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Marine plants are emerging as versatile resources for bioactive compounds with antioxidant, antibacterial, anti-inflammatory, and anticancer properties. Beyond their therapeutic potential, marine extracts offer agronomic and industrial value as biostimulants, natural pigments, biodegradable packaging materials, and green corrosion inhibitors, and serve as reducing agents in the synthesis of biomedical nanoparticles. This review integrates evidence from 256 studies (2011–2025), revealing rapid growth in the field over the past two years. The findings highlight the capacity of marine extracts to enhance crop and livestock productivity, yield stable natural dyes, create smart polysaccharide-based films, and protect metals via phenolic and sulfated polysaccharide fractions. Nanoparticles synthesized from these extracts exhibit improved biological performance. By linking agricultural, industrial, and biomedical perspectives, this work underscores the multifaceted potential of marine plant extracts and outlines future priorities in molecular characterization, strain development, and scalable green processing.

In recent years, the supercritical CO2 extraction method has gained attention due to its use of environmentally friendly, non-toxic solvents, ability to operate at lower temperatures that do not cause the degradation of bioactive compounds, and capacity for rapid extraction. This method is particularly notable for isolating bioactive compounds from plants. The extracts obtained have shown superior properties due to their activity against diseases such as cancer, which is one of the leading causes of death worldwide. The aim of this study is to provide an in-depth understanding of the supercritical CO2 extraction method, as well as to discuss its advantages and disadvantages. Furthermore, the study includes specific data on various plant materials, detailing the following parameters: plant name and region, bioactive compounds or compound classes, extraction temperature (°C), pressure (bar), time (minutes), co-solvent used, and flow rate. Additionally, this study covers extensive research on the isolation of bioactive compounds and the efficacy of the obtained extracts against cancer.

In this study, Rheum tataricum L. extracts were obtained using various green extraction techniques, including supercritical CO 2 , subcritical ethanol, and ultrasound-assisted extraction, each performed under optimized parameters. The phytochemical content of the extracts was analyzed using the LC-MS/MS technique, quantifying 53 phytochemicals. Additionally, the in vitro antioxidant properties and antibacterial activities of the extracts were evaluated against Staphylococcus aureus and Enterococcus faecalis as gram-positive bacteria, and Escherichia coli and Pseudomonas aerugino sa as gram-negative bacteria. According to the results, the extracts were rich in catechin, epicatechin, cyranoside, and chlorogenic acid. Extracts obtained via ultrasonic extraction demonstrated stronger antioxidant properties. The IC 50 values for the DPPH radical scavenging activity of obtained extracts ranged between 0.0173 mg/mL and 0.0400 mg/mL. The highest total phenolic content was found in the UAE-M-4h extract (213.44 mg GAE/mL). The extracts prepared with UAE-MeOH-2h-4h, UAE-EtOH-2h-4h, Sbc-EtOH-E-140-60-80, Sc-90 atm, and Sc-400 atm showed antibacterial activity against both Gram-positive and Gram-negative bacteria at varying rates (MIC range: 31.25 to 250 μg/mL). Based on the all results, the ultrasound assisted extraction proved superior to the other techniques. This study, utilizing three different extraction methods with varying variables such as temperature, pressure, and extraction time, has provided significant insights into which extraction method should be employed for isolating specific phytochemicals or for therapeutic purposes, based on the differing antibacterial results observed. The findings highlight the importance of selecting the appropriate extraction method depending on the target phytochemical or desired antibacterial effect in treatment applications.

Rheum cordatum Losinsk is a plant species distributed in Kazakhstan but remains relatively understudied despite its promising biological potential. The present study aimed to explore leaf extracts of R. cordatum by utilizing advanced green extraction technologies including supercritical CO2 (ScCO2), subcritical ethanol (Sc) and ultrasound-assisted extraction (UAE) to characterize their phytochemical composition and evaluate their antioxidant and antimicrobial activities. A total of 53 phytochemical compounds were identified, with gallic acid (30.71 µg/mg UAE-EtOH-4h), rutin (21.93 µg/mg ScCO2-150) and hesperidin (14.98 µg/mg ScCO2-150) being notably abundant. Among the tested extracts, ScCO2 extraction at 150 bar (ScCO2-150) demonstrated the highest antioxidant activity, exhibiting IC50 values of 0.0132 mg/mL (DPPH) and 0.0462 mg/mL (ABTS), coupled with the highest total phenolic content (140 mg GAE/g). Moreover, the ScCO2-150 extract showed pronounced antimicrobial efficacy, particularly against Bacillus subtilis Pseudomonas aeruginosa and Staphylococcus aureus, with minimum inhibitory concentrations (MIC) ranging from 125 to 250 µg/mL. These findings highlight the considerable potential of R. cordatum leaves as a valuable, abundant and sustainable source of natural antioxidants and antimicrobial agents, with supercritical CO2 extraction presenting substantial advantages in selectively obtaining bioactive phytochemicals.

This study aimed to compare the efficiency of different green extraction methods for obtaining bioactive compounds from the roots of Rheum cordatum Losinsk and to evaluate their antioxidant and antimicrobial properties. The presence of some important phytochemicals in the extracts obtained using ultrasound-assisted extraction (UAE), subcritical ethanol extraction (Sbc-EtOH), and supercritical CO2 (ScCO2) extraction was determined by LC-MS/MS, and their antioxidant and antimicrobial properties were examined against Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, and Escherichia coli. The goal was to determine the optimal extraction conditions that maximize the yield of bioactive compounds while preserving their biological properties. Different pressures (100 bar and 400 bar) were tested in UAE extraction, different solvents and times were tested in Sbc-EtOH extraction, and different pressures were tested in ScCO2 extraction. Most of the 53 important phenolic compounds have been extracted using the ScCO2 extraction method, either exclusively or in the highest amounts. It has been observed that more and higher amounts of phenolic compounds were extracted at lower pressure. The highest antioxidant activity was exhibited by the ScCO2 extracts. Additionally, the ScCO2-100 extract obtained at 100 bar showed strong antimicrobial activity, with a minimum inhibitory concentration (MIC) ranging from 31.25 to 250 μg/mL. Gallic acid, epicatechin gallate, epigallocatechin gallate, and catechin were found in extracts. Additionally, molecular docking studies against the 1QWZ, 2ANQ, 3H77, and 6QXS proteins revealed that epicatechin exhibited docking scores of −6.127, −9.479, −5.836, and −7.067 kcal/mol, respectively.

Currently, during the period of intensive development of scientific production, it is important to obtain phytopreparations from sources of raw materials of plant origin. The biological diversity of plants is amazing. The study of the composition of aquatic plants rich in active substances of biotechnological significance is currently an urgent problem. Biologically active substances are involved in various regenerative reactions and metabolic processes in the organism, being part of enzymes. Alkaloids are important nitrogenous compounds found in the plant and are widely used in medicine. The aim of the present study was to identify alkaloid compounds from the composition of the aquatic plant Pistia stratiotes, grown in a model experiment in laboratory conditions by highly effective liquid chromatography and determine the molecular structure by nuclear magnetic resonance. In addition, based on the molecular structure of alkaloid compounds found in the aquatic plant Pistia stratiotes, a study of the properties of pharmaceutical activity was conducted on the pharmaceutical site POM (Petra/Osiris/Molinspiration). According to the results of the study, 4 types of identified alkaloids were identified by the IR, 1H, 13C-NMR method. They: 1-Aza-10-methoxy-4-methyl-2-oxo-1,2-dihydroanthracene-9-O-b-D-glucopyranoside, 4,6-dimethoxy-8-prenyloxyfuroquinoline, 4,7-dimethoxy-6 - (3’ - methyl-3’ - methoxy-2 ' - oxy) butyl-oxifuroquinoline , 4,7-dimethoxy-6 - (3’ - methyl-2’ - oxy-3 ' - chlorine)butyloxifuroquinoline. As a result of the analysis of the identified POM alkaloids (Petra/Osiris/Molinspiration), predictions of antitumor activity were made. The presence of a (NHd+--- Od-) moiety indicates a potential antitumor pharmacophore site. The challenge is to verify our hypothesis experimentally and to confront virtual POM data and real anticancer screening.

In this study, L. extracts were obtained using various green extraction techniques, including supercritical CO , subcritical ethanol, and ultrasound-assisted extraction, each performed under optimized parameters. The phytochemical content of the extracts was analyzed using the LC-MS/MS technique, quantifying 53 phytochemicals. Additionally, the antioxidant properties and antibacterial activities of the extracts were evaluated against and as gram-positive bacteria, and and sa as gram-negative bacteria. According to the results, the extracts were rich in catechin, epicatechin, cyranoside, and chlorogenic acid. Extracts obtained via ultrasonic extraction demonstrated stronger antioxidant properties. The IC values for the DPPH radical scavenging activity of obtained extracts ranged between 0.0173 mg/mL and 0.0400 mg/mL. The highest total phenolic content was found in the UAE-M-4h extract (213.44 mg GAE/mL). The extracts prepared with UAE-MeOH-2h-4h, UAE-EtOH-2h-4h, Sbc-EtOH-E-140-60-80, Sc-90 atm, and Sc-400 atm showed antibacterial activity against both Gram-positive and Gram-negative bacteria at varying rates (MIC range: 31.25 to 250 μg/mL). Based on the all results, the ultrasound assisted extraction proved superior to the other techniques. This study, utilizing three different extraction methods with varying variables such as temperature, pressure, and extraction time, has provided significant insights into which extraction method should be employed for isolating specific phytochemicals or for therapeutic purposes, based on the differing antibacterial results observed. The findings highlight the importance of selecting the appropriate extraction method depending on the target phytochemical or desired antibacterial effect in treatment applications.

In recent years, the supercritical CO extraction method has gained attention due to its use of environmentally friendly, non-toxic solvents, ability to operate at lower temperatures that do not cause the degradation of bioactive compounds, and capacity for rapid extraction. This method is particularly notable for isolating bioactive compounds from plants. The extracts obtained have shown superior properties due to their activity against diseases such as cancer, which is one of the leading causes of death worldwide. The aim of this study is to provide an in-depth understanding of the supercritical CO extraction method, as well as to discuss its advantages and disadvantages. Furthermore, the study includes specific data on various plant materials, detailing the following parameters: plant name and region, bioactive compounds or compound classes, extraction temperature (°C), pressure (bar), time (minutes), co-solvent used, and flow rate. Additionally, this study covers extensive research on the isolation of bioactive compounds and the efficacy of the obtained extracts against cancer.

Nutrients produce various secondary metabolites, including biologically active compounds such as antifungals. The composition of E. Crassipes aquatic plant contains biologically active substances. In this article, the composition of substances in E. Crassipes was identified using IR, 1H, and 13C-NMR methods. The identified substances were characterized for biological activity using the PASS online program. This was based on their molecular structure. As a result of the program, compounds showing activity against light, viruses, earwigs, and bacteria were developed. The program's scope included testing the substances' antimicrobial activity using agar diffusion assay in experiments. Substances were extracted from the aquatic plant via chromatography-mass spectrometry, and their activity against earwigs was examined. The study revealed efficacy against Candida albicans and Candida utilis earwigs.

Losinsk is a plant species distributed in Kazakhstan but remains relatively understudied despite its promising biological potential. The present study aimed to explore leaf extracts of by utilizing advanced green extraction technologies including supercritical CO (ScCO ), subcritical ethanol (Sc) and ultrasound-assisted extraction (UAE) to characterize their phytochemical composition and evaluate their antioxidant and antimicrobial activities. A total of 53 phytochemical compounds were identified, with gallic acid (30.71 µg/mg UAE-EtOH-4h), rutin (21.93 µg/mg ScCO -150) and hesperidin (14.98 µg/mg ScCO -150) being notably abundant. Among the tested extracts, ScCO extraction at 150 bar (ScCO -150) demonstrated the highest antioxidant activity, exhibiting IC values of 0.0132 mg/mL (DPPH) and 0.0462 mg/mL (ABTS), coupled with the highest total phenolic content (140 mg GAE/g). Moreover, the ScCO -150 extract showed pronounced antimicrobial efficacy, particularly against and , with minimum inhibitory concentrations (MIC) ranging from 125 to 250 µg/mL. These findings highlight the considerable potential of leaves as a valuable, abundant and sustainable source of natural antioxidants and antimicrobial agents, with supercritical CO extraction presenting substantial advantages in selectively obtaining bioactive phytochemicals.