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This study examines the Thomas/twin motif in the Gospels of John and Thomas, which plays a significant role in each. By analyzing the motif’s meaning, deployment, and development in the two Gospels against Mesopotamian models, this study brings a fresh perspective to the much-debated topic of the Gospel of Thomas’s place of origin. This study demonstrates that Thomas betrays a knowledge of cuneiform polyvalence and argues that this corroborates the historical tradition that it originated in Mesopotamia. The findings also support the claim that the work is theologically sophisticated despite its disarming surface appearance. Similarly, Mesopotamian hermeneutics shed light on some enigmas of the Fourth Gospel’s symbolism, esotericism, and theology conveyed in the rhetorical and symbolic role of Thomas called Didymos. This study concludes that, in both Gospels, the figure of Thomas/twin is paradigmatic for every adherent of Jesus, but the Gospels have drawn on Mesopotamian sources in different ways.

The book of Joshua is a book-length crux interpretum. Its cultivation of two concurrent narratives that contradict one another has fascinated commentators since antiquity. This is only one of its hermeneutically challenging features. Most modern commentaries attribute these features to an uneven process of redaction. Focusing on chapters 1–12, this essay argues that incongruity, ambiguity, and disjunction are essential elements of a rhetorical strategy in which form and content are imaginatively correlated, and that the text contains many cryptic clues that are necessary to elucidate its meaning. It contends that Joshua is the product of a bold literary innovation that is motivated by a sustained and uncompromising determination to unsettle facile assumptions about YHWH and Israel’s history. It concludes that the book challenges us to re-evaluate not only the answers we thought it gave, but even the questions we ask of it.

The empirical study of the role of sperm competition in the evolution of sexual traits has historically been problematic through the inability either to measure sperm competition levels directly in the present or to reconstruct changes in the evolutionary past. Here, we develop and test a procedure based on paternity data that potentially permits both. For our pilot study, we use the rate of change of the seminal protein gene SEMG2 for catarrhine primates published by Dorus et al. (Nat Genet 36:1326–1329, 2004). From their data, Dorus et al. proposed a two-part hypothesis: (1) sperm competition plays a role in the evolution of the SEMG2 gene and (2) higher levels of sperm competition generate more positive selection for change in SEMG2 than lower levels. Dorus et al. were limited, however, by being able to use only proxy measures of sperm competition and only seven “recent” segments of catarrhine primate phylogeny. Here, we develop a “timeline procedure” that permits the Dorus hypothesis to be tested using data from across the whole of catarrhine phylogeny. Our analysis supports part (1) of the Dorus hypothesis but questions part (2), suggesting instead that changes in level of sperm competition have a more powerful influence on the rate of evolution of traits than the level of sperm competition itself. We conclude that the timeline procedure developed here could be a valuable investigative tool in the role of sperm competition in the evolution of sexual traits measured over evolutionary time such as SEMG2.

To assess the potential of whole-genome sequencing (WGS) to replicate and augment results from conventional blood-based newborn screening (NBS). Research-generated WGS data from an ancestrally diverse cohort of 1,696 infants and both parents of each infant were analyzed for variants in 163 genes involved in disorders included or under discussion for inclusion in US NBS programs. WGS results were compared with results from state NBS and related follow-up testing. NBS genes are generally well covered by WGS. There is a median of one (range: 0–6) database-annotated pathogenic variant in the NBS genes per infant. Results of WGS and NBS in detecting 28 state-screened disorders and four hemoglobin traits were concordant for 88.6% of true positives (n = 35) and 98.9% of true negatives (n = 45,757). Of the five infants affected with a state-screened disorder, WGS identified two whereas NBS detected four. WGS yielded fewer false positives than NBS (0.037 vs. 0.17%) but more results of uncertain significance (0.90 vs. 0.013%). WGS may help rule in and rule out NBS disorders, pinpoint molecular diagnoses, and detect conditions not amenable to current NBS assays.

The list in Judg 10:6 of the gods of the surrounding nations to which Israel adhered in preference to YHWH is unprecedented in its detail. Moreover, it forms the literal center of the book of Judges according to the masoretic verse count. In the composition's rhetorical plan, similarly, it constitutes the fulcrum in the account of the relations between YHWH and his people. The worship of these deities and the syncretistic application of aspects of their cults to normative Yahwism provoke the response from Israel's god that he will deliver them no more and that they should \"appeal to the gods you have chosen\" for deliverance. This rupture in the relationship sets the scene for Jephthah's rise. The Gileadites, in extremis, take the initiative to engineer a human solution to a divine problem by approaching Jephthah, a social outcast with proven leadership and combat skills. This article analyzes the place and role of Jephthah in Judges; the repercussions of his brief ascendancy; his relationship with the minor judges, as well as with Ehud and Abimelech; and the meaning of the shibboleth incident. The conclusions challenge the widely held scholarly view, originally proposed by Martin Noth, that Jephthah is the common denominator between the judge-deliverer figures and the minor judges. In addition, it advances a new interpretation of the significance of the choice of the noun shibboleth as the password at the Jordan fords.

A method of producing perovskite-sensitized solar cells by sequential — as opposed to single-step — deposition of the perovskite’s components onto a nanoporous titanium oxide film allows for greater reproducibility of device performance and a record power conversion efficiency of 15 per cent. Solar energy at the double Solution-processable solid-state solar cells that use organic–inorganic perovskites as the light-harvesting material (pigment) can in principle show impressive power conversion efficiencies, but their performance can vary significantly from device to device owing to the uncontrolled way in which the pigment is usually deposited. Julian Burschka and colleagues report a two-step deposition process that minimizes morphological variations in the pigment, resulting in solar cells with greatly improved reproducibility and power conversion efficiencies of about 15% — a new record for this class of solar cell. Following pioneering work 1 , solution-processable organic–inorganic hybrid perovskites—such as CH 3 NH 3 PbX 3 (X = Cl, Br, I)—have attracted attention as light-harvesting materials for mesoscopic solar cells 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 . So far, the perovskite pigment has been deposited in a single step onto mesoporous metal oxide films using a mixture of PbX 2 and CH 3 NH 3 X in a common solvent. However, the uncontrolled precipitation of the perovskite produces large morphological variations, resulting in a wide spread of photovoltaic performance in the resulting devices, which hampers the prospects for practical applications. Here we describe a sequential deposition method for the formation of the perovskite pigment within the porous metal oxide film. PbI 2 is first introduced from solution into a nanoporous titanium dioxide film and subsequently transformed into the perovskite by exposing it to a solution of CH 3 NH 3 I. We find that the conversion occurs within the nanoporous host as soon as the two components come into contact, permitting much better control over the perovskite morphology than is possible with the previously employed route. Using this technique for the fabrication of solid-state mesoscopic solar cells greatly increases the reproducibility of their performance and allows us to achieve a power conversion efficiency of approximately 15 per cent (measured under standard AM1.5G test conditions on solar zenith angle, solar light intensity and cell temperature). This two-step method should provide new opportunities for the fabrication of solution-processed photovoltaic cells with unprecedented power conversion efficiencies and high stability equal to or even greater than those of today’s best thin-film photovoltaic devices.

Germline mutations are the source of evolution and contribute substantially to many health-related processes. Here we use whole-genome deep sequencing data from 693 parents–offspring trios to examine the de novo point mutations (DNMs) in the offspring. Our estimate for the mutation rate per base pair per generation is 1.05 × 10 −8 , well within the range of previous studies. We show that maternal age has a small but significant correlation with the total number of DNMs in the offspring after controlling for paternal age (0.51 additional mutations per year, 95% CI: 0.29, 0.73), which was not detectable in the smaller and younger parental cohorts of earlier studies. Furthermore, while the total number of DNMs increases at a constant rate for paternal age, the contribution from the mother increases at an accelerated rate with age.These observations have implications related to the incidence of de novo mutations relating to maternal age. The study of germline mutations has been greatly enhanced by massive parallel sequencing technologies. Here the authors use deep sequencing data from nearly 700 parent-child trios to show maternal age has a small but significant correlation with the number of de novo mutations in the offspring.

Purpose The International Ki67 Working Group (IKWG) has developed training for immunohistochemistry (IHC) scoring reproducibility and recommends cut points of ≤ 5% and ≥ 30% for prognosis in ER+, HER2−, stage I/II breast cancer. We examined scoring reproducibility following IKWG training and evaluated these cut points for selecting patients for further testing with the 21-gene Recurrence Score (RS) assay. Methods We included 307 women aged 50+ years with node-negative, ER+PR+HER2− breast cancer and with available RS results. Slides from the diagnostic biopsy were stained for Ki67 and scored using digital image analysis (IA). Two IHC pathologists underwent IKWG training and visually scored slides, blinded to each other and IA readings. Interobserver reproducibility was examined using intraclass correlation (ICC) and Kappa statistics. Results Depending on reader, 8.8–16.0% of our cohort had Ki67 ≤ 5% and 11.4–22.5% had scores ≥ 30%. The ICC for Ki67 scores by the two pathologists was 0.82 (95% CI 0.78–0.85); it was 0.79 (95% CI 0.74–0.83) for pathologist 1 and IA and 0.76 (95% CI 0.71–0.80) for pathologist 2 and IA. For Ki67 scores ≤ 5%, the percentages with RS < 26 were 92.6%, 91.8%, and 90.9% for pathologist 1, pathologist 2, and IA, respectively. For Ki67 scores ≥ 30%, the percentages with RS ≥ 26 were 41.5%, 51.4%, and 27.5%, respectively. Conclusion The IKWG’s Ki67 training resulted in moderate to strong reproducibility across readers but cut points had only moderate overlap with RS cut points, especially for Ki67 ≥ 30% and RS ≥ 26; thus, their clinical utility for a 21-gene assay testing pathway remains unclear.

Background The CTN-0067 CHOICES trial tests implementation of extended-release naltrexone (XR-NTX) versus treatment-as-usual (TAU) for opioid use disorders (OUD) in HIV clinics to improve HIV viral suppression. The study team investigated recruitment strategies to elucidate the barriers and facilitators to recruitment and enrollment in the study. Main text Methods: Semi-structured, in-depth, digitally recorded interviews were completed with study recruitment-related staff and medical providers ( n  = 26) from six participating HIV clinics in the fall of 2018. Interviews probed 1) factors that might prevent prospective participants from engaging in study recruitment and enrollment procedures and 2) strategies used by study staff that encourage eligible patient participation. Interviews were transcribed and thematically analyzed using a content analysis approach. Results: All respondents reported that barriers to recruitment and enrollment included challenging patient social and structural factors (e.g., homelessness or living environments with high substance use, criminal justice involvement), difficulty locating patients with unsuppressed HIV viral load and OUD within the HIV clinic, time-consuming study enrollment processes, and stigma around HIV and OUD which inhibited treatment seeking. Some respondents observed that distrust of research and researchers impeded recruitment activities in the community. A specific medication-related barrier was patient fear of opioid abstinence required prior to XR-NTX induction. Facilitators of recruitment included use of trusted peer outreach/recruitment workers in the community, hospitalizations that offered windows of opportunities for screening and XR-NTX induction, providing participant transportation, and partnerships with harm reduction organizations for referrals. Conclusions Though study personnel encountered barriers to recruitment in the CHOICES study, persons with untreated HIV and OUD can be enrolled in multisite clinical trials by using enhanced recruitment strategies that extend outside of the HIV clinic. Employing peer outreach workers and collaborating with syringe service programs may be especially helpful in facilitating recruitment and merit inclusion in similar study protocols.

This paper examines the tactical interaction between drones and tanks in modern warfare through game theory, particularly focusing on Stackelberg equilibrium and backward induction. It describes a high-stakes conflict between two teams: one using advanced drones for attack, and the other defending using tanks. The paper conceptualizes this as a sequential game, illustrating the complex strategic dynamics similar to Stackelberg competition, where moves and countermoves are carefully analyzed and predicted.