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Synchronous primary malignant brain tumors are rare. We present a 5-year-old boy with synchronous glioblastoma and medulloblastoma. Both tumor samples had positive p53 stain and loss of PMS2 and MLH1 stains. The child had multiple café au lait spots and a significant family history of cancer. After subtotal resection of both tumors, he received craniospinal radiation with concomitant temozolomide followed by chemotherapy, alternating cycles of cisplatin/lomustine/vincristine with temozolomide. Then, he started maintenance treatment with cis-retinoic acid (100 mg/m 2 /day for 21 days). He remained asymptomatic for 34 months despite a follow-up brain MRI consistent with glioblastoma relapse 9 months before his death. Cis-retinoic acid may have contributed to prolong survival in this child with a probable biallelic mismatch repair syndrome.

The utilization of electrospinning method in drug delivery has been increasingly popular in recent years, with the ability to incorporate drugs and enhance dissolution; this technique is used to improve the dissolution of poorly water?soluble 6mercaptopurine and. 6-mercaptopurine and poly (vinyl pyrrolidone) solutions were spun using simple electrospinning technique. Loading efficiency and electrospinning yield were affected by polymer concentration during the optimization process, as well as nanofiber diameter. The concentration of polymer also affected both the number of beads formed and the amount of drug released. polymer (PVP) negatively affected the electros pun yield, but the loading efficiency and in vitro dissolution rate were largely controlled by the PVP content in the optimization formulas. In addition to reducing the diameter of the fibers, the increased polymer concentrations had a positive impact on reducing the number of beads. The physicochemical characterization of the prepared formulas indicate that the drug was found as a molecular dispersion within the polymer matrix or as an amorphous state. In vitro dissolution studies indicates about 68 ± 4.16 release in less than 2 minutes in HCL solution medium compared to a negligibledissolution of physical mixture and free drug. From the derived results, the electro spun 6- mercaptopurine?loaded nanofibers pave the way for enhance the dissolution for insoluble low bioavailability class II drugs.

As a result of its capacity to combine pharmaceuticals and enhance solubility, electrospinning has been increasingly popular in recent years. 6mercaptopurine, a drug that is notoriously difficult to dissolve in water,can now be more easily dissolved with this technique. 6-mercaptopurine/polyvinylpyrrolidone and polyethylene oxide solutions were spun using simple electrospinning