Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
183
result(s) for
"Ball, Heather"
Sort by:
Truth or Consequences: Academic Instruction Librarians as Information Literacy and Critical Thinking Activists
The graphic edition of Snyder's On Tyranny (2021) states \"truth dies in four modes,\" which is a contemporary synthesis connected to Klemperer's Language of the Third Reich (1957). The researchers connected these four modes to information literacy (IL) instruction-but would others? The researchers surveyed academic librarians engaged in IL instruction on whether they felt they addressed any of the modes in their work. The researchers also asked whether they believe the ACRL Framework for Information Literacy for Higher Education works to circumvent any of the four modes. Nearly 150 librarians responded and, while most respondents were unfamiliar with the two texts referenced and their thoughts were mixed, many saw their work and the Framework as antagonistically related to Mode 1 (Open Hostility to Verifiable Reality). This paper discusses survey results and their implications for better understanding of how academic librarians engaged in IL instruction view their work in a socio-political context.
Journal Article
In Vivo Senescence in the Sbds-Deficient Murine Pancreas: Cell-Type Specific Consequences of Translation Insufficiency
Genetic models of ribosome dysfunction show selective organ failure, highlighting a gap in our understanding of cell-type specific responses to translation insufficiency. Translation defects underlie a growing list of inherited and acquired cancer-predisposition syndromes referred to as ribosomopathies. We sought to identify molecular mechanisms underlying organ failure in a recessive ribosomopathy, with particular emphasis on the pancreas, an organ with a high and reiterative requirement for protein synthesis. Biallelic loss of function mutations in SBDS are associated with the ribosomopathy Shwachman-Diamond syndrome, which is typified by pancreatic dysfunction, bone marrow failure, skeletal abnormalities and neurological phenotypes. Targeted disruption of Sbds in the murine pancreas resulted in p53 stabilization early in the postnatal period, specifically in acinar cells. Decreased Myc expression was observed and atrophy of the adult SDS pancreas could be explained by the senescence of acinar cells, characterized by induction of Tgfβ, p15(Ink4b) and components of the senescence-associated secretory program. This is the first report of senescence, a tumour suppression mechanism, in association with SDS or in response to a ribosomopathy. Genetic ablation of p53 largely resolved digestive enzyme synthesis and acinar compartment hypoplasia, but resulted in decreased cell size, a hallmark of decreased translation capacity. Moreover, p53 ablation resulted in expression of acinar dedifferentiation markers and extensive apoptosis. Our findings indicate a protective role for p53 and senescence in response to Sbds ablation in the pancreas. In contrast to the pancreas, the Tgfβ molecular signature was not detected in fetal bone marrow, liver or brain of mouse models with constitutive Sbds ablation. Nevertheless, as observed with the adult pancreas phenotype, disease phenotypes of embryonic tissues, including marked neuronal cell death due to apoptosis, were determined to be p53-dependent. Our findings therefore point to cell/tissue-specific responses to p53-activation that include distinction between apoptosis and senescence pathways, in the context of translation disruption.
Journal Article
Altering Dynamics of Autonomic Processing Therapy (ADAPT) trial: a novel, targeted treatment for reducing anxiety in joint hypermobility
Background
Hypermobility is a poorly recognised and understood musculoskeletal disorder thought to affect around 20% of the population. Hypermobility is associated with reduced physiological and psychological functioning and quality of life and is a known risk factor for the development of an anxiety disorder. To date, no evidence-based, targeted treatment for anxiety in the context of hypermobility exists. The present intervention (ADAPT—Altering Dynamics of Autonomic Processing Therapy) is a novel therapy combining bio-behavioural training with cognitive approaches from clinical health psychology targeting the catastrophisation of internal sensations, with aim to improve autonomic trait prediction error.
Method
Eighty individuals with diagnosed hypermobility will be recruited and the efficacy of ADAPT to treat anxiety will be compared to an Emotion-Focused Supportive Therapy (EFST) comparator therapy in a randomised controlled trial. The primary treatment target will be post therapy score on the Beck Anxiety Inventory, and secondary outcomes will also be considered in relation to interoception, depression, alexithymia, social and work adjustment, panic symptoms and dissociation. Due to COVID restrictions, the intervention will be moved to online delivery and qualitative assessment of treatment tolerance to online therapy will also be assessed.
Discussion
Online delivery of an intervention targeting anxiety would improve the quality of life for those experiencing anxiety disorder and help to reduce the £11.7 billion that anxiety disorders cost the UK economy annually.
Trial registration
World Health Organization
ISRCTN17018615
. Registered on 20th February 2019; trial protocol version 2
Journal Article
Using Critical Race Theory to Inform a Multi-Session Information Literacy Workshop Series for First-Year Students of Color
This study sought to understand individualized information literacy instruction for first-year students of color in higher education, and the impact of that instruction on student performance and confidence levels. The study was conducted at a four-year doctoral granting higher education institution and was designed as a QUAL+quan convergent mixed-methods study. It utilized critical race theory (CRT) as its theoretical framework, a participatory action research (PAR) approach for its design, and critical pedagogical practices to tailor the instructional content and delivery. The instruction was designed as a multi-session information literacy workshop series delivered outside of the traditional classroom and was comprised of six one-hour sessions: an initial focus group, four information literacy sessions focusing on specific aspects of the research process, and semi-structured interviews. Data collected through discussions, open-ended activities with rubrics, and pre- and post-series surveys, were analyzed to determine whether the instructional series impacted student learning outcomes. The results showed the series had a positive impact on student performance and their confidence levels pertaining to understanding and applying information literacy concepts. The study is significant as it is the first to specifically utilize CRT and PAR in a multi-session information literacy workshop series for first-year students of color delivered outside of the traditional classroom setting and can serve as a model for other institutions.
Dissertation
In Vivo Senescence in the Sbds-Deficient Murine Pancreas: Cell-Type Specific Consequences of Translation Insufficiency
Genetic models of ribosome dysfunction show selective organ failure, highlighting a gap in our understanding of cell-type specific responses to translation insufficiency. Translation defects underlie a growing list of inherited and acquired cancer-predisposition syndromes referred to as ribosomopathies. We sought to identify molecular mechanisms underlying organ failure in a recessive ribosomopathy, with particular emphasis on the pancreas, an organ with a high and reiterative requirement for protein synthesis. Biallelic loss of function mutations in SBDS are associated with the ribosomopathy Shwachman-Diamond syndrome, which is typified by pancreatic dysfunction, bone marrow failure, skeletal abnormalities and neurological phenotypes. Targeted disruption of Sbds in the murine pancreas resulted in p53 stabilization early in the postnatal period, specifically in acinar cells. Decreased Myc expression was observed and atrophy of the adult SDS pancreas could be explained by the senescence of acinar cells, characterized by induction of Tgfβ, p15Ink4b and components of the senescence-associated secretory program. This is the first report of senescence, a tumour suppression mechanism, in association with SDS or in response to a ribosomopathy. Genetic ablation of p53 largely resolved digestive enzyme synthesis and acinar compartment hypoplasia, but resulted in decreased cell size, a hallmark of decreased translation capacity. Moreover, p53 ablation resulted in expression of acinar dedifferentiation markers and extensive apoptosis. Our findings indicate a protective role for p53 and senescence in response to Sbds ablation in the pancreas. In contrast to the pancreas, the Tgfβ molecular signature was not detected in fetal bone marrow, liver or brain of mouse models with constitutive Sbds ablation. Nevertheless, as observed with the adult pancreas phenotype, disease phenotypes of embryonic tissues, including marked neuronal cell death due to apoptosis, were determined to be p53-dependent. Our findings therefore point to cell/tissue-specific responses to p53-activation that include distinction between apoptosis and senescence pathways, in the context of translation disruption.
Journal Article
An investigation into the use of the transporters dvd to enhance emotion recognition in children with an autistic spectrum condition
Baron-Cohen (2002) developed an intervention for children with a diagnosis of Autistic Spectrum Conditions (ASC) which utilises a DVD called the Transporters. The Transporters is a make- believe world of imaginary characters where vehicles have feelings and contains a combination of systematic elements such as trains and trams with human faces. The development of the Transporters is based on the ‘empathizing-systemizing’ theory. That is, in contrast to difficulties with emotion recognition, individuals with ASC have been shown to have an enhanced ability in ‘systemizing’ compared to typically developing children (Baron- Cohen, 2002). An experimental design with multiple baselines was used to assess the impact of the Transporters DVD intervention on the emotion recognition of children with Highly Functioning Autism (HFA). A repeated measures method was used whereby participants completed three measures at Time 1, 2 and 3. The intervention took place between Time 2 and Time 3. Performance was compared across all three times using an analysis of variance statistical test. There was no significant difference between Time 2 and 3 for any of the measures. The results from this research would suggest that more evidence is needed about the use of the Transporters within a school context before Educational Psychologists and other professionals recommend the Transporters as a tool to enhance emotion recognition when used in schools.
Dissertation
