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Brewer’s spent grain (BSG), the main by-product of the brewing industry, is a rich source of arabinoxylans (AXs) and hydroxycinnamic acids, particularly ferulic acid (FA), which contribute to its prebiotic potential. This study evaluates the prebiotic properties of residual solid from an enzymatically treated BSG, compared to the properties of BSG as a non-enzymatically hydrolyzed control. Although the residual solid exhibited total polyphenol (2581.96 ± 70.63 mg/100 g dry weight) and FA (180.84 ± 3.28 mg/100 g dry weight) contents comparable to those of the non-hydrolyzed control (2500.38 ± 284.20 and 179.59 ± 3.30 mg/100 g dry weight, respectively), the AX content was significantly higher (14,084.81 ± 185.72 mg/100 g), accompanied by a lower degree of feruloylation (12.84 ± 0.23 mg FA/g AX), higher antioxidant activity (64,825.35 ± 4011.24 μmol TE/100 g), and structural changes visualized by scanning electron microscopy. In addition, in vitro colonic fermentation showed a delayed butyrogenic profile, with increased butyrate production compared to the control (3.17 ± 1.44 mM). Microbiota analysis by fluorescence in situ hybridization (FISH) coupled with flow cytometry indicated an increase in butyrate-producing bacteria, including Faecalibacterium prausnitzii (+5.90) and Eubacterium rectale (+6.88). Growth of Bacteroides, Lactobacillus, and Bifidobacterium spp. was also promoted. Overall, these findings suggest that enzymatic processing of BSG can generate a residual solid with modified structural characteristics and potential prebiotic functionality, supporting its potential application as a fermentable flour ingredient in functional foods.

Epidermolysis bullosa (EB) is an inherited disorder characterised by skin fragility and the appearance of blisters and wounds. Patient wounds are often colonised or infected with bacteria, leading to impaired healing, pain and high risk of death by sepsis. Little is known about the impact of bacterial composition and susceptibility in wound resolution, and there is a need for longitudinal studies to understand healing outcomes with different types of bacterial colonisation. A prospective longitudinal study of 70 wounds from 15 severe EB patients (Junctional and Recessive Dystrophic EB) from Chile. Wounds were selected independently of their infected status. Wound cultures, including bacterial species identification, composition and Staphylococcus aureus (SA) antibiotic susceptibility were registered. Wounds were separated into categories according to their healing capacity, recognising chronic, and healing wounds. Hundred‐one of the 102 wound cultures were positive for bacterial growth. From these, 100 were SA‐positive; 31 were resistant to Ciprofloxacin (31%) and only seven were methicillin‐resistant SA (7%). Ciprofloxacin‐resistant SA was found significantly predominant in chronic wounds (**P < .01). Interestingly, atoxigenic Corynebacterium diphtheriae (CD) was identified and found to be the second most abundant recovered bacteria (31/101), present almost always in combination with SA (30/31). CD was only found in Recessive Dystrophic EB patients and not related to wound chronicity. Other less frequent bacterial species found included Pseudomonas aeruginosa, Streptococus spp. and Proteus spp. Infection was negatively associated with the healing status of wounds.

Resumen: La Escala Wechsler de Inteligencia para Niños - Quinta Edición es la más reciente actualización de estas escalas. Esta nueva edición fue lanzada el año 2014 en Estados Unidos y presenta mejoras relevantes respecto de versiones anteriores, como una estructura factorial actualizada que incluye un mayor número de indicadores, nuevos puntajes de proceso y nuevos procedimientos para la construcción de las normas. Estas mejoras son relevantes en el contexto nacional, puesto que la versión que estaba previamente disponible en Chile era WISC-IIIv.ch, cuya estructura factorial data del año 1991, aunque fue estandarizada el año 2007 para la población chilena. En este artículo se presenta el procedimiento de estandarización de WISC-V para la población chilena. Este procedimiento incluye la traducción, adaptación y construcción de normas. Se presenta evidencia de validez y confiabilidad, así como también los resultados de la aplicación del instrumento a muestras de grupos especiales, como discapacidad intelectual (24), trastorno de déficit atencional con hiperactividad (27), trastorno del espectro autista (26), trastorno específico del lenguaje (56) y población rural (47). Los resultados dan cuenta de excelentes resultados de confiabilidad, así como de un excelente ajuste al modelo factorial utilizado para la versión norteamericana. Por último, se presenta evidencia de validez convergente entre WISC-V y otras versiones de estas escalas de inteligencia, como WAIS-IV y WISC-IIIv.ch. También se presentan comparaciones de rendimiento entre los tres tipos de dependencia educativa existentes en Chile, así como también de comparaciones entre género. Los resultados de esta investigación dan cuenta que la estandarización chilena de WISC-V cuenta con excelentes características psicométricas que hacen recomendable su uso en el país.

The Wechsler Intelligence Scale for Children — Fifth Edition is the most recent update to this scale, launched originally in 2014 in the United Stated. WISC-V includes several improvements from previous versions, such as an updated factorial structure that includes more indexes, new process scores and new procedures for norming. These improvements are particularly relevant in the Chilean context, since the previous version available in the country was the WISC-IIIv.ch, whose factorial structure dates from 1991, although it was standardized for Chilean population in 2007. This article presents the standardization process for the WISC-V, which includes the translation, adaptation and norming procedures for the Chilean population. It includes evidence for reliability and validity, and also results for various special groups samples, such as intellectual disability (24), attentional deficit disorder with hyperactivity (27), autism spectrum disorder (26), specific language disorder (56) and rural population (47). The Chilean data shows excellent reliability results and an excellent adjustment to the factorial model used in the North American version. This research provides evidence for convergent validity between WISC-V and other versions of these scales, such as the WAIS-IV and the WISC-IIIv.ch. Finally, we perform a comparison between private, voucher and public schools using this scale and a comparison between male and female performance in this scale. The main finding of this research is that the Chilean standardization of the WISC-V has excellent psychometric properties that allow recommending the use of this instrument in the country.