Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
5,459
result(s) for
"Bai, Jin"
Sort by:
Neoantigen-targeted TCR-engineered T cell immunotherapy: current advances and challenges
Adoptive cell therapy using T cell receptor-engineered T cells (TCR-T) is a promising approach for cancer therapy with an expectation of no significant side effects. In the human body, mature T cells are armed with an incredible diversity of T cell receptors (TCRs) that theoretically react to the variety of random mutations generated by tumor cells. The outcomes, however, of current clinical trials using TCR-T cell therapies are not very successful especially involving solid tumors. The therapy still faces numerous challenges in the efficient screening of tumor-specific antigens and their cognate TCRs. In this review, we first introduce TCR structure-based antigen recognition and signaling, then describe recent advances in neoantigens and their specific TCR screening technologies, and finally summarize ongoing clinical trials of TCR-T therapies against neoantigens. More importantly, we also present the current challenges of TCR-T cell-based immunotherapies, e.g., the safety of viral vectors, the mismatch of T cell receptor, the impediment of suppressive tumor microenvironment. Finally, we highlight new insights and directions for personalized TCR-T therapy.
Journal Article
المدينة المحرمة في 600 عام = Forbidden city = Cheng
هي أكبر فضاء معماري موجود، وهي بحجمها واتساع رقعتها، تدل على هيمنة الإمبراطورية على العالم، وأيا كانت قوة ونفوذ المرء فإنه بمجرد دخوله المدينة المحرمة، يجد نفسه أشبه بحبة رمل في صحراء واسعة، لا أهمية له، وعليه أن يخضع لهيمنة ذلك الفضاء، وأن يخضع سيره وجلوسه لقوانين ذلك الفضاء ؛ أما بالنسبة للإمبراطور فالوضع مختلف، فهو وحده سيد المكان، فهو لا يخضع في ظهوره وفي أي مناسبة لأي قيد أو شرط، في جلوسه على عرش التنين في قاعة الانسجام الأسمى، يصبح مركز الكون، ولا سيطرة للفضاء الواسع عليه. عندما يفقد الناس ذواتهم في القصور الضخمة ففي ذلك استعارة لسلطة الإمبراطور على رعاياه المبنية على أساس معماري حينما يمر الإمبراطور في القصر يفرض هيمنته على الجميع.
Book
BayeSED-GALAXIES. I. Performance Test for Simultaneous Photometric Redshift and Stellar Population Parameter Estimation of Galaxies in the CSST Wide-field Multiband Imaging Survey
The forthcoming Chinese Space Station Telescope (CSST) wide-field multiband imaging survey will produce seven-band photometric spectral energy distributions (SEDs) for billions of galaxies. The effective extraction of astronomical information from these massive data sets of SEDs relies on the techniques of SED synthesis (or modeling) and SED analysis (or fitting). We evaluate the performance of the latest version of the BayeSED code combined with SED models with increasing complexity for simultaneously determining the photometric redshifts and stellar population parameters of galaxies in this survey. By using an empirical statistics–based mock galaxy sample without SED modeling errors, we show that the random observational errors in photometries are more important sources of errors than the parameter degeneracies and Bayesian analysis method and tool. By using a Horizon-AGN hydrodynamical simulation–based mock galaxy sample with SED modeling errors about the star formation histories (SFHs) and dust attenuation laws (DALs), the simple typical assumptions lead to significantly worse parameter estimation with CSST photometries only. SED models with more flexible (or complicated) forms of SFH/DAL do not necessarily lead to better estimation of redshift and stellar population parameters. We discuss the selection of the best SED model by means of Bayesian model comparison in different surveys. Our results reveal that Bayesian model comparison with Bayesian evidence may favor SED models with different complexities when using photometries from different surveys. Meanwhile, the SED model with the largest Bayesian evidence tends to give the best performance of parameter estimation, which is clearer for photometries with higher discriminative power.
Journal Article
Metabolic Syndrome Risk after Gestational Diabetes: A Systematic Review and Meta-Analysis
A number of studies have been conducted to investigate the risk of metabolic syndrome (MS) after gestational diabetes mellitus (GDM), but the results are contradictory. Accordingly, we performed a systematic review and meta-analysis to assess the association between these two conditions. The aim was to better understand the risks of MS with prior gestational diabetes.
Pubmed, ISI Web of Science, and Cochrane databases from September 1, 1979 to July 11, 2013 were searched to identify relevant studies. 17 studies containing 5832 women and 1149 MS events were included. We calculated the odds ratio (OR) with 95% confidence interval (CI) in analysis for each study using a random-effect or fixed-effect model. We also determined heterogeneity among these 17 articles and their publication bias.
Women with a history of gestational diabetes had a significantly higher risk of MS than those who had a normal pregnancy (OR, 3.96; 95% CI, 2.99 to 5.26), but had significant heterogeneity (I (2) = 52.6%). The effect remained robust (OR, 4.54; 95% CI, 3.78-5.46) in the subgroup of Caucasians, but no association (OR, 1.28; 95% CI, 0.64-2.56) was found in Asians. Heterogeneity was reduced (body mass index (BMI) matched group I (2) = 14.2%, BMI higher in the GDM group I (2) = 13.2%) in the subgroup of BMI. In addition, mothers with higher BMI in the GDM group had higher risk of MS than those in the BMI matched group (BMI higher in GDM group OR, 5.39; 95% CI, 4.47-6.50, BMI matched group OR, 2.53; 95% CI, 1.88-3.41).
This meta-analysis demonstrated increased risk of MS after gestational diabetes. Therefore, attention should be given to preventing or delaying the onset of MS in GDM mothers, particularly in Caucasian and obese mothers.
Journal Article
Targeting NAMPT‐OPA1 for treatment of senile osteoporosis
Senescence of bone marrow mesenchymal stem cells (BMSCs) impairs their stemness and osteogenic differentiation, which is the principal cause of senile osteoporosis (SOP). Imbalances in nicotinamide phosphoribosyltransferase (NAMPT) homeostasis have been linked to aging and various diseases. Herein, reduction of NAMPT and impaired osteogenesis were observed in BMSCs from aged human and mouse. Knockdown of Nampt in BMSCs promotes lipogenic differentiation and increases age‐related bone loss. Overexpression of Nampt ameliorates the senescence‐associated (SA) phenotypes in BMSCs derived from aged mice, as well as promoting osteogenic potential. Mechanistically, NAMPT inhibits BMSCs senescence by facilitating OPA1 expression, which is essential for mitochondrial dynamics. The defect of NAMPT reduced mitochondrial membrane potential, interfered with mitochondrial fusion，and increased SA protein and phenotypes. More importantly, we have confirmed that P7C3, the NAMPT activator, is a novel strategy for reducing SOP bone loss. P7C3 treatment significantly prevents BMSCs senescence by improving mitochondrial function through the NAMPT‐OPA1 signaling axis. Taken together, these results reveal that NAMPT is a regulator of BMSCs senescence and osteogenic differentiation. P7C3 is a novel molecule drug to prevent the pathological progression of SOP. This study shows that reduced nicotinamide phosphoribosyltransferase (NAMPT) levels are linked to aging‐related BMSC dysfunction. NAMPT regulates BMSC senescence by promoting OPA1 expression, crucial for mitochondrial dynamics. The NAMPT activator P7C3 enhances mitochondrial function via the NAMPT‐OPA1 axis and helps prevent SOP, highlighting its potential as a therapeutic strategy.
Journal Article
LINC00460/DHX9/IGF2BP2 complex promotes colorectal cancer proliferation and metastasis by mediating HMGA1 mRNA stability depending on m6A modification
Background
Increasing studies have shown that long noncoding RNAs (lncRNAs) are pivotal regulators participating in carcinogenic progression and tumor metastasis in colorectal cancer (CRC). Although lncRNA long intergenic noncoding RNA 460 (LINC00460) has been reported in CRC, the role and molecular mechanism of LINC00460 in CRC progression still requires exploration.
Methods
The expression levels of LINC00460 were analyzed by using a tissue microarray containing 498 CRC tissues and their corresponding non-tumor adjacent tissues. The correlations between the LINC00460 expression level and clinicopathological features were evaluated. The functional characterization of the role and molecular mechanism of LINC00460 in CRC was investigated through a series of in vitro and in vivo experiments.
Results
LINC00460 expression was increased in human CRC, and high LINC00460 expression was correlated with poor five-year overall survival and disease-free survival. LINC00460 overexpression sufficiently induced the epithelial–mesenchymal transition and promoted tumor cell proliferation, migration, and invasion in vitro and tumor growth and metastasis in vivo. In addition, LINC00460 enhanced the protein expression of high-mobility group AT-hook 1 (HMGA1) by directly interacting with IGF2BP2 and DHX9 to bind the 3′ untranslated region (UTR) of HMGA1 mRNA and increased the stability of HMGA1 mRNA. In addition, the N6-methyladenosine (m6A) modification of HMGA1 mRNA by METTL3 enhanced HMGA1 expression in CRC. Finally, it suggested that HMGA1 was essential for LINC00460-induced cell proliferation, migration, and invasion.
Conclusions
LINC00460 may be a novel oncogene of CRC through interacting with IGF2BP2 and DHX9 and bind to the m6A modified HMGA1 mRNA to enhance the HMGA1 mRNA stability. LINC00460 can serve as a promising predictive biomarker for the diagnosis and prognosis among patients with CRC.
Journal Article
Morphology of Optical Changing-look Active Galactic Nuclei–Host Galaxies: Evidence for an Important Role of Mergers
Optical changing-look active galactic nuclei (CL-AGNs) are characterized by the (dis)appearance of broad emission lines on unexpectedly short timescales. However, the underlying mechanisms and their potential connection to host-galaxy properties are still unclear. In this work, we present an analysis of the morphology for 63 low-redshift CL-AGNs (z < 0.15) selected from the largest CL-AGN catalog to date, using images from DESI DR10 and employing both nonparametric methods and visual inspection. We find that CL-AGN hosts exhibit a concentration like late-type spirals, asymmetry like early-type spirals, and smoothness like ellipticals. This is confirmed by their Gini − M20 coefficients, suggesting weak/modest disturbances. Based upon our visual inspection, we further identify that 18 (29%) out of 63 sources are mergers, among which ∼56% (10/18) show shell features. Compared to different non-CL-AGN samples, CL-AGN hosts have a higher (∼2×) possibility of being merging systems. Our results indicate that mergers/interactions may play an important role in driving the changing-look behavior.
Journal Article
Expanding uncapped translation and emerging function of circular RNA in carcinomas and noncarcinomas
Circular RNAs (circRNAs) are classified as noncoding RNAs because they are devoid of a 5’ end cap and a 3’ end poly (A) tail necessary for cap-dependent translation. However, increasing numbers of translated circRNAs identified through high-throughput RNA sequencing overlapping with polysome profiling indicate that this rule is being broken. CircRNAs can be translated in cap-independent mechanism, including IRES (internal ribosome entry site)-initiated pattern, MIRES (m
6
A internal ribosome entry site) -initiated patterns, and rolling translation mechanism (RCA). CircRNA-encoded proteins harbour diverse functions similar to or different from host proteins. In addition, they are linked to the modulation of human disease including carcinomas and noncarcinomas. CircRNA-related translatomics and proteomics have attracted increasing attention. This review discusses the progress and exclusive characteristics of circRNA translation and highlights the latest mechanisms and regulation of circRNA translatomics. Furthermore, we summarize the extensive functions and mechanisms of circRNA-derived proteins in human diseases, which contribute to a better understanding of intricate noncanonical circRNA translatomics and proteomics and their therapeutic potential in human diseases.
Journal Article
Associations of circadian syndrome with gout and hyperuricemia: a cross‑sectional analysis of NHANES 2007–2018
Background
Gout and hyperuricemia, driven by elevated uric acid (UA). Circadian syndrome (CircS), a cluster of cardiometabolic risk factors related to circadian disruption, may interact with these conditions, but evidence remains limited. Understanding the potential associations of CircS with gout and hyperuricemia is crucial for effective health interventions.
Objective
To explore the associations of CircS with gout and hyperuricemia.
Materials and methods
This cross-sectional study utilized data from six National Health and Nutrition Examination Survey (NHANES) cycles (2007–2018). Participants aged ≥ 20 years with complete data on gout status, serum UA, and CircS were included. Gout was determined by self-reported physician diagnosis (questionnaire item MCQ160), and hyperuricemia was defined as serum UA > 7.0 mg/dL (men) or > 6.0 mg/dL (women), measured via uricase-based enzymatic assay. Survey-weighted logistic regression models were used to evaluate the associations of CircS with gout and hyperuricemia, adjusting for potential covariates. To assess nonlinear correlations, a restricted cubic spline (RCS) analysis was conducted. Sensitivity analysis was performed to test the stability of results.
Results
The study incorporated a total of 30,157 participants aged 20 years or older, out of which 14,698 were male. After full adjustment, those with CircS had higher odds of gout (OR = 1.34, 95% CI [1.03, 1.73],
P
= 0.03) and hyperuricemia (OR = 1.25, 95% CI [1.11, 1.41],
P
< 0.001) compared with individuals without CircS. A gradual increase in serum UA levels was associated with CircS. The RCS curve displays a nonlinear relationship between UA levels and CircS. Sensitivity analyses, including stratified analyses across key covariates and trend tests for CircS scores, consistently demonstrated that the associations of CircS with gout and hyperuricemia remained robust.
Conclusion
This study identified that CircS was significantly associated with both gout and hyperuricemia in the US general population. The risk of these conditions increased in parallel with rising CircS scores. Elevated UA levels were also associated with a higher incidence of CircS. Given the limitations inherent to the cross-sectional design, further longitudinal studies are required to establish causality and elucidate underlying mechanisms.
Journal Article