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Nail lacquers or nail paints may be defined as viscous or semi-liquid preparations that are intended for the decoration of the nails of the fingers and toes. Nail lacquers form the most commonly used the most popular type of manicure preparations. It can help our nails grow longer and stronger. It has become an essential step for many self-care routines. An attempt was made to prepare nail lacquer containing natural antifungal agent obtained from extract of pomegranate (Punica granatum) peel which are employed for the treatment of onychomycosis, a fungal infection of nail. This was expected to improve chemical efficacy and improve patient compliance. The film forming polymer, permeation enhancer and solvent, along with extract was optimized for component release, stability and convenience of application. The formulation was prepared by simple mixing and using magnetic stirrer which was analyzed for nonvolatile content, gloss, smoothness to flow, drying time, viscosity, adhesion, permeation studies and antifungal studies. Among all the formulations of nail lacquer prepared, F5 exhibited good nonvolatile content and zone of inhibition. Pomegranate peel extract nail lacquer can be used irrespective of the sex of patient for the treatment of onychomycosis.