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result(s) for
"Aubry, Alexandre"
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Three-dimensional ultrasound matrix imaging
2023
Matrix imaging paves the way towards a next revolution in wave physics. Based on the response matrix recorded between a set of sensors, it enables an optimized compensation of aberration phenomena and multiple scattering events that usually drastically hinder the focusing process in heterogeneous media. Although it gave rise to spectacular results in optical microscopy or seismic imaging, the success of matrix imaging has been so far relatively limited with ultrasonic waves because wave control is generally only performed with a linear array of transducers. In this paper, we extend ultrasound matrix imaging to a 3D geometry. Switching from a 1D to a 2D probe enables a much sharper estimation of the transmission matrix that links each transducer and each medium voxel. Here, we first present an experimental proof of concept on a tissue-mimicking phantom through ex-vivo tissues and then, show the potential of 3D matrix imaging for transcranial applications.
Ultrasound is a flexible and powerful medical tool. Yet, brain imaging has remained elusive so far for ultrasound due to the blurring induced by the skull. Here, a 3D non-invasive approach is proposed to make the skull digitally transparent and image brain tissues at unprecedented resolution.
Journal Article
Distortion matrix approach for ultrasound imaging of random scattering media
by
Aubry, Alexandre
,
Frappart, Thomas
,
Fink, Mathias
in
Acoustic microscopy
,
Acoustics
,
Applied Physical Sciences
2020
Focusing waves inside inhomogeneous media is a fundamental problem for imaging. Spatial variations of wave velocity can strongly distort propagating wave fronts and degrade image quality. Adaptive focusing can compensate for such aberration but is only effective over a restricted field of view. Here, we introduce a full-field approach to wave imaging based on the concept of the distortion matrix. This operator essentially connects any focal point inside the medium with the distortion that a wave front, emitted from that point, experiences due to heterogeneities. A time-reversal analysis of the distortion matrix enables the estimation of the transmission matrix that links each sensor and image voxel. Phase aberrations can then be unscrambled for any point, providing a full-field image of the medium with diffraction-limited resolution. Importantly, this process is particularly efficient in random scattering media, where traditional approaches such as adaptive focusing fail. Here, we first present an experimental proof of concept on a tissue-mimicking phantom and then, apply the method to in vivo imaging of human soft tissues. While introduced here in the context of acoustics, this approach can also be extended to optical microscopy, radar, or seismic imaging.
Journal Article
Harnessing forward multiple scattering for optical imaging deep inside an opaque medium
by
Balondrade, Paul
,
Boccara, Claude
,
Aubry, Alexandre
in
639/624/1075/1076
,
639/624/1107/510
,
Cornea
2024
As light travels through a disordered medium such as biological tissues, it undergoes multiple scattering events. This phenomenon is detrimental to in-depth optical microscopy, as it causes a drastic degradation of contrast, resolution and brightness of the resulting image beyond a few scattering mean free paths. However, the information about the inner reflectivity of the sample is not lost; only scrambled. To recover this information, a matrix approach of optical imaging can be fruitful. Here, we report on a de-scanned measurement of a high-dimension reflection matrix
R
via low coherence interferometry. Then, we show how a set of independent focusing laws can be extracted for each medium voxel through an iterative multi-scale analysis of wave distortions contained in
R
. It enables an optimal and local compensation of forward multiple scattering paths and provides a three-dimensional confocal image of the sample as the latter one had become digitally transparent. The proof-of-concept experiment is performed on a human opaque cornea and an extension of the penetration depth by a factor five is demonstrated compared to the state-of-the-art.
Microscopy exploits light scattering to image biological tissues, but heterogeneities distort wave trajectories, creating a foggy image. A digital approach is proposed to harness these complex paths and reveal the inner structure of opaque media.
Journal Article
Reflection Matrix Approach for Quantitative Imaging of Scattering Media
2020
We present a physically intuitive matrix approach for wave imaging and characterization in scattering media. The experimental proof of concept is performed with ultrasonic waves, but this approach can be applied to any field of wave physics for which multielement technology is available. The concept is that focused beam forming enables the synthesis, in transmit and receive, of an array of virtual transducers which map the entire medium to be imaged. The interelement responses of this virtual array form a focused reflection matrix from which spatial maps of various characteristics of the propagating wave can be retrieved. Here we demonstrate (i) a local focusing criterion that enables the image quality and the wave velocity to be evaluated everywhere inside the medium, including in random speckle, and (ii) a highly resolved spatial mapping of the prevalence of multiple scattering, which constitutes a new and unique contrast for ultrasonic imaging. The approach is demonstrated for a controllable phantom system and for in vivo imaging of the human abdomen. More generally, this matrix approach opens an original and powerful route for quantitative imaging in wave physics.
Journal Article
A digital solution towards deep optical imaging
2025
Computational back-projection and averaging of as little as 25 scattered fields from an object enables imaging through turbid media without using a guide star or knowledge of the reflection matrix.
Journal Article
A digital solution towards deep optical imaging
2025
Computational back-projection and averaging of as little as 25 scattered fields from an object enables imaging through turbid media without using a guide star or knowledge of the reflection matrix.
Journal Article
Alerting, orienting, and executive control in intellectually gifted children
by
Bourdin, Béatrice
,
Aubry, Alexandre
in
Adolescent
,
attention network test
,
attentional processes
2021
Introduction Intellectually gifted children have higher performance in many domains of attention than intellectually average children. However, these empirical findings are not consistent in the literature. Few studies investigated the characteristics of alerting, orienting, and executive control networks in intellectually gifted children. The aim of our study was to investigate their characteristics of attentional abilities compared to intellectually average children. Method Fifty‐five intellectually gifted children (age range 8–14 years old) were compared to 55 intellectually average children (age range 8–14 years old) using the Attention Network Test (ANT) to assess these three attentional constructs. Results Intellectually gifted children made fewer errors than intellectually average children in the processing of the ANT. In terms of attention network scores, they also outperformed intellectually average children in executive control only. Conclusion Intellectually gifted children do not differ from intellectual average children in terms of the speed of processing in a speeded task such as ANT, but they stand out in terms of accuracy of processing. Intellectually gifted children have better ability to focus volitionally in order to solve a simple perceptual conflict than intellectually average children. The aim of this study was to investigate the characteristics of three attentional networks in intellectually gifted children. The findings show the intellectually gifted children have better ability to focus volitionally in order to solve a simple perceptual conflict than intellectually average children.
Journal Article
Cloaking, trapping and superlensing of lamb waves with negative refraction
by
Laurent, Jérôme
,
Lemoult, Fabrice
,
Prada, Claire
in
639/166/988
,
639/624/399/1015
,
639/766/25/3927
2021
We report on experimental and numerical implementations of devices based on the negative refraction of elastic guided waves, the so-called Lamb waves. Consisting in plates of varying thickness, these devices rely on the concept of complementary media, where a particular layout of negative index media can cloak an object with its anti-object or trap waves around a negative corner. The diffraction cancellation operated by negative refraction is investigated by means of laser ultrasound experiments. However, unlike original theoretical predictions, these intriguing wave phenomena remain, nevertheless, limited to the propagating component of the wave-field. To go beyond the diffraction limit, negative refraction is combined with the concept of metalens, a device converting the evanescent components of an object into propagating waves. The transport of an evanescent wave-field is then possible from an object plane to a far-field imaging plane. Twenty years after Pendry’s initial proposal, this work thus paves the way towards an elastic superlens.
Journal Article
Matrix imaging as a tool for high-resolution monitoring of deep volcanic plumbing systems with seismic noise
by
Giraudat, Elsa
,
Burtin, Arnaud
,
Aubry, Alexandre
in
Arrays
,
Earthquake resistance
,
Engineering Sciences
2024
Volcanic eruptions necessitate precise monitoring of magma pressure and inflation for improved forecasting. Understanding deep magma storage is crucial for hazard assessment, yet imaging these systems is challenging due to complex heterogeneities that disrupt standard seismic migration techniques. Here we map the magmatic and hydrothermal system of the La Soufrière volcano in Guadeloupe by analyzing seismic noise data from a sparse geophone array under a matrix formalism. Seismic noise interferometry provides a reflection matrix containing the signature of echoes from deep heterogeneities. Using wave correlations resistant to disorder, matrix imaging successfully unscrambles wave distortions, revealing La Soufrière's internal structure down to 10 km with 100 m resolution. This method surpasses the diffraction limit imposed by geophone array aperture, providing crucial data for modeling and high-resolution monitoring. We see matrix imaging as a revolutionary tool for understanding volcanic systems and enhancing observatories' abilities to monitor dynamics and forecast eruptions.
Journal Article
Multi-spectral reflection matrix for ultrafast 3D label-free microscopy
by
Balondrade, Paul
,
Boccara, Claude
,
Guigui, Nicolas
in
639/624/1075/1076
,
639/624/1107/510
,
Aberration
2024
Label-free microscopy exploits light scattering to obtain a three-dimensional image of biological tissues. However, light propagation is affected by aberrations and multiple scattering, which drastically degrade the image quality and limit the penetration depth. Multi-conjugate adaptive optics and time-gated matrix approaches have been developed to compensate for aberrations but the associated frame rate is extremely limited for three-dimensional imaging. Here we develop a multi-spectral matrix approach to solve these fundamental problems. On the basis of a sparse illumination scheme and an interferometric measurement of the reflected wave field at multiple wavelengths, the focusing process can be optimized in post-processing for any voxel by addressing independently each frequency component of the reflection matrix. A proof-of-concept experiment shows a three-dimensional image of an opaque human cornea over a 0.1 mm
3
field of view at a 290 nm resolution and a 1 Hz frame rate. This work paves the way towards a fully digital microscope allowing real-time, in vivo, quantitative and deep inspection of tissues.
Based on the acquisition of a multi-spectral reflection matrix at a high frame rate, a fully digital microscope overcomes aberrations and multiple scattering to provide a three-dimensional image of an ex vivo opaque cornea at a resolution of 0.29 μm and 0.5 μm in the transverse and axial directions, respectively.
Journal Article