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Few studies have investigated the perception of vestibular stimuli when they occur in sequences. Here, three experiments ( n total = 33) are presented that focus on intravestibular motion sequences and the underlying perceptual decision-making process. Natural vestibular stimulation (yaw rotation or translation) was used to investigate the discrimination process of the direction of a subsequent spatially congruent or incongruent translation or rotation. The few existing studies focusing on unimodal motion sequences have uncovered self-motion aftereffects, similar to the visual motion aftereffect, possibly due to altered processing of sensory stimuli. An alternative hypothesis predicts a shift of spatial attention due to the cue motion influencing perception of the subsequent motion stimulus. The results show that participants systematically misjudged the direction of motion stimuli well above the detection threshold if the direction of the preceding cue motion stimulus was congruent with the direction of the target (a motion aftereffect). Hierarchical drift diffusion models were used to analyze the data. The results suggest that altered perceptual decision-making and the resulting misperceptions are likely to originate in altered processing of sensory vestibular information.

The Extremely Large Telescopes (ELTs), thanks to their large apertures and cutting-edge Multi-Conjugate Adaptive Optics (MCAO) systems, promise to deliver sharper and deeper data even than the JWST. SHARP is a concept study for a near-IR (0.95-2.45 \\(\\mu\\)m) spectrograph conceived to fully exploit the collecting area and the angular resolution of the upcoming generation of ELTs. In particular, SHARP is designed for the 2nd port of MORFEO@ELT. Composed of a Multi-Object Spectrograph, NEXUS, and a multi-Integral Field Unit, VESPER, MORFEO-SHARP will deliver high angular (\\(\\sim\\)30 mas) and spectral (R\\(\\simeq\\)300, 2000, 6000, 17000) resolution, outperforming NIRSpec@JWST (100 mas). SHARP will enable studies of the nearby Universe and the early Universe in unprecedented detail. NEXUS is fed by a configurable slit system deploying up to 30 slits with \\(\\sim\\)2.4 arcsec length and adjustable width, over a field of about 1.2\"\\(\\times\\)1.2\" (35 mas/pix). Each slit is fed by an inversion prism able to rotate by an arbitrary angle the field that can be seen by the slit. VESPER is composed of 12 probes of 1.7\"\\(\\times\\)1.5\" each (spaxel 31 mas) probing a field 24\"\\(\\times\\)70\". SHARP is conceived to exploit the ELTs apertures reaching the faintest flux and the sharpest angular resolution by joining the sensitivity of NEXUS and the high spatial sampling of VESPER to MORFEO capabilities. This article provides an overview of the scientific design drivers, their solutions, and the resulting optical design of the instrument achieving the required optical performance.

The next generation of Extremely Large Telescopes (ELTs), with their wide apertures and advanced Multi-Conjugate Adaptive Optics (MCAO) systems, will provide unprecedented sharp and deep observations, even surpassing the capabilities of James Webb Space Telescope (JWST). SHARP, a near-infrared (0.95-2.45 {\\mu}m) spectrograph, is designed to optimally exploit the collecting area and angular resolution of these forthcoming ELTs, and specifically optimized for the MCAO unit MORFEO at the ELT. SHARP includes two main units: NEXUS, a Multi-Object Spectrograph (MOS), and VESPER, a multi-Integral Field Unit. This paper outlines the opto-mechanical design of SHARP based on the scientific requirements of the project. The optical design is engineered to meet project specifications, featuring a compact mechanical structure that minimizes the required cryogenic power while ensuring ease of access for maintenance and straightforward assembly procedures.

A deep understanding of the life-cycle of galaxies, particularly those of high mass, requires clarifying the mechanisms that regulate star formation (SF) and its abrupt shutdown (quenching), often capable of stopping SF rates of hundreds of solar masses per year. What initially triggers quenching, and what sustains the quiescent state thereafter, especially given the frequent presence of large gas reservoirs or even massive gas inflows, are unsolved key issues. Ultimately, the crucial connection between the galaxy life-cycle and the surrounding Intergalactic (IGM) and Circumgalactic (CGM) Medium remains largely unclear. Addressing these issues requires studying star formation, chemical enrichment, and quenching homogeneously up to high redshift. The upcoming AO-assisted Extremely Large Telescope (ELT), will deliver sharper and deeper data than the JWST. SHARP is a concept study for a near-IR (0.95-2.45 mu) spectrograph designed to fully exploit the capabilities of ELT. Designed for multi-object slit spectroscopy and multi-Integral Field spectroscopy, SHARP points to achieve angular resolutions (~30 mas) far superior to NIRSpec at JWST(100 mas) to decipher and reconstruct the life-cycle oa galaxies.

What can we learn from nature?The study of the physical, chemical and structural properties of well-known minerals in the geo- and biosphere creates new opportunities for innovative applications in technology, environment or medicine.

Aging leads to a gradual decline in physical activity and disrupted energy homeostasis. The NAD + -dependent SIRT6 deacylase regulates aging and metabolism through mechanisms that largely remain unknown. Here, we show that SIRT6 overexpression leads to a reduction in frailty and lifespan extension in both male and female B6 mice. A combination of physiological assays, in vivo multi-omics analyses and 13 C lactate tracing identified an age-dependent decline in glucose homeostasis and hepatic glucose output in wild type mice. In contrast, aged SIRT6-transgenic mice preserve hepatic glucose output and glucose homeostasis through an improvement in the utilization of two major gluconeogenic precursors, lactate and glycerol. To mediate these changes, mechanistically, SIRT6 increases hepatic gluconeogenic gene expression, de novo NAD + synthesis, and systemically enhances glycerol release from adipose tissue. These findings show that SIRT6 optimizes energy homeostasis in old age to delay frailty and preserve healthy aging. Aging is associated with increased frailty and disrupted energy homeostasis. Here, the authors show that SIRT6 overexpression extends the lifespan of male and female mice and demonstrate that SIRT6 optimizes energy homeostasis in old age, which delays frailty and preserves healthy aging.

Advances in the surgical and systemic therapeutic landscape of hepatocellular carcinoma have increased the complexity of patient management. A dynamic adaptation of the available staging-based algorithms is required to allow flexible therapeutic allocation. In particular, real-world hepatocellular carcinoma management increasingly relies on factors independent of oncological staging, including patients’ frailty, comorbid burden, critical tumour location, multiple liver functional parameters, and specific technical contraindications impacting the delivery of treatment and resource availability. In this Policy Review we critically appraise how treatment allocation strictly based on pretreatment staging features has shifted towards a more personalised treatment approach, in which expert tumour boards assume a central role. We propose an evidence-based framework for hepatocellular carcinoma treatment based on the novel concept of multiparametric therapeutic hierarchy, in which different therapeutic options are ordered according to their survival benefit (ie, from surgery to systemic therapy). Moreover, we introduce the concept of converse therapeutic hierarchy, in which therapies are ordered according to their conversion abilities or adjuvant abilities (ie, from systemic therapy to surgery).

Foot ulcers account for 15% of comorbidities associated with diabetes. Presently, no device allows the status of foot ulcers to be continuously monitored when patients are not hospitalized. In this study, we describe a temperature and a pH sensor capable of monitoring diabetic foot and venous leg ulcers developed in the frame of the seventh framework program European Union project SWAN-iCare (smart wearable and autonomous negative pressure device for wound monitoring and therapy). Temperature is measured by exploiting the variations in the electrical resistance of a nanocomposite consisting of multiwalled carbon nanotubes and poly(styrene-b-(ethylene- -butylene)-b-styrene). The pH sensor used a graphene oxide (GO) layer that changes its electrical potential when pH changes. The temperature sensor has a sensitivity of ~85 Ω/°C in the range 25°C-50°C and a high repeatability (maximum standard deviation of 0.1% over seven repeated measurements). For a GO concentration of 4 mg/mL, the pH sensor has a sensitivity of ~42 mV/pH and high linearity (R2=0.99).

Obesity prevalence is growing progressively even among older age groups. Controversy exists about the potential harms of obesity in the elderly. Debate persists about the relation between obesity in old age and total or disease-specific mortality, the definition of obesity in the elderly, its clinical relevance, and about the need for its treatment. Knowledge of age-related body composition and fat distribution changes will help us to better understand the relationships between obesity, morbidity and mortality in the elderly. Review of the literature supports that central fat and relative loss of fat-free mass may become relatively more important than BMI in determining the health risk associated with obesity in older ages. Weight gain or fat redistribution in older age may still confer adverse health risks (for earlier mortality, comorbidities conferring independent adverse health risks, or for functional decline). Evaluation of comorbidity and weight history should be performed in the elderly in order to generate a comprehensive assessment of the potential adverse health effects of overweight or obesity. The risks of obesity in the elderly have been underestimated by a number of confounders such as survival effect, competing mortalities, relatively shortened life expectancy in older persons, smoking, weight change and unintentional weight loss. Identification of elderly subjects with sarcopenic obesity is probably clinically relevant, but the definition of sarcopenic obesity, the benefits of its clinical identification, as well as its relation to clinical consequences require further study. Studies on the effect of voluntary weight loss in the elderly are scarce, but they suggest that even small amounts of weight loss (between 5–10% of initial body weight) may be beneficial. In older as well as in younger adults, voluntary weight loss may help to prevent the adverse health consequences of obesity.