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This article provides theoretical conditions for the use and meaning of a stability analysis around a mean flow. As such, it may be considered as an extension of the works by McKeon & Sharma (J. Fluid Mech., vol. 658, 2010, pp. 336–382) to non-parallel flows and by Turton et al. (Phys. Rev. E, vol. 91 (4), 2015, 043009) to broadband flows. Considering a Reynolds decomposition of the flow field, the spectral (or temporal Fourier) mode of the fluctuation field is found to be equal to the action on a turbulent forcing term by the resolvent operator arising from linearisation about the mean flow. The main result of the article states that if, at a particular frequency, the dominant singular value of the resolvent is much larger than all others and if the turbulent forcing at this frequency does not display any preferential direction toward one of the suboptimal forcings, then the spectral mode is directly proportional to the dominant optimal response mode of the resolvent at this frequency. Such conditions are generally met in the case of weakly non-parallel open flows exhibiting a convectively unstable mean flow. The spatial structure of the singular mode may in these cases be approximated by a local spatial stability analysis based on parabolised stability equations (PSE). We have also shown that the frequency spectrum of the flow field at any arbitrary location of the domain may be predicted from the frequency evolution of the dominant optimal response mode and the knowledge of the frequency spectrum at one or more points. Results are illustrated in the case of a high Reynolds number turbulent backward facing step flow.

East Africa frequently experiences extreme hydrological events, such as droughts and floods, underscoring the urgent need for improved hydrological simulations to enhance prediction accuracy and mitigate losses. A major challenge lies in the limited quality of precipitation data and constraints on model capabilities. To address these challenges, the upper and middle Tana River basin, characterized by its sensitivity to drought, vulnerability to flooding, and data availability, was selected as a case study. We performed convection-permitting (CP) regional climate simulations using the Weather Research and Forecasting (WRF) model and conducted hydrological simulations with a lake–reservoir-integrated WRF Hydrological modeling system (WRF-Hydro) driven by the CPWRF outputs. Our results show that the CPWRF-simulated precipitation outperforms ERA5 when benchmarked against Integrated Multi-satellite Retrievals for GPM (Global Precipitation Measurement) (IMERG), with evident bias reduction in seasonal precipitation mainly over the Mount Kenya region and with a probability of light rainfall (1–15 mm d−1) during the dry season. Improved precipitation enhances the hydrological simulation, significantly reducing false peak occurrences and increasing the Nash–Sutcliffe efficiency (NSE) by 0.53 in the calibrated lake-integrated WRF-Hydro model (LakeCal) driven by CPWRF output compared to ERA5-driven simulations. Additionally, the lake–reservoir module increases the sensitivity of river discharge to spin-up time and affects discharge through lake–reservoir-related parameters, although adjustments to the parameters (i.e., the runoff infiltration rate, Manning's roughness coefficient, and the groundwater component) have minimal effects on discharge, particularly during the dry season. The inclusion of the lake–reservoir module effectively reduces the model-data bias in WRF-Hydro simulations, particularly for the dry-season flow and peak flow, resulting in an NSE increase of 1.67 between LakeCal and LakeNan (model without the lake–reservoir module). Notably, 24 % of the NSE improvement is attributed to CPWRF and 76 % is attributed to the lake–reservoir module. These findings highlight the enhanced capability of hydrological modeling when combining CPWRF simulations with the lake–reservoir module, providing a valuable tool for improving flood and drought predictability in data-scarce regions like East Africa.

Background Nocardia cyriacigeorgica is recognized as one of the most prevalent etiological agents of human nocardiosis. Human exposure to these Actinobacteria stems from direct contact with contaminated environmental matrices. The full genome sequence of N. cyriacigeorgica strain GUH-2 was studied to infer major trends in its evolution, including the acquisition of novel genetic elements that could explain its ability to thrive in multiple habitats. Results N. cyriacigeorgica strain GUH-2 genome size is 6.19 Mb-long, 82.7% of its CDS have homologs in at least another actinobacterial genome, and 74.5% of these are found in N. farcinica . Among N. cyriacigeorgica specific CDS, some are likely implicated in niche specialization such as those involved in denitrification and RuBisCO production, and are found in regions of genomic plasticity (RGP). Overall, 22 RGP were identified in this genome, representing 11.4% of its content. Some of these RGP encode a recombinase and IS elements which are indicative of genomic instability. CDS playing part in virulence were identified in this genome such as those involved in mammalian cell entry or encoding a superoxide dismutase. CDS encoding non ribosomal peptide synthetases (NRPS) and polyketide synthases (PKS) were identified, with some being likely involved in the synthesis of siderophores and toxins. COG analyses showed this genome to have an organization similar to environmental Actinobacteria. Conclusion N. cyriacigeorgica GUH-2 genome shows features suggesting a diversification from an ancestral saprophytic state. GUH-2 ability at acquiring foreign DNA was found significant and to have led to functional changes likely beneficial for its environmental cycle and opportunistic colonization of a human host.

Background Ectopic abnormal parathyroid glands are relatively common in the superior mediastinum but are rarely situated in the aortopulmonary window (APW). The embryological origin of these abnormal parathyroid glands is controversial. The purpose of this investigation was to investigate the embryological origin and the surgical management of abnormal parathyroid glands situated in the APW. Methods The databases of patients operated on for primary, secondary, and tertiary hyperparathyroidism at eight European medical centers with a special interest in endocrine surgery were reviewed to identify those with APW adenomas. Demographic features, localization procedures, and perioperative and pathology findings were documented. The embryological origin was determined based on the number and position of identified parathyroid glands. Results Nineteen (0.24%) APW parathyroid tumors were identified in 7,869 patients who underwent an operation for hyperparathyroidism (HPT) and 181 patients (2.3%) with mediastinal abnormal parathyroid glands. Ten patients had primary, eight had secondary, and one had tertiary HPT. Sixteen patients had undergone previous unsuccessful cervical exploration. In three patients, an APW adenoma was suspected by preoperative localization studies and was cured at the initial operation. Sixteen patients had persistent HPT of whom 15 were reoperated, resulting in 6 failures. Evaluation of 17 patients who had bilateral neck exploration allowed us to determine the most probable origin of the APW parathyroid tumors: 12 were supernumerary, 4 appeared to originate from a superior, and 1 from an inferior gland. Conclusions Abnormal parathyroid glands situated in the APW are rare and usually identified after an unsuccessful cervical exploration. Preoperative imaging of the mediastinum and neck are essential. The origin of these ectopically situated tumors is probably, as suggested by our data, from a supernumerary fifth parathyroid gland or from abnormal migration of a superior parathyroid gland during the embryologic development.

Background Ectopic abnormal parathyroid glands are relatively common in the superior mediastinum but are rarely situated in the aortopulmonary window (APW). The embryological origin of these abnormal parathyroid glands is controversial. The purpose of this investigation was to investigate the embryological origin and the surgical management of abnormal parathyroid glands situated in the APW. Methods The databases of patients operated on for primary, secondary, and tertiary hyperparathyroidism at eight European medical centers with a special interest in endocrine surgery were reviewed to identify those with APW adenomas. Demographic features, localization procedures, and perioperative and pathology findings were documented. The embryological origin was determined based on the number and position of identified parathyroid glands. Results Nineteen (0.24%) APW parathyroid tumors were identified in 7,869 patients who underwent an operation for hyperparathyroidism (HPT) and 181 patients (2.3%) with mediastinal abnormal parathyroid glands. Ten patients had primary, eight had secondary, and one had tertiary HPT. Sixteen patients had undergone previous unsuccessful cervical exploration. In three patients, an APW adenoma was suspected by preoperative localization studies and was cured at the initial operation. Sixteen patients had persistent HPTof whom 15 were reoperated, resulting in 6 failures. Evaluation of 17 patients who had bilateral neck exploration allowed us to determine the most probable origin of the APW parathyroid tumors: 12 were supernumerary, 4 appeared to originate from a superior, and 1 from an inferior gland. Conclusions Abnormal parathyroid glands situated in the APW are rare and usually identified after an unsuccessful cervical exploration. Preoperative imaging of the mediastinum and neck are essential. The origin of these ectopically situated tumors is probably, as suggested by our data, from a supernumerary fifth parathyroid gland or from abnormal migration of a superior parathyroid gland during the embryologic development.