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GLUT2, glucose sensing and glucose homeostasis
The glucose transporter isoform GLUT2 is expressed in liver, intestine, kidney and pancreatic islet beta cells, as well as in the central nervous system, in neurons, astrocytes and tanycytes. Physiological studies of genetically modified mice have revealed a role for GLUT2 in several regulatory mechanisms. In pancreatic beta cells, GLUT2 is required for glucose-stimulated insulin secretion. In hepatocytes, suppression of GLUT2 expression revealed the existence of an unsuspected glucose output pathway that may depend on a membrane traffic-dependent mechanism. GLUT2 expression is nevertheless required for the physiological control of glucose-sensitive genes, and its inactivation in the liver leads to impaired glucose-stimulated insulin secretion, revealing a liver-beta cell axis, which is likely to be dependent on bile acids controlling beta cell secretion capacity. In the nervous system, GLUT2-dependent glucose sensing controls feeding, thermoregulation and pancreatic islet cell mass and function, as well as sympathetic and parasympathetic activities. Electrophysiological and optogenetic techniques established that
Glut2
(also known as
Slc2a2
)-expressing neurons of the nucleus tractus solitarius can be activated by hypoglycaemia to stimulate glucagon secretion. In humans, inactivating mutations in
GLUT2
cause Fanconi–Bickel syndrome, which is characterised by hepatomegaly and kidney disease; defects in insulin secretion are rare in adult patients, but
GLUT2
mutations cause transient neonatal diabetes. Genome-wide association studies have reported that
GLUT2
variants increase the risks of fasting hyperglycaemia, transition to type 2 diabetes, hypercholesterolaemia and cardiovascular diseases. Individuals with a missense mutation in
GLUT2
show preference for sugar-containing foods. We will discuss how studies in mice help interpret the role of GLUT2 in human physiology.
Journal Article
The rise of business ethics
\"In 1973, Daniel Bell argued that corporations in post-industrial societies increasingly needed to behave in accord with widely accepted social norms, particularly in terms of ethical behavior and social responsibility. Yet widespread criticism of business behavior was not an invention of the 1960s and 70s or a product of changing commercial norms. The key feature historically has been business scandal. Understandings of how the field of business ethics has emerged are undeveloped, however. This book is the first attempt to explain the conditions which saw a focus develop on business ethics especially in the 1960s and 70s, and how the broader field developed to encompass related notions such as corporate governance, corporate social responsibility, ethical leadership, sustainable business and responsible management education. The Rise of Business Ethics provides an introduction and analysis of the key developments in contemporary business ethics by examining them in terms of their diachronic development - the key thinkers, the key issues, the key institutions and how they each contributed to contemporary understandings of business ethics, governance and practice. Addressing the topic from a European as well as North American perspective, The Rise of Business Ethics will be of interest to researchers, academics, and students in the fields of business ethics, business and society, business history, organization studies and political economy\"-- Provided by publisher.
Book
Networks in Production: Asset Pricing Implications
In this paper, I examine asset pricing in a multisector model with sectors connected through an input-output network. Changes in the network are sources of systematic risk reflected in equilibrium asset prices. Two characteristics of the network matter for asset prices: network concentration and network sparsity. These two production-based asset pricing factors are determined by the structure of the network and are computed from input-output data. Consistent with the model predictions, I find return spreads of 4.6% and −3.2% per year on sparsity and concentration beta-sorted portfolios, respectively.
Journal Article
Variations in the Availability of Pollen Resources Affect Honey Bee Health
Intensive agricultural systems often expose honey bees (Apis mellifera L.) to large temporal variations in the availability (quantity, quality and diversity) of nutritional resources. Such nutritional irregularity is expected to affect honey bee health. We therefore tested under laboratory conditions the effect of such variation in pollen availability on honey bee health (survival and nursing physiology-hypopharyngeal gland development and vitellogenin expression). We fed honey bees with different diets composed of pollen pellets collected by honey bees in an agricultural landscape of western France. Slight drops (5-10%) in the availability of oilseed rape (Brassica napus L.) pollen resulted in significant reductions of all tested variables. Despite some variations in taxonomic diversity and nutritional quality, the pollen mixes harvested over the season had a similar positive influence on honey bee health, except for the one collected in late July that induced poor survival and nursing physiology. This period coincided with the mass-flowering of maize (Zea mays L.), an anemophilous crop which produces poor-quality pollen. Therefore, changes in bee health were not connected to variations in pollen diversity but rather to variations in pollen depletion and quality, such as can be encountered in an intensive agricultural system of western France. Finally, even though pollen can be available ad libitum during the mass-flowering of some crops (e.g. maize), it can fail to provide bees with diet adequate for their development.
Journal Article
Local Scale Comparisons of Biodiversity as a Test for Global Protected Area Ecological Performance: A Meta-Analysis
Terrestrial protected areas (PAs) are cornerstones of global biodiversity conservation. Their efficacy in terms of maintaining biodiversity is, however, much debated. Studies to date have been unable to provide a general answer as to PA conservation efficacy because of their typically restricted geographic and/or taxonomic focus, or qualitative approaches focusing on proxies for biodiversity, such as deforestation. Given the rarity of historical data to enable comparisons of biodiversity before/after PA establishment, many smaller scale studies over the past 30 years have directly compared biodiversity inside PAs to that of surrounding areas, which provides one measure of PA ecological performance. Here we use a meta-analysis of such studies (N = 86) to test if PAs contain higher biodiversity values than surrounding areas, and so assess their contribution to determining PA efficacy. We find that PAs generally have higher abundances of individual species, higher assemblage abundances, and higher species richness values compared with alternative land uses. Local scale studies in combination thus show that PAs retain more biodiversity than alternative land use areas. Nonetheless, much variation is present in the effect sizes, which underscores the context-specificity of PA efficacy.
Journal Article
Primeval kinship : how pair-bonding gave birth to human society
\"In this book Kenneth Abraham explores the development and interdependency of the tort liability regime and the insurance system in the United States during the twentieth century and beyond, including the events of September 11, 2001\"--Jacket.
Book
Collective Emotions and Social Resilience in the Digital Traces After a Terrorist Attack
After collective traumas such as natural disasters and terrorist attacks, members of concerned communities experience intense emotions and talk profusely about them. Although these exchanges resemble simple emotional venting, Durkheim’s theory of collective effervescence postulates that these collective emotions lead to higher levels of solidarity in the affected community. We present the first large-scale test of this theory through the analysis of digital traces of 62,114 Twitter users after the Paris terrorist attacks of November 2015. We found a collective negative emotional response followed by a marked long-term increase in the use of lexical indicators related to solidarity. Expressions of social processes, prosocial behavior, and positive affect were higher in the months after the attacks for the individuals who participated to a higher degree in the collective emotion. Our findings support the conclusion that collective emotions after a disaster are associated with higher solidarity, revealing the social resilience of a community.
Journal Article