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"Awan, Nishat"
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Words and objects in transposing desire and making space
In this article I will explore the relationship between space, language and
objects and interrogate the role of language as a signifier for the
transformation of space through cultural difference. My work is informed by the
context and the methods of postcolonialism and specifically the notion of
hybridity. If the hybridity of a postcolonial identity is acknowledged, then the
space where these identities are negotiated could also be seen as sharing
qualities of overlap and mixing. Influenced by psychoanalytic theories of the
self and its relation to others, postcolonial theory has used strategies of
‘mimicry’ and ‘hybridity’ as motifs
to provide a vocabulary that shifts colonial relations out of the dialectic of
oppressor and oppressed. But following Lefebvre's idea that all space
is social space, and Foucault's spatialisation of power, the move
from the historic preoccupation with time to a spatialisation of the processes
of knowledge production, allows postcolonial thinking to go beyond the
complicities of identity politics, which has been one of the major criticisms of
this mode of thought. As an architect, this opens up certain possibilities of
interrogating postcolonial subjectivity through the spaces that are occupied and
used by those who are implicated within it. This paper will focus on one such
space: a park in East London.
Journal Article
Diasporic urbanism: concepts, agencies & 'mapping otherwise'
The term ‘diasporic urbanism’ addresses the difficulties of operating with diasporic space and of accommodating the material complexities of migrant lives. It proposes displacement and reterritorialisations as methodologies and ‘mapping otherwise’ as a tool for representing and working with migrant spatialities. Diasporic space is theorised as a relational space, whilst diasporic subjectivity is described as ‘nomadic consciousness’. The politics of the diaspora are addressed through the need to accommodate conflict (Mouffe) and through introducing ‘things’ and ‘matters of concern’ (Latour) into the democratic relationship. These concepts were tested in practice through my research which focuses examples of diasporic agencies in the everyday. From the Turkish and Kurdish kahve to a street whose physicality forces a certain visibility on to those who traverse it, to a park in East London that through being claimed by one diasporic group has come to symbolise wider notions of political representation. The mapping of these particular spaces has addressed the question: within the networked, global condition of the migrant, what objects, subjects and processes can play the role of mediation and translation that is required between ‘here and there’, or between the layers of this multiple subject? The need for such approaches is apparent in the increasing diversity of European cities. The everyday geographies of people’s lives can easily lose themselves in the enormity of the questions and the complexities of the issues surrounding migration. Yet, it is exactly the specificity of individual lives, the way that geo-political borders and territories inscribe themselves onto the intimate topology of migrant and diasporic bodies, half-here and half-there, that is so difficult to account for. This then is the challenge set down for ‘diasporic urbanism’—how to make the conditions necessary for those other than the privileged to participate in the imagining of our cities.
Dissertation
Mining the SNPs of Human Low Density Lipoprotein (LDL) related Gene APOB through in silico Approaches
ABSTRACT Apolipoprotein B (APOB) is the major part of low density lipoprotein (LDL), with two major isoforms: APOB100 and APOB48 found in the human body. Both isoforms are involved in the formation and transport of chylomicron and LDL-cholesterol. Point mutations in APOB may lead to change in protein stereochemistry, which may result in premature coronary artery disease, familial hypobetalipoproteinemia, hypocholesterolemia, mono-genic dyslipisimias and other atherogenic events in CVD. Here we evaluated the impact of all missense and non-coding single nucleotide polymorphisms (SNPs) of APOB retrieved from dbSNP using 17 different computational tools and further evaluated the structural impact of these convergent deleterious SNPs on APOB through HOPE. We found 9 missenses, 15 intronic or regulatory region SNPs and 2 were found in miRNA target sites of APOB. Out of these variant, the rs13306194 (Arg532Trp) was found in the conserved region of protein domain, which can potentially disrupt overall chemical structure and function of the APOB. Six missense SNPs in the coding, and 17 SNPs in non-coding regions are proposed as novel most deleterious variants of APOB. We also try to predict the structural model of APOB through protein docking. The results indicate the applicability of in silico approach to propose the most deleterious SNPs of APOB that should be prioritize for future genetic association studies in cohort of cardiovascular patients. While their structural impact on APOB may suggest these predicted nsSNPs possibly be a better drug target and contribute to the treatment and better understanding of human cardiovascular disease.
Journal Article