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Background: The prevalence of e-cigarettes is steadily increasing among nurses globally, leading to detrimental impacts on their mental well-being. The rising prevalence of vape (e-cigarette) utilization among nurses individuals is worrisome, given the scarcity of information about risk factors and health implications. This study examines the correlation between personality qualities and the usage of e-cigarettes among nurses, as well as the impact on their mental health. A descriptive cross-sectional design study was conducted at Baquba Teaching Hospital in Diyala Governorate. A non-probability purposive sample was used to include 200 nurses working at Baquba Teaching Hospital, Diyala. Data were collected using a self-administered questionnaire from January 10, 2024 to February 29, 2024. The study instruments consist of two parts. First, the demographic sheet included sociodemographic information about the participants. The second part includes a measure of the personality assessment questionnaire (PAQ). The collected data were analysed using SPSS version 26. The user of the electronic cigar demonstrated a significant level of moderation across all dimensions of personality traits. Electronic cigar users exhibited a notable positive correlation between their years of experience in nursing and personality attributes. These new findings improve our comprehension of the factors that may make nurses more susceptible to electronic cigar use and the possible consequences for their mental well-being and lifestyle. The findings indicate that certain cognitive and personality qualities are associated with an increased risk of vaping. These findings can be used to develop targeted intervention techniques.