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According to Kim and Jeong (2016), isolated orbital fractures are encountered in 4-16% of all facial fractures, and orbital fractures composed approximately 30--55% of the zygomaticomaxillary complex (ZMC) and naso-orbital-ethmoid (NOE) fractures. The ideal material for orbital floor fracture repair is one that is resorbable, osteoconductive, resistant to infection, minimally reactive, does not induce capsule formation, has a half-life that allows significant bone in-growth to occur, and is cheap and readily available. In this article, we report a case of a young female with an orbital floor fracture managed surgically using conchal cartilage and a review of literature.

Chennai is one of the four major metropolitan cities in India, and is located in the southeastern part of the country. The average rate of population growth of the city is 25 % per decade and this is recurrently reducing the green-covered area in the city. Exceptionally, during the post-economic liberalization period (i.e., between the years 1997 and 2007), the city lost up to 99 % of its green-covered areas at some parts. Subsequently, the Chennai City started to experience wide range of environmental issues, including groundwater pollution and the effects of groundwater depletion. As a consequence of these factors, a study was undertaken to determine the impact of urbanization on the groundwater quality. In the present study, groundwater samples were collected from 54 stations from the study area during the premonsoon and postmonsoon seasons for the year 2011–2012 and were analyzed for physico-chemical parameters and trace elements. The type of water that predominated in the study area was assessed based on hydrochemical facies. The study of the hydrochemical characteristics of the major ions in these waters shows that in premonsoon, the alkalis and the alkaline earth metals are found to be balanced by chlorides and bicarbonates and sulphates, respectively. Reverse ion exchange study illustrates that Ca, Mg and Na concentrations are interrelated through reverse ion exchange. Box and whisker plots illustrate the seasonal effect on the chemical parameters of the groundwater. Gibbs’ diagram reveals that the chemical composition of the groundwater in the study area is predominated by rock–water interaction. Besides, suitability of groundwater for irrigation was evaluated based on sodium adsorption ratio, Kelley’s ratio, magnesium ratio, Wilcox and USSL diagrams.

In machining processes, cutting tools play a dominant role in producing quality products. The quality of finished goods is directly related to the cutting tool condition. Several types of research have been carried out in cutting tool condition monitoring. On the other hand, the manufacturing industries should be aware of the cutting tool selection, operating conditions, and performance of cutting tools. This article emphasizes the performance of coated cutting tools and tool materials for various machining operations. Nowadays, the nanocoating of CNC tool inserts increases the wear resistance, vibration emissions, metal removal rate, etc. These coating techniques influence the manufacturing industry to increase the productivity and quality of the finished goods and reduce the machining cost. The performance of thin film multilayered coatings such as TiN, TiAlN, AlTiN, Ti, and TiCN on plain silicon carbide tool inserts is revealed by the researchers to guide the manufacturing industry for proper tool selection and standard machining inputs for metal removal operation. The influence of coating material such as TiBN, TiN, TiAlN, and CrAlSiN in cutting tools leads to increase the life time of the cutting tools, which decreases the material sticking and cutting forces. Titanium carbo nitride is wear-resistant and corrosion-resistant. Compared to TiCN, TiAlN is harder due to the higher hardness of 32 GPa. This article concludes the material selection based on the work piece material which yields good metal removal with less cutting forces. The article concludes the cutting material selection based on the work piece for machining operations.

Importin β-superfamily nuclear import receptors (NIRs) mitigate mislocalization and aggregation of RNA-binding proteins (RBPs), like FUS and TDP-43, which are implicated in neurodegenerative diseases. NIRs potently disaggregate RBPs by recognizing their nuclear localization signal (NLS). However, disease-causing mutations in NLS compromise NIR binding and activity. Here, we define features that characterize the anti-aggregation activity of NIR and NLS. We find that high binding affinity between NIR and NLS, and optimal NLS location relative to the aggregating domain plays a role in determining NIR disaggregation activity. A designed FUS chimera (FUS IBB ), carrying the importin β binding (IBB) domain, is solubilized by importin β in vitro, translocated to the nucleus in cultured cells, and downregulates the expression of endogenous FUS. In this study, we posit that guiding the mutual recognition of NLSs and NIRs will aid the development of therapeutics, illustrated by the highly soluble FUS IBB replacing the aggregation-prone endogenous FUS. This study developed a FUS chimera (FUSIBB) with a highly efficient anti-aggregation signal that is engaged by a nuclear import receptor, Importin beta. FUSIBB can mitigate aggregation and reduce expression of a neurodegeneration-linked protein, FUS.

Tinnitus refers to the perception of sound without any external stimuli which can be pulsatile or non-pulsatile. Dilated mastoid emissary vein (MEV) can cause pulsatile tinnitus. Herein, we report a case of persistent pulsatile tinnitus with dilated MEV managed successfully with percutaneous coiling of MEV in a 36 years male.

The aim of the present study was to assess the arsenic (As) transformation potential of endophytic bacteria isolated from roots of Pteris vittata plant. The endophytic bacterium was tested for minimal inhibitory concentration (MIC) against As. The endophytic strain RPT exhibited the highest resistance to As(V) (400 mg/l). Phylogenetic analysis of the 16S rRNA sequence suggested that strain RPT was a member of genus Citrobacter . The As transformation assay revealed As(III) oxidation and As(V) reduction potential of Citrobacter sp. RPT. The As resistance mechanism was further confirmed by amplification of arsC and aoxB genes. The growth kinetics of strain RPT was altered slightly in the presence of different concentration (100–400 mg/l) of As stress. Temperature and pH influenced the As removal rate. The maximum As removal was observed at pH 7.0 (74%) and 37 °C (70.9%). The results suggest that strain RPT can survive under the As stress and has been identified as a potential candidate for application in bioremediation of As in contaminated environments.