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Fossil fuel dependency in developed countries is worrisome due to the lack of energy security that traditional energy generation provides. In order to prevent future energy problems and to maintain a sustainable society, some countries are starting to develop renewable energy sources. In this research, biomass energy is introduced as a solution not only to reduce fossil fuel dependency, but also to improve municipal solid waste management. The purpose of this report is to construct a distributed power generation system combining the superheated steam gasification of solid waste and photovoltaic panels, and to verify the feasibility of generating power at the consumption site. It also focuses on optimizing the current waste superheated steam gasification system and compares the superheated steam gasification technology with other waste to energy technologies, such as downdraft air gasification and solid waste direct combustion. Finally, the report analyzes the economic, environmental and energetic viability of the above mentioned distributed generation system, which is located in a medium size mall surrounded by a community of 20,000 inhabitants. As a result, it was found that a distributed generation system composed by waste superheated steam gasification and photovoltaic panels is perfectly feasible, since its long term economic performance shows high profitability.

Background The French PRODIGE 7 trial, published on January 2021, has raised doubts about the specific survival benefit provided by HIPEC with oxaliplatin 460 mg/m 2 (30 minutes) for the treatment of peritoneal metastases from colorectal cancer. However, several methodological flaws have been identified in PRODIGE 7, specially the HIPEC protocol or the choice of overall survival as the main endpoint, so its results have not been assumed as definitive, emphasizing the need for further research on HIPEC. It seems that the HIPEC protocol with high-dose mytomicin-C (35 mg/m 2 ) is the preferred regime to evaluate in future clinical studies. Methods GECOP-MMC is a prospective, open-label, randomized, multicenter phase IV clinical trial that aims to evaluate the effectiveness of HIPEC with high-dose mytomicin-C in preventing the development of peritoneal recurrence in patients with limited peritoneal metastasis from colon cancer (not rectal), after complete surgical cytoreduction. This study will be performed in 31 Spanish HIPEC centres, starting in March 2022. Additional international recruiting centres are under consideration. Two hundred sixteen patients with PCI ≤ 20, in which complete cytoreduction (CCS 0) has been obtained, will be randomized intraoperatively to arm 1 (with HIPEC) or arm 2 (without HIPEC). We will stratified randomization by surgical PCI (1–10; 11–15; 16–20). Patients in both arms will be treated with personalized systemic chemotherapy. Primary endpoint is peritoneal recurrence-free survival at 3 years. An ancillary study will evaluate the correlation between surgical and pathological PCI, comparing their respective prognostic values. Discussion HIPEC with high-dose mytomicin-C, in patients with limited (PCI ≤ 20) and completely resected (CCS 0) peritoneal metastases, is assumed to reduce the expected risk of peritoneal recurrence from 50 to 30% at 3 years. Trial registration EudraCT number: 2019–004679-37; Clinicaltrials.gov: NCT05250648 (registration date 02/22/2022, ).

Germline inactivating mutations in BRCA1 and BRCA2 genes are responsible for Hereditary Breast and Ovarian Cancer Syndrome (HBOCS). Genetic testing of these genes is available, although approximately 15% of tests identify variants of uncertain significance (VUS). Classification of these variants into pathogenic or non-pathogenic type is an important challenge in genetic diagnosis and counseling. The aim of the present study is to functionally assess a set of 7 missense VUS (Q1409L, S1473P, E1586G, R1589H, Y1703S, W1718L and G1770V) located in the C-terminal region of BRCA1 by combining in silico prediction tools and structural analysis with a transcription activation (TA) assay. The in silico prediction programs gave discrepant results making its interpretation difficult. Structural analysis of the three variants located in the BRCT domains (Y1703S, W1718L and G1770V) reveals significant alterations of BRCT structure. The TA assay shows that variants Y1703S, W1718L and G1770V dramatically compromise the transcriptional activity of BRCA1, while variants Q1409L, S1473P, E1586G and R1589H behave like wild-type BRCA1. In conclusion, our results suggest that variants Y1703S, W1718L and G1770V can be classified as likely pathogenic BRCA1 mutations.

Los temas que giran en torno a la publicidad han generado gran interés, tanto por los efectos persuasivos de la misma, como por la influencia sobre el comportamiento de los individuos a la que va dirigida. Desde sus orígenes nos encontramos diversas controversias, que  motivan investigaciones sobre la publicidad y su percepción e interpretación por parte del público. En este trabajo se pretende analizar la publicidad del alcohol, en la revista Muy Interesante, por una muestra de estudiantes de las Universidades Públicas de la Provincia de Alicante. La muestra se compone de 380 inserciones de 51 marcas de bebidas alcohólicas diferentes. Nuestro propósito es doble; 1. Describir los contenidos de los mensajes publicitarios localizados; 2. Identificar los valores subyacentes en la publicidad de alcohol. El análisis fue realizado por dos grupos de informantes claves: uno compuesto por siete estudiantes universitarios de diferentes titulaciones y sexo, y otro integrado por siete expertos de distintas áreas relacionadas con el objeto de estudio. La recogida de información se realizó a través de un cuestionario estructurado.

The topics concerning advertising arise great interest because of the persuasive effects of publicity but also for its influence on the behaviour of the individuals to whom it is directed. From the beginning we found several controversies, which motivate research on advertising and its perception and interpretation on the part of the public. In this work we aim at analyzing the advertising of alcohol, in Muy Interesante magazine, taking as a sample students from State Universities in the Province of Alicante. The sample consists of 380 insertions of 51 brands of different alcoholic drinks. Our intention is double; 1. To describe the contents of the spotted advertising messages; 2. To identify the underlying values in the advertising of alcohol. The analysis was performed by two groups of key reporters: one consisted off seven university students from different qualifications and sex, and another one integrated by seven experts of different areas related to the main goals of this study.. The gathering of information was done through a structured questionnaire. [PUBLICATION ABSTRACT]