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"Baker, Lawrence"
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Animal rights and welfare : a documentary and reference guide
\"Through the use of primary source documents, readers can learn about key opinions and legislation in the important field of animal rights and welfare--a current and highly relevant topic\"-- Provided by publisher.
Book
Contrasting nitrogen and phosphorus budgets in urban watersheds and implications for managing urban water pollution
Managing excess nutrients remains a major obstacle to improving ecosystem service benefits of urban waters. To inform more ecologically based landscape nutrient management, we compared watershed inputs, outputs, and retention for nitrogen (N) and phosphorus (P) in seven subwatersheds of the Mississippi River in St. Paul, Minnesota. Lawn fertilizer and pet waste dominated N and P inputs, respectively, underscoring the importance of household actions in influencing urban watershed nutrient budgets. Watersheds retained only 22% of net P inputs versus 80% of net N inputs (watershed area-weighted averages, where net inputs equal inputs minus biomass removal) despite relatively low P inputs. In contrast to many nonurban watersheds that exhibit high P retention, these urban watersheds have high street density that enhanced transport of P-rich materials from landscapes to stormwater. High P exports in storm drainage networks and yard waste resulted in net P losses in some watersheds. Comparisons of the N/P stoichiometry of net inputs versus storm drain exports implicated denitrification or leaching to groundwater as a likely fate for retained N. Thus, these urban watersheds exported high quantities of N and P, but via contrasting pathways: P was exported primarily via stormwater runoff, contributing to surface water degradation, whereas N losses additionally contribute to groundwater pollution. Consequently, N management and P management require different strategies, with N management focusing on reducing watershed inputs and P management also focusing on reducing P movement from vegetated landscapes to streets and storm drains.
Journal Article
JFK : \Superman comes to the supermarket\ ; a pointed portrait of a political campaign
With his Hollywood good looks, boundless enthusiasm, and mesmeric media presence, John F. Kennedy was destined to capture the imaginations of over 70 million Americans who watched the nation s first televised presidential debate. Just days after winning the election by the narrowest margin in history, Kennedy himself said, It was the TV more than anything else that turned the tide. But one man begged to differ: writer Norman Mailer, who bragged that his pro-Kennedy treatise, Superman Comes to the Supermarket, had won the election for Kennedy. Whether or not that was the case, the article, published in Esquire magazine just weeks before polls opened, did redefine political reporting and journalism itself, spawning a form that would be called New Journalism. Mailer's frank, first-person, irreverent voice reflected on Kennedy's cult of personality, calling him the existential hero who could awaken the nation from its postwar slumber and staunchly conformist Eisenhower years.
Book
It Is Not Easy Being Green: Recognizing Unintended Consequences of Green Stormwater Infrastructure
Green infrastructure designed to address urban drainage and water quality issues is often deployed without full knowledge of potential unintended social, ecological, and human health consequences. Though understood in their respective fields of study, these diverse impacts are seldom discussed together in a format understood by a broader audience. This paper takes a first step in addressing that gap by exploring tradeoffs associated with green infrastructure practices that manage urban stormwater including urban trees, stormwater ponds, filtration, infiltration, rain gardens, and green roofs. Each green infrastructure practice type performs best under specific conditions and when targeting specific goals, but regular inspections, maintenance, and monitoring are necessary for any green stormwater infrastructure (GSI) practice to succeed. We review how each of the above practices is intended to function and how they could malfunction in order to improve how green stormwater infrastructure is designed, constructed, monitored, and maintained. Our proposed decision-making framework, using both biophysical (biological and physical) science and social science, could lead to GSI projects that are effective, cost efficient, and just.
Journal Article
Estimating the Cost of Industry Investment in Drug Research and Development
Research and development (R&D) costs factor into considerations of the tradeoffs between prices, intellectual property protection, and incentivizing innovation, all of which can have implications for policy development. Yet, there is little consensus on the actual cost of R&D for new drugs. We review and synthesize papers estimating drug R&D costs incurred by industry. We find a substantial range of per-drug costs, from $113 million to just over $6 billion in 2018 dollars. This range includes estimates covering all new drugs, new molecular entities, and drugs in specific therapeutic classes. The range is narrower—$318 million to $2.8 billion—for estimates of the per-drug cost for new molecular entities. We discuss the data sources, methods, and assumptions used in each study to provide context for the wide range in existing estimates. Differences in definitions, methods, and assumptions lead to large divergences in the main estimates, and the combination of fragmented data sources and different assumptions across studies means that the resulting estimates that can rarely be directly compared.We suggest areas for future research and data collection that would result in more comparable and robust estimates to inform ongoing policy discussion.
Journal Article
Reopening California: Seeking robust, non-dominated COVID-19 exit strategies
The COVID-19 pandemic required significant public health interventions from local governments. Although nonpharmaceutical interventions often were implemented as decision rules, few studies evaluated the robustness of those reopening plans under a wide range of uncertainties. This paper uses the Robust Decision Making approach to stress-test 78 alternative reopening strategies, using California as an example. This study uniquely considers a wide range of uncertainties and demonstrates that seemingly sensible reopening plans can lead to both unnecessary COVID-19 deaths and days of interventions. We find that plans using fixed COVID-19 case thresholds might be less effective than strategies with time-varying reopening thresholds. While we use California as an example, our results are particularly relevant for jurisdictions where vaccination roll-out has been slower. The approach used in this paper could also prove useful for other public health policy problems in which policymakers need to make robust decisions in the face of deep uncertainty.
Journal Article
A transition management framework to stimulate a circular phosphorus system
As the global population is projected to increase by two billion people by 2050, so will the demand for phosphorus (P), an essential nutrient for all living organisms and a major driver of eutrophication. To sustainably meet these challenges, we apply the conceptual framework of transition management (TM) to demonstrate how the trajectory of the current linear P use system could be strategically shifted toward a more circular P system. We present US case studies to examine P transitions management in intensive agriculture, wastewater disposal, and food waste management. Our goal is twofold. By first understanding past transitions in P management in the USA, we can build upon these insights for future management. This can then be applied to other global regions such as developing countries to bypass stages of transition as they intensify agriculture, incorporate sewers into cities, and expand waste management, to avoid becoming entrenched in unsustainable P management. We suggest how spaces for experimentation and collaboration can be created, how and which actor networks can be mobilized, and what action strategies and policies can be recommended to accelerate their transition to P sustainability. Our case studies show that while substantial improvements have been made, the transition toward a circular economy of P is far from complete. Our findings point to the value of utilizing TM for future progress in the US Development of TM frameworks for managing P in other regions of the world may enable them to achieve sustainable P development faster and more effectively than the USA.
Journal Article
Artificial intelligence applications used in the clinical response to COVID-19: A scoping review
Research into using artificial intelligence (AI) in health care is growing and several observers predicted that AI would play a key role in the clinical response to the COVID-19. Many AI models have been proposed though previous reviews have identified only a few applications used in clinical practice. In this study, we aim to (1) identify and characterize AI applications used in the clinical response to COVID-19; (2) examine the timing, location, and extent of their use; (3) examine how they relate to pre-pandemic applications and the U.S. regulatory approval process; and (4) characterize the evidence that is available to support their use. We searched academic and grey literature sources to identify 66 AI applications that performed a wide range of diagnostic, prognostic, and triage functions in the clinical response to COVID-19. Many were deployed early in the pandemic and most were used in the U.S., other high-income countries, or China. While some applications were used to care for hundreds of thousands of patients, others were used to an unknown or limited extent. We found studies supporting the use of 39 applications, though few of these were independent evaluations and we found no clinical trials evaluating any application’s impact on patient health. Due to limited evidence, it is impossible to determine the extent to which the clinical use of AI in the pandemic response has benefited patients overall. Further research is needed, particularly independent evaluations on AI application performance and health impacts in real-world care settings.
Journal Article
Decomposition of tree leaf litter on pavement: implications for urban water quality
Leaf litter may be an important source of nutrients to stormwater and ultimately contribute to eutrophication of surface waters associated with urbanization. Thus, understanding decomposition and nutrient release from leaf litter that falls on impervious surfaces is important for stormwater management. However, few studies have examined leaf litter decomposition in the unique urban environment of the street gutter. We compared decomposition of leaf litter of five street tree species in a parking lot gutter in St. Paul, Minnesota, USA. In contrast to our expectations, comparisons with past studies revealed that litter decomposed more rapidly in the gutter than in nearby natural areas. And decomposition rates were as rapid as those measured in other urban settings (forests and streams), with most species losing 80 % of their initial mass after 1 year. Litter of most species had retained more than half of its initial N and P after 1 year. However, in contrast to N, litter P dynamics largely were uncoupled from litter mass dynamics, with litter P increasing and decreasing unpredictably over the year. Short-term (24 h) laboratory studies revealed that litter had the potential to lose a high fraction of its initial P, with high variation among species (from 27 to 88 %), and a smaller fraction of its initial N (<10 %) via leaching. Thus, street tree species may differ in their potential contributions to nutrients that are released during decomposition. Our results suggest that careful selection of street tree species and timely removal of litterfall have significant potential to reduce nutrient fluxes from streets to storm drains, particularly for P.
Journal Article
Nitrogen Balance for the Central Arizona-Phoenix (CAP) Ecosystem
A detailed fixed nitrogen (N) mass balance was constructed for the Central Arizona-Phoenix (CAP) ecosystem. Input of fixed N input to the ecosystem was$98\\ {\\rm Gg}\\ {\\rm y}^{-1}$. Of this, humans deliberately imported or mediated the fixation of$51\\ {\\rm Gg}\\ {\\rm N}\\ {\\rm y}^{-1}$; combustion processes added another$36\\ {\\rm Gg}\\ {\\rm y}^{-1}$. Fixation by desert plants, wet deposition, and surface water input accounted for 11% of total N input. Total fixed N output was$78\\ {\\rm Gg}\\ {\\rm N}\\ {\\rm y}^{-1}$, a large component of which was gaseous N products of combustion and denitrification. Computed accumulation of N was$21\\ {\\rm Gg}\\ {\\rm y}^{-1}$(total input minus total output) or alternatively,$17\\ {\\rm Gg}\\ {\\rm y}^{-1}$(summing individual accumulation fluxes). Key uncertainties include dry deposition of atmospheric N and changes in soil storage. Inputs to the urban and agricultural components of the ecosystem were an order of magnitude higher than inputs to the desert. Human hydrologic modifications in this ecosystem promote the accumulation and volatilization of N while keeping riverine export low (3% of input). Interplay among the form and amount of N inputs, edaphic and climatic characteristics of the system, hydrologic modifications, and deliberate efforts to reduce N pollution controls the fate of N in human-dominated ecosystems.
Journal Article