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The Cyril Scott companion : unity in diversity
This Companion explores the life and work of this remarkably creative man. It provides a comprehensive analysis and appraisal of all the available music and includes a complete catalogue of his musical works, along with a discography. Several works...both music and literary are here newly catalogued and discussed. Altogether, the volume gives a broad picture of Scott's entire output in literary, dramatic and philosophical genres.--Publisher
Book
Reduced Clinical and Economic Burden Through Evidence‐Based Dressing Selection for Wound Management: Findings From a Systematic Literature Review and Meta‐Analysis
The growing burden of wounds is placing pressure on clinicians and healthcare providers globally. This study aimed to determine the impact of using a hydrocellular polyurethane foam dressing (HPFD) on weekly dressing changes in mixed aetiology wounds. A systematic literature review was performed to identify studies reporting HPFD use versus other/previous dressings via PubMed, EMBASE and the Cochrane Library. A total of four studies were found reporting the use of HPFD in comparison to other dressings (386 patients), with 3 of these studies specifically providing data for HPFD use versus other (non‐HPFD) foam dressings (136 patients). Meta‐analysis revealed mean differences of −1.66 [95% CI −1.87;−1.48] and −1.23 [95% CI −1.65;−0.83] dressing changes per week in favour of HPFD versus other dressings and other foam dressings, respectively. A cost calculator model assessed the economic impact of this reduction of dressing change frequency from US and UK payer perspectives and found a 41% and 36% relative reduction in dressing change‐related costs in hospital/clinic and community settings for both perspectives. These findings were stable under sensitivity analyses, which identified clinical time as being the predominant driver of costs in all settings. These findings highlight the importance of appropriate evidence‐based dressing selection in enabling the extension of dressing wear times. Key Points The increasing burden of wound management weighs heavily on already stretched clinical and financial resources within healthcare systems. Use of specific evidence‐based dressings led to a reduction in the number of mean weekly dressing changes in a variety of healthcare settings and wounds when compared to previously used dressings. A health economic model estimated that the reduction in dressing changes resulted in substantial cost savings, primarily through a reduction in nursing time. Evidence‐based dressing selection can drive meaningful efficiencies in wound care delivery by releasing clinical resource and reducing costs.
Journal Article
Practical Considerations of Dissolved Oxygen Levels for Platelet Function under Hypoxia
Investigating human platelet function in low-oxygen environments is important in multiple settings, including hypobaric hypoxia (e.g., high altitude), sea level hypoxia-related disease, and thrombus stability. These studies often involve drawing blood from which platelets are isolated and analysed at atmospheric conditions or re-exposed to low oxygen levels in hypoxia chambers before testing. However, it remains unknown how the in vitro handling of the samples itself changes their dissolved oxygen concentration, which might affect platelet function and experimental results. Here, we prepared healthy donor platelet-rich plasma and washed platelet (WP) suspensions and exposed them to 2% oxygen. We found that the use of hypoxia pre-equilibrated tubes, higher platelet concentrations (>2 × 108/mL versus 2 × 107/mL), smaller volumes (600 µL versus 3 mL), and presence of plasma reduced the time for samples to reach 2% oxygen. Notably, oxygen levels decreased below 2% in most suspensions, but also in WP maintained at atmospheric 21% oxygen. Additionally, platelet spreading on fibrinogen was decreased when using hypoxic fibrinogen-coated culture plates regardless of the oxygen percentage (2% or 21%) in which platelet incubation took place. Thus, sample handling and experimental conditions should be carefully monitored in platelet-hypoxia studies as they might compromise results interpretation and comparison across studies.
Journal Article
Empirical Estimates of the Elasticity of Factor Substitution: Some Economic Considerations
The importance of the elasticity of factor substitution in the analysis of dynamic economic phenomena is beyond dispute. The reason for its significance is not difficult to discover: one of the most important tools of economic dynamics--the production function --is, under certain assumptions, determined uniquely by the form and value of the elasticity...
Journal Article
Stock up
Today's market environment is characterized by concerns - warranted or not - over a lack of pricing power (or outright deflation), a double-dip recession, the possibility of war in the Middle East and outright fraud on the part of many companies. All of that contributes to a situation in which few market watchers are prepared to take a clear position one way or the other. One can use training or forecast economic profits to come up with a measure of under or overvaluation. But even on a trailing basis, the US market was undervalued by more than 30% at the end of September.
Trade Publication Article
Is the business cycle dead again?
The most important structural change? The changed attitudes of central bankers! This may sound strange, but consider this. Every single recession in the post World War II era has been caused by monetary policy. We know why: inflation had accelerated to worrisome levels; interest rates had to be driven high enough to ensure that everyone lost their pricing power -- i.e., high enough to bring the economy to its knees. By contrast, Central banks today are prepared to raise rates to remove any inflation threat; that can be accomplished by engineering a slowdown, not a recession. If successful, Central banks can be counted on to provide whatever liquidity is required to finance non-inflationary growth. Yes, there can be mistakes, but as long as we are dealing with only an inflation threat, not entrenched and accelerating inflation, policies can be easily reversed to correct those mistakes. [PUBLICATION ABSTRACT]
Trade Publication Article