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Chester B. Pond, L. Edwin Smart, DeWitt W. Krueger, M. M. Daugherty, Lynn A. Stiles, William G. Herzel, Shelby S. Reid, Jr., Denzel C. Cline, Beulah B. Thull, W. O. Suiter, Ernest M. Black, and John H. Russell discuss the functions of a research section (p. 168), research in California (p. 170), Delaware (p. 173), Illinois (p. 173), Kentucky (p. 175), Louisiana (p. 177), Michigan (p. 180), New York (p. 180, 181), North Carolina (p. 182), Oklahoma (p. 186), and Virginia (p. 186).

BackgroundAdoptive cellular therapy (ACT) is a promising treatment for synovial sarcoma (SS) with reported response rates of over 50%. However, more work is needed to obtain deeper and more durable responses. SS has a ‘cold’ tumor immune microenvironment with low levels of major histocompatibility complex (MHC) expression and few T-cell infiltrates, which could represent a barrier toward successful treatment with ACT. We previously demonstrated that both MHC expression and T-cell infiltration can be increased using systemic interferon gamma (IFN-γ), which could improve the efficacy of ACT for SS.Case presentationWe launched a phase I trial incorporating four weekly doses of IFN-γ in an ACT regimen of high-dose cyclophosphamide (HD Cy), NY-ESO-1-specific T cells, and postinfusion low-dose interleukin (IL)-2. Two patients were treated. While one patient had significant tumor regression and resultant clinical benefit, the other patient suffered a fatal histiocytic myocarditis. Therefore, this cohort was terminated for safety concerns.ConclusionWe describe a new and serious toxicity of immunotherapy from IFN-γ combined with HD Cy-based lymphodepletion and low-dose IL-2. While IFN-γ should not be used concurrently with HD Cy or with low dose IL-2, IFN-γ may still be important in sensitizing SS for ACT. Future studies should avoid using IFN-γ during the immediate period before/after cell infusion.Trial registration numbers NCT04177021, NCT01957709, and NCT03063632.

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Passivity, Resistance, and Collaboration: Intellectual Choices in Occupied Shanghai, 1937-1945. By Poshek Fu. Stubborn Twig: Three Generations in the Life of a Japanese-American Family. By Lauren Kessler. The Limits of British Influence: South Asia and the Anglo-American Relationship, 1947-56. By Anita Inder Singh. The European City. By Leonardo Benevolo. Translated by Carl Ipsen. Palmerston's Foreign Policy: 1848. By George J. Billy. The Merchant Adventurers of England: The Company and the Crown, 1494-1564. By Douglas R. Bisson. In the Beginning: The Advent of the Modern Age, Europe in the 1840s. By Jerome Blum. Niebuhr and His Age: Reinhold Niebuhr's Prophetic Role in the Twentieth Century. By Charles C. Brown. William Cobbett and Rural Popular Culture. By Ian Dyck. The Cultivation of Hatred. By Peter Gay. Lord Curzon: The Last of the British Moghuls. By Nyana Goradia. Anglo-French Naval Rivalry, 1840-1870. By C. I. Hamilton. 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