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"Andrei, C"
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Early-life adversity and cortisol response to social stress: a meta-analysis
Early-life adversity has been associated with a life-long increased risk for psychopathology and chronic health problems. These long-term negative effects have been explained through stress sensitization, which may involve dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis through either increased or decreased reactivity. The present meta-analysis assessed for the first time the effect of early-life adversity on cortisol response to social stress. Thirty data sets were included in the meta-analysis, in which early-life adversity and salivary cortisol response to social stress were assessed in 4292 individuals of different ages. Results indicated a moderate effect size (
g
= −0.39) in overall cortisol levels across studies. Separate analyses of cortisol at different stages of response showed large effect sizes at peak and recovery, and a moderate effect at baseline. Heterogeneity was large in this sample of studies and several moderators were identified. The effect size was larger in studies that focused on maltreatment compared to those that included other adversities, and in adults compared to children and adolescents. Percent of women in each sample and methodological quality were positive predictors of the effect size. Publication bias may be present, but the analysis was hampered by the high heterogeneity. Therefore, these results support the association between early-life adversity and blunted cortisol response to social stress, and they suggest that the long-term negative effects of early-life adversity may reach maximum levels in adults.
Journal Article
Dark Personality, Empathy, and Prosocial Behavior in Convicted Offenders
The complex interplay between social cognition (empathy and theory of mind), the dark core of personality, and prosociality in convicted offenders has not been thoroughly explored, yet it is deemed essential for predicting and reducing criminal behavior. We aimed to address this intersection in a sample of convicted offenders (
N
= 86), using the
EmpaToM
paradigm. The dark factor of personality was a negative predictor of helping behavior in the
EmpaToM
, self-reported prosociality, and self-reported empathy. It was also negatively related to
EmpaToM
empathy, especially its Callousness and Sadism dimensions. However, it was not significantly associated with self-reported or applied theory of mind abilities. The negative effect of the Dark Factor on the
EmpaToM
intention to help in emotionally negative situations was mediated by decreased empathy measured in the same task. Our results highlight the importance of considering the dark personality core together with social cognition in the development of prosocial behavior and, implicitly, in increasing the effectiveness of specifically targeted rehabilitation interventions. Also, the current findings offer preliminary evidence supporting the external and construct validity of a modified
EmpaToM
for a prison context.
Journal Article
Childhood maltreatment and emotion regulation in everyday life: an experience sampling study
Childhood maltreatment is a major risk factor for psychopathology, and increasing evidence suggests that emotion regulation is one of the underlying mechanisms. However, most of this evidence comes from single assessments of habitual emotion regulation, which may not overlap with spontaneous emotion regulation in daily life and which fail to account for within-individual variability in emotion regulation across multiple contexts. In the present study, we investigated the relation between history of childhood maltreatment, positive and negative affect, and multiple dimensions of spontaneous emotion regulation (strategy use, emotion regulation goals, emotion regulation success and effort) in everyday life, using experience sampling method (3 assessments/day, for 10 consecutive days), in a sample of healthy volunteers (N = 118). Multilevel modeling results indicated that childhood maltreatment was associated with lower positive affect and higher negative affect. Childhood maltreatment was also related to lower use of reappraisal and savoring (but not suppression, rumination and distraction), reduced emotion regulation success (but not effort), as well as lower levels of and higher within-individual variability of hedonic (but not instrumental) emotion regulation goals. These results provide ecological evidence for multiple differences in emotion regulation in individuals with a history of childhood maltreatment.
Journal Article
Cardiovascular effects of Glucagon-like peptide 1 (GLP-1) receptor agonists
Patients with type 2 diabetes have a several-fold increased risk of developing cardiovascular disease when compared with nondiabetic controls. Myocardial infarction and stroke are responsible for 75% of all death in patients with diabetes, who present a 2-4× increased incidence of death from coronary artery disease. Patients with diabetes are considered for cardiovascular disease secondary prevention because their risk level is similar to that reported in patients without diabetes who have already suffered a myocardial infarction. More recently, with a better risk factors control, mainly in intensive LDL cholesterol targets with statins, a significant decrease in acute cardiovascular events was observed in population with diabetes. Together with other major risk factors, type 2 diabetes must be considered as an important cause of cardiovascular disease.
Glucagon like peptide-1 receptor agonists represent a novel class of anti-hyperglycemic agents that have a cardiac-friendly profile, preserve neuronal cells and inhibit neuronal degeneration, an anti-inflammatory effect in liver protecting it against steatosis, increase insulin sensitivity, promote weight loss, and increase satiety or anorexia.
This review is intended to rationally compile the multifactorial cardiovascular effects of glucagon-like peptide-1 receptor agonists available for the treatment of patients with type 2 diabetes.
Journal Article
Post-Processing Techniques to Enhance the Quality of Metallic Parts Produced by Additive Manufacturing
Additive manufacturing (AM) processes can produce three-dimensional (3D) near-net-shape parts based on computer-aided design (CAD) models. Compared to traditional manufacturing processes, AM processes can generate parts with intricate geometries, operational flexibility and reduced manufacturing time, thus saving time and money. On the other hand, AM processes face complex issues, including poor surface finish, unwanted microstructure phases, defects, wear tracks, reduced corrosion resistance and reduced fatigue life. These problems prevent AM parts from real-time operational applications. Post-processing techniques, including laser shock peening, laser polishing, conventional machining methods and thermal processes, are usually applied to resolve these issues. These processes have proved their capability to enhance the surface characteristics and physical and mechanical properties. In this study, various post-processing techniques and their implementations have been compiled. The effect of post-processing techniques on additively manufactured parts has been discussed. It was found that laser shock peening (LSP) can cause severe strain rate generation, especially in thinner components. LSP can control the surface regularities and local grain refinement, thus elevating the hardness value. Laser polishing (LP) can reduce surface roughness up to 95% and increase hardness, collectively, compared to the as-built parts. Conventional machining processes enhance surface quality; however, their influence on hardness has not been proved yet. Thermal post-processing techniques are applied to eliminate porosity up to 99.99%, increase corrosion resistance, and finally, the mechanical properties’ elevation. For future perspectives, to prescribe a particular post-processing technique for specific defects, standardization is necessary. This study provides a detailed overview of the post-processing techniques applied to enhance the mechanical and physical properties of AM-ed parts. A particular method can be chosen based on one’s requirements.
Journal Article
Anger and emotion regulation strategies: a meta-analysis
The hypothesis that maladaptive emotion regulation plays a central role in anger problems has driven the development of cognitive-behavioral interventions for anger and has stimulated a wealth of studies. However, this work is heterogeneous, drawing on multiple theories from clinical psychology and affective science, and focusing on multiple dimensions of emotion regulation. In addition, previous findings have not always been consistent. The present meta-analysis aimed to characterize associations between anger and emotion regulation strategies (i.e., avoidance, acceptance, distraction, reappraisal, rumination, suppression). A systematic search was conducted, and 81 studies (115 effect sizes) were included in the analysis. The results indicated consistent positive associations between anger and avoidance, rumination, and suppression, and consistent negative associations between anger and acceptance, and reappraisal. The relation between anger and distraction could not be analyzed. Heterogeneity was large in all analyses, and multiple differences between studies, including type of anger, clinical status, criminal status, type of culture, study quality, and sample sex distribution, influenced the effect sizes. Overall, the present findings support the view that anger is consistently associated with the differential use of multiple emotion regulation strategies and suggest methodological improvements for future studies.
Journal Article
Metal Matrix Composites Synthesized by Laser-Melting Deposition: A Review
Metal matrix composites (MMCs) present extraordinary characteristics, including high wear resistance, excellent operational properties at elevated temperature, and better chemical inertness as compared to traditional alloys. These properties make them prospective candidates in the fields of aerospace, automotive, heavy goods vehicles, electrical, and biomedical industries. MMCs are challenging to process via traditional manufacturing techniques, requiring high cost and energy. The laser-melting deposition (LMD) has recently been used to manufacture MMCs via rapid prototyping, thus, solving these drawbacks. Besides the benefits mentioned above, the issues such as lower ultimate tensile strength, yield strength, weak bonding between matrix and reinforcements, and cracking are still prevalent in parts produced by LMD. In this article, a detailed analysis is made on the MMCs manufactured via LMD. An illustration is presented on the LMD working principle, its classification, and dependent and independent process parameters. Moreover, a brief comparison between the wire and powder-based LMDs has been summarized. Ex- and in-situ MMCs and their preparation techniques are discussed. Besides this, various matrices available for MMCs manufacturing, properties of MMCs after printing, possible complications and future research directions are reviewed and summarized.
Journal Article
3D Printing at Micro-Level: Laser-Induced Forward Transfer and Two-Photon Polymerization
Laser-induced forward transfer (LIFT) and two-photon polymerization (TPP) have proven their abilities to produce 3D complex microstructures at an extraordinary level of sophistication. Indeed, LIFT and TPP have supported the vision of providing a whole functional laboratory at a scale that can fit in the palm of a hand. This is only possible due to the developments in manufacturing at micro- and nano-scales. In a short time, LIFT and TPP have gained popularity, from being a microfabrication innovation utilized by laser experts to become a valuable instrument in the hands of researchers and technologists performing in various research and development areas, such as electronics, medicine, and micro-fluidics. In comparison with conventional micro-manufacturing methods, LIFT and TPP can produce exceptional 3D components. To gain benefits from LIFT and TPP, in-detail comprehension of the process and the manufactured parts’ mechanical–chemical characteristics is required. This review article discusses the 3D printing perspectives by LIFT and TPP. In the case of the LIFT technique, the principle, classification of derivative methods, the importance of flyer velocity and shock wave formation, printed materials, and their properties, as well as various applications, have been discussed. For TPP, involved mechanisms, the difference between TPP and single-photon polymerization, proximity effect, printing resolution, printed material properties, and different applications have been analyzed. Besides this, future research directions for the 3D printing community are reviewed and summarized.
Journal Article
Laser microtextured titanium implant surfaces reduce in vitro and in situ oral biofilm formation
Micro- or nano-topography can both provide antimicrobial properties and improve osseointegration of dental implant titanium surfaces. Laser treatment is one of the best surface microtexturing techniques. The aim of this study was to evaluate in vitro and in situ biofilm formation on a laser-treated titanium surface, comparing it with two conventional surfaces, machined and grit-blasted.
For the in vitro experiment, an oral microcosm biofilm model was developed on the surface of titanium disks and reference human enamel using a bioreactor for 48 h. For the in situ experiment, titanium implants with laser-treated, machined and grit-blasted surfaces were mounted on intraoral trays and worn by ten volunteers for 48 h. Biofilm formation was quantitatively evaluated, and surfaces were analyzed using confocal laser scanning microscopy, scanning electron microscopy and energy-dispersive X-ray spectroscopy.
Biofilm structures with a prevalence of viable cells covered most of the machined, grit-blasted and human enamel surfaces, whereas less dense biofilm structures with non-confluent microcolonies were observed on the laser-treated titanium. Laser-treated titanium showed the lowest biofilm formation, where microorganisms colonized the edges of the laser-created pits, with very few or no biofilm formation observed inside the pits.
The biofilm formation pattern observed was similar to that in the in vitro experiment. Confocal laser scanning microscopy showed complete coverage of the implant threads, with mostly viable cells in grit-blasted and machined specimens. Unexpectedly, laser-treated specimens showed few dead microbial cells colonizing the bottom of the threads, while an intense colonization was found on the threading sides.
This data suggests that laser-created microtopography can reduce biofilm formation, with a maximum effect when the surface is blasted orthogonally by the laser beam. In this sense the orientation of the laser beam seems to be relevant for the biological interaction with biofilms.
Journal Article