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The Dolomites (European Alps) are a UNESCO World Heritage Site known to harbor distinctive communities of carabid beetles adapted to high-altitude environments, whose composition is shaped mainly by landform and habitat type. We aimed to assess the conservation priority of carabid beetle communities in the Brenta mountain group (Italy). We used the Index of Natural Value (INV), based on the relative frequencies and abundances of highly specialized Alpine species, as a proxy of the sensitivity to disturbance, and, thus, to the vulnerability of the carabid beetle communities to extinction. We used information on Natura 2000 habitat cover to produce a map for identifying areas of the Brenta Dolomites inhabited by the carabid beetle communities most relevant for conservation. We also report on the main differences in terms of species composition between the investigated communities. We found a positive correlation between vulnerability and altitude. Specifically, the most vulnerable communities were recorded in high-altitude habitat types (limestone cliffs and pavements, calcareous and calcschist screes, and alpine calcareous grasslands). Alkaline fens resulted in having the least vulnerable community, while those in all other habitats (bush and forests) were found to have intermediate levels of vulnerability.

The high altitude mountain slopes of the Dolomites (Italian Alps) are characterized by great habitat and landform heterogeneities. In this paper, we investigated the effect of Nature 2000 habitat and landform types in driving the high altitude ground beetle (Carabidae) distribution in the Western Dolomites (Brenta group, Italy). We studied the carabid assemblages collected in 55 sampling points distributed in four Nature 2000 habitat types and four landform types located between 1860 and 2890 m above sea level (a.s.l.). Twenty-two species, half of them Alpine endemics, were sampled. Species richness and taxonomic distinctness did not show any significant difference among habitat types; conversely, these differences became significant when the landform type was considered. Total activity density and the frequency of brachypterous, endemic and predatory species showed significant differences between both habitat and landform types. Indicator species analysis identified twelve species linked to a specific habitat type and thirteen species linked to a specific landform type. Canonical correspondence analysis showed that altitude and vegetation cover drove the species distribution in each habitat and landform type while the aspect had a weak effect. Our results highlight the need for a geomorphological characterization of the sampling points when high altitude ground-dwelling arthropods are investigated.

Human-induced environmental alterations in the Alps may importantly affect small mammal species, but evidence in this sense is limited. We live-trapped small rodents in the Central-Eastern Italian Alps in three close-by habitat types (rocky scree, alpine grassland, and heath) at 2100 m a.s.l. during summer-fall, in 1997 and 2016. We compared small rodent assemblages through a Redundancy Detrended Analysis (RDA). In both surveys, we detected two specialist species, i.e., the common vole (Microtus arvalis) and the snow vole (Chionomys nivalis), and, unexpectedly, the forest generalist bank vole (Myodes glareolus). In 1997, grassland was mainly occupied by the common vole, while the bank vole and the snow vole were sympatric in the other habitats. In 2016, the snow vole was detected only in the scree, while other species did not show distribution changes. We discuss a series of hypotheses that might have driven the differences observed across decades, among which is a species-specific response to abiotic and biotic environmental alterations, with the alpine habitat specialist moving out of sub-optimal habitats. We encourage further research on this topic, e.g., via long-term longitudinal studies.

Carabid beetles are a group of insects that have been widely investigated in their relationship with environmental features of terrestrial habitats. We leveraged our knowledge on the main factors driving the species composition of carabid beetle communities in the Dolomites UNESCO World Heritage Site (Brenta mountain group, Italian Alps) to gain knowledge on which protected habitats host the most demanding and localized species. This will allow targeting conservation efforts on carabid beetle communities that are more sensitive to habitat disturbance and to climate change. We found that the most vulnerable communities inhabit rocky habitats at the highest altitudes and that, in general, vulnerability increases with altitude. We also found that habitats at the highest altitudes differ significantly in community composition compared to nearly all the other habitat types.

Forest vegetation structure assessment is a time expensive effort with traditional methods. The Mobile Laser Scanner (MLS) technology can greatly speed up field works, achieve detailed quantification of three-dimensional forest structure at detailed resolution and drive forest management to increase the conservation status of forests-specialist bird species. In this study, using Mobile hand-held Laser Scanner (MLS), we calculated a fine-scale vegetation density index (namely the Plant Density Index, PDI) to characterize the vertical structure of forest subcanopy (0-10 m). The collected MLS point clouds were used to estimate the abundance of Potential Hiding Refuges (PHR) for the hazel grouse (Tetrastes bonasia), a sedentary bird extremely sensitive to forest structure and composition. The study was carried out in 10 plots located in the Adamello Brenta Geopark (Southern Alps, Italy). The species was detected in 8 out of 18 transects in an uneven-aged spruce forest with a discontinuous tree cover. The PDI decreases as the height increases, showing greater value in the shrub and herbaceous layer while the upper values are represented by trees stems, and branches. Visibility analysis of lower understory, highlighted PHR mean value of 73.2% (sd = 9.2%). In our area, PDI and PHR revealed that the environmental factors for hazel grouse occurrence are forests with open habitats, understory vegetation, and good hiding opportunities. Our study is the first application that uses MLS derived parameters to describe the ecological niche of a grouse and we presented the surveyed area as \"case report\" of hazel grouse habitat. Competing Interest Statement The authors have declared no competing interest. Footnotes * https://zenodo.org/record/5653007#.YYjsYp7MKnU

Polycystic ovary syndrome (PCOS) is a heterogeneous and extremely common disease with symptoms that vary with the age of the patient, typically characterized by hyperandrogenism, chronic oligo-anovulation, and/or several metabolic disorders. The syndrome includes various phenotypes, and the pathogenesis is multifactorial, often involving insulin resistance. This feature is closely related to ovarian dysfunction, inflammation, hyperandrogenism, and metabolic disorders, which characterize and complicate the syndrome. Therapy currently considers both lifestyle improvements and medications, and must be tailored on a case-by-case basis. To date, the published studies have not arrived at a definition of the most suitable therapy for each individual case and many of the drugs used are still off-label. In this review, we discuss some controversial diagnostic and therapeutic aspects of PCOS, such as the role of insulin resistance, inflammation, and hyperandrogenism. We also evaluated the advantages and disadvantages of contraceptive therapy and antiandrogens.

GENERAL CONSIDERATIONS The study by Yan and co-workers 1 sought to review the literature reports on diagnostic criteria and biochemical and clinical success after surgery in patients with unilateral hyperaldosteronism. Since the discovery of the disease, many studies have tried to establish the criteria for diagnosis and operability of unilateral forms. A recent meta-analysis evaluated the accuracy of adrenal imaging examinations for the evaluation of unilateral forms, considering the result of AVS. A similar effect after long-term treatment with aldosterone receptors blockers in patients with primary aldosteronism could lead to a restoration of proper functioning of the renin-angiotensin-aldosterone system as demonstrated in cases of idiopathic hyperaldosteronism that have recovered from the condition after prolonged treatment with anti-aldosteronics. 15 CONCLUSIVE REMARKS Clinical and biochemical success is not a sufficient criterion to understand the future of these patients, as pointed in the reference study. 1 Most of the guidelines have focused on biochemical or clinical parameters assessment after surgery, but future studies will need to assess subsequent long-term cardiovascular risk comparing the long-term effects of adrenalectomy and those of chronic therapy with aldosterone receptors blockers combined with other hypotensive agents.

[...]the average intake of sodium for most Americans is more than 3 g per day and similar results are reported in oriental countries, where salt is added to many foods. 2 The purpose of these recommendations is to progressively reduce the daily salt intake of Americans improving their quality of life and increasing lifespan itself. A similar situation has been demonstrated in patients taking furosemide and thiazides, which on the one hand reduce blood pressure, but on the other hand accentuate the inflammatory state and cardiovascular risk. 6 Therefore, it is always recommended to combine a potassium-sparing drug such as spironolactone and its derivatives. 7 These considerations show how important the intervention of the specialist is in deciding on both diet and medication needed in the treatment of hypertension. Some studies have considered sodium intake either by questionnaires or by assessment of 24-h sodium excretion, while others have assessed sodium excretion in a spot urine sample. 8 All these assessments can be a source of error both for eventual treatments and for genetic differences in the body's response to salt intake.

Background The correct establishment of the human gut microbiota represents a crucial development that commences at birth. Different hypotheses propose that the infant gut microbiota is derived from, among other sources, the mother’s fecal/vaginal microbiota and human milk. Results The composition of bifidobacterial communities of 25 mother-infant pairs was investigated based on an internal transcribed spacer (ITS) approach, combined with cultivation-mediated and genomic analyses. We identified bifidobacterial strains/communities that are shared between mothers and their corresponding newborns. Notably, genomic analyses together with growth profiling assays revealed that bifidobacterial strains that had been isolated from human milk are genetically adapted to utilize human milk glycans. In addition, we identified particular bacteriophages specific of bifidobacterial species that are common in the viromes of mother and corresponding child. Conclusions This study highlights the transmission of bifidobacterial communities from the mother to her child and implies human milk as a potential vehicle to facilitate this acquisition. Furthermore, these data represent the first example of maternal inheritance of bifidobacterial phages, also known as bifidophages in infants following a vertical transmission route.

Polycystic ovary syndrome (PCOS) is a heterogeneous and extremely common disease with symptoms that vary with the age of the patient, typically characterized by hyperandrogenism, chronic oligo-anovulation, and/or several metabolic disorders. The syndrome includes various phenotypes, and the pathogenesis is multifactorial, often involving insulin resistance. This feature is closely related to ovarian dysfunction, inflammation, hyperandrogenism, and metabolic disorders, which characterize and complicate the syndrome. Therapy currently considers both lifestyle improvements and medications, and must be tailored on a case-by-case basis. To date, the published studies have not arrived at a definition of the most suitable therapy for each individual case and many of the drugs used are still off-label. In this review, we discuss some controversial diagnostic and therapeutic aspects of PCOS, such as the role of insulin resistance, inflammation, and hyperandrogenism. We also evaluated the advantages and disadvantages of contraceptive therapy and antiandrogens.