date secure healthcare setup. In this paper, we review both the existing and latest developments in the field of healthcare by implementing blockchain as a model. We also discuss the applications of blockchain, along with the challenges faced and future perspectives.
A new simulated annealing algorithm for simultaneous open-pit and waste dump scheduling in mining complexes
Production scheduling models for open-pit mining complexes determine the optimal sequence for extracting mining blocks while adhering to technical and operational constraints. Although various mathematical models are available in the literature, solving them for large-scale operations remains computationally intensive. This challenge becomes more complex when models aim to simultaneously schedule block extraction and waste dumping, as this introduces additional variables and constraints, further complicating the problem. This paper presents a novel Simulated Annealing (SA)-based algorithm as a solution method for the simultaneous optimisation of block extraction and waste dumping sequences in open-pit mining complexes. The proposed approach incorporates an innovative variable reduction technique and a heuristic for generating reliable initial solutions. Numerical results show that the proposed algorithm achieves an NPV within 6.08% of the exact solution derived through a commercial solver while reducing the runtime by 82%. More importantly, for relatively larger instances that commercial solver fails to resolve, the proposed method maintains robust performance and delivers high-quality solutions within reasonable computational times.
Biological control of bacterial wilt in tomato through the metabolites produced by the biocontrol fungus, Trichoderma harzianum
Background Ralstonia solanacearum causes bacterial wilt disease in tomato and other crops resulting in huge economic losses worldwide. Several measures have been explored for the control of R. solanacearum , but the desired control level of the disease through sustainable and ecofriendly way is still awaited. Main body In this study, fungal metabolites produced by Trichoderma harzianum were investigated in the form of crude extract for the management of R. solanacearum both in vitro and in planta in tomato plants. In in vitro investigation, fungal metabolites were checked for their antibacterial potential at different concentrations (30, 60, 90, 120, 150, and 180 mg ml −1 ) and bacterial cell morphology was observed under scanning electron microscopy (SEM). In a greenhouse experiment, different application times (0, 3, and 6 days before transplantation DBT) and doses (0, 3, 6, and 9%) of the fungal metabolites were tested for their effects on soil bacterial population, disease severity and plant growth of tomato plants. The in vitro evaluation showed a strong antibacterial activity of fungal metabolites in concentration dependent manner. The highest concentration 180 mg ml −1 produced maximum inhibition zone (20.2 mm) having non-significant difference with the inhibition zone (20.5 mm) produced by the standard antibiotic streptomycin. The SEM analysis revealed severe morphological destructions of bacterial cells. In case of greenhouse experiment, the highest decrease in soil bacterial population, lowest disease severity, and maximum increase in plant growth parameters were obtained by highest dose (9%) and longest application time (6 DBT). Conclusion The fungal metabolites produced by T. harzianum could be used as low-cost, environment-friendly, and sustainable management strategy for the control of R. solanacearum in tomato plants.
Continuous control actions learning and adaptation for robotic manipulation through reinforcement learning
This paper presents a learning-based method that uses simulation data to learn an object manipulation task using two model-free reinforcement learning (RL) algorithms. The learning performance is compared across on-policy and off-policy algorithms: Proximal Policy Optimization (PPO) and Soft Actor-Critic (SAC). In order to accelerate the learning process, the fine-tuning procedure is proposed that demonstrates the continuous adaptation of on-policy RL to new environments, allowing the learned policy to adapt and execute the (partially) modified task. A dense reward function is designed for the task to enable an efficient learning of the agent. A grasping task involving a Franka Emika Panda manipulator is considered as the reference task to be learned. The learned control policy is demonstrated to be generalizable across multiple object geometries and initial robot/parts configurations. The approach is finally tested on a real Franka Emika Panda robot, showing the possibility to transfer the learned behavior from simulation. Experimental results show 100% of successful grasping tasks, making the proposed approach applicable to real applications.
Exploring the role of Islamic Fintech in combating the aftershocks of COVID-19: The open social innovation of the Islamic financial system
The purpose of the current study is to investigate the role of the Islamic financial system in recovery post-COVID-19 and the way Fintech can be utilized to combat the economic reverberations created by COVID-19. The global financial crisis of 2008 has established the credentials of the Islamic financial system as a sustainable financial system which can save the long run interests of the average citizens around the world while adding value to the real economy. The basic ethical tenets available in the Islamic financial system make it more suited and readymade to fight the economic aftershocks of a pandemic like COVID-19. The basic principles of ethical Islamic finance have solid connections to financial stability and corporate social responsibility within the wide-reaching business context. With the emergence of Financial technology (Fintech) it has provided a missing impetus to the Islamic financial system to compete on equal ground with its conventional counterpart and prove its mettle. The study uses discourse analysis along with the content analysis to extract content and draw a conclusion. The findings of the study indicate that COVID-19 pandemic has provided the opportunity for the social and open innovation to grow and finance world have turned to open innovation to provide a speedy, timely, reliable, and sustainable solution to the world. The findings of the study provide significant implications for governments and policy makers in efficient application of Fintech and innovative Islamic financial services to fight the economic consequences of the COVID-19 pandemic.
Biodegradation of plastics: current scenario and future prospects for environmental safety
Plastic is a general term used for a wide range of high molecular weight organic polymers obtained mostly from the various hydrocarbon and petroleum derivatives. There is an ever-increasing trend towards the production and consumption of plastics due to their extensive industrial and domestic applications. However, a wide spectrum of these polymers is non-biodegradable with few exceptions. The extensive use of plastics, lack of waste management, and casual community behavior towards their proper disposal pose a significant threat to the environment. This has raised growing concerns among various stakeholders to devise policies and innovative strategies for plastic waste management, use of biodegradable polymers especially in packaging, and educating people for their proper disposal. Current polymer degradation strategies rely on chemical, thermal, photo, and biological procedures. In the presence of proper waste management strategies coupled with industrially controlled biodegradation facilities, the use of biodegradable plastics for some applications such as packaging or health industry is a promising and attractive option for economic, environmental, and health benefits. This review highlights the classification of plastics with special emphasis on biodegradable plastics and their rational use, the identified mechanisms of plastic biodegradation, the microorganisms involved in biodegradation, and the current insights into the research on biodegradable plastics. The review has also identified the research gaps in plastic biodegradation followed by future research directions.