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Autism spectrum disorder (ASD) is a developmental disorder of the brain characterized by shortfall in the social portfolio of an individual and abbreviated interactive and communication aspects rendering stereotypical behavior and pitfalls in a child’s memory, thinking, and learning capabilities. The incidence of ASD has accelerated since the past decade, portraying environment as one of the primary assets, comprising of metallic components aiming to curb the neurodevelopmental pathways in an individual. Many regulations like Clean Air Act and critical steps taken by countries all over the globe, like Sweden and the USA, have rendered the necessity to study the effects of environmental metallic components on ASD progression. The review focuses on the primary metallic components present in the environment (aluminum, lead, mercury, and arsenic), responsible for accelerating ASD symptoms by a set of general mechanisms like oxidative stress reduction, glycolysis suppression, microglial activation, and metalloprotein disruption, resulting in apoptotic signaling, neurotoxic effects, and neuroinflammatory responses. The effect of these metals can be retarded by certain protective strategies like chelation, dietary correction, certain agents (curcumin, mangiferin, selenium), and detoxification enhancement, which can necessarily halt the neurodegenerative effects. Graphical abstract

Firms spend a substantial amount on lobbying—devoting financial resources on teams of lobbyists to further their interests among regulatory stakeholders. Previous research acknowledges that lobbying positively influences firm value, but no studies have examined the parallel effects for customers. Building on the attention-based view (ABV) of the firm, the authors examine these customer effects. Findings reveal that lobbying negatively affects customer satisfaction such that the positive relationship between lobbying and firm value is mediated by losses to customer satisfaction. These findings suggest a dark side of lobbying and challenge current thinking. However, several customer-focused moderators attenuate the negative effect of lobbying on customer satisfaction, predicted by ABV theory, including the chief executive officer’s background (marketing vs. other functional area) and the firm’s strategic use of resources (advertising spending, research-and-development spending, or lobbying for product market issues). These moderators ensure consistency between lobbying and customer priorities or direct firm attention toward customers even while firms continue to lobby. Finally, the authors verify that lobbying reduces the firm’s customer focus by measuring this focus directly using text analysis of firm communications with shareholders. Collectively, the research provides managerial implications for navigating both lobbying activities and customer priorities, and public policy implications for lobbying disclosure requirements.

Evolutionarily, man is a terrestrial mammal, adapted to land. Aviation and now space/microgravity environment, hence, pose new challenges to our physiology. Exposure to these changes affects the human body in acute and chronic settings. Since skin reflects our mental and physical well-being, any change/side effects of this environment shall be detected on the skin. Aerospace industry offers a unique environment with a blend of all possible occupational disorders, encompassing all systems of the body, particularly the skin. Aerospace dermatologists in the near future shall be called upon for their expertise as we continue to push human physiological boundaries with faster and more powerful military aircraft and look to colonize space stations and other planets. Microgravity living shall push dermatology into its next big leap-space, the final frontier. This article discusses the physiological effects of this environment on skin, effect of common dermatoses in aerospace environment, effect of microgravity on skin, and occupational hazards of this industry.

Being sessile, plants are subjected to a diverse array of environmental stresses during their life span. Exposure of plants to environmental stresses results in the generation of reactive oxygen species (ROS). These activated oxygen species tend to oxidize various cellular biomolecules like proteins, nucleic acids, and lipids, a process that challenges the core existence of the cell. To prevent the accumulation of these ROS and to sustain their own survival, plants have developed an intricate antioxidative defence system. The antioxidative defence system comprises various enzymatic and nonenzymatic molecules, produced to counter the adverse effect of environmental stresses. A sizable number of these molecules belong to the category of compounds called secondary metabolites. Secondary metabolites are organic compounds that are not directly involved in the growth and development of plants but perform specialized functions under a given set of conditions. Absence of secondary metabolites results in long-term impairment of the plant’s survivability. Such compounds generally include pigments, phenolics, and so on. Plant phenolic compounds such as flavonoids and lignin precursors have been reported to accumulate in response to various biotic and abiotic stresses and are regarded as crucial defence compounds that can scavenge harmful ROS. Another important category of plant metabolites, called brassinosteroids, exhibit stress regulatory and growth-promoting activity and are classified as phytohormones. Elucidation of the physiological and molecular effects of secondary metabolites and brassinosteroids have catapulted them as highly promising and environment-friendly natural substances, suitable for wider application in plant protection and crop yield promotion. The present review focuses on our current understanding of how plants respond to the generation of excessive ROS and the role of secondary metabolites and brassinosteroids in countering the adverse effects of environmental stresses.

Crop growth and productivity has largely been vulnerable to various abiotic and biotic stresses that are only set to be compounded due to global climate change. Therefore developing improved varieties and designing newer approaches for crop improvement against stress tolerance have become a priority now-a-days. However, most of the crop improvement strategies are directed toward staple cereals such as rice, wheat, maize etc., whereas attention on minor cereals such as finger millet [ (L.) Gaertn.] lags far behind. It is an important staple in several semi-arid and tropical regions of the world with excellent nutraceutical properties as well as ensuring food security in these areas even during harsh environment. This review highlights the importance of finger millet as a model nutraceutical crop. Progress and prospects in genetic manipulation for the development of abiotic and biotic stress tolerant varieties is also discussed. Although limited studies have been conducted for genetic improvement of finger millets, its nutritional significance in providing minerals, calories and protein makes it an ideal model for nutrition-agriculture research. Therefore, improved genetic manipulation of finger millets for resistance to both abiotic and biotic stresses, as well as for enhancing nutrient content will be very effective in millet improvement. Apart from the excellent nutraceutical value of finger millet, its ability to tolerate various abiotic stresses and resist pathogens make it an excellent model for exploring vast genetic and genomic potential of this crop, which provide us a wide choice for developing strategies for making climate resilient staple crops.

One of the most significant manifestations of environmental stress in plants is the increased production of Reactive Oxygen Species (ROS). These ROS, if allowed to accumulate unchecked, can lead to cellular toxicity. A battery of antioxidant molecules is present in plants for keeping ROS levels under check and to maintain the cellular homeostasis under stress. Ascorbate peroxidase (APX) is a key antioxidant enzyme of such scavenging systems. It catalyses the conversion of H O into H O, employing ascorbate as an electron donor. The expression of APX is differentially regulated in response to environmental stresses and during normal plant growth and development as well. Different isoforms of APX show differential response to environmental stresses, depending upon their sub-cellular localization, and the presence of specific regulatory elements in the upstream regions of the respective genes. The present review delineates role of APX isoforms with respect to different types of abiotic stresses and its importance as a key antioxidant enzyme in maintaining cellular homeostasis.

Background Cellulose, one of the most abundantly available natural polymers, is highly present in the cell walls of plants. Its versatile properties such as low toxicity, mechanical strength, biocompatibility, biodegradability make it suitable for use in drug delivery systems. They can be used in various dosage forms, including tablets, capsules, films, and nano- or microparticles among others. Main body of abstract Cellulose-based formulations are often used as excipients also, which helps to deliver the active drug to the body and improve the drug’s stability, solubility, or bioavailability. Cellulose derivatives such as nanocellulose, ethyl cellulose, methylcellulose, carboxymethyl cellulose, bacterial cellulose, hydroxypropyl cellulose, thiolated cellulose, phosphorylated cellulose, sulfated cellulose, and microcrystalline cellulose are commonly used in pharmaceutical formulations. Conclusion This review highlights the formulations, modifications techniques, and preparation methods of various cellulose-based drug delivery systems such as solvent evaporation, wet and dry granulation, solvent casting, electrospinning, and spray drying. It also focuses on the role of modified cellulose-based pharmaceutical formulations for controlled drug release and targeted delivery applications. The challenges and future prospective of cellulose-based drug delivery systems including the scalability and regulatory considerations are also explored.

Salinity stress is a major abiotic factor that severely limits global crop productivity. It disturbs plant water relations, ion homeostasis and redox balance, leading to reduced plant growth and productivity. Conventional practices have only partially alleviated these constraints, especially in the rapidly expanding salt-affected areas, driven by climate change and unsustainable irrigation practices. In this context, copper-based nanoparticles (Cu-NPs) have emerged as promising nano-agrochemicals, capable of modulating multiple stress-responsive pathways. This review summarizes the current knowledge on the morpho-physiological, biochemical and molecular mechanisms implicated in salinity tolerance in tomato and critically evaluates how Cu based nanoparticles modulate cellular homeostasis to improve salt resilience. Evidence from physiological, biochemical and ionic studies indicates that Cu based nanoparticles stabilize cellular metabolism under saline conditions, by strengthening antioxidant defense, improve Na + exclusion and K + retention and protect photosynthetic performance. Proteomic investigations further reveal that in Cu-NP-treated tomato plants, the aforementioned cellular alternations are coordinated through stress signaling proteins and involve energy metabolism. Thus, providing a mechanistic basis for the observed phenotypic benefits. Genotype as well as concentration dependent responses emphasize that Cu-NP efficacy is maximized at intermediate doses under moderate stress, while excessive application can trigger copper toxicity and redox imbalance. The review also discusses potential environmental risks, regulatory gaps and standardization challenges associated with deployment of copper-based nanoparticles under field conditions. By integrating multi-scale evidence, the review provides a conceptual framework for rationally designing Cu-NP based interventions and identifies key research priorities for their safe and effective use in tomato cultivation.

Background: Psoriasis continues to have unmet needs in its management despite introduction of newer molecules. Monotherapy with these newer agents may not achieve therapeutic goals in all cases, hence necessitating their combinations with other molecules. Improved understanding of newer as well as conventional treatment modalities and experiences in their combinations hence necessitates therapeutic guidelines for their use in psoriasis. Objective: To review the combinations of treatments reported in literature and recommendations for their use based on best current evidence in literature. Methods: A literature review of MEDLINE database for studies evaluating combinations of newer therapies with conventional therapies in psoriasis was done. Newer therapies were identified as biologic disease modifying anti rheumatic drugs and other molecules such as apremilast while conventional therapies included methotrexate, cyclosporine, or retinoids, phototherapy and others. The therapeutic guidelines are proposed with the aim to provide evidenced based approach to combine newer and conventional agents in day-to-day psoriasis management. Findings: Combination of acitretin and narrow band ultraviolet B (NB-UVB)/Psoralen with ultraviolet A (PUVA) achieves faster clearance and allows reduction of dose of the latter. A variable outcome is reported of methotrexate with TNF-α inhibitors vs. TNF-α inhibitors alone, although addition of methotrexate appears to reduce immunogenicity of TNF-α inhibitors thereby preventing formation of anti-drug antibodies especially in case of infliximab. While combination of acitretin and PUVA is beneficial, combining TNF-α inhibitors and phototherapy too produces better and faster results but long term risks of Non Melanoma Skin Cancers (NMSCs) may preclude their use together. Combination of cyclosporine and phototherapy is not recommended due to greater chances of NMSCs. Adding phototherapy to Fumaric Acid Esters (FAEs) improves efficacy. Apremilast can be safely combined with available biologic agents in patients with plaque psoriasis or psoriatic arthritis not responding adequately to biologics alone. Hydroxyurea and acitretin may be used together increasing their efficacy and reducing doses of both and hence their adverse effects. Conclusion: Selected clinical scenarios shall benefit from combinations therapies, improving efficacy of both conventional and newer agents and at the same time helping reduce toxicity of higher dosages when used individually.

The world has never been prepared for global pandemics like the COVID-19, currently posing an immense threat to the public and consistent pressure on the global healthcare systems to navigate optimized tools, equipments, medicines, and techno-driven approaches to retard the infection spread. The synergized outcome of artificial intelligence paradigms and human-driven control measures elicit a significant impact on screening, analysis, prediction, and tracking the currently infected individuals, and likely the future patients, with precision and accuracy, generating regular international and national data on confirmed, recovered, and death cases, as the current status of 3,820,869 infected patients worldwide. Artificial intelligence is a frontline concept, with time-saving, cost-effective, and productive access to disease management, rendering positive results in physician assistance in high workload conditions, radiology imaging, computational tomography, and database formulations, to facilitate availability of information accessible to researchers all over the globe. The review tends to elaborate the role of industry 4.0 technology, fast diagnostic procedures, and convolutional neural networks, as artificial intelligence aspects, in potentiating the COVID-19 management criteria and differentiating infection in SARS-CoV-2 positive and negative groups. Therefore, the review successfully supplements the processes of vaccine development, disease management, diagnosis, patient records, transmission inhibition, social distancing, and future pandemic predictions, with artificial intelligence revolution and smart techno processes to ensure that the human race wins this battle with COVID-19 and many more combats in the future.