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A bstract Thermal light dark matter (LDM) with particle masses in the 1 MeV–1 GeV range could successfully explain the observed dark matter abundance as a relic from the primordial Universe. In this picture, a new feeble interaction acts as a “portal” between the Standard Model and LDM particles, allowing for the exploration of this paradigm at accelerator experiments. In the last years, the “missing energy” experiment NA64 e at CERN SPS (Super Proton Synchrotron) has set world-leading constraints in the vector-mediated LDM parameter space, by exploiting a 100 GeV electron beam impinging on an electromagnetic calorimeter, acting as an active target. In this paper, we report a detailed description of the analysis of a preliminary measurement with a 70 GeV/c positron beam at NA64 e , performed during summer 2023 with an accumulated statistics of 1 . 596 × 10 10 positrons on target (hereafter referred to as e + OT). This data set was analyzed with the primary aim of evaluating the performance of the NA64 e detector with a lower energy positron beam, towards the realization of the post-LS3 program. The analysis results, other than additionally probing unexplored regions in the LDM parameter space, provide valuable information towards the future NA64 e positron campaign.

The X-ARAPUCA device is the baseline choice for the photon detection system of the first far detector module of the DUNE experiment. We present the results of the first complete characterization of a small scale X-ARAPUCA prototype, which is a slice of a full DUNE module. Its total detection efficiency in liquid argon was measured with three different ionizing radiations: \\(\\) particles, \\(\\)'s and muons and resulted to be \\(\\)2.2% when the active silicon photomultipliers were biased at +5.0 V of over voltage, corresponding to a Photon Detection Efficiency around 50% at room temperature. This value comfortably satisfies the requirements of the first DUNE far detector module (detection efficiency \\(>\\)2.0%) and allows to achieve an energy resolution comparable to the one achievable with the Time Projection Chambers for energies below 10 MeV, which is the region relevant for Supernova neutrino detection.

After rapid approval and installation, the SND@LHC Collaboration was able to gather data successfully in 2022 and 2023. Neutrino interactions from νμs originating at the LHC IP1 were observed. Since muons constitute the major background for neutrino interactions, the muon flux entering the acceptance was also measured. To improve the rejection power of the detector and to increase the fiducial volume, a third Veto plane was recently installed. The energy resolution of the calorimeter system was measured in a test beam. This will help with the identification of νe interactions that can be used to probe charm production in the pseudo-rapidity range of SND@LHC (7.2 < η < 8.4). Events with three outgoing muons have been observed and are being studied. With no vertex in the target, these events are very likely from muon trident production in the rock before the detector. Events with a vertex in the detector could be from trident production, photon conversion, or positron annihilation. To enhance SND@LHC’s physics case, an upgrade is planned for HL-LHC that will increase the statistics and reduce the systematics. The installation of a magnet will allow the separation of νμ from ν¯μ

Thermal light dark matter (LDM) with particle masses in the 1 MeV - 1 GeV range could successfully explain the observed dark matter abundance as a relic from the primordial Universe. In this picture, a new feeble interaction acts as a \"portal\" between the Standard Model and LDM particles, allowing for the exploration of this paradigm at accelerator experiments. In the last years, the \"missing energy\" experiment NA64e at CERN SPS (Super Proton Synchrotron) has set world-leading constraints in the vector-mediated LDM parameter space, by exploiting a 100 GeV electron beam impinging on an electromagnetic calorimeter, acting as an active target. In this paper, we report a detailed description of the analysis of a preliminary measurement with a 70 GeV positron beam at NA64e, performed during summer 2023 with an accumulated statistic of 1.6 x 10^10 positrons on target. This data set was analyzed with the primary aim of evaluating the performance of the NA64e detector with a lower energy positron beam, towards the realization of the post-LS3 program. The analysis results, other than additionally probing unexplored regions in the LDM parameter space, provide valuable information towards the future NA64e positron campaign.

Since its approval in 2016, NA64 has pioneered light dark matter (LDM) searches with electron, positron, muon, and hadron beams. The experiment has successfully met its primary objectives, as outlined in the EPPS input (2018), and even exceeded them, producing results that demonstrate its ability to operate in a near-background-free environment. The Physics Beyond Collider (PBC) initiative at CERN recognizes NA64's contributions as complementary and worthy of continued exploration. Its key advantage over beam-dump approaches is that the signal rate scales as the square of the coupling rather than the fourth power, reducing the required number of beam particles for the same sensitivity. To fully exploit the NA64 physics potential, an upgrade during LS3 will enable the experiment to run in background-free mode at higher SPS beam rates. Planned upgrades include: (a) improved detector hermeticity with a new veto hadron calorimeter, (b) enhanced particle identification with a synchrotron radiation detector, and (c) increased beam rates via upgraded electronics. With the recently strengthened NA64 collaboration, stable operations and timely data analysis are planned for LHC Run 4. The expected beam exposures are approximately 1e13 electrons, 1e11 positrons (at 40 and 60 GeV), and 2e13 muons on target. This will allow NA64 to explore new LDM parameter space, with the potential for discovery or conclusive exclusion of many well-motivated models.

NA64 is a fixed-target experiment at the CERN SPS designed to search for Light particle Dark Matter (LDM) candidates with masses in the sub-GeV range. During the 2016-2022 runs, the experiment obtained the world-leading constraints, leaving however part of the well-motivated region of parameter space suggested by benchmark LDM models still unexplored. To further improve sensitivity, as part of the upgrades to the setup of NA64 at the CERN SPS H4 beamline, a prototype veto hadron calorimeter (VHCAL) was installed in the downstream region of the experiment during the 2023 run. The VHCAL, made of Cu-Sc layers, was expected to be an efficient veto against upstream electroproduction of large-angle hadrons or photon-nuclear interactions, reducing the background from secondary particles escaping the detector acceptance. With the collected statistics of \\(4.4\\times10^{11}\\) electrons on target (EOT), we demonstrate the effectiveness of this approach by rejecting this background by more than an order of magnitude. This result provides an essential input for designing a full-scale optimized VHCAL to continue running background-free during LHC Run 4, when we expect to collect \\(10^{13}\\) EOT. Furthermore, this technique combined with improvements in the analysis enables us to decrease our missing energy threshold from 50 GeV to 40 GeV thereby enhancing the signal sensitivity of NA64.

We present the first results from a proof-of-concept search for dark sectors via invisible decays of pseudoscalar \\(\\eta\\) and \\(\\eta'\\) mesons in the NA64h experiment at the CERN SPS. Our novel technique uses the charge-exchange reaction of 50 GeV \\(\\pi^-\\) on nuclei of an active target as the source of neutral mesons. The \\(\\eta, \\eta' \\to invisible\\) events would exhibit themselves via a striking signature - the complete disappearance of the incoming beam energy in the detector. No evidence for such events has been found with \\(2.9\\times10^{9}\\) pions on target accumulated during one day of data taking. This allows us to set a stringent limit on the branching ratio \\({\\rm Br}(\\eta' \\to invisible) < 2.1 \\times 10^{-4}\\) improving the current bound by a factor of \\(\\simeq3\\). We also set a limit on \\({\\rm Br}(\\eta \\to invisible) < 1.1 \\times 10^{-4}\\) comparable with the existing one. These results demonstrate the great potential of our approach and provide clear guidance on how to enhance and extend the sensitivity for dark sector physics from future searches for invisible neutral meson decays.

In this white paper, we outline some of the scientific opportunities and challenges related to detection and reconstruction of low-energy (less than 100 MeV) signatures in liquid argon time-projection chamber (LArTPC) detectors. Key takeaways are summarized as follows. 1) LArTPCs have unique sensitivity to a range of physics and astrophysics signatures via detection of event features at and below the few tens of MeV range. 2) Low-energy signatures are an integral part of GeV-scale accelerator neutrino interaction final states, and their reconstruction can enhance the oscillation physics sensitivities of LArTPC experiments. 3) BSM signals from accelerator and natural sources also generate diverse signatures in the low-energy range, and reconstruction of these signatures can increase the breadth of BSM scenarios accessible in LArTPC-based searches. 4) Neutrino interaction cross sections and other nuclear physics processes in argon relevant to sub-hundred-MeV LArTPC signatures are poorly understood. Improved theory and experimental measurements are needed. Pion decay-at-rest sources and charged particle and neutron test beams are ideal facilities for experimentally improving this understanding. 5) There are specific calibration needs in the low-energy range, as well as specific needs for control and understanding of radiological and cosmogenic backgrounds. 6) Novel ideas for future LArTPC technology that enhance low-energy capabilities should be explored. These include novel charge enhancement and readout systems, enhanced photon detection, low radioactivity argon, and xenon doping. 7) Low-energy signatures, whether steady-state or part of a supernova burst or larger GeV-scale event topology, have specific triggering, DAQ and reconstruction requirements that must be addressed outside the scope of conventional GeV-scale data collection and analysis pathways.

Microquasars are laboratories for the study of jets of relativistic particles produced by accretion onto a spinning black hole. Microquasars are near enough to allow detailed imaging of spatial features across the multiwavelength spectrum. The recent extension measurement of the spatial morphology of a microquasar, SS 433, to TeV gamma rays 1 localizes the acceleration of electrons at shocks in the jet far from the black hole 2 . V4641 Sagittarii (V4641 Sgr) is a similar binary system with a black hole and B-type main-sequence companion star and has an orbit period of 2.8 days (refs.  3 , 4 ). It stands out for its super-Eddington accretion 5 and for its radio jet, which is one of the fastest superluminal jets in the Milky Way. Previous observations of V4641 Sgr did not report gamma-ray emission 6 . Here we report TeV gamma-ray emission from V4641 Sgr that reveals particle acceleration at similar distances from the black hole as SS 433. Furthermore, the gamma-ray spectrum of V4641 Sgr is among the hardest TeV spectra observed from any known gamma-ray source and is detected above 200 TeV. Gamma rays are produced by particles, either electrons or protons, of higher energies. Because energetic electrons lose energy more quickly the higher their energy, such a spectrum either very strongly constrains the electron-production mechanism or points to the acceleration of high-energy protons. This suggests that large-scale jets from microquasars could be more common than previously expected and that they could be a notable source of galactic cosmic rays 7 – 9 . Ultra-high-energy gamma-ray emission from the microquasar V4641 Sagittarii is reported, suggesting that large-scale jets from microquasars could be more common than previously thought and also could be a notable source of galactic cosmic rays.

The strategies adopted by viruses to reprogram the translation and protein quality control machinery and promote infection are poorly understood. Here, we report that the viral ubiquitin deconjugase (vDUB)—encoded in the large tegument protein of Epstein-Barr virus (EBV BPLF1)—regulates the ribosomal quality control (RQC) and integrated stress responses (ISR). The vDUB participates in protein complexes that include the RQC ubiquitin ligases ZNF598 and LTN1. Upon ribosomal stalling, the vDUB counteracts the ubiquitination of the 40 S particle and inhibits the degradation of translation-stalled polypeptides by the proteasome. Impairment of the RQC correlates with the readthrough of stall-inducing mRNAs and with activation of a GCN2-dependent ISR that redirects translation towards upstream open reading frames (uORFs)- and internal ribosome entry sites (IRES)-containing transcripts. Physiological levels of active BPLF1 promote the translation of the EBV Nuclear Antigen (EBNA)1 mRNA in productively infected cells and enhance the release of progeny virus, pointing to a pivotal role of the vDUB in the translation reprogramming that enables efficient virus production. Here, the authors show how the vDUB from the large tegument protein from the human herpes virus can reprogram translation in host cells by modulating the activity of the ribosome quality machinery and activating the integrated stress response.