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result(s) for
"Ayala Nunes, Lara"
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Determination of Markers of Successful Implementation of Mental Health Apps for Young People: Systematic Review
2022
Smartphone apps have the potential to address some of the current issues facing service provision for young people's mental health by improving the scalability of evidence-based mental health interventions. However, very few apps have been successfully implemented, and consensus on implementation measurement is lacking.
This review aims to determine the proportion of evidence-based mental health and well-being apps that have been successfully adopted and sustained in real-world settings. A secondary aim is to establish if key implementation determinants such as coproduction, acceptability, feasibility, appropriateness, and engagement contribute toward successful implementation and longevity.
Following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, an electronic search of 5 databases in 2021 yielded 18,660 results. After full-text screening, 34 articles met the full eligibility criteria, providing data on 29 smartphone apps studied with individuals aged 15 to 25 years.
Of 34 studies, only 10 (29%) studies were identified that were evaluating the effectiveness of 8 existing, commercially available mental health apps, and the remaining 24 (71%) studies reported the development and evaluation of 21 newly developed apps, of which 43% (9/21) were available, commercially or otherwise (eg, in mental health services), at the time of enquiry. Most studies addressed some implementation components including adoption, acceptability, appropriateness, feasibility, and engagement. Factors including high cost, funding constraints, and lengthy research processes impeded implementation.
Without addressing common implementation drivers, there is considerable redundancy in the translation of mobile mental health research findings into practice. Studies should embed implementation strategies from the outset of the planned research, build collaborations with partners already working in the field (academic and commercial) to capitalize on existing interventions and platforms, and modify and evaluate them for local contexts or target problems and populations.
PROSPERO CRD42021224365; https://tinyurl.com/4umpn85f.
Journal Article
Time to deterioration of patient-reported outcome endpoints in cancer clinical trials: targeted literature review and best practice recommendations
2024
Background
Time to deterioration (TTD) endpoints are often utilized in the analysis of patient-reported outcome (PRO) data in oncology clinical trials but different endpoint definitions and analysis frameworks exist that can impact result interpretation. This review examined the analysis, reporting and heterogeneity of TTD endpoints in the literature, the impact of analysis methods on results, and provides recommendations for future trials.
Methods
A targeted literature review of articles published between 2017 and 2022 was performed to collate TTD endpoints reported in oncology randomized controlled trials (RCTs). Details of endpoints and results were extracted including; deterioration definition, PRO assessment schedule, methods for handling intercurrent events, statistical analysis methods, main trial results (overall survival and/or progression-free survival) and TTD endpoint results.
Results
Seventy RCTs were included covering 849 individual TTD endpoints. There were 17 primary cancer types, with lung (26%), breast (11%), and prostate (7%) cancers the most common. Most trials (71%) were for people with advanced cancer. Full definitions of TTD endpoints were often missing. There were no clear trends for a specific TTD definition within cancer types or stages. However, statistical analysis methods were consistent among trials.
Conclusion
The TTD definition can vary and is ultimately driven by the research question. Points to consider for successfully implementing PRO TTD endpoints in oncology include consideration of the trial setting (e.g., early vs. advanced cancer), expected treatment effect (e.g., improvement vs. worsening), likely adverse event profile (including early vs. delayed) and PRO data collection frequency in order to improve utility of these endpoints.
Journal Article
The Barratt Impulsiveness Scale-11 Among a School Sample of Portuguese Male and Female Adolescents
by
Pechorro, Pedro
,
Ayala-Nunes, Lara
,
Nunes, Cristina
in
Adolescents
,
Aggression
,
Alcohol abuse
2016
Few personality traits are as socially relevant as impulsivity, but few self-report measures have been specifically developed for adolescents and children. The aim of the present study was to examine the psychometric properties of the Barratt Impulsiveness Scale version 11 (BIS-11) among a mixed-gender sample of 782 Portuguese youth (
M
= 15.87 years;
SD
= 1.72), in a school context. Confirmatory factor analysis revealed the expected 6-factor first-order structure, but the 3-factor second-order factorial structure did not present a good fit. Cross-gender measurement invariance was demonstrated only in terms of weak invariance. Nonetheless, the Portuguese adaptation of the BIS-11 demonstrated some generally acceptable psychometric properties of internal consistency, mean inter-item correlation, convergent validity, discriminant validity, and criterion-related validity of statistically significant associations with conduct disorder symptoms, alcohol abuse, drug use, and unprotected sex. The use of the BIS-11 among the male and female youth population is psychometrically justified, and it can be a useful measure to identify impulsive adolescents who are at considerable risk of personal injury and present a potential source of injury to others.
Journal Article
Quality of life of Portuguese and Spanish adolescents. A comparative study between natives and immigrants
by
Lemos, Ida
,
Coronado, Cecilia Montilla
,
Oliva, Cristina Romero
in
Adolescent
,
Children & youth
,
Comparative studies
2016
Abstract The aim of this study was to analyse differences in quality of life (QOL) between Spanish and Portuguese immigrant and native adolescents. In total, 475 native and immigrant adolescents (52% boys) from Algarve (Portugal) and Huelva (Spain), aged between 12 and 17 years old, were assessed with the KIDSCREEN-52. QOL dimensions were not related to most academic variables, with the exception of number of school failures, Financial Resources and Social Support from Peers. Multivariate analysis of variance (MANOVA) was used to examine statistical differences in adolescents QOL. Age differences in QOL levels were not found. Girls reported worse QOL levels on Physical Wellbeing than boys (F = 10.32, p = .001, η2 =.02). Immigrant Portuguese adolescents scored higher on Mood (F = 17.57, p = .000, η2 =.11), and native Portuguese adolescents scored higher on Social Acceptance (F = 4.87, p = .002, η2 =.033). Immigrant and native adolescents had similar levels of perceived QOL. Overall, it seems that in both countries, the living contexts for immigrant and native adolescents are fairly homogeneous. Resumo Neste estudo são analisadas as diferenças na qualidade de vida (QVD) entre adolescentes imigrantes e nativos de Espanha e Portugal. Avaliou-se a QDV percebida de 475 adolescentes nativos e imigrantes (52% rapazes) entre os 12 e os 17 anos de idade do Algarve (Portugal) e Huelva (Espanha) através do questionário KIDSCREEN-52 e o perfil sociodemográfico. As dimensões da QDV não estavam associadas à maioria das variáveis acadêmicas, excetuando o número de repetições, recursos econômicos e apoio dos pares. Para analisar as diferenças da QVD entre os adolescentes foram realizadas análises de variância multivariada (MANOVA). Não se encontraram diferenças na QDV por idade. As raparigas reportaram piores níveis de QDV no bem-estar físico do que os rapazes (F = 10.32, p = .001, η2 =.02). Os adolescentes portugueses imigrantes mostraram níveis mais elevados no Humor (F = 17.57, p = .000, η2 =.11) e os nativos obtiveram pontuações mais altas na Aceitação social (F = 4.87, p = .002, η2 =.033). Os resultados sugerem que os adolescentes imigrantes e nativos têm níveis semelhantes de QDV percebida. Em conjunto, parece que nos dois países os contextos vitais dos adolescentes nativos e imigrantes são bastante homogêneos.
Journal Article
The Brief COPE: Measurement Invariance and Psychometric Properties among Community and At-Risk Portuguese Parents
by
Pechorro, Pedro
,
Martins, Cátia
,
Ayala-Nunes, Lara
in
Adaptation
,
Adaptation, Psychological
,
Children & youth
2021
Parenting generally brings about high internal and external demands, which can be perceived as stressful when they exceed families’ resources. When faced with such stressors, parents need to deploy several adaptive strategies to successfully overcome these challenges. One of such strategies is coping, an important cognitive and behavioural skill. In this study, we intended to examine the psychometric properties of Carver’s (1997) Brief COPE (Coping Orientation to Problems Experienced), extending its cross-cultural validity among a Portuguese sample of community and at-risk parents. The sample comprised community (n = 153) and at-risk (n = 116) parents who completed the brief COPE, the Family Adaptability and Cohesion Scales and the Parenting Stress Index—Short Form. Confirmatory factor analysis, internal consistency, cross sample invariance, convergent and discriminant validity were analysed. Data from the confirmatory factor analysis revealed that the 14-factor model obtained the best fit. The results provided evidence that the Brief COPE is a psychometrically sound instrument that shows measurement invariance across samples and good reliability. Our findings demonstrated that the Portuguese version of brief COPE is a useful, time-efficient tool for both practitioners and researchers who need to assess coping strategies, a relevant construct in family context.
Journal Article
The ENRICH Marital Satisfaction (EMS) Scale: A Psychometric Study in a Sample of Portuguese Parents
2022
Marital satisfaction is a key construct in the assessment of a couple’s relationship, and it encompasses aspects such as the feelings of affection, trust, and companionship that arise from the exchanges between spouses. The ENRICH Marital Satisfaction (EMS) Scale has been widely used as a reliable measure to assess marital satisfaction. In the present study, we aimed to analyze the psychometric properties and the factor structure of the EMS Scale in a sample of Portuguese parents. A total of 205 mothers and fathers participated; 107 were women (52%), and 98 were men (48%), and the mean age was 38.39 years (SD = 5.85). The majority were two-parent families (89.3%), with children between the ages of 1 and 13 years (M = 6.90), 53% of whom were boys. The participants completed the EMS Scale together with the Parenting Stress Index Short Form and the Parenting Alliance Inventory. The results from a confirmatory factor analysis corroborate the two-dimensional structure of the instrument, with internal validity and reliability values that were suitable for application in the Portuguese population. The EMS Scale can be an important resource, with good psychometric quality, for professionals and researchers, which can be used in assessment and intervention programs, both at the individual and couple levels.
Journal Article
Coping and social support as moderators: Relationship between financial threat and negative psychological outcomes
by
Pinto, Patrícia Susana Lopes Guerrilha dos Santos
,
Ayala-Nunes, Lara
,
Leal, Ana Rita Cavaco
in
Behavioral Science and Psychology
,
Coping
,
Coping (Psychology)
2021
Between 2011 and 2014 Portugal faced an economic crisis. During a crisis, individuals develop threat perceptions regarding their financial situation. When individuals perceive that their financial situation worsens, negative psychological outcomes emerge. The present study assessed the relationship between financial threat and three negative psychological outcomes (stress, anxiety, and depression), and tested the moderating role of proactive coping and social support, individually and combined, on this relationship. The moderating role of sociodemographic variables (age, gender, marital status, and professional situation) was also considered. A sample of 729 participants, 33.9% males and 66.1% females, was collected online between March–June 2013. Structural equation modeling was used to evaluate the obtained data. Financial threat was positively and significantly associated with stress, anxiety, and depression. Proactive coping moderated the relationship between financial threat and depression. Social support, individually and combined with proactive coping, did not moderate the relationship between financial threat and any of the negative psychological outcomes. Age moderated the relationship between financial threat and stress. The main implications of this study are presented, as well as its limitations and suggestions for future works.
Journal Article
Evaluating the Appropriateness of Existing Health-Related Quality of Life Measures in Lichen Planus
by
Ayala-Nunes, Lara
,
Sharp, Rosie
,
Schruf, Eva
in
Care and treatment
,
Clinical outcomes
,
Dermatology
2023
Introduction
Lichen planus (LP) is an inflammatory skin disorder that can present in various forms across the body, including lesions on the skin (cutaneous LP [CLP]), scalp (lichen planopilaris [LPP]) and mucosal regions (mucosal LP [MLP]). Several existing patient-reported outcome measures (PROMs) were identified for potential use in LP clinical development programs. This study aimed to assess the content validity and psychometric measurement properties of the Dermatology Life Quality Index (DLQI), Epworth Sleepiness Scale (ESS), Scalpdex and Oral Lichen Planus Symptom Severity Measure (OLPSSM) in an LP population.
Methods
Patients completed the PROs at various time points as part of an international Phase 2 clinical study in adults with MLP (
n
= 37), LPP (
n
= 37) and CLP (
n
= 37). Test-retest reliability, construct validity and sensitivity to change were assessed. In addition, qualitative cognitive debriefing interviews were conducted with adults with MLP (
n
= 20), LPP (
n
= 19) and CLP (
n
= 19) in the USA and Germany to examine the PROM content validity.
Results
The DLQI demonstrated adequate reliability and validity, although its ability to detect change was modest and most items were considered not relevant in qualitative interviews. The ESS had good reliability but limited evidence of validity and ability to detect change. Conceptual relevance varied according to the qualitative interview data. The Scalpdex was miscellaneous across domains, but the ‘Symptoms’ domain performed well overall. Overall, Scalpdex concepts were reported as relevant by most LPP patients interviewed. The OLPSSM demonstrated good psychometric properties and strong evidence of content validity.
Conclusions
The psychometric and qualitative findings support the use of the OLPSSM and Scalpdex within specific LP subtypes but cautioned use of the DLQI. Administration of the ESS is not recommended in LP because of its poor psychometric performance. Given these limitations, further validation of non-specific disease measures is needed and/or the development of additional LP-specific PROMs.
Trial Registration
NCT04300296.
Journal Article
Parenting stress predictors in mothers of families at psychosocial risk
by
Lemos, Ida
,
Ayala Nunes, Lara
,
Nunes, Cristina
in
Behavior problems
,
Child adjustment
,
Competence
2014
In this study we analyzed the associations between parenting stress, parental sense of competence and the contribution of socio-demographical and psychological factors to the explanation of parenting stress. Participants were 80 Portuguese mothers, recipients of the child protection services. Results showed high levels of parenting stress, especially in unemployed mothers with adolescent children, and significant associations between parenting stress and perceived parental competences. Maternal role satisfaction and employment were the most robust factors on the explanation of parenting stress, predicting 37% of the variance.
Journal Article