Explore the vast range of titles available.

Vibrational performance for a structure, in majority of the cases, is estimated/ predicted using frequency domain solvers. Linearity and Time-invariance are imposed onto the structure for solving in frequency domain. In this research, vibrational performance of two mechanical mounting methods for a hot-swappable electronic PCB have been analyzed and experimented upon, in the range of 7 to 300 Hz. Natural frequencies were first estimated using Linear Modal Analysis and the response up to 500 Hz was obtained through Harmonic analysis. The resonance was predicted at 440.8 Hz for both the mounting methods. Experiments were conducted on both the setups to determine the natural frequencies through a sinusoidal sweep. Resonance was observed at 110 Hz and 193 Hz for Setup-I & II, respectively. These large deviations led to investigation on factors which played a major role in shifting the frequencies, arising out of both mounting methods. Limitations of linear modal analysis were highlighted. A method (computational + FFT) is devised for estimating the natural frequencies in which time domain response was coupled with Fast Fourier Transform (FFT). Validation against the testing showed that the suggested method predicted the non-linear natural frequencies with a significantly improved accuracy (Nominal deviation < 2%) for both the setups.

Instead of NASA TLx which is not validated for medical tasks, more objective functional near infrared spectroscopy (fNIRS) of the frontal cortex would have been a reliable alternative [4]. Confounding factors like time taken for setting up the ventilator, applying the mask effectively, changing settings during resuscitation if needed, size of mask, skills levels and experience of personnel have been overlooked. Taylor, N; Wyres, M; Bollard, M; Kneafsey, R. Use of functional near-infrared spectroscopy to evaluate cognitive change when using healthcare simulation tools.

Potential complications include respiratory distress, oxygen dependence, dysphagia, poor weight gain, nerve compression, chest wall deformities, hypoplastic ribs, hypoplastic lungs, gastric volvulus, vascular abnormalities, congenital heart disease and kidney or musculoskeletal defects. In older children, recurrent respiratory infections or obesity, along with abnormal diaphragmatic findings on X-ray of the chest, may warrant further evaluation, including an upper gastrointestinal series to rule out gastric volvulus.2 3 Surgical management, typically diaphragmatic plication, carries postoperative risks and requires strict follow-up. Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research.

The urachus is an embryonic tube that connects the upper portion of the bladder to the umbilicus and normally obliterates during embryonic development, forming the median umbilical ligament. Incomplete obliteration of the urachus can result in various anomalies such as congenital patent urachus, umbilical urachal sinus, vesico-urachal diverticulum and urachal cyst. We report a term neonate who presented with swelling and discharge from the umbilical region, which through clinical evaluation and radiological investigations, was diagnosed as an infected umbilical urachal sinus.

Goldenhar syndrome, also recognised as oculo-auriculo-vertebral spectrum, is a very rare condition distinguished by a diverse array of clinical abnormalities affecting the ocular, auditory, vertebral and various organ systems. The pathophysiology of this condition is not fully elucidated due to its inherent genetic variability and rarity. In this report, we present a case of Goldenhar syndrome in a toddler boy, aiming to enhance the existing body of literature on this condition.

A previously healthy adolescent girl presented with oral ulcer, skin and mucosal bleeding for 20 days. On evaluation, she was found to have autoimmune haemolytic anaemia, autoimmune thrombocytopenia, low complement levels and positive antinuclear antibodies with very high titres (1:3200). The anaemia responded to intravenous immunoglobulin and intravenous methylprednisolone, but thrombocytopenia was refractory. She received two doses of rituximab, 2 weeks apart, after which the bleeding manifestations subsided and platelet counts normalised. Here, we present a case of childhood systemic lupus erythematosus with autoimmune haemolytic anaemia and refractory thrombocytopenia at the disease onset and its response to rituximab.

Hepatitis A is a common cause of acute infectious hepatitis in children, transmitted through the faeco-oral route. Although mostly self-limiting, cholestasis is a rare but known complication of acute hepatitis A in children. This report presents an adolescent girl who developed cholestatic features following hepatitis A infection and successful treatment with oral steroid therapy. Prolonged cholestasis jaundice (PCJ) is a known manifestation of hepatitis A infection, characterised by prolonged fever, pruritus and jaundice. While the exact mechanisms causing PCJ are not fully understood, immunological-mediated responses could play a role. Treatment options for PCJ are limited, and there is no currently accepted standard of care. Steroids have shown promise in treating PCJ, as observed in this case and a few other reported cases. When other therapies fail to alleviate symptoms, corticosteroids should be considered as a potential treatment option. However, further studies are required to conclusively establish their efficacy.

There was no history of a nail-biting habit, trauma, drug intake or similar complaints in any family members. In most cases, spontaneous regrowth of the nail occurs within 12 weeks.1 2 Atypical presentations, such as isolated involvement of toenails, recurrent involvement of fingernails and a familial pattern with simultaneous presentation in family members, have also been reported in idiopathic onychomadesis.3–5 Onychomadesis can present throughout the entire paediatric age group, starting from the neonatal period. For most cases, no specific treatment is required. [...]an appropriate history should be elicited to rule out common causes.

Metachromatic leukodystrophy (MLD) is an autosomal recessive disorder caused by deficiency in arylsulfatase A activity, leading to accumulation of sulfatide substrates. Diagnostic and monitoring procedures include demonstration of reduced arylsulfatase A activity in peripheral blood leukocytes or detection of sulfatides in urine. However, the development of a screening test is challenging because of instability of the enzyme in dried blood spots (DBS), the widespread occurrence of pseudodeficiency alleles, and the lack of available urine samples from newborn screening programs. We measured individual sulfatide profiles in DBS and dried urine spots (DUS) from MLD patients with LC-MS/MS to identify markers with the discriminatory power to differentiate affected individuals from controls. We also developed a method for converting all sulfatide molecular species into a single species, allowing quantification in positive-ion mode upon derivatization. In DBS from MLD patients, we found up to 23.2-fold and 5.1-fold differences in total sulfatide concentrations for early- and late-onset MLD, respectively, compared with controls and pseudodeficiencies. Corresponding DUS revealed up to 164-fold and 78-fold differences for early- and late-onset MLD patient samples compared with controls. The use of sulfatides converted to a single species simplified the analysis and increased detection sensitivity in positive-ion mode, providing a second option for sulfatide analysis. This study of sulfatides in DBS and DUS suggests the feasibility of the mass spectrometry method for newborn screening of MLD and sets the stage for a larger-scale newborn screening pilot study.