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"Avery, John"
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Human beige adipocytes for drug discovery and cell therapy in metabolic diseases
Human beige adipocytes (BAs) have potential utility for the development of therapeutics to treat diabetes and obesity-associated diseases. Although several reports have described the generation of beige adipocytes in vitro, their potential utility in cell therapy and drug discovery has not been reported. Here, we describe the generation of BAs from human adipose-derived stem/stromal cells (ADSCs) in serum-free medium with efficiencies >90%. Molecular profiling of beige adipocytes shows them to be similar to primary BAs isolated from human tissue. In vitro, beige adipocytes exhibit uncoupled mitochondrial respiration and cAMP-induced lipolytic activity. Following transplantation, BAs increase whole-body energy expenditure and oxygen consumption, while reducing body-weight in recipient mice. Finally, we show the therapeutic utility of BAs in a platform for high-throughput drug screening (HTS). These findings demonstrate the potential utility of BAs as a cell therapeutic and as a tool for the identification of drugs to treat metabolic diseases.
Methods to generate beige adipocytes from a human cell source are inefficient. Here, the authors present a protocol that efficiently generates beige adipocytes from human adipose-derived stem cells (ADSCs), which have potential utility in therapeutic development relating to metabolic diseases such as type 2 diabetes.
Journal Article
Adventures of a ballad hunter
Growing up beside the Chisholm Trail, captivated by the songs of passing cowboys and his friend Nat Blythe, an African American farmhand, John A. Lomax developed a passion for American folk songs that ultimately made him one of the foremost authorities on this fundamental aspect of Americana. Across many decades and throughout the country, Lomax and his informants created over five thousand recordings of America's musical heritage, including ballads, blues, children's songs, fiddle tunes, field hollers, lullabies, play-party songs, religious dramas, spirituals, and work songs. He acted as honorary curator of the Archive of American Folk Song at the Library of Congress, directed the Slave Narrative Project of the WPA, and cofounded the Texas Folklore Society. Lomax's books include Cowboy Songs and Other Frontier Ballads, American Ballads and Folk Songs, Negro Folk Songs as Sung by Leadbelly, and Our Singing Country, the last three coauthored with his son Alan Lomax. Adventures of a Ballad Hunter is a memoir of Lomax's eventful life. It recalls his early years and the fruitful decades he spent on the road collecting folk songs, on his own and later with son Alan and second wife Ruby Terrill Lomax. Vibrant, amusing, often haunting stories of the people he met and recorded are the gems of this book, which also gives lyrics for dozens of songs. Adventures of a Ballad Hunter illuminates vital traditions in American popular culture and the labor that has gone into their preservation.
Book
Generalized sturmians and atomic spectra
This book describes the generalized Sturmian method, which offers a fresh approach to the calculation of atomic spectra. Generalized Sturmians are isoenergetic solutions to an approximate many-electron Schrödinger equation with a weighted potential. The weighting factors are chosen in such a way as to make all of the solutions correspond to a given energy. The advantage of such an isoenergetic basis set is that every basis function has the correct turning point behavior needed for efficient synthesis of the wave function. The book also discusses methods for automatic generation of symmetry-adapted basis sets. Calculations using the generalized Sturmian method are presented and compared with experimental results from the NIST database. The relationship of Sturmians to harmonic polynomials and hyperspherical harmonics is also described. Methods for treating angular functions and angular integrals by means of harmonic projection are discussed, and these methods are shown to be especially useful for relativistic calculations. A final chapter discusses application of the generalized Sturmian method to the calculation of molecular spectra.
eBook
Who were the Brothers Grimm?
Jacob and Wilhelm Grimm were born in 1780s Germany and were inseparable throughout their childhood. While pursuing their law degrees, the two became fascinated with folktales and folk songs. Together, they researched and published centuries of folklore in their famous early nineteenth-century compilation, Children's and Household Tales. Thanks to the Brothers Grimm, German folk tales like \"Rumpelstiltskin,\" \"Little Red Ridinghood,\" and \"Hansel and Gretel\" are still enjoyed by children throughout the world.
BOOK
Against the Institution of War
Among the topics discussed is the current crisis of civilization, to which the institution of war in an era of all-destroying thermonuclear weapons strongly contributes. Another issue that is discussed is the human emotional tendency that might be called \"tribalism\". It is our tendency to be kind and altruistic towards members of our own group, and extremely hostile towards groups that are perceived to be competing with or threatening our own. Probably this tendency was built into the genes of our ancestors when they lived in small, genetically homogeneous tribes, competing for territory on the grasslands of Africa. Another important topic discussed is the need for effective and just global governance. It is argued that the United Nations should be strengthened by converting it into a federation, with a greatly increased income, and the power to make laws that are binding on individuals. The International Criminal Court, established by the Treaty of Rome, is discussed as an important first step towards individual accountability. It is my hope that this article will contribute to our understanding of Human Security.
Journal Article
The War in Ukraine Must Stop Now
The extreme dangers of nuclear war are discussed against the background of Russia's brutal and illegal invasion of Ukraine, during which Vladimir Putin put Russia 's nuclear weapons on high alert. It is recommended that the United States and its allies should stop sending arms to Ukraine, that they should halt the eastward expansion of NATO, and that they should withdraw nuclear weapons from positions close to Russia. A diplomatic solution to the conflict must be found under the wise guidance of UN Secretary-General Guterres.
Journal Article
Maternal Malaria Induces a Procoagulant and Antifibrinolytic State That Is Embryotoxic but Responsive to Anticoagulant Therapy
Low birth weight and fetal loss are commonly attributed to malaria in endemic areas, but the cellular and molecular mechanisms that underlie these poor birth outcomes are incompletely understood. Increasing evidence suggests that dysregulated hemostasis is important in malaria pathogenesis, but its role in placental malaria (PM), characterized by intervillous sequestration of Plasmodium falciparum, proinflammatory responses, and excessive fibrin deposition is not known. To address this question, markers of coagulation and fibrinolysis were assessed in placentae from malaria-exposed primigravid women. PM was associated with significantly elevated placental monocyte and proinflammatory marker levels, enhanced perivillous fibrin deposition, and increased markers of activated coagulation and suppressed fibrinolysis in placental plasma. Submicroscopic PM was not proinflammatory but tended to be procoagulant and antifibrinolytic. Birth weight trended downward in association with placental parasitemia and high fibrin score. To directly assess the importance of coagulation in malaria-induced compromise of pregnancy, Plasmodium chabaudi AS-infected pregnant C57BL/6 mice were treated with the anticoagulant, low molecular weight heparin. Treatment rescued pregnancy at midgestation, with substantially decreased rates of active abortion and reduced placental and embryonic hemorrhage and necrosis relative to untreated animals. Together, the results suggest that dysregulated hemostasis may represent a novel therapeutic target in malaria-compromised pregnancies.
Journal Article
Energy, resources, and the long-term future
The world is rapidly approaching the end of the fossil fuel era. This timely book reviews the historical background for this crisis and provides a comprehensive discussion of its important aspects. It contrasts the Utopian writings of Condorcet, Godwin and Adam Smith, with the more pessimistic views of Malthus and Ricardo. It then discusses the characteristics of mainstream industrialism, as well as the ecological counterculture. The final chapters of the book study the present position regarding both non-renewable and renewable resources, and the problem of reducing the economic trauma that will result from the depletion of fossil fuels, especially the future impact of high petroleum prices on agriculture in relation to global population growth.
eBook
Information theory and evolution
Information Theory and Evolution discusses the phenomenon of life, including its origin and evolution (and also human cultural evolution), against the background of thermodynamics, statistical mechanics, and information theory. Among the central themes is the seeming contradiction between the second law of thermodynamics and the high degree of order and complexity produced by living systems. This paradox has its resolution in the information content of the Gibbs free energy that enters the biosphere from outside sources, as the author will show. The role of information in human cultural evolution is another focus of the book.
eBook