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Individuals with paraphilic interests in sexual violence or children may be more likely to sexually offend if they possess offense-supportive cognitions. These cognitions may develop in response to childhood adversity. However, this idea is largely based on research in men convicted of sexual offenses and may not generalize to non-incarcerated adults with paraphilic interests. In a sample of 178 adults screened for paraphilic interests in violence or children (from the general Czech population), we hypothesized that childhood sexual abuse and emotional neglect would be associated with offense-supportive cognitions about rape and child molestation. Participants came from a nationally representative sample of Czech adults and were selected if they self-reported high levels of sexual interest in violence and/or children. Participants completed an online survey with self-report measures of sexual orientation, offense-supportive cognitions (Bumby RAPE and MOLEST scales), and childhood sexual abuse and emotional neglect (Childhood Trauma Questionnaire). Controlling for gender, age, and sexual orientation, we found that both rape-supportive cognitions and child molestation-supportive cognitions were significantly associated with higher levels of childhood sexual abuse, but not emotional neglect. These findings indicate that childhood sexual abuse may lead to offense-supportive cognitions among men and women with paraphilia.

Rationale Disruption of auditory event-related evoked potentials (ERPs) P300 and mismatch negativity (MMN), electrophysiological markers of attentive and pre-attentive cognitive processing, is repeatedly described in psychosis and schizophrenia. Similar findings were observed in a glutamatergic model of psychosis, but the role of serotonergic 5-HT 2A receptors in information processing is less clear. Objectives We studied ERPs in a serotonergic model of psychosis, induced by psilocybin, a psychedelic with 5-HT 2A/C agonistic properties, in healthy volunteers. Methods Twenty subjects (10M/10F) were given 0.26 mg/kg of psilocybin orally in a placebo-controlled, double-blind, cross-over design. ERPs (P300, MMN) were registered during the peak of intoxication. Correlations between measured electrophysiological variables and psilocin serum levels and neuropsychological effects were also analyzed. Results Psilocybin induced robust psychedelic effects and psychotic-like symptoms, decreased P300 amplitude ( p  = 0.009) but did not affect the MMN. Psilocybin’s disruptive effect on P300 correlated with the intensity of the psychedelic state, which was dependent on the psilocin serum levels. We also observed a decrease in N100 amplitude ( p  = 0.039) in the P300 paradigm and a negative correlation between P300 and MMN amplitude ( p  = 0.014). Conclusions Even though pre-attentive cognition (MMN) was not affected, processing at the early perceptual level (N100) and in higher-order cognition (P300) was significantly disrupted by psilocybin. Our results have implications for the role of 5-HT 2A receptors in altered information processing in psychosis and schizophrenia.

In the last years, there has been a considerable increase of research into the neuroimaging correlates of inter-individual temperament and character variability-an endeavour for which the term 'personality neuroscience' was coined. Among other neuroimaging modalities and approaches, substantial work focuses on functional connectivity in resting state (rs-FC) functional magnetic resonance imaging data. In the current paper, we set out to independently query the questions asked in a highly cited study that reported a range of functional connectivity correlates of personality dimensions assessed by the widely used 'Big Five' Personality Inventory. Using a larger sample (84 subjects) and an equivalent data analysis pipeline, we obtained widely disagreeing results compared to the original study. Overall, the results were in line with the hypotheses of no relation between functional connectivity and personality, when more precise permutation-based multiple testing procedures were applied. The results demonstrate that as with other neuroimaging studies, great caution should be applied when interpreting the findings, among other reasons due to multiple testing problem involved at several levels in many neuroimaging studies. Of course, the current study results can not ultimately disprove the existence of some link between personality and brain's intrinsic functional architecture, but clearly shows that its form is very likely different and much more subtle and elusive than was previously reported.

The relationship between personality and brain activity has been an increasingly popular topic of neuroscientific research. However, the limitations of both personality measures and neuroimaging, as well as methodological issues, continue to pose challenges to its understanding. The naturalistic viewing condition has been shown to enhance individual differences and might, therefore, be of benefit to the endeavor. Here, we thus examine this relationship using naturalistic fMRI of 82 healthy subjects. We implemented a simple dimensionality reduction method to characterize brain activity by its 'typicality', assessed a range of personality traits using widely-used personality inventories, and tested the relationship between the two. We found that there is, indeed, a relationship between personality and the typicality of brain activity, which appears to be most consistently manifested by lower typicality in subjects with higher Neuroticism/Harm Avoidance. Our results highlight the usefulness of naturalistic viewing data for exploring the relationship between individual differences in personality and brain activity.Competing Interest StatementThe authors have declared no competing interest.Footnotes* Minor adjustments to wording for clarity; addition of an Appendix.* https://osf.io/795hb/

There are many reasons for utilising 3D animation and virtual reality in sexuality research. Apart from providing a mean with which to (re)experience certain situations there are four main advantages: a) bespoke animated stimuli can be created and customized, which is especially important when researching paraphilia and sexual preferences, b) stimulus production is less expensive and easier to produce compared to real world stimuli, c) virtual reality allows us to capture data such as physiological reasons to stimuli, that we would not be able to otherwise (without resorting to self-report measures which are especially problematic in this research domain), d) ethical, legal, and health and safety issues are less complex since neither physical nor psychological harm is caused to animated characters allowing for the safe presentation of stimuli involving vulnerable targets. The animation sub-group has been exploring so far several production quality levels and various animation procedures in a number of available software. The aim is to develop static as well as dynamic, interactive sexual stimuli for sexual diagnostic and therapeutic purposes. We are aware of number of ethical issues related to the use of virtual reality in proposed research are analysed in this chapter.