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The unprecedented growth of the novel coronavirus (SARS-CoV-2) as a severe acute respiratory syndrome escalated to the coronavirus disease 2019 (COVID-19) pandemic. It has created an unanticipated global public health crisis that is spreading rapidly in India as well, posing a serious threat to 1350 million persons. Among the factors, population density is foremost in posing a challenge in controlling the COVID-19 contagion. In such extraordinary times, evidence-based knowledge is the prime requisite for pacifying the effect. In this piece, we have studied the district wise transmissions of the novel coronavirus in five south Indian states until 20th July 2020 and its relationship with their respective population density. The five states are purposefully selected for their records in better healthcare infrastructure vis-à-vis other states in India. The study uses Pearson’s correlation coefficient to account for the direct impact of population density on COVID-19 transmission rate. Response surface methodology approach is used to validate the correlation between density and transmission rate and spatiotemporal dynamics is highlighted using Thiessen polygon method. The analysis has found that COVID-19 transmission in four states (Kerala, Tamil Nadu, Karnataka and Telangana) strongly hinges upon the spatial distribution of population density. In addition, the results indicate that the long-term impacts of the COVID-19 crisis are likely to differ with demographic density. In conclusion, those at the helm of affairs must take cognizance of the vulnerability clusters together across districts.

Little genomic data is available for typhoid fever from island nations, though the disease has a moderately high burden there. Sikorski et al. (M. J. Sikorski, T. H. Hazen, S. N. Desai, S. Nimarota-Brown, et al., mBio 13:e01920-22, 2022, https://doi.org/10.1128/mbio.01920-22 ) studied 306 Salmonella enterica serovar Typhi genomes from the Samoan Islands collected during 1983 to 2020 and reported dominance of a rare genotype, 3.5.4, and no H58 (genotype 4.3.1). Little genomic data is available for typhoid fever from island nations, though the disease has a moderately high burden there. Sikorski et al. (M. J. Sikorski, T. H. Hazen, S. N. Desai, S. Nimarota-Brown, et al., mBio 13:e01920-22, 2022, https://doi.org/10.1128/mbio.01920-22 ) studied 306 Salmonella enterica serovar Typhi genomes from the Samoan Islands collected during 1983 to 2020 and reported dominance of a rare genotype, 3.5.4, and no H58 (genotype 4.3.1). They found pansusceptibility of all isolates to three first lines of antimicrobial agents (ampicillin, chloramphenicol, and cotrimoxazole). This commentary evaluates the importance of these findings for the Samoan Islands and how they can help the global typhoid community. The microbial community in the environment and human gut could have played a role in the lack of antimicrobial resistance (AMR). However, drug-resistant strains may arrive soon at the island, as their international spread is common. Further investigation would help the global typhoid community to better understand the evolution of an isolated pathogen community and the effect of vaccination there.

Cold stress has always been a significant limitation for plant development and causes substantial decreases in crop yield. Some temperate plants, such as Arabidopsis, have the ability to carry out internal adjustment, which maintains and checks the metabolic machinery during cold temperatures. This cold acclimation process requires prior exposure to low, chilling temperatures to prevent damage during subsequent freezing stress and maintain the overall wellbeing of the plant despite the low-temperature conditions. In comparison, plants of tropical and subtropical origins, such as rice, are sensitive to chilling stress and respond differently to low-temperature stress. Plants have evolved various physiological, biochemical, and molecular mechanisms to sense and respond to low-temperature stress, including membrane modifications and cytoskeletal rearrangement. Moreover, the transient increase in cytosolic calcium level leads to the activation of many calcium-binding proteins and calcium-dependent protein kinases during low-temperature stress. Recently, mitogen-activated protein kinases have been found to regulate low-temperature signaling through ICE1. Besides, epigenetic control plays a crucial role during the cold stress response. This review primarily focuses on low-temperature stress experienced by plants and their strategies to overcome it. We have also reviewed recent progress and previous knowledge for a better understanding of plant cold stress response.

Clavibacter is an agriculturally important bacterial genus comprising nine host-specific species/subspecies including C. nebraskensis ( Cn ), which causes Goss's wilt and blight of maize. A robust, simple, and field-deployable method is required to specifically detect Cn in infected plants and distinguish it from other Clavibacter species for quarantine purposes and timely disease management. A multiplex Recombinase Polymerase Amplification (RPA) coupled with a Lateral Flow Device (LFD) was developed for sensitive and rapid detection of Clavibacter and Cn directly from infected host. Unique and conserved genomic regions, the ABC transporter ATP-binding protein CDS/ABC-transporter permease and the MFS transporter gene, were used to design primers/probes for specific detection of genus Clavibacter and Cn, respectively. The assay was evaluated using 52 strains, representing all nine species/subspecies of Clavibacter, other closely related bacterial species, and naturally- and artificially-infected plant samples; no false positives or negatives were detected. The RPA reactions were also incubated in a closed hand at body temperature; results were again specific. The assay does not require DNA isolation and can be directly performed using host sap. The detection limit of 10 pg (~ 3000 copies) and 100 fg (~ 30 copies) was determined for Clavibacter - and Cn -specific primers/probes, respectively. The detection limit for Cn -specific primer/probe set was decreased to 1 pg (~ 300 copies) when 1 µL of host sap was added into the RPA reaction containing tenfold serially diluted genomic DNA; though no effect was observed on Clavibacter -specific primer/probe set. The assay is accurate and has applications at point-of-need diagnostics. This is the first multiplex RPA assay for any plant pathogen.

In the pursuit of constructing a sustainable world for all through the instrumental seventeen Sustainable Development Goals, the COVID-19 pandemic emerged and affected the efforts concentrated on these goals. Therefore, there is a pressing need to analyze the extent of the impact that unfolded from the pandemic on each Sustainable Development Goal and further to direct the post-pandemic situation to accelerate the progress in every goal. Besides, there exists a knowledge gap in understanding the Sustainable Development Goals and its interaction with each goal through synergic and trade-off effects. To address the aforementioned imperative problems, this study is formulated to perform an impact assessment as well as to provide direction in the post-pandemic environment to effectively progress towards the Sustainable Development Goals by using a hybrid qualitative and quantitative framework. A detailed investigation is carried out to examine the pandemic impacts in every goal, and a quantified impact analysis is performed in terms of the targets of the Sustainable Development Goals with the aid of ranking methodology. The results indicate that SDG 1 and SDG 8 are the most impacted goal. To provide deeper perspectives into the Sustainable Development Goals, a critical analysis of the targets and indicators is performed to characterize the goals from their elemental point of view, such as nature of goals, depending factors, locus of the goal, and Sustainable Development Goal interactions. Further, a novel parameter, the degree of randomness, is proposed whose application in environmental research is immense. The impact on each goal and impact interaction between all the SDGs are also mapped, through which the dynamics of Sustainable Development Goal interactions is elaborated. In context with the post-pandemic scenario, the strategies to achieve the Sustainable Development Goals with environmental focus are presented with prioritization factor that supports quick recovery. The introduced prioritization factor is formulated by employing a multi-criteria analysis methodology. In addition, the fundamental elements of SDGs are built upon one another to frame an optimized and effective approach to achieving the SDGs in the post-pandemic environment. Despite the strategies, a conceptual framework to align the business practices with the SDGs is propounded. This study deep down would provide a unique perspective to the research community and would impart deeper knowledge in connection with sustainability, while the solutions framed would steer the policy and decision-makers.

Background Wandering spleen is a rare clinical entity with a less than 0.2% reporting incidence rate. In this case, the spleen is present abnormally in the abdominal or pelvic cavity instead of its normal anatomical location. The aetiology is either congenital or acquired. The condition is caused by the absence or maldevelopment of the spleen's suspensory ligaments, which holds the spleen static in the left hypochondrium. Case presentation A 27-year-old female patient presented to the emergency department with complaints of abdominal pain, fever, nausea, vomiting, and constipation for three days. A palpable movable mass was found during the physical examination, and torsion of the wandering spleen’s pedicle was confirmed by CT scan. Open splenectomy was performed, and the patient was recovered uneventfully. Conclusion Even though ectopic spleen is a rare disease, clinicians should be aware of its incidence. Early diagnosis in the case of an acute abdomen is vital for the preservation of the spleen. Patients presented with acute abdomen and absence of splenic shadow under left hemidiaphragm should be suspected, and further radiological investigation will confirm the diagnosis. Surgery is the gold standard for wandering spleen with either splenopexy or splenectomy, depending on the spleen's condition during surgery.

Information and Communication Technology (ICT) has become one of the basic building blocks of modern society. This research attempts to highlight the use of ICT by science teachers with respect to their classroom practices, administration, personal use and professional development. The data was collected from 30 science teachers working in schools of Delhi/NCR. To collect the data on the above cited domains a self-made questionnaire was administered. Prior permission and consent was taken to collect the data from the selected subjects. Obtained raw data was first tabulated and then statistically analysed by using descriptive as well as chi square tests. The findings of statistical analysis revealed that browsing internet to collect learning material and to prepare science lessons were practiced by teachers more frequently. Many teachers have undergone either introductory or equipment-specific training, however very few of them have received training in advanced courses on internet use (creating websites, video-conferencing, etc.). As far as perception of science teachers regarding use of ICT in science teachers was considered, findings revealed that most of the teachers were found very optimistic in using ICT while teaching.

Purpose Collaborative information searching is common for people when planning their group trip. However, little research has explored how tourists collaborate during information search. Existing tourism Web portals or search engines rarely support tourists’ collaborative information search activities. Taking advantage of previous studies of collaborative tourism information search behavior, in the current paper the purpose of this paper is to propose the design of a collaborative search system collaborative tourism information search (ColTIS) to support online information search and travel planning. Design/methodology/approach ColTIS was evaluated and compared with Google Talk-embedded Tripadvisor.com through a user study involving 18 pairs of participants. The data included pre- and post-search questionnaires, web search logs and chat history. For quantitative measurement, statistical analysis was performed using SPSS; for log data and the qualitative feedback from participants, the content analysis was employed. Findings Results suggest that collaborative query formulation, division of search tasks, chatting and results sharing are important means to facilitate tourists’ collaborative search. ColTIS was found to outperform Tripadvisor significantly regarding the ease of use, collaborative support and system usefulness. Originality/value The innovation of the study lies in the development of an integrated real-time collaborative tourism information search system with unique features. These features include collaborative query reformulation, travel planner and automatic result and query sharing that assist multiple people search for holiday information together. For system designers and tourism practitioners, implications are provided.

The new computational technologies and 3D printers have the ability to alter how we construct our surroundings. The additive manufacturing (AM) is a novel way for creating three-dimensional objects by layering materials like plastic, metal, concrete, sand, and other materials. The impact of 3D printing in the construction sector should not be underestimated, as it has the potential to reduce a variety of determining elements such as the construction process, material costs, and the overall project timeline. The 3D printing, allows creating a work of art quickly, easily, and in great detail. 3D printers can create a wide range of objects, including buildings, sculptures, automobile components, toys, shoes, furniture, clothing, weaponry, machines, electronic gadgets, human body parts, and much more. The application of 3D printing in architecture and building construction has evolved from scale modelling to a full-size final product. The paper analyses this novel technology, as well as its possible applications and future prospects. The purpose of this paper is to investigate the use of 3D printing in the architectural, interior and product design sector through newly constructed pioneering examples, research, and discussion of some of the future trends that will make this technology more cost efficient. The systematic literature review has been explored through internet and secondary data from relevant published academic literature from journals articles and research papers. The case study method is used to identify extensive information through an in-depth analysis of existing cases in architectural, interior and product design.

In this paper, we prove coincidence point results for a pair of self mappings defined on a metric space employing a comparison function and a locally T -transitive binary relation. Our results extend and generalize several known results especially those are contained in Alam and Imdad [Filomat 31 (14) (2017) 4421-4439] and Arif et al . [Miskolc Math. Notes 23 (1) (2022) 71-83]. Finally, we construct some examples to demonstrate the accomplished improvements in our newly proved results in this paper.