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"Anderson, Ann"
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Aesthetic Aerogel Window Design for Sustainable Buildings
Transport of heat through windows accounts for more than 25% of heating and cooling losses in residential buildings. Silica-based aerogels are translucent with extremely low thermal conductivity, which make them attractive for incorporation into the interspaces of glazing units. Widespread incorporation of monolithic-silica-aerogel-based windows could result in significant energy savings associated with the heating and cooling of buildings. However, monolithic silica aerogels do not have the optical clarity of vision glass, due to light scattering by the solid matrix, and often have surface imperfections, both of which render these materials less appealing for glazing applications. Here, we demonstrate a variety of approaches to preparing aesthetically pleasing monolithic silica aerogel by a rapid supercritical extraction method for incorporation into glazing units, including: (1) process improvements that result in monoliths with higher visible light transmission; (2) innovative mold design for the preparation of uniform aerogel monoliths; (3) glazing designs that use thinner monoliths; and (4) the incorporation of artistic effects using dyes and laser etching to prepare glazing units with mosaic- or stained-glass-like patterns in which surface imperfections are perceived as features of the design rather than flaws.
Journal Article
The impact of iron supplementation on the preterm neonatal gut microbiome: A pilot study
The gastrointestinal microbiome in preterm infants exhibits significant influence on optimal outcomes-with dysbiosis shown to substantially increase the risk of the life-threatening necrotizing enterocolitis. Iron is a vital nutrient especially during the perinatal window of rapid hemoglobin production, tissue growth, and foundational neurodevelopment. However, excess colonic iron exhibits potent oxidation capacity and alters the gut microbiome-potentially facilitating the proliferation of pathological bacterial strains. Breastfed preterm infants routinely receive iron supplementation starting 14 days after delivery and are highly vulnerable to morbidities associated with gastrointestinal dysbiosis. Therefore, we set out to determine if routine iron supplementation alters the preterm gut microbiome.
After IRB approval, we collected stool specimens from 14 infants born <34 weeks gestation in the first, second, and fourth week of life to assess gut microbiome composition via 16S rRNA sequencing.
We observed no significant differences in either phyla or key genera relative abundance between pre- and post-iron timepoints. We observed notable shifts in infant microbiome composition based on season of delivery.
Though no obvious indication of iron-induced dysbiosis was observed in this unique study in the setting of prematurity, further investigation in a larger sample is warranted to fully understand iron's impact on the gastrointestinal milieu.
Journal Article
Africa and World War II
\"This volume considers the military, economic, and political significance of Africa during World War II\"--First page of book.
Book
Understanding influenza vaccination attitudes and behaviors: An assessment of health decision-making preferences
Less than half of American adults comply with annual influenza vaccination recommendations. Stagnating flu vaccination rates suggest new approaches, particularly ones using theory-based approaches, are needed to better understand influenza vaccination beliefs, behaviors, and intentions. Health decision-making preferences are an important consideration rarely accounted for in understanding vaccination behavior and thus may provide further insight into stagnating vaccination rates. Building on the work of Groopman and Hartzband (2012), this study considers health decision-making preferences as a determinant of vaccination attitudes and behavior and introduces an instrument for measuring them. We constructed a measure of health decision-making preferences using population representative surveys of U.S. adults 18 years old and older, drawn from the National Opinion Research Center's (NORC) AmeriSpeak® Panel. We used ordinary least squares (OLS) regression to determine the relative explanatory power of health decision-making preferences in predicting vaccine confidence, vaccine hesitancy, recent vaccination behavior and future vaccination intention. In an initial assessment, our health decision-making preferences measure was significantly correlated with measures of vaccine confidence and vaccine hesitancy, prior flu vaccination and flu vaccination intentions.
•Using health survey data, we operationalized the “Medical Mind” concept for application to vaccination.•There is a positive relationship between the health decision-making preference measure and support of influenza vaccines.•Higher health decision-making preference scores are positively correlated with past and future vaccination behavior.•Health decision-making preferences hold significant value for advancing our understanding of adults' influenza vaccination.
Journal Article
Business skills all-in-one
There are some things that will never go out of style, and good business skills are one of them. With the help of this informative book, youll learn how to wear multiple hats in the workplace no matter what comes your waywithout ever breaking a sweat.Compiled from eight of the best Dummies books on business skills topics, Business Skills All-in-One For Dummies offers everything you need to hone your abilities and translate them into a bigger paycheck. Whether youre tasked with marketing or accounting responsibilitiesor anything in betweenthis all-encompassing reference makes it easier than ever to tackle your job with confidence.
Book
Elevated Blood Pressure in Newborns From Hypertensive Disorders of Pregnancy During the Immediate Postnatal Period
Hypertensive disorders of pregnancy (HDP) impact up to 22% of pregnancies. Offspring from HDP, face an increased risk of future cardiovascular disease, with elevated blood pressure reported as early as childhood. Additionally, primary vascular endothelial cells derived from HDP demonstrate dysfunction in vitro. These data suggest that HDP affect fetal development in ways that impair long‐term vascular function, supporting the developmental origins of health and disease (DOHaD) theory that health risks begin before birth. However, it remains unclear at what point these physiological changes first emerge and can be detected systemically. To assess whether changes in cardiovascular function can be detected in the immediate post‐natal period, we conducted a retrospective analysis of 1655 maternal–infant dyads delivered between the years 2012 and 2025. Using inverse probability weighted regression adjustment, we assessed associations between HDP and newborn heart rate (HR) and blood pressure (BP). Gestational hypertension (GH) and preeclampsia (PE) were associated with higher newborn mean arterial (+2.1 mmHg, p = 0.02; +2.9 mmHg, p = 0.04) and diastolic BP (+2.0 mmHg, p = 0.02; +2.6 mmHg, p = 0.04) compared to normotension (NT). GH was also associated with increased newborn systolic blood pressure (+2.3 mmHg, p = 0.04) and increased variability of newborn HR and diastolic BP (+1 bpm, p = 0.009; +1.4 mmHg, p = 0.001) compared to normotension. These findings suggest that subtle but measurable newborn cardiovascular alterations associated with GH and PE are present at birth. While the mechanisms remain to be elucidated, these early alterations provide additional temporal insight into the DOHaD in HDP and may reflect underlying vascular dysfunction.
Journal Article
Womens work
Womens work was a magazine edited by Alison Knowles and Annea Lockwood that featured text-based and instructional performance scores by twenty-five women artists. In the original publication of Issue 1, Nye Ffarrabas appeared as Bici Forbes and Annea Lockwood appeared as Anna Lockwood. In the original publication of Issue 2, Ann Noël appeared as Ann Williams.
Book
The manipulation of apoptosis for cancer therapy using BH3-mimetic drugs
Apoptosis is a form of programmed cell death that is regulated by the balance between prosurvival and proapoptotic BCL-2 protein family members. Evasion of apoptosis is a hallmark of cancer that arises when this balance is tipped in favour of survival. One form of anticancer therapeutic, termed ‘BH3-mimetic drugs’, has been developed to directly activate the apoptosis machinery in malignant cells. These drugs bind to and inhibit specific prosurvival BCL-2 family proteins, thereby mimicking their interaction with the BH3 domains of proapoptotic BCL-2 family proteins. The BCL-2-specific inhibitor venetoclax is approved by the US Food and Drug Administration and many regulatory authorities worldwide for the treatment of chronic lymphocytic leukaemia and acute myeloid leukaemia. BH3-mimetic drugs targeting other BCL-2 prosurvival proteins have been tested in preclinical models of cancer, and drugs targeting MCL-1 or BCL-XL have advanced into phase I clinical trials for certain cancers. As with all therapeutics, efficacy and tolerability need to be carefully balanced to achieve a therapeutic window whereby there is significant anticancer activity with an acceptable safety profile. In this Review, we outline the current state of BH3-mimetic drugs targeting various prosurvival BCL-2 family proteins and discuss emerging data regarding primary and acquired resistance to these agents and approaches that may overcome this. We highlight issues that need to be addressed to further advance the clinical application of BH3-mimetic drugs, both alone and in combination with additional anticancer agents (for example, standard chemotherapeutic drugs or inhibitors of oncogenic kinases), for improved responses in patients with cancer.BH3-mimetic drugs have been designed to directly induce apoptosis in cancer cells by targeting prosurvival BCL-2 family proteins. This Review discusses their continued development and the challenges arising from their implementation in the clinic, such as resistance or on-target toxic effects, and the approaches that could be harnessed to overcome these obstacles.
Journal Article