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Plexiform neurofibroma is a complication of the NF1 mutation in neurofibromatosis that results in overactivity of the RAS pathway. Selumetinib, a mitogen-activated protein kinase (MAPK) kinase inhibitor, induced tumor regressions in a majority of patients. Neurofibromatosis type 1 is a common genetic disorder that is characterized by multiple manifestations including tumors of the nervous system. 1 , 2 Plexiform neurofibromas develop in 20 to 50% of persons with neurofibromatosis type 1 and can cause substantial complications including pain, functional impairment, disfigurement, and malignant transformation. 3 – 7 Most plexiform neurofibromas are diagnosed in early childhood and grow most rapidly during this period. 8 , 9 Complete surgical resection of these tumors is often not feasible, and regrowth of the tumor after incomplete surgical resection has been observed. 10 , 11 The NF1 product neurofibromin functions as a negative regulator of RAS activity. Lack . . .

In this article, I engage with the scholarship and praxis of Caribbean feminists and post-colonial scholars, using the term brackish (the place where salt and freshwater meet) as a metaphor, to (re)think Black Caribbean feminisms as ecologies that produce aliveness despite harsh regional conditions. I argue that over many decades, Caribbean feminists have built and sustained vibrant ecologies of thought and practice to address the ways in which we are all similarly and disparately impacted by social, political, economic, environmental, and other conditions within the region and by each other, and have adopted ethical ways to coexist. I posit that engaging with Caribbean feminist ecologies helps us to think about all the ways in which we are connected in this environment, whether literally or metaphorically, and how for Black, and specifically Black Caribbean people, our physical environment, and our relationships with living nonhuman or other-thanhuman beings can tell us much about what it means to create and sustain life generous and interspecies.

In this article I place María Lugones's concept of “world”-travelling in conversation with José Esteban Munóz's disidentification to posit a theory of “world”-travelling as facilitating a disidentificatory practice women of color use in the academe. Herein I propose the possibility of future-making through a praxis that surpasses survival, by traveling between these two theoretical frames, with the purpose of moving with travelling to envisioning and creating new “worlds” within and beyond the academe. I combine these two theories—queer theory and critical transnational feminism—to articulate from a position of (un)ease the radical potential of loving those (un)like us, and travelling with them in between “worlds.” In this essay I seek to advance a radical praxis of feminist loving and its possibilities to create new “worlds.”

In this article I engage with the work of Sylvia Wynter, Christina Sharpe, and Kevin Quashie, weaving in my own personal narrative of being presumed nonhuman to detail the everyday struggles Black women academics face. Herein I also illustrate how these struggles become sites of resistance, building, and hope. Keywords: Academia, Black women, Human, Quiet, Sylvia Wynter, The Wake

This viewpoint discusses the importance of upholding non-retrogression in the human rights system, particularly in relation to gender-based violence and accountability norms. The authors, a collective of academics and advocates, highlight the need for comprehensive standards that recognize new understandings of harm and extend state obligations to prevent abuses by nonstate actors. They argue that conflicting expert statements on gender and gender-based violence can lead to normative retrogressions, threatening decades of progress in gender analysis. The authors critique the current practices of the UN Special Rapporteur on violence against women and girls, pointing out normatively retrogressive efforts that undermine existing protections. They emphasize the principles of non-retrogression and accountability as essential for the prevention of gender-based violence and the protection of health rights. The authors call for greater transparency, ethical practices, and constructive civil society critiques to guide and safeguard professional practices by experts and ensure the independence of the human rights system., particularly in relation to gender-based violence. The authors, highlight the need for comprehensive standards that recognize new understandings of harm and extend state obligations to prevent abuses by nonstate actors. They argue that accountability norms for gender-based violence are essential for advancing state accountability and protecting the right to health. The authors critique UN expert practices that contribute to normative retrogressions and call for constructive civil society critiques to guide and safeguard professional practices. They specifically focus on the UN Special Rapporteur on violence against women and girls, highlighting normatively retrogressive efforts that threaten fragile achievements in gender equality. The authors emphasize the principles of non-retrogression and accountability in human rights law, stressing the importance of maintaining existing standards while expanding human rights protections. They propose that the Office of the United Nations High Commissioner for Human Rights take a more strategic and proactive approach to ensuring transparency and ethical practices within the UN human rights system.

The cascading and compounding effects of recent natural hazards and disruptive events in Australia have been much discussed. It's timely to examine the cascading and compounding benefits that can be achieved through successive disaster-response initiatives.

Background Neurofibromatosis type 1 (NF1) is a tumor‐predisposition disorder that arises due to pathogenic variants in tumor suppressor NF1. NF1 has variable expressivity that may be due, at least in part, from heritable elements such as modifier genes; however, few genetic modifiers have been identified to date. Methods In this study, we performed a genome‐wide association analysis of the number of café‐au‐lait macules (CALM) that are considered a tumor‐like trait as a clinical phenotype modifying NF1. Results A borderline genome‐wide significant association was identified in the discovery cohort (CALM1, N = 112) between CALM number and rs12190451 (and rs3799603, r2 = 1.0; p = 7.4 × 10−8) in the intronic region of RPS6KA2. Although, this association was not replicated in the second cohort (CALM2, N = 59) and a meta‐analysis did not show significantly associated variants in this region, a significant corroboration score (0.72) was obtained for the RPS6KA2 signal in the discovery cohort (CALM1) using Complementary Pairs Stability Selection for Genome‐Wide Association Studies (ComPaSS‐GWAS) analysis, suggesting that the lack of replication may be due to heterogeneity of the cohorts rather than type I error. Conclusion rs12190451 is located in a melanocyte‐specific enhancer and may influence RPS6KA2 expression in melanocytes—warranting further functional studies. In this study, we performed a genome‐wide association analysis of the number of café‐au‐lait macules (CALM) that are considered a tumor‐like trait as a clinical phenotype modifying neurofibromatosis type 1. A borderline genome‐wide significant association was identified in the discovery cohort (CALM1, N = 112) between CALM number and rs12190451 (p = 7.4 × 10–8) in the intronic region of RPS6KA2. rs12190451 is located in a melanocyte‐specific enhancer and may influence expression of RPS6KA2, a biologically compelling candidate as a NF1 genetic modifier, since the protein is phosphorylated and activated by RAS‐MAPK pathway kinases ERK1/2 that act downstream of RAS and neurofibromin.

I've just switched off the engine, killing the lights, when someone's banging on the car roof. A rangy young man in ragged shorts and t-shirt appears beside me, brandishing a bush-knife and wrenching at the locked door, his mouth open in a fury of yelling. In front, a boy about sixteen holds a rock as big as his head, poised to plunge it through the windshield. The lamp on my cabin's front porch - so near yet so far - backlights a third youth squinting through the passenger window's dark glass. He has a gun...

I've just switched off the engine, killing the lights, when someone's banging on the car roof. A rangy young man in ragged shorts and t-shirt appears beside me, brandishing a bush-knife and wrenching at the locked door, his mouth open in a fury of yelling. In front, a boy about sixteen holds a rock as big as his head, poised to plunge it through the windshield. The lamp on my cabin's front porch - so near yet so far - backlights a third youth squinting through the passenger window's dark glass. He has a gun...