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Chloroplasts and mitochondria are subcellular bioenergetic organelles with their own genomes and genetic systems. DNA replication and transmission to daughter organelles produces cytoplasmic inheritance of characters associated with primary events in photosynthesis and respiration. The prokaryotic ancestors of chloroplasts and mitochondria were endosymbionts whose genes became copied to the genomes of their cellular hosts. These copies gave rise to nuclear chromosomal genes that encode cytosolic proteins and precursor proteins that are synthesized in the cytosol for import into the organelle into which the endosymbiont evolved. What accounts for the retention of genes for the complete synthesis within chloroplasts and mitochondria of a tiny minority of their protein subunits? One hypothesis is that expression of genes for protein subunits of energy-transducing enzymes must respond to physical environmental change by means of a direct and unconditional regulatory control—control exerted by change in the redox state of the corresponding gene product. This hypothesis proposes that, to preserve function, an entire redox regulatory system has to be retained within its original membrane-bound compartment. Colocation of gene and gene product for redox regulation of gene expression (CoRR) is a hypothesis in agreement with the results of a variety of experiments designed to test it and which seem to have no other satisfactory explanation. Here, I review evidence relating to CoRR and discuss its development, conclusions, and implications. This overview also identifies predictions concerning the results of experiments that may yet prove the hypothesis to be incorrect.

It is unclear at present whether psychopathic tendencies are associated with lower or higher levels of emotional awareness (EA). Given that psychopathy includes a proficiency for manipulating others, one might expect an elevated ability to identify and use information about others’ emotions. On the other hand, empathic deficits in psychopathy could arise from reduced emotional awareness. Further, heterogeneity in psychopathy may also play a role, wherein ‘secondary’ psychopathy is associated with early adversity and high negative affect, while ‘primary’ psychopathy is not. In this paper, we tested the relationship between EA and psychopathic tendencies in 177 undergraduate students (40 males) who completed the levels of emotional awareness scale (LEAS), the triarchic psychopathy measure (TPM), the affective (empathy-related) subscales of the interpersonal reactivity index (IRI), and two measures of early adversity: the childhood experiences of care and abuse questionnaire (CECA) and the childhood trauma questionnaire (CTQ). We found that lower LEAS scores were associated with higher TPM and lower IRI empathy scores, but these relationships were primarily present in those with early adversity and high negative affect. This suggests that lower EA may be selectively associated with higher levels of secondary psychopathy, while those with higher levels of primary psychopathy remain capable of higher EA.

Investigations into action monitoring have consistently detailed a frontocentral voltage deflection in the event-related potential (ERP) following the presentation of negatively valenced feedback, sometimes termed the feedback-related negativity (FRN). The FRN has been proposed to reflect a neural response to prediction errors during reinforcement learning, yet the single-trial relationship between neural activity and the quanta of expectation violation remains untested. Although ERP methods are not well suited to single-trial analyses, the FRN has been associated with theta band oscillatory perturbations in the medial prefrontal cortex. Mediofrontal theta oscillations have been previously associated with expectation violation and behavioral adaptation and are well suited to single-trial analysis. Here, we recorded EEG activity during a probabilistic reinforcement learning task and fit the performance data to an abstract computational model (Q-learning) for calculation of single-trial reward prediction errors. Single-trial theta oscillatory activities following feedback were investigated within the context of expectation (prediction error) and adaptation (subsequent reaction time change). Results indicate that interactive medial and lateral frontal theta activities reflect the degree of negative and positive reward prediction error in the service of behavioral adaptation. These different brain areas use prediction error calculations for different behavioral adaptations, with medial frontal theta reflecting the utilization of prediction errors for reaction time slowing (specifically following errors), but lateral frontal theta reflecting prediction errors leading to working memory-related reaction time speeding for the correct choice.

In this study we compared 3.7 million rawinsonde observations from 232 stations over Europe and North America with proximal vertical profiles from ERA5 and MERRA-2 to examine how well reanalysis depicts observed convective parameters. Larger differences between soundings and reanalysis are found for thermodynamic theoretical parcel parameters, low-level lapse rates, and low-level wind shear. In contrast, reanalysis best represents temperature and moisture variables, mid-tropospheric lapse rates, and mean wind. Both reanalyses underestimate CAPE, low-level moisture, and wind shear, particularly when considering extreme values. Overestimation is observed for low-level lapse rates, midtropospheric moisture, and the level of free convection. Mixed-layer parcels have overall better accuracy when compared to most-unstable parcels, especially considering convective inhibition and lifted condensation level. Mean absolute error for both reanalyses has been steadily decreasing over the last 39 years for almost every analyzed variable. Compared to MERRA-2, ERA5 has higher correlations and lower mean absolute errors. MERRA-2 is typically drier and less unstable over central Europe and the Balkans, with the opposite pattern over western Russia. Both reanalyses underestimate CAPE and CIN over the Great Plains. Reanalyses are more reliable for lower elevation stations and struggle along boundaries such as coastal zones and mountains. Based on the results from this and prior studies we suggest that ERA5 is likely one of the most reliable available reanalyses for exploration of convective environments, mainly due to its improved resolution. For future studies we also recommend that computation of convective variables should use model levels that provide more accurate sampling of the boundary layer conditions compared to less numerous pressure levels.

Reichenbach’s principle asserts that if two observed variables are found to be correlated, then there should be a causal explanation of these correlations. Furthermore, if the explanation is in terms of a common cause, then the conditional probability distribution over the variables given the complete common cause should factorize. The principle is generalized by the formalism of causal models, in which the causal relationships among variables constrain the form of their joint probability distribution. In the quantum case, however, the observed correlations in Bell experiments cannot be explained in the manner Reichenbach’s principle would seem to demand. Motivated by this, we introduce a quantum counterpart to the principle. We demonstrate that under the assumption that quantum dynamics is fundamentally unitary, if a quantum channel with input A and outputs B and C is compatible with A being a complete common cause of B and C , then it must factorize in a particular way. Finally, we show how to generalize our quantum version of Reichenbach’s principle to a formalism for quantum causal models and provide examples of how the formalism works.

Transcranial focused ultrasound (tFUS) is an emerging method for non-invasive neuromodulation akin to transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS). tFUS offers several advantages over electromagnetic methods including high spatial resolution and the ability to reach deep brain targets. Here we describe two experiments assessing whether tFUS could modulate mood in healthy human volunteers by targeting the right inferior frontal gyrus (rIFG), an area implicated in mood and emotional regulation. In a randomized, placebo-controlled, double-blind study, participants received 30 s of 500 kHz tFUS or a placebo control. Visual Analog Mood Scales (VAMS) assessed mood four times within an hour (baseline and three times after tFUS). Participants who received tFUS reported an overall increase in Global Affect (GA), an aggregate score from the VAMS scale, indicating a positive shift in mood. Experiment 2 examined resting-state functional (FC) connectivity using functional magnetic resonance imaging (fMRI) following 2 min of 500 kHz tFUS at the rIFG. As in Experiment 1, tFUS enhanced self-reported mood states and also decreased FC in resting state networks related to emotion and mood regulation. These results suggest that tFUS can be used to modulate mood and emotional regulation networks in the prefrontal cortex.

Long-term trends in the historical frequency of environments supportive of atmospheric convection are unclear, and only partially follow the expectations of a warming climate. This uncertainty is driven by the lack of unequivocal changes in the ingredients for severe thunderstorms (i.e., conditional instability, sufficient low-level moisture, initiation mechanism, and vertical wind shear). ERA5 hybrid-sigma data allow for superior characterization of thermodynamic parameters including convective inhibition, which is very sensitive to the number of levels in the lower troposphere. Using hourly data we demonstrate that long-term decreases in instability and stronger convective inhibition cause a decline in the frequency of thunderstorm environments over the southern United States, particularly during summer. Conversely, increasingly favorable conditions for tornadoes are observed during winter across the Southeast. Over Europe, a pronounced multidecadal increase in low-level moisture has provided positive trends in thunderstorm environments over the south, central, and north, with decreases over the east due to strengthening convective inhibition. Modest increases in vertical wind shear and storm-relative helicity have been observed over northwestern Europe and the Great Plains. Both continents exhibit negative trends in the fraction of environments with likely convective initiation. This suggests that despite increasing instability, thunderstorms in a warming climate may be less likely to develop due to stronger convective inhibition and lower relative humidity. Decreases in convective initiation and resulting precipitation may have long-term implications for agriculture, water availability, and the frequency of severe weather such as large hail and tornadoes. Our results also indicate that trends observed over the United States cannot be assumed to be representative of other continents.

Background Progesterone is a critical hormone in early pregnancy. A low level of serum progesterone is associated with threatened miscarriage. We aim to establish the distribution of maternal serum progesterone in normal pregnancies compared to pregnancies complicated by threatened miscarriage from 5 to 13 weeks gestation. Methods This is a single centre, prospective cohort study of 929 patients. Women from the Normal Pregnancy [NP] cohort were recruited from antenatal clinics, and those in the Threatened Miscarriage [TM] cohort were recruited from emergency walk-in clinics. Women with multiple gestations, missed, incomplete or inevitable miscarriage were excluded from the study. Quantile regression was used to characterize serum progesterone levels in the NP and TM cohorts by estimating the 10th, 50th and 90th percentiles from 5 to 13 weeks gestation. Pregnancy outcome was determined at 16 weeks of gestation. Subgroup analysis within the TM group compared progesterone levels of women who subsequently miscarried with those who had ongoing pregnancies at 16 weeks of gestation. Results Median serum progesterone concentration demonstrated a linearly increasing trend from 57.5 nmol/L to 80.8 nmol/L from 5 to 13 weeks gestation in the NP cohort. In the TM cohort, median serum progesterone concentration increased from 41.7 nmol/L to 78.1 nmol/L. However, median progesterone levels were uniformly lower in the TM cohort by approximately 10 nmol/L at every gestation week. In the subgroup analysis, median serum progesterone concentration in women with ongoing pregnancy at 16 weeks gestation demonstrated a linearly increasing trend from 5 to 13 weeks gestation. There was a marginal and non-significant increase in serum progesterone from 19.0 to 30.3 nmol/L from 5 to 13 weeks gestation in women who eventually had a spontaneous miscarriage. Conclusions Serum progesterone concentration increased linearly with gestational age from 5 to 13 weeks in women with normal pregnancies. Women with spontaneous miscarriage showed a marginal and non-significant increase in serum progesterone. This study highlights the pivotal role of progesterone in supporting an early pregnancy, with lower serum progesterone associated with threatened miscarriage and a subsequent complete miscarriage at 16 weeks gestation.

In this study we investigate convective environments and their corresponding climatological features over Europe and the United States. For this purpose, National Lightning Detection Network (NLDN) and Arrival Time Difference long-range lightning detection network (ATDnet) data, ERA5 hybrid-sigma levels, and severe weather reports from the European Severe Weather Database (ESWD) and Storm Prediction Center (SPC) Storm Data were combined on a common grid of 0.25° and 1-h steps over the period 1979–2018. The severity of convective hazards increases with increasing instability and wind shear (WMAXSHEAR), but climatological aspects of these features differ over both domains. Environments over the United States are characterized by higher moisture, CAPE, CIN, wind shear, and midtropospheric lapse rates. Conversely, 0–3-km CAPE and low-level lapse rates are higher over Europe. From the climatological perspective severe thunderstorm environments (hours) are around 3–4 times more frequent over the United States with peaks across the Great Plains, Midwest, and Southeast. Over Europe severe environments are the most common over the south with local maxima in northern Italy. Despite having lower CAPE (tail distribution of 3000–4000 J kg−1 compared to 6000–8000 J kg−1 over the United States), thunderstorms over Europe have a higher probability for convective initiation given a favorable environment. Conversely, the lowest probability for initiation is observed over the Great Plains, but, once a thunderstorm develops, the probability that it will become severe is much higher compared to Europe. Prime conditions for severe thunderstorms over the United States are between April and June, typically from 1200 to 2200 central standard time (CST), while across Europe favorable environments are observed from June to August, usually between 1400 and 2100 UTC.

In this work, long-term trends in convective parameters are compared between ERA5, MERRA-2, and observed rawinsonde profiles over Europe and the United States including surrounding areas. A 39-yr record (1980–2018) with 2.07 million quality-controlled measurements from 84 stations at 0000 and 1200 UTC is used for the comparison, along with collocated reanalysis profiles. Overall, reanalyses provide signals that are similar to observations, but ERA5 features lower biases. Over Europe, agreement in the trend signal between rawinsondes and the reanalyses is better, particularly with respect to instability (lifted index), low-level moisture (mixing ratio), and 0–3-km lapse rates as compared with mixed trends in the United States. However, consistent signals for all three datasets and both domains are found for robust increases in convective inhibition (CIN), downdraft CAPE (DCAPE), and decreases in mean 0–4-km relative humidity. Despite differing trends between continents, the reanalyses capture well changes in 0–6-km wind shear and 1–3-km mean wind with modest increases in the United States and decreases in Europe. However, these changes are mostly insignificant. All datasets indicate consistent warming of almost the entire tropospheric profile, which over Europe is the fastest near ground whereas across the Great Plains it is generally between 2 and 3 km above ground level, thus contributing to increases in CIN. Results of this work show the importance of intercomparing trends between various datasets, as the limitations associated with one reanalysis or observations may lead to uncertainties and lower our confidence in how parameters are changing over time.