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Purpose This paper aims at evaluating the effects of muscle load on knee kinematics and stability after TKA and second at evaluating the effect of TKA surgery on knee kinematics and stability; and third, at correlating the stability in passive conditions and the stability in active, muscle loaded conditions. Methods Fourteen fresh frozen cadaveric knee specimens were tested under passive and active condition with and without external loads involving a varus/valgus and internal/external rotational torque before and after TKA surgery using two in-house developed and previously validated test setups. Results Introduction of muscle force resulted in increased valgus (0.98°) and internal rotation of the femur (4.64°). TKA surgery also affected the neutral path kinematics, resulting in more varus (1.25°) and external rotation of the femur (5.22°). All laxities were significantly reduced by the introduction of the muscle load and after implantation of the TKA. The presence of the implant significantly affects the active varus/valgus laxity. This contrasts with the rotational laxity, in which case the passive laxity is the main determinant for the active laxity. For the varus/valgus laxity, the passive laxity is also a significant predictor of the active laxity. Conclusion Knee stability is clearly affected by the presence of muscle load. This points to the relevance of appropriate rehabilitation with focus on avoiding muscular atrophy. At the same time, the functional, muscle loaded stability strongly relates to the passive, ligament-based stability. It remains therefore important to assess knee stability at the time of surgery, since the passive laxity is the only predictor for functional stability in the operating theatre. Level of evidence Case series, Level IV.

Purpose The goal is to evaluate contralateral knee joint laxity and ascertain whether or not contralateral symmetry is observable. Secondary, a validation of a knee laxity testing rig is provided. Methods Seven pairs of cadaveric knee specimens have been tested under passive conditions with and without external loads, involving a varus/valgus and an external/internal rotational torque and an anteroposterior shear force. Results Through the range of motion, the width of the varus/valgus laxity, internal/external laxity and anterior/posterior laxity for the medial and lateral compartment show no significant differences between left and right leg. These findings allow us to validate the setup, especially for relative values of laxity based on anatomical measures and knee joint biomechanics. Conclusion A multidirectional laxity symmetry has been demonstrated for the intact knee and its contralateral knee in passive conditions as in an anesthetized patient. The passive laxity evaluation setup has been validated. Our work furthermore demonstrated a pronounced difference in anteroposterior mobility between the medial and lateral compartment of the knee, with a more stable medial side and more mobile lateral side. Clinical relevance The contralateral knee can be used as reference for determining optimal knee laxity peri-operatively in total knee replacement and ligament reconstruction. Level of evidence Level IV, Case series

ObjectiveTo examine the effects of autoregulated (AUTO) and non-autoregulated (NAUTO) blood flow restriction (BFR) application on adverse effects, performance, cardiovascular and perceptual responses during resistance exercise.MethodsFifty-six healthy participants underwent AUTO and NAUTO BFR resistance exercise in a randomised crossover design using a training session with fixed amount of repetitions and a training session until volitional failure. Cardiovascular parameters, rate of perceived effort (RPE), rate of perceived discomfort (RPD) and number of repetitions were investigated after training, while the presence of delayed onset muscle soreness (DOMS) was verified 24 hours post-session. Adverse events during or following training were also monitored.ResultsAUTO outperformed NAUTO in the failure protocol (p<0.001), while AUTO scored significantly lower for DOMS 24 hours after exercise (p<0.001). Perceptions of effort and discomfort were significantly higher in NAUTO compared with AUTO in both fixed (RPE: p=0.014, RPD: p<0.001) and failure protocol (RPE: p=0.028, RPD: p<0.001). Sixteen adverse events (7.14%) were recorded, with a sevenfold incidence in the fixed protocol for NAUTO compared with AUTO (NAUTO: n=7 vs AUTO: n=1) and five (NAUTO) vs three (AUTO) adverse events in the failure protocol. No significant differences in cardiovascular parameters were found comparing both pressure applications.ConclusionAutoregulation appears to enhance safety and performance in both fixed and failure BFR-training protocols. AUTO BFR training did not seem to affect cardiovascular stress differently, but was associated with lower DOMS, perceived effort and discomfort compared with NAUTO.Trial registration number NCT04996680.

Purpose The assistance of robot technology is introduced into the operating theatre to improve the precision of a total knee arthroplasty. However, as with all new technology, new technology requires a learning curve to reach adequate proficiency. The primary aim of this study was to identify the learning curve of an imageless robotic system with standardised laxity testing. The secondary aim of this study was to evaluate the accuracy of the intra-operative coronal alignment during the learning curve. Methods A prospective study was performed on 30 patients undergoing robot-assisted total knee arthroplasty with an imageless robotic system (Corin, Massachusetts, USA) associated with a dedicated standardised laxity testing device. The learning curve of all surgical steps was assessed with intra-operative video monitoring. As comparison, the total surgical time of the last 30 patients receiving conventional total knee arthroplasty by the same surgeon and with the same implant was retrospectively assessed. Coronal lower limb alignment was evaluated pre- and post-operatively on standing full-leg radiographs. Results CUSUM (cumulative summation) analysis has shown inflexion points in multiple steps associated with robot-assisted surgery between one and 16 cases, which indicates the progression from the learning phase to the proficiency phase. The inflexion point for total operative time occurred after nine cases. Robot-assisted total knee surgery required significantly longer operative times than the conventional counterpart, with an average increase of 22 min. Post-operative limb and implant alignment was not influenced by a learning curve. Conclusion The introduction of an imageless robotic system with standardised laxity assessment for total knee arthroplasty results in a learning curve of nine cases based on operative time. Compared to conventional surgery, the surgeon is not able to reach time neutrality with the robotic platform. There is no learning curve associated with coronal limb or implant alignment. This study enables orthopaedic surgeons to understand the implementation of this surgical system and its specific workflow into clinical practice.

Background Recently, patient-specific guides (PSGs) have been introduced, claiming a significant improvement in accuracy and reproducibility of component positioning in TKA. Despite intensive marketing by the manufacturers, this claim has not yet been confirmed in a controlled prospective trial. Questions/purposes We (1) compared three-planar component alignment and overall coronal mechanical alignment between PSG and conventional instrumentation and (2) logged the need for applying changes in the suggested position of the PSG. Methods In this randomized controlled trial, we enrolled 128 patients. In the PSG cohort, surgical navigation was used as an intraoperative control. When the suggested cut deviated more than 3° from target, the use of PSG was abandoned and marked as an outlier. When cranial-caudal position or size was adapted, the PSG was marked as modified. All patients underwent long-leg standing radiography and CT scan. Deviation of more than 3° from the target in any plane was defined as an outlier. Results The PSG and conventional cohorts showed similar numbers of outliers in overall coronal alignment (25% versus 28%; p = 0.69), femoral coronal alignment (7% versus 14%) (p = 0.24), and femoral axial alignment (23% versus 17%; p = 0.50). There were more outliers in tibial coronal (15% versus 3%; p = 0.03) and sagittal 21% versus 3%; p = 0.002) alignment in the PSG group than in the conventional group. PSGs were abandoned in 14 patients (22%) and modified in 18 (28%). Conclusions PSGs do not improve accuracy in TKA and, in our experience, were somewhat impractical in that the procedure needed to be either modified or abandoned with some frequency. Level of Evidence Level I, therapeutic study. See instructions for authors for a complete description of levels of evidence.

Purpose Studies on dynamic intraligamentary stabilization (DIS) of acute anterior cruciate ligament (ACL) ruptures reported failure rates similar to those of conventional ACL reconstruction. This study aimed to determine whether surgeon experience with DIS is associated with revision rates or patient-reported outcomes. The hypothesis was that more experienced surgeons achieved better outcomes following DIS due to substantial learning curve. Methods The authors prospectively enrolled 110 consecutive patients that underwent DIS and evaluated them at a minimum of 2 years. The effects of independent variables (surgeon experience, gender, age, adjuvant procedures, tear location, preinjury Tegner score, time from injury to surgery, and follow-up) on four principal outcomes (revision ACL surgery, any re-operation, IKDC and Lysholm score) were analyzed using univariable and multivariable regressions. Results From the 110 patients enrolled, 14 patients (13%) were lost to follow-up. Of the remaining 96 patients, 11 underwent revision ACL surgery, leaving 85 patients for clinical assessment at a mean of 2.2 ± 0.4 years (range 2.0–3.8). Arthroscopic reoperations were performed in 26 (27%) patients, including 11 (11%) revision ACL surgeries. Multivariable regressions revealed: (1) no associations between the reoperation rate and the independent variables, (2) better IKDC scores for ‘designer surgeons’ ( b  = 10.7; CI 4.9–16.5; p  < 0.001), higher preinjury Tegner scores ( b  = 2.5, CI 0.8–4.2; p  = 0.005), and younger patients ( b  = 0.3, CI 0.0–0.6; p  = 0.039), and (3) better Lysholm scores for ‘designer surgeons’ ( b  = 7.8, CI 2.8–12.8; p  = 0.005) and preinjury Tegner score ( b  = 1.9, CI 0.5–3.4; p  = 0.010). Conclusion Surgeon experience with DIS was not associated with rates of revision ACL surgery or general re-operations. Future, larger-scaled studies are needed to confirm these findings. Patients operated by ‘designer surgeons’ had slightly better IKDC and Lysholm scores, which could be due to better patient selection and/or positively biased attitudes of both surgeons and patients. Level of evidence Level II, prospective comparative study.

Purpose The influence of type and intensity of sports during growth on knee alignment was investigated. The second aim was to ascertain whether the distal femur or proximal tibia contribute most to knee alignment. Also, the influence of field position and leg dominancy on knee alignment in soccer players was audited. Methods Standardized full-leg standing digital radiographs were obtained from 100 males and 100 females on which 8 different alignment parameters were measured. Participants were questioned on their sports activities during different stages of growth. Sports activities were graded according to the Tegner score. Results The mean (±SD) hip–knee–ankle angle (HKA) was significantly lower ( p  < 0.001) in high-activity male athletes (−2.8° ± 2.4°) than in low-activity male athletes (−0.9° ± 1.9°). No differences in HKA were observed between different activity levels in females. Males who practiced soccer between 10–12 years and 15–17 years had, in turn, a lower HKA than athletes practicing other high-activity sports in these age categories (mean difference ≥1.2°, p  ≤ 0.046). The most contributing factor for the varus alignment in male soccer players was a lower medial proximal tibial angle (MPTA). Conclusion High-activity sports participation during youth is associated with varus alignment at the end of growth in males. The most pronounced bowlegs were observed in male soccer players, and this was primarily determined by the proximal tibia. Adjustments in loads applied to the knees during skeletal growth in males might prevent the development of varus alignment and associated pathology, but further studies are required. Level of evidence Diagnostic study, Level III.

Introduction Post-cam dislocation in TKA is a rare complication after posterior stabilized TKA. Purpose Four cases of posterior dislocation of the tibia relative to the femur are described in one current posterior stabilized design. Conclusion Specific design features in one contemporary high flexion TKA design contribute to high dislocation rates.

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The bone-machine interface is a vital first step for biomechanical testing. It remains challenging to restore the original alignment of the specimen with respect to the test setup. To overcome this issue, we developed a methodology based on virtual planning and 3D printing. In this paper, the methodology is outlined and a proof of concept is presented based on a series of cadaveric tests performed on our knee simulator. The tests described in this paper reached an accuracy within 3–4° and 3–4mm with respect to the virtual planning. It is however the authors׳ belief that the method has the potential to achieve an accuracy within one degree and one millimeter. Therefore, this approach can aid in reducing the imprecisions in biomechanical tests (e.g. knee simulator tests for evaluating knee kinematics) and improve the consistency of the bone-machine interface.