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Measurements of x-ray-driven implosions with charged particles have resulted in the quantitative characterization of critical aspects of indirect-drive inertial fusion. Three types of spontaneous electric fields differing in strength by two orders of magnitude, the largest being nearly one-tenth of the Bohr field, were discovered with time-gated proton radiographie imaging and spectrally resolved proton self-emission. The views of the spatial structure and temporal evolution of both the laser drive in a hohlraum and implosion properties provide essential insight into, and modeling validation of, x-ray-driven implosions.

Silicon carbide fiber/silicon carbide matrix (SiC-SiC) composites exhibit remarkable material properties, including high temperature strength and stability under irradiation. These qualities have made SiC-SiC composites extremely desirable for use in advanced nuclear reactor concepts, where higher operating temperatures and longer lives require performance improvements over conventional metal alloys. However, fabrication efficiency advances need to be achieved. SiC composites are typically produced using chemical vapor infiltration (CVI), where gas phase precursors flow into the fiber preform and react to form a solid SiC matrix. Forced flow CVI utilizes a pressure gradient to more effectively transport reactants into the composite, reducing fabrication time. The fabrication parameters must be well understood to ensure that the resulting composite has a high density and good performance. To help optimize this process, a computer model was developed. This model simulates the transport of the SiC precursors, the deposition of SiC matrix on the fiber surfaces, and the effects of byproducts on the process. Critical process parameters, such as the temperature and reactant concentration, were simulated to identify infiltration conditions which maximize composite density while minimizing the fabrication time.

We have conducted experiments on the Omega laser at the University of Rochester that have produced jets of supersonic Ti impacting and being deflected by a ball of high density plastic. These mm-sized jets of dense plasma are highly complex, have large Reynolds numbers, and, given sufficient time and shear, should produce a fully turbulent flow. The experiments are diagnosed with a point-projection backlighter, resulting in a single image per shot. Simulations of the 3D hydrodynamics capture the large-scale features of the experimental data fairly well while missing some of the smaller scale turbulent-like phenomena. This is to be expected given the limited characterization of the targets as well as the finite resolution of the 3D simulations. If Euler scaling holds, these experiments should model larger astrophysical jets in objects such as HH 110 where an outflow can be seen colliding with a molecular cloud. However, Euler scaling demands that not only the isothermal internal Mach numbers of the two systems be similar but also that any dissipative mechanisms, such as radiative cooling or viscous dissipation, be of equal importance relative to each other. Similar equations of state are required as well. We discuss such issues in the context of these experiments and simulations.

Extended abstract of a paper presented at Microscopy and Microanalysis 2012 in Phoenix, Arizona, USA, July 29 – August 2, 2012.

ENVY is not one of the deadly sins Silvio Berlusconi would have admitted to a few years ago. Gluttony certainly, as his money helped AC Milan to monopolise Italian football. But envy was for others. How life has changed for him and his once-omnipotent club. As Italy embraces the new Serie A campaign, Milan have their noses pressed to the window as someone else buys the most expensive items in the shop. Lazio have supplanted the former champions as the high-rollers with a GBP 65m summer spending spree. In the process, Sergio Cragnotti has elbowed Berlusconi out of the way too. The multi- millionaire has ploughed fortunes from his firm - Italy's largest producer of canned tomatoes - into his football dream team. He also steered Lazio on to the stock exchange, the first Serie A club to have a listing and something that Berlusconi craved. No one is tipping Milan for the Scudetto. Small wonder, given that Berlusconi's side finished 11th and 10th in the last two Serie A championships and failed to qualify for Europe. Those halcyon days of a decade ago, when Milan won the European Cup three times and the Italian league five times, seem a long time ago. Indeed, the money which bought Milan so much joy, eventually became its downfall. Maybe its ill-gotten roots -in the eyes of the Italian inland revenue - meant that everything Berlusconi has touched in recent years has turned to dust.

Background/Objectives: Leishmaniasis constitutes one of the most fatal parasitic diseases globally, adversely impacting the health of individuals residing in both intertropical and temperate zones. In these geographical areas, the administration of treatment is often inconsistent and largely ineffective with the available pharmaceuticals, as these exhibit more pronounced side effects than the therapeutic advantages they purport to provide. Methods: Consequently, the current investigation seeks to engage in molecular modeling of novel pharmacological candidates incorporating 1,2,3 disubstituted triazole moieties, coordinated with CuII metal centers, in pursuit of promising bioactive properties. Results: Two complexes were prepared and X-ray analysis revealed a comparable structural configuration surrounding the copper (II) atom. The planar square coordination geometry was elucidated through the assessment of the τ4=0 (tau four) parameters. The comprehensive characterization encompasses HRMS-ESI (+), NMR, elemental analyses, mid-infrared, and UV-vis spectroscopic techniques. Time-dependent density functional theory (TD-DFT) analyses will substantiate the findings obtained through UV-vis spectroscopy. Crucially, the biological assays against Leishmania (L.) amazonensis revealed that Complex 1 exhibited outstanding potency against the intracellular amastigote form, demonstrating a half-maximal inhibitory concentration (IC50) of 0.4 µM. This activity was 6-fold higher than that of amphotericin B (IC50 = 2.5 µM) and 33-fold higher than pentamidine (IC50 = 13.3 µM). Furthermore, Complex 1 showed a promising selectivity index (SI = 9.7) against amastigotes, surpassing the reference drugs and meeting the criteria for a lead compound. While less active on promastigotes, both complexes demonstrated high stability in DMSO solution, a prerequisite for biological testing. Conclusions: These results unequivocally identify Complex 1 as a highly promising candidate for the development of new antileishmanial therapies, warranting further in vivo studies.

The insulator-to-metal transition occurring in magnetite is known as the Verwey transition, and its precise mechanism has recently come under renewed attention. Using pump–probe X-ray diffraction and optical reflectivity techniques, the dynamics of excitations known as trimerons are now examined, revealing the switching limits of this ubiquitous oxide material. As the oldest known magnetic material, magnetite (Fe 3 O 4 ) has fascinated mankind for millennia. As the first oxide in which a relationship between electrical conductivity and fluctuating/localized electronic order was shown 1 , magnetite represents a model system for understanding correlated oxides in general. Nevertheless, the exact mechanism of the insulator–metal, or Verwey, transition has long remained inaccessible 2 , 3 , 4 , 5 , 6 , 7 , 8 . Recently, three-Fe-site lattice distortions called trimerons were identified as the characteristic building blocks of the low-temperature insulating electronically ordered phase 9 . Here we investigate the Verwey transition with pump–probe X-ray diffraction and optical reflectivity techniques, and show how trimerons become mobile across the insulator–metal transition. We find this to be a two-step process. After an initial 300 fs destruction of individual trimerons, phase separation occurs on a 1.5±0.2 ps timescale to yield residual insulating and metallic regions. This work establishes the speed limit for switching in future oxide electronics 10 .

We show that magnetic skyrmions can be stabilised at room temperature in continuous [Ir/Co/Pt]5 multilayers on SiO2/Si substrates without the prior application of electric current or magnetic field. While decreasing the Co thickness, a transition of the magnetic domain patterns from worm-like state to separated stripes is observed. The skyrmions are clearly imaged in both states using magnetic force microscopy. The density of skyrmions can be significantly enhanced after applying the “in-plane field procedure”. Our results provide means to manipulate magnetic skyrmion density, further allowing for the optimised engineering of skyrmion-based devices.

Screening mammography aims to identify breast cancer at earlier stages of the disease, when treatment can be more successful 1 . Despite the existence of screening programmes worldwide, the interpretation of mammograms is affected by high rates of false positives and false negatives 2 . Here we present an artificial intelligence (AI) system that is capable of surpassing human experts in breast cancer prediction. To assess its performance in the clinical setting, we curated a large representative dataset from the UK and a large enriched dataset from the USA. We show an absolute reduction of 5.7% and 1.2% (USA and UK) in false positives and 9.4% and 2.7% in false negatives. We provide evidence of the ability of the system to generalize from the UK to the USA. In an independent study of six radiologists, the AI system outperformed all of the human readers: the area under the receiver operating characteristic curve (AUC-ROC) for the AI system was greater than the AUC-ROC for the average radiologist by an absolute margin of 11.5%. We ran a simulation in which the AI system participated in the double-reading process that is used in the UK, and found that the AI system maintained non-inferior performance and reduced the workload of the second reader by 88%. This robust assessment of the AI system paves the way for clinical trials to improve the accuracy and efficiency of breast cancer screening. An artificial intelligence (AI) system performs as well as or better than radiologists at detecting breast cancer from mammograms, and using a combination of AI and human inputs could help to improve screening efficiency.

Ultrafast heat transport in nanoscale metal multilayers is of great interest in the context of optically induced demagnetization, remagnetization and switching. If the penetration depth of light exceeds the bilayer thickness, layer-specific information is unavailable from optical probes. Femtosecond diffraction experiments provide unique experimental access to heat transport over single digit nanometer distances. Here, we investigate the structural response and the energy flow in the ultrathin double-layer system: gold on ferromagnetic nickel. Even though the excitation pulse is incident from the Au side, we observe a very rapid heating of the Ni lattice, whereas the Au lattice initially remains cold. The subsequent heat transfer from Ni to the Au lattice is found to be two orders of magnitude slower than predicted by the conventional heat equation and much slower than electron–phonon coupling times in Au. We present a simplified model calculation highlighting the relevant thermophysical quantities. Heat transport in ultrathin metal layers is important for potential applications in optical‐magnetic switching, but difficult to access experimentally. Here, the authors use ultrafast X‐ray diffraction to directly probe and explain unexpected time‐dependent transport behavior in Au–Ni nanolayers.