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The complex and interconnected infrastructure of smart cities offers several opportunities for attackers to exploit vulnerabilities and carry out cyberattacks that can have serious consequences for the functioning of cities’ critical infrastructures. This study aims to address this phenomenon and characterize the dimensions of security risks in smart cities and present mitigation proposals to address these risks. The study adopts a qualitative methodology through the identification of 62 European research projects in the field of cybersecurity in smart cities, which are underway during the period from 2022 to 2027. Compared to previous studies, this work provides a comprehensive view of security risks from the perspective of multiple universities, research centers, and companies participating in European projects. The findings of this study offer relevant scientific contributions by identifying 7 dimensions and 31 sub-dimensions of cybersecurity risks in smart cities and proposing 24 mitigation strategies to face these security challenges. Furthermore, this study explores emerging cybersecurity issues to which smart cities are exposed by the increasing proliferation of new technologies and standards.

This study aimed to explore the diversity of open-innovation practices that are adopted in Portuguese SMEs considering the outside-in, inside-out, and coupled paradigms. A quantitative study was carried out considering a sample of 187 Portuguese SMEs. The findings revealed that these organizations favored the adoption of the outside-in paradigm. The inside-out model was the least relevant, especially for smaller companies (i.e., small and micro-companies). The most adopted outside-in practices were the integration of external knowledge from suppliers and clients; in the inside-out model, licensing processes were more important; while in the coupled model, joint ventures and network consortiums stood out. The increase in the innovation capacity of these organizations was highlighted as the most relevant benefit, while the lack of resources and difficulties in integrating knowledge emerged as challenges. This study is especially relevant for the establishment of public-support policies that promote the involvement of Portuguese SMEs in open-innovation processes.

The coronavirus disease 2019 (COVID-19) pandemic has created strong pressure on national health critical care systems. After its initial impact in Asia, the highest case growth is now in the Americas. The South American countries face a strong challenge due to the vulnerabilities of their health systems and the fragile socio-economic conditions of their population. This perspective looks at the impact of COVID-19 in South America and argues that the health critical care systems of these countries are particularly vulnerable due to the underestimation of the number of cases currently confirmed and the strong need for treatment of these patients in intensive care units (ICUs). In particular, Bolivia will need to increase the number of ICU beds 60-fold while Brazil will need to grow 12-fold to meet the growth rates of COVID-19 by the end of July 2020. In this sense, it is argued that national and transnational measures should be taken urgently to face this challenge. Furthermore, it is necessary to perform tests to detect COVID-19 cases earlier to alleviate the need for internment in ICUs.

Southwestern Amazonia is considered an early centre of plant domestication in the New World, but most of the evidence for this hypothesis comes from genetic data since systematic archaeological fieldwork in the area is recent. This paper provides first-hand archaeobotanical evidence of food production from early and middle Holocene (ca. 9,000-5000 cal. BP) deposits at Teotonio, an open-air site located on a 40 m-high bluff on the south bank of the Madeira river. Such evidence includes the presence of local and exotic domesticates such as manioc (Manihot esculenta), squash (Cucurbita sp.) and beans (Phaseolus sp.), alongside edible fruits such as pequiá (Caryocar sp.) and guava (Psidium sp.) that point to the beginnings of landscape domestication. The results contribute to an ever-growing number of studies that posit southwest Amazonia as an important centre for early crop domestication and experimentation, and which highlight the longue-durée of human impacts on tropical forest biodiversity around the world.

The adoption of open innovation poses significant challenges that are important to explore. Studies in this field have mainly focused on exploring the causes of the failure of open innovation among large companies. This study addresses this research gap by employing a sample of 297 Portuguese small- and medium-sized enterprises (SMEs) to explore, through a quantitative study, whether the dimensions and causes of failure differ between large organizations and SMEs. A total of seven dimensions of causes of failure are considered, including strategy-related, organizational structure, organizational culture, knowledge and intellectual property management, management skill and action, resources, and interfirm collaboration. The findings reveal significant differences in four of these seven dimensions: the main causes of failure are related to the resources and management processes of open innovation in SMEs, while large companies face more challenges in the organizational structure and culture components. This study offers theoretical insights into the gaps in the literature to better understand the challenges facing open innovation. Furthermore, this study offers practical guidelines for SMEs to identify and mitigate these main obstacles, promoting better innovation management practices.

Sustainable initiatives play a crucial role in promoting digital health equity by addressing barriers to access and ensuring equitable use of digital health technologies and services. These initiatives may arise in various contexts, including local collaborative networks that emerge in the municipal context. This study aims to identify and characterize the municipal initiatives that have been developed in Portugal to promote digital health equity. It adopts a mixed methods approach to initially quantify the distribution of these projects in the Portuguese territory and, at a later stage, to understand the level of influence of these projects, considering their impact on individual, interpersonal, community, and societal levels. The findings identified 22 municipal sustainable initiatives and concluded that there is a strong relationship between the areas of community and individual influence. The results of this study are relevant to deepening the knowledge of bottom-up innovation in the digital health field and establishing public policies to increase the impact of these projects at the territorial level, the communities involved, and the social objectives addressed, contributing to greater social cohesion.

Complex rearrangement patterns and mitotic errors are hallmarks of most pancreatic ductal adenocarcinomas (PDAC), a disease with dismal prognosis despite some therapeutic advances in recent years. DNA double-strand breaks (DSB) bear the greatest risk of provoking genomic instability, and DNA damage repair (DDR) pathways are crucial in preserving genomic integrity following a plethora of damage types. Two major repair pathways dominate DSB repair for safeguarding the genome integrity: non-homologous end joining and homologous recombination (HR). Defective HR, but also alterations in other DDR pathways, such as BRCA1, BRCA2, ATM and PALB2, occur frequently in both inherited and sporadic PDAC. Personalised treatment of pancreatic cancer is still in its infancy and predictive biomarkers are lacking. DDR deficiency might render a PDAC vulnerable to a potential new therapeutic intervention that increases the DNA damage load beyond a tolerable threshold, as for example, induced by poly (ADP-ribose) polymerase inhibitors. The Pancreas Cancer Olaparib Ongoing (POLO) trial, in which olaparib as a maintenance treatment improved progression-free survival compared with placebo after platinum-based induction chemotherapy in patients with PDAC and germline BRCA1/2 mutations, raised great hopes of a substantially improved outcome for this patient subgroup. This review summarises the relationship between DDR and PDAC, the prevalence and characteristics of DNA repair mutations and options for the clinical management of patients with PDAC and DNA repair deficiency.

Digital transformation plays a significant role in modernizing and improving the efficiency of ports around the world. However, digitalization also brings a set of challenges that ports must face. They have to respond to several unique challenges because of the complexity of their operations and the varying demands of stakeholders. This study seeks to identify and summarize the challenges of digital transformation processes in ports. For this purpose, the World Ports Sustainability Program database was used. The findings revealed 74 digitalization initiatives carried out by ports, which makes it possible to recognize 7 dimensions and 32 sub-dimensions of challenges to the digital transformation process. Among the identified dimensions are port infrastructure, the interconnection between various systems, the port organization model, regulation, security and privacy, market evolution, and the establishment of partnerships to implement these projects. The results of this study are relevant to mitigate the risks of the digitalization process in ports and respond to market needs that demand greater transparency and visibility of their operations.

This article presents the results of a round-robin test performed by 13 international research groups in the framework of the activities of the RILEM Technical Committee 260 RSC “Recommendations for use of superabsorbent polymers in concrete construction”. Two commercially available superabsorbent polymers (SAP) with different chemical compositions and gradings were tested in terms of their kinetics of absorption in different media; demineralized water, cement filtrate solution with a particular cement distributed to every participant and a local cement chosen by the participant. Two absorption test methods were considered; the tea-bag method and the filtration method. The absorption capacity was evaluated as a function of time. The results showed correspondence in behaviour of the SAPs among all participants, but also between the two test methods, even though high scatter was observed at early minutes of testing after immersion. The tea-bag method proved to be more practical in terms of time dependent study, whereby the filtration method showed less variation in the absorption capacity after 24 h. However, absorption followed by intrinsic, ion-mediated desorption of a specific SAP sample in the course of time was not detected by the filtration method. This SAP-specific characteristic was only displayed by the tea-bag method. This demonstrates the practical applicability of both test methods, each one having their own strengths and weaknesses at distinct testing times.

Introduction and hypothesis There has been an increasing need for the terminology on the conservative management of female pelvic floor dysfunction to be collated in a clinically based consensus report. Methods This Report combines the input of members and elected nominees of the Standardization and Terminology Committees of two International Organizations, the International Urogynecological Association (IUGA) and the International Continence Society (ICS), assisted at intervals by many external referees. An extensive process of nine rounds of internal and external review was developed to exhaustively examine each definition, with decision-making by collective opinion (consensus). Before opening up for comments on the webpages of ICS and IUGA, five experts from physiotherapy, neurology, urology, urogynecology, and nursing were invited to comment on the paper. Results A Terminology Report on the conservative management of female pelvic floor dysfunction, encompassing over 200 separate definitions, has been developed. It is clinically based, with the most common symptoms, signs, assessments, diagnoses, and treatments defined. Clarity and ease of use have been key aims to make it interpretable by practitioners and trainees in all the different specialty groups involved in female pelvic floor dysfunction. Ongoing review is not only anticipated, but will be required to keep the document updated and as widely acceptable as possible. Conclusion A consensus-based terminology report for the conservative management of female pelvic floor dysfunction has been produced, aimed at being a significant aid to clinical practice and a stimulus for research.