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Artemisia judaica L. (Family: Asteraceae) exhibited antioxidant, anti-inflammatory, and antiapoptotic effects. The in vitro cytotoxic activity of A. judaica ethanolic extract was screened against a panel of cancer cell lines. The results revealed its cytotoxic activity against a lung cancer (A549) cell line with a promising IC50 of 14.2 μg/mL compared to doxorubicin as a standard. This was confirmed through the downregulation of antiapoptotic genes, the upregulation of proapoptotic genes, and the cell cycle arrest at the G2/M phase. Further in vivo study showed that a solid tumor mass was significantly reduced, with a tumor inhibition ratio of 54% relative to doxorubicin therapy in a Xenograft model. From a chemical point of view, various classes of natural products have been identified by liquid chromatography combined with tandem mass spectrometry (LC-MS/MS). The docking study of the detected metabolites approved their cytotoxic activity through their virtual binding affinity towards the cyclin-dependent kinase 2 (CDK-2) and epidermal growth factor receptor (EGFR) active sites. Finally, A. judaica is a fruitful source of polyphenols that are well-known for their antioxidant and cytotoxic activities. As such, the previously reported polyphenols with anti-lung cancer activity were quantified by high-performance liquid chromatography coupled with a diode array detector (HPLC-DAD). Rutin, quercetin, kaempferol, and apigenin were detected at concentrations of 6 mg/gm, 0.4 mg/gm, 0.36 mg/gm, and 3.9 mg/gm of plant dry extract, respectively. It is worth noting that kaempferol and rutin are reported for the first time. Herein, A. judaica L. may serve as an adjuvant therapy or a promising source of leading structures in drug discovery for lung cancer treatment.

Cichorium endivia L. (Asteraceae) is a wide edible plant that grows in the Mediterranean region. In this study, a phytochemical investigation of C. endivia L. ethanolic extract led to the isolation of stigmasterol (1), ursolic acid (2), β-amyrin (3), azelaic acid (4), vanillic acid (5), (6S, 7E)-6-hydroxy-4,7-megastigmadien-3,9-dione (S(+)-dehydrovomifoliol) (6), 4-hydroxy phenyl acetic acid (7), vomifoliol (8), ferulic acid (9), protocatechuic acid (10), kaempferol (11), p. coumaric acid (12), and luteolin (13). In addition, the total phenolic content as well as the in vitro antioxidant activity of C. endivia L. extract were estimated. Moreover, we inspected the potential gonado-protective effect of C. endivia crude extract, its phenolic fraction, and the isolated coumaric, vanillic, and ferulic acids against methotrexate (MTX)-induced testicular injury in mice. There were seven groups: normal control, MTX control, MTX + C. endivia crude extract, MTX + C. endivia phenolic fraction, MTX + isolated coumaric acid, MTX + isolated vanillic acid, and MTX + isolated ferulic acid. MTX was given by i.p. injection of a 20 mg/kg single dose. The crude extract and phenolic fraction were given with a dose of 100 mg/kg/day, whereas the compounds were given at a dose of 10 mg/kg/day. A histopathological examination was done. The testosterone level was detected in serum together with the testicular content of malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), interleukin 1β (IL-1β), IL-6, tumor necrosis factor alpha (TNF-α), nuclear factor kappa B (NF-κB), B-cell lymphoma 2 (Bcl-2), Bcl-2 associated x protein (Bax), p53, and miR-29a. C. endivia crude extract, the phenolic fraction, and the isolated compounds showed significant elevation in their levels of testosterone, CAT, SOD, Bcl-2 with a significant decrease in their levels of MDA, TNF-α, IL-1β, IL-6, NF-κB, Bax, P53, and miR-29a compared to those of the MTX control group. In conclusion, C. endivia mitigated MTX-induced germ cell toxicity via anti-inflammatory, antioxidant, and antiapoptotic effects.

Achillea fragrantissima (Forssk) Sch. Bip. (Asteraceae) is one of the most important medicinal plant species in Egypt. Phytochemical investigation of the methanolic extract of A. fragrantissima led to the isolation of two phenolic compounds Piceol ( 1 ) and Veratric acid ( 2 ), which are reported for the first time from this plant. In addition, four known flavonoid compounds; Eupatilin 7-methyl ether ( 3 ), Chrysosplenol D ( 4 ), Cirsiliol ( 5 ), and Cirsimaritin ( 6 ) were isolated. Structure elucidation was achieved using spectroscopic techniques, including one-dimensional and two-dimensional nuclear magnetic resonance. Potential cytotoxic activities of the isolated compounds were measured by the sulphorhodamine B assay. Compounds 1 , 2 , 3 , 4, 5 , and 6 displayed cytotoxic activity against (MCF7) with IC 50 values of 18.2, 15.7, 9.5, 8.33, 3.23, and 3.83 µg/ml, respectively, and against (HepG2) with IC 50 values of 19.4, 41.2, 28.3, 20.8, 23.8, and 23.8 µg/ml, respectively. Also there was moderate cytotoxic activity against (A549) with IC 50 values of 17.8, 13.6, 3.98, and 10.3 µg/ml for the compounds 1 , 2 , 4 and 5 , respectively, and against (HeLa) with IC 50 values of 10.1, 10.4, 4.88, and 3.98 µg/ml for the compounds 3 , 4 , 5 , and 6 , respectively. In addition, compounds 4 and 5 showed cytotoxic activity against (PC3) with IC 50 values of 3.83 and 3.98 µg/ml, respectively. An in silico study was performed, where cirsiliol ( 5 ) and piceol ( 1 ) were docked into the active sites of the crystal structures of PI3K and Akt, two protein kinases which are involved in prostate and breast cancer proliferation and survival.

Cichorium endivia L. (Asteraceae) is a wide edible plant that grows in the Mediterranean region. In this study, a phytochemical investigation of C. endivia L. ethanolic extract led to the isolation of stigmasterol (1), ursolic acid (2), β-amyrin (3), azelaic acid (4), vanillic acid (5), (6S, 7E)-6-hydroxy-4,7-megastigmadien-3,9-dione (S(+)-dehydrovomifoliol) (6), 4-hydroxy phenyl acetic acid (7), vomifoliol (8), ferulic acid (9), protocatechuic acid (10), kaempferol (11), p. coumaric acid (12), and luteolin (13). In addition, the total phenolic content as well as the in vitro antioxidant activity of C. endivia L. extract were estimated. Moreover, we inspected the potential gonado-protective effect of C. endivia crude extract, its phenolic fraction, and the isolated coumaric, vanillic, and ferulic acids against methotrexate (MTX)-induced testicular injury in mice. There were seven groups: normal control, MTX control, MTX + C. endivia crude extract, MTX + C. endivia phenolic fraction, MTX + isolated coumaric acid, MTX + isolated vanillic acid, and MTX + isolated ferulic acid. MTX was given by i.p. injection of a 20 mg/kg single dose. The crude extract and phenolic fraction were given with a dose of 100 mg/kg/day, whereas the compounds were given at a dose of 10 mg/kg/day. A histopathological examination was done. The testosterone level was detected in serum together with the testicular content of malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), interleukin 1β (IL-1β), IL-6, tumor necrosis factor alpha (TNF-α), nuclear factor kappa B (NF-κB), B-cell lymphoma 2 (Bcl-2), Bcl-2 associated x protein (Bax), p53, and miR-29a. C. endivia crude extract, the phenolic fraction, and the isolated compounds showed significant elevation in their levels of testosterone, CAT, SOD, Bcl-2 with a significant decrease in their levels of MDA, TNF-α, IL-1β, IL-6, NF-κB, Bax, P53, and miR-29a compared to those of the MTX control group. In conclusion, C. endivia mitigated MTX-induced germ cell toxicity via anti-inflammatory, antioxidant, and antiapoptotic effects.

In the next twenty years, the scarcity of food shortage and drinking water will appear in Egypt due to the growth of industries and agriculture. This paper develops a conceptual design of the new technologies in the field of water–energy–food in new cities. Border lines are the internal relationship, external influence, and linkage system evaluation for WEF nexus. The major problems of using fossil energy in desalination are emissions and non-renewability, as well as the preference for dispersed freshwater production instead of concentrated output. The design of a desalination system that is integrated with renewable energies is critical these days. This type of system can also reduce the production of environmental pollutants due to reduced energy consumption and transfer of freshwater. GIS data from the United Nations have confirmed the existence of an underground reservoir in Wadi-Dara that can cultivate 1000 acres using smart farming techniques to reach a circular economy for an integrated solution between the water–energy nexus. The possibility of cultivating a hundred acres in Wadi-Dara on the Red Sea coast exists, through which about one million people could be settled. In this comprehensive review, we conducted a deep study in order to establish a sustainable integrated lifestyle in the Dara Valley region in terms of the availability of potable water, clean energy, and agriculture. Sustainable integrated solutions were conducted for seawater desalination using beach sand filtration wells as a pretreatment for seawater using renewable energy, e.g., wind energy (18% wind turbines), and photovoltaic panels (77% PV panels). Strategic food will be cultivated using smart farming that includes an open ponds cultivation system of microalgal cells to synthesis (5.0% of bio-fuel (. Aqua agriculture and aquaponics will cultivate marine culture and integrate mangrove, a shrimp aquaculture. A municipal waste water treatment is conceived for the irrigation of shrubby forests and landscapes. Mixotrophic cultures were explored to achieve a sustained ecological balance. Food, poultry and animal waste management, as well as a cooker factory, were included in the overall design. The environmental impact assessment (EIA) study shows a low risk due to anticipated net zero emissions, a 75% green city, and optimal waste recycling. This research assists in combining research efforts to address the challenging processes in nexus research and build resilient and sustainable water, energy, and food systems.

Listeriosis is a severe zoonotic disease caused by Listeria monocytogenes ( L. monocytogenes ), which can be acquired through animal source foods. This pathogen shows unique virulence fitness allowing it to penetrate and survive inside host cells causing extremely dangerous symptoms. Therefore, we aimed to correlate the clinical outcomes with the antimicrobial resistance and virulence profiles of L. monocytogenes . This is crucial for improving disease management, developing new therapeutic strategies, enhancing public health and food safety, and advancing scientific knowledge. Therefore, we assessed the antimicrobial resistance and virulence profiles of L. monocytogenes isolated from various sources, along with their potential to cause disease, using an in vivo rabbit model. Based on identification criteria, 47 L. monocytogenes isolates (15.7%) were recovered with the highest detection rates among rabbits (22%). Unfortunately, all the investigated isolates showed multidrug resistance (MDR) as well as multi-virulent profiles with 45 highly heterogeneous clusters. Noteworthy, the degree of illnesses of the experimentally infected rabbits was dependent on the virulence profiles. Specific nervous manifestations and severe histopathological alterations were observed in experimental rabbits infected with highly virulent isolates confirming that the potential ability of this pathogen to produce a disease is not always decipherable from its virulence arrays. Finally, it was confirmed that managing infections caused by L. monocytogenes has become increasingly challenging due to its high antimicrobial resistance, strong virulence, and the severe pathological effects linked to its virulence factors.

Liquefied Petroleum Gas (LPG) recovery in debutanizer columns presents challenges in balancing operational efficiency and process stability under varying conditions. Conventional control strategies often fail to sustain optimal recovery. This study integrates process modeling and control, using Aspen HYSYS for steady-state simulation and dynamic implementation of model predictive control (MPC). Response surface methodology (RSM) was applied to steady-state simulation results to analyze key process variables. Feed molar flow rate was the most influential factor, while pressure-related variables showed minor but statistically significant effects. The quadratic model and 3D response surfaces confirmed key interactions. A regression decision tree model was developed in MATLAB to support deployment of artificial intelligence-enhanced MPC (AI-enhanced MPC). MPC improved LPG recovery from 99.73 to 99.85%, reduced reboiler duty from 1,557,000 to 1,550,000 kcal/h, and reflux flow from 281.2 to 271 kgmole/h. AI-enhanced MPC further increased recovery to 99.9%, reduced reboiler duty to 1,501,956 kcal/h, condenser duty to 2,415,726 kcal/h, and reflux flow to 262.6 kgmole/h, indicating superior energy efficiency and control precision. Although feed molar flow remained dominant, both control systems regulated its impact via pressure, temperature, and reflux. Product temperature dropped from 49.88 °C to 49.24 °C, and pressure from 12.39 to 11.95 bar, indicating enhanced thermal stability. The novelty of this study lies in integrating RSM with both conventional and AI-enhanced model predictive control, forming a hybrid framework enabling steady-state optimization and dynamic control for improved LPG recovery. The proposed framework supports industrial LPG recovery by improving energy efficiency, product quality, and dynamic stability.

To evaluate central quadrantectomy and nipple resection with areola preservation (CQ-NR-AP) as a new reconstructive oncoplastic technique Versus Grisotti flap mammoplasty (GFM) in central malignant tumors of the breast extending to the nipple, in terms of time procedures, breast symmetry, patient satisfaction, postoperative complications, and local recurrence. The current study is a single-blind, single-center, randomized, controlled trial that was performed between May 2018 and May 2023 in the breast surgery unit of University Hospitals. This trial involved 40 individuals who had central breast lesions that extended to the nipple and were monitored for two years following surgery. As regards the mean intra-operative time in minutes, in the group (I) was 80.1 with a standard deviation of ± 13.9, and ingroup (II) was 138.9 with a standard deviation of ± 14.02 (p = 0.001). The seroma was detected in zero cases in group (I) and 2(10%) cases in group II (p = 0.487) and those two cases were managed by aspiration only. Regarding, the wound infection was found in one case (5%) in group (I) and 3(15%) cases in group II (p = 0.605). Regarding patient satisfaction and breast, symmetry was much better in the group (I). The safety and ease of central quadrantectomy and nipple resection with areola preservation were demonstrated in a two-year follow-up, with a lower incidence of complications compared to the Grisotti flap mammoplasty technique. Furthermore, this approach was associated with higher patient satisfaction, which is a significant achievement in the management of centrally located breast tumors.

In the present study, the synthesis, using the wet co-precipitation method, and characterization of Mg 1 / 3 Ni 1 / 3 Co 1 / 3 Fe 2 - x Gd x O 4 , with x  = 0.00, 0.02 and 0.08 wt% nanoparticles were reported. The X-ray powder diffraction (XRD) and transmission electron microscopy (TEM) confirm the formation of nano-spinel ferrite. The crystallite size of Mg 1 / 3 Ni 1 / 3 Co 1 / 3 Fe 2 - x Gd x O 4 nanoparticles decreased, resulting from the microstrain induced by Gd 3+ substitution. However, the lattice parameter “ a ” increased, in agreement with the difference between the ionic radii of Fe 3+ and Gd 3+ ions. X-ray photoelectric spectroscopy (XPS) measurements were conducted to verify the elemental composition, valency, and cationic distribution. Furthermore, Fourier-Transform Infrared spectroscopy (FTIR) was used in combination with XPS to estimate the force constants, elasticity parameters, and Debye temperature. Vickers microhardness measurements were carried out to investigate the mechanical behavior of the prepared samples and determine Young’s modulus. The values of Young’s modulus obtained from the microhardness measurements are larger than those obtained from FTIR measurements. However, the results, obtained from both techniques, showed an enhancement with Gd 3+ doping.

Background This paper presents the results of a systematic review to identify practical strategies to create the institutions, skills, values, and norms that will improve health systems resilience. Methods A PRISMA 2020 compliant systematic review identified peer-reviewed and gray literature on practical strategies to make health systems more resilient. Investigators screened 970 papers to identify 65 English language papers published since 2015. Results Practical strategies focus efforts on system changes to improve a health system’s resilience components of collective knowing, collective thinking, and collaborative doing. The most helpful studies identified potential lead organizations to serve as the stewards of resilience improvement, and these were commonly in national and local departments of public health. Papers on practical strategies suggested possible measurement tools to benchmark resilience components in efforts to focus on performance improvement and ways to sustain their use. Essential Public Health Function (EPHF) measurement and improvement tools are well-aligned to the resilience agenda. The field of health systems resilience lacks empirical trials linking resilience improvement interventions to outcomes. Conclusions The rigorous assessment of practical strategies to improve resilience based on cycles of measurement should be a high priority.