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The depletion of the ozone layer and climate change have increased exposure to ultraviolet (UV) radiation, driving the search for natural photoprotective agents. Marine macroalgae, particularly Gracilaria sp. (Rhodophyta) and Sargassum polyceratium (Ochrophyta), are rich in UV-absorbing bioactives, such as mycosporine-like amino acids (MAAs) and fucoxanthin, offering natural alternatives to synthetic sunscreens. This study aimed to develop and optimize a nanoemulsion incorporating both algal extracts, with MAAs and fucoxanthin strategically distributed in the aqueous and oil phases, respectively, to enhance synergistic broad-spectrum UV protection. MAAs were quantified in Gracilaria sp. using UHPLC-DAD, revealing 8.03 mg/g dry weight, primarily composed of shinorine and porphyra-334. Fucoxanthin was identified in S. polyceratium at 0.98 mg/g dry weight. A Box–Behnken design (BBD) was employed to optimize the nanoemulsion, targeting minimal droplet size and optimal ζ potential. The resulting formulation achieved a droplet size less than 100 nm and a ζ potential less than −25.0 mV. In vitro spectrophotometric analysis demonstrated significant photoprotective potential. The nanoemulsion containing only 375 ppm of algal extracts exhibited a UVA ratio of 1.25 and a critical wavelength of 379 nm, meeting the criteria for broad-spectrum protection and outperforming the commercial natural filter Helioguard®365. These results confirm the efficacy of combining red and brown algae extracts in a nanoemulsion platform to deliver sustainable, low-dose photoprotection. This work presents, for the first time, the incorporation of red and brown algae extracts into a single nanoemulsion system, representing a novel strategy to maximize the combined photoprotective potential of MAAs and fucoxanthin. Ultimately, this investigation contributes to the growing field of marine-derived sunscreens and supports the advancement of “blue beauty” innovations aligned with eco-conscious formulation principles.

The lips, due to their unique anatomical characteristics of a thin stratum corneum, the absence of sebaceous glands, and limited melanin content are particularly vulnerable to ultraviolet (UV) radiation, necessitating specialized photoprotective care. While facial sunscreens are widely available, the development of lip-specific sun protection products remains underexplored. This study aims to analyze technological trends and innovations in lip photoprotection by reviewing patents published between 2014 and 2024. A comprehensive patent search using the IPC code A61Q19 and the keywords “lip” and “sunscreen” identified 17 relevant patents across China, the United States, and Japan. The patents were examined for active ingredients, formulation strategies, and use of botanical or sustainable excipients. The findings revealed that patented formulations predominantly rely on well-established UV filters such as zinc oxide, titanium dioxide, octyl methoxycinnamate, and avobenzone, often combined with antioxidants like ferulic acid and rutin for enhanced efficacy. Lipid-based excipients were widely used to improve texture, hydration, and product stability. Although many formulations exhibit a conservative ingredient profile, the strategic combination of UV filters with natural antioxidants and moisturizing lipids demonstrates a multifunctional approach aimed at enhancing both protection and user experience.

Background: Polysaccharides such as carrageenans, extracted from red algae, are widely used in food and pharmaceutical industries due to their gelling, stabilizing, and emulsifying properties. However, the potential of carrageenan extracted from Hypnea musciformis, a red macroalga native to tropical coastal regions, remains underexplored, particularly in terms of its emulsifying properties. Objective: To evaluate the emulsifying potential of carrageenan extracted from H. musciformis by comparing the physicochemical stability of emulsions formulated with this biopolymer to those stabilized with sodium alginate (ALG), a widely used reference polysaccharide. Methods: Oil-in-water emulsions containing 20% sesame oil were elaborated using varying concentrations of carrageenan or ALG. Their physical stability was assessed through droplet size distribution, polydispersity index (PDI), zeta potential, surface tension, and visual inspection over 31 days of storage at room temperature. Results: Emulsions stabilized with carrageenan exhibited comparable droplet size, PDI, and surface tension values to those formulated with ALG, indicating similar emulsifying capacity. Notably, formulations containing 1% carrageenan demonstrated enhanced long-term physical stability. Zeta potential values remained consistently negative (−35 mV to −45 mV), suggesting electrostatic stabilization. Conclusion: Carrageenan extracted from Hypnea musciformis demonstrated effective emulsifying properties in 20% sesame oil emulsions, comparable to those of ALG. These findings support its potential as a natural emulsifier for food and cosmetic formulations, highlighting the relevance of exploring underutilized marine resources for biotechnological applications.

Introduction: Parkinson’s disease (PD) is mainly characterized by motor symptoms including muscle rigidity, resting tremor and bradykinesia. However, the management of the non-motor symptoms represent a relevant clinical challenger in PD. These non-motor symptoms include cognitive and sleep disturbance and there is evidence that cannabinoids may represent alternative and effective treatments for non-motor symptoms of PD.

Background/Objectives: The main contraceptive options for men are condoms, vasectomy and coitus interruptus. Clinical and preclinical trials are being conducted to develop a new male contraceptive (NMC), which can be either hormonal or non-hormonal. A patent landscape and literature review of clinical studies from the last 10 years were carried out to discuss clinical perspectives and sociocultural aspects related to the use of NMC. Methods: An integrative review of clinical aspects was conducted using eleven clinical trials, and a discussion of sociocultural aspects was conducted using thirteen articles. Results: Studies of non-hormonal contraceptives, particularly vaso-occlusive methods, are in more advanced clinical phases, demonstrating contraceptive potential and reversibility. In addition to clinical trials, efforts to develop NMC include addressing gender disparities and understanding masculinity. Alternative technologies and methods for contraception were identified as key to the development of NMC. Despite clinical and technological advances, there is a need to expand clinical studies on male contraceptives, involving larger samples, long-term follow-ups, and reversibility tests. There is a global social need that both men and women should have a wide variety of contraceptive options. Conclusions: This review emphasizes the importance of exploring new technologies for male contraceptives to expand options while optimizing the satisfaction and safety of these contraceptive options for the population.