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"Amado, Elisa"
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The menino : a story based on real events
\"When the new baby arrives, both the baby and the parents are in for a steep learning curve. In this book, born out of personal experience, internationally renowned author/illustrator Isol brings us a dual narrative and guide. For babies, there's a rich range of images of babies and all their functions to look at. From crying, to nursing, to peeing and pooing, to looking, to hearing, to deciding that this weird new world they've entered is worth staying in (because they finally recognize that in every grown-up they see there is a former baby), there are hours of fun and amusement, since babies love nothing better than looking at and talking about themselves. For parents, this is a wonderful exploration of the new world this stranger-baby brings with him or her. Amusingly written, the text presents in a humorous, wry way all the facets of the new baby's reality. A great gift for new parents both before and after baby is born.\"--Amazon website.
Book
Cousins
The Guatemalan author and Nicaraguan illustrator, both of whom now live in Toronto, have produced a book that reflects their dual backgrounds of Latin America and North America. The young (unnamed) girl in this story lives with her grandmother and father in a quiet, comfortable home with many books. After school, she visits her other grandmother in her noisy, bustling house that overflows with her Latin American relatives, including cousin Mariana. She is very taken with the religious artefacts on display there, especially the baby Jesus statue and the moonstone rosary, and is jealous that Mariana, who is Catholic, is about to take her first communion. Inexplicably, she steals the rosary, but her guilt weighs more than the moonstones and drives her to confess to a Catholic priest.
Magazine Article
Beautiful Griselda
Princess Griselda's vanity becomes her undoing as her beauty is so great that it causes men's heads to fall off at the sight of her.
Book
No
A young bear isn't interested in the idea of hibernating for the winter, despite his mother's warnings about the cold, wind, and snow.
Book
Petit, the monster
Petit wonders how he can be both a good boy who takes care of his toys and a bad boy who doesn't like to share his toys.
Book
Mapping PTBP2 binding in human brain identifies SYNGAP1 as a target for therapeutic splice switching
Alternative splicing of neuronal genes is controlled partly by the coordinated action of polypyrimidine tract binding proteins (PTBPs). While PTBP1 is ubiquitously expressed, PTBP2 is predominantly neuronal. Here, we define the PTBP2 footprint in the human transcriptome using brain tissue and human induced pluripotent stem cell-derived neurons (iPSC-neurons). We map PTBP2 binding sites, characterize PTBP2-dependent alternative splicing events, and identify novel PTBP2 targets including
SYNGAP1
, a synaptic gene whose loss-of-function leads to a complex neurodevelopmental disorder. We find that PTBP2 binding to
SYNGAP1
mRNA promotes alternative splicing and nonsense-mediated decay, and that antisense oligonucleotides (ASOs) that disrupt PTBP binding redirect splicing and increase
SYNGAP1
mRNA and protein expression. In
SYNGAP1
haploinsufficient iPSC-neurons generated from two patients, we show that PTBP2-targeting ASOs partially restore
SYNGAP1
expression. Our data comprehensively map PTBP2-dependent alternative splicing in human neurons and cerebral cortex, guiding development of novel therapeutic tools to benefit neurodevelopmental disorders.
Dawicki-McKenna and Felix et al comprehensively map binding and alternative splicing by PTBP2 in human brain and neurons, thus identifying splice switching therapeutic strategies for the neurodevelopmental disorder associated gene SYNGAP1.
Journal Article
Doggy slippers : poems
A collection of poems about pets inspired by children who sent the author humorous anecdotes about their pets.
Book
Beta-Lactam Antibiotic Concentrations and the Acquisition of Multi-Drug Resistant Bacteria in Critically Ill Patients
Antimicrobial resistance (AMR) is a worldwide healthcare emergency. Whether insufficient beta-lactam antibiotic concentrations can be associated with AMR emergence remains controversial. This is a retrospective single-center cohort study including patients admitted to the intensive care unit of a tertiary university hospital from 2009 to 2014, who required a broad-spectrum beta-lactam antibiotic and had at least one therapeutic drug monitoring (TDM). Patients were categorized as having inadequate drug levels if the trough concentration (Cmin) fell below the clinical breakpoint for Pseudomonas aeruginosa. AMR was defined according to breakpoints recommended by the European Committee on Antimicrobial Susceptibility Testing (EUCAST) using the disk diffusion method. A total of 444 patients (male sex, n = 313, 71%; female sex, n = 131, 29%; mean age 58 ± 15 years) were enrolled in the study. Patients received piperacillin/tazobactam (n = 168), ceftazidime/cefepime (n = 58) or meropenem (n = 218); among them, 65 (15%) had insufficient drug levels. Nine of these 65 (13.8%) patients with insufficient antibiotic levels acquired at least one pathogen with AMR within 15 days of TDM, when compared to 84/379 (22%) in the other group (OR 0.56 [95%CI 0.27–1.19]; p = 0.13). In a multivariable competing-risk analysis including male gender, APACHE score on admission, previous colonization by other MDR bacteria, urinary catheter, central venous catheter, mechanical ventilation, previous hospitalization and previous surgery, insufficient antibiotic levels were not associated with AMR acquisition (sHR 0.84 [95% CI 0.42–1.68]). Similar results were found when a higher threshold was used to define insufficient drug levels (Cmin < 4 times the clinical breakpoint). In conclusion, insufficient beta-lactam levels were not independently associated with AMR acquisition. Future prospective studies are needed to evaluate better the relationship between low drug levels and antibiotic resistance acquisition.
Journal Article