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"Aparicio, Antonio"
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Social Entrepreneurship in Non-Profit and Profit Sectors : Theoretical and Empirical Perspectives
This volume examines the theoretical and empirical landscape of social entrepreneurship in both non-profit and profit sectors. It extends the traditional view of social entrepreneurship to include the environmental and institutional factors that affect the emergence of social entrepreneurship activities, such as formal laws, regulations, procedures and informal institutions. The editors aim to provide evidence and increased understanding of this growing phenomenon. Social Entrepreneurship is gaining recognition as a key element of economic and social development. It embraces a wide set of situations with a broad scope of activities in for-profit and non-profit organizations interested in social performance and/or in economically profitable performance, with an emphasis on achieving social aim. In the strict sense, social entrepreneurship corresponds to entrepreneurs whose main concern is to achieve social objectives rather than to obtain personal financial profits. However, there is still much to be learned about the dynamics and processes of social entrepreneurship. The current literature in the field has tended to focus on psychological experiences and personal characteristics, or on organizational perspectives such as resources, capabilities and leadership. This book intends to provide theoretical frameworks and empirical studies to this very new and broad field. Specifically, this book provides a collection of contemporary research in the following topics: How to create opportunity through social innovation How to detect entrepreneurial opportunity to meet social needs How to develop social entrepreneurship, while still seeking profits How to discover opportunities for different forms of social entrepreneurship Featuring contributions from around the world, this book is a valuable source for students, academics, researchers, policy makers, and professionals in the area of social entrepreneurship.
Book
In Vitro Bile Salt Hydrolase (BSH) Activity Screening of Different Probiotic Microorganisms
Bile salt hydrolase (BSH) activity in probiotic strains is usually correlated with the ability to lower serum cholesterol levels in hypercholesterolemic patients. The objective of this study was the evaluation of BSH in five probiotic strains of lactic acid bacteria (LAB) and a probiotic yeast. The activity was assessed using a qualitative direct plate test and a quantitative high-performance thin- layer chromatography assay. The six strains differed in their BSH substrate preference and activity. Lactobacillus plantarum DGIA1, a potentially probiotic strain isolated from a double cream cheese from Chiapas, Mexico, showed excellent deconjugation activities in the four tested bile acids (69, 100, 81, and 92% for sodium glycocholate, glycodeoxycholate, taurocholate, and taurodeoxycholate, respectively). In the case of the commercial probiotic yeast Saccharomyces boulardii, the deconjugation activities were good against sodium glycodeoxycholate, taurocholate, and taurodeoxycholate (100, 57, and 63%, respectively). These last two results are part of the novelty of the work. A weak deconjugative activity (5%) was observed in the case of sodium glycocholate. This is the first time that the BSH activity has been detected in this yeast.
Journal Article
Microwave-assisted extraction of functional compounds from plants: A Review
In recent decades, the scientific community has become interested in improving the extraction of bioactive compounds from plants through new extraction techniques. Microwave-assisted extraction (MAE) is an innovative and effective method to extract compounds from different plants of agronomic, medicinal, nutritional, or cosmetic interest. This technique is considered environmentally friendly, as it uses non-toxic solvents. In addition, its energy consumption is lower than conventional extraction techniques. Likewise, this extraction avoids the degradation of the compounds, making it a feasible method. For microwave extraction to be efficient, the following parameters must be considered: solvent characteristics, volume, exposure time, temperature, size and characteristics of plant material, power (MHz), and type of equipment. This review focuses on the interactions of various factors involved to achieve a successful extraction process. The optimization and importance of microwave extraction technology in the research of plant bioactive compounds are discussed in this review article.
Journal Article
Prebiotic Potential of Agave angustifolia Haw Fructans with Different Degrees of Polymerization
Inulin-type fructans are the most studied prebiotic compounds because of their broad range of health benefits. In particular, plants of the Agave genus are rich in fructans. Agave-derived fructans have a branched structure with both β-(2→1) and β-(2→6) linked fructosyl chains attached to the sucrose start unit with a degree of polymerization (DP) of up to 80 fructose units. The objective of this work was to assess the prebiotic potential of three Agave angustifolia Haw fructan fractions (AFF) with different degrees of polymerization. The three fructan fractions were extracted from the agave stem by lixiviation and then purified by ultrafiltration and ion exchange chromatography: AFF1, AFF2 and AFF3 with high (3–60 fructose units), medium (2–40) and low (2–22) DP, respectively. The fructan profile was determined with high-performance anion exchange chromatography with pulsed amperometric detection (HPAEC-PAD), which confirmed a branched fructan structure. Structural elucidation was performed by Fourier Transform Infra-Red Spectroscopy. The AFF spectrum shows characteristic fructan bands. The prebiotic effect of these fractions was assessed in vitro through fermentation by Bifidobacterium and Lactobacillus strains. Four growth patterns were observed. Some bacteria did not grow with any of the AFF, while other strains grew with only AFF3. Some bacteria grew according to the molecular weight of the AFF and some grew indistinctly with the three fructan fractions.
Journal Article
Regularizing effect in singular semilinear problems
We analyze how different relations in the lower order terms lead to the same regularizing effect on singular problems whose model is in Ω, u = 0 on ∂Ω, where Ω is a bounded open set of is a nonnegative function in L1(Ω) and g(x,s) is a Carathéodory function. In a framework where no solution is expected, we prove its existence (regularizing effect) whenever the datum f interacts conveniently either with the boundary of the domain or with the lower order term.
Journal Article
Intervals of bifurcation points for semilinear elliptic problems
In this article, we study the behavior of multiple continua of solutions to the semilinear elliptic problem
where
is a bounded open subset of
and
is a nonnegative continuous real function with multiple zeros. We analyze both the behavior of unbounded continua of solutions having norm between consecutive zeros of
, and the asymptotic behavior of the multiple unbounded continua in the case in which
has a countable infinite set of positive zeros. In both cases, we pay special attention to the multiplicity results they give rise to. For the model cases
and
with
, we show the surprising fact that there are some values of
for which every
is a bifurcation point (either from infinity or from zero) that is not a branching point.
Journal Article
The Hubble Space Telescope UV Legacy Survey of Galactic Globular Clusters. XXIII. Proper-motion Catalogs and Internal Kinematics
A number of studies based on the data collected by the Hubble Space Telescope (HST) GO-13297 program “HST Legacy Survey of Galactic Globular Clusters: Shedding UV Light on Their Populations and Formation” have investigated the photometric properties of a large sample of Galactic globular clusters and revolutionized our understanding of their stellar populations. In this paper, we expand upon previous studies by focusing our attention on the stellar clusters’ internal kinematics. We computed proper motions for stars in 56 globular clusters and one open cluster by combining the GO-13297 images with archival HST data. The astrophotometric catalogs released with this paper represent the most complete and homogeneous collection of proper motions of stars in the cores of stellar clusters to date, and expand the information provided by the current (and future) Gaia data releases to much fainter stars and into the crowded central regions. We also census the general kinematic properties of stellar clusters by computing the velocity dispersion and anisotropy radial profiles of their bright members. We study the dependence on concentration and relaxation time, and derive dynamical distances. Finally, we present an in-depth kinematic analysis of the globular cluster NGC 5904.
Journal Article
Anti-Inflammatory Activity of Different Agave Plants and the Compound Cantalasaponin-1
Species of the agave genus, such as Agave tequilana, Agave angustifolia and Agave americana are used in Mexican traditional medicine to treat inflammation-associated conditions. These plants’ leaves contain saponin compounds which show anti-inflammatory properties in different models. The goal of this investigation was to evaluate the anti-inflammatory capacity of these plants, identify which is the most active, and isolate the active compound by a bio-directed fractionation using the ear edema induced in mice with 12-O-tetradecanoylphorbol-13-acetate (TPA) technique. A dose of 6 mg/ear of acetone extract from the three agave species induced anti-inflammatory effects, however, the one from A. americana proved to be the most active. Different fractions of this species showed biological activity. Finally the F5 fraction at 2.0 mg/ear induced an inhibition of 85.6%. We identified one compound in this fraction as (25R)-5α-spirostan-3β,6α,23α-triol-3,6-di-O-β-D-glucopyranoside (cantalasaponin-1) through 1H- and 13C-NMR spectral analysis and two dimensional experiments like DEPT NMR, COSY, HSQC and HMBC. This steroidal glycoside showed a dose dependent effect of up to 90% of ear edema inhibition at the highest dose of 1.5 mg/ear.
Journal Article
The Effects of Agave Fructans in a Functional Food Consumed by Patients with Irritable Bowel Syndrome with Constipation: A Randomized, Double-Blind, Placebo-Controlled Trial
Irritable bowel syndrome displays three different subtypes: constipation (IBS-C), diarrhea (IBS-D), and mixed (IBS-M). Treatment with dietary fiber is used, with consideration given both to the chemical composition of the fiber and to the different subtypes of IBS. The IBS-D subtype is usually treated with a low-FODMAPs diet, whereas the IBS-C subtype suggests prebiotics and probiotics to promote microbiota restoration. The aim of this study was to assess the effects of employing agave fructans as the soluble fiber of a jelly (Gelyfun®gastro) containing 8 g per serving in the IBS-C group (n = 50), using a randomized, double-blind, time-limited trial for four weeks. We evaluated changes in the frequency and types of bowel movements through the Bristol scale, and the improvement of the condition was evaluated using quality of life (IBS-QOL) and anxiety–depression (HADS) scales. The main results were that the number of bowel movements increased by more than 80%, with at least one stool per day from fifteen days onwards, without a laxative effect for the group treated. Finally, the quality of life with the prebiotic jelly was significantly improved compared to the placebo in all specific domains, in addition to significantly reducing anxiety and depression.
Journal Article
Identification and Quantification of β-Sitosterol β-d-Glucoside of an Ethanolic Extract Obtained by Microwave-Assisted Extraction from Agave angustifolia Haw
β-sitosterol β-d-glucoside (BSSG) was extracted from “piña” of the Agave angustifolia Haw plant by microwave-assisted extraction (MAE) with a KOH solution such as a catalyst and a conventional maceration method to determine the best technique in terms of yield, extraction time, and recovery. The quantification and characterization of BSSG were done by high-performance thin layer chromatography (HPTLC), Fourier-transform infrared spectroscopy (FT-IR), and high-performance liquid chromatography−electrospray ionization−mass spectrometry (HPLC-ESI-MS). With an extraction time of 5 s by MAE, a higher amount of BSSG (124.76 mg of β-sitosterol β-d-glucoside/g dry weight of the extract) than those for MAE extraction times of 10 and 15 s (106.19 and 103.97 mg/g dry weight respectively) was shown. The quantification of BSSG in the extract obtained by 48 h of conventional maceration was about 4–5 times less (26.67 mg/g dry weight of the extract) than the yields reached by the MAE treatments. MAE achieved the highest amount of BSSG, in the shortest extraction time while preserving the integrity of the compound’s structure.
Journal Article