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Background: Due to the rigorous demands of nursing school, students often experience stress leading to anxiety and depression. Exploring nursing students' self-care behaviors may provide insights into how self-care is associated with mental health. This study examined the self-care behaviors of nursing students as predictors of mental health outcomes. Method: This cross-sectional study involved a sample of 2,685 undergraduate nursing students. Independent variables included exercise, sleep, emotional resilience, and loneliness. Mental health outcomes included anxiety, depression, and flourishing. Data were analyzed using descriptive statistics, correlations, and hierarchical linear regression. Results: Exercise was a significant predictor of flourishing. Sleep was a significant predictor of anxiety and depression. Emotional resilience and loneliness were significant predictors of all mental health outcomes. Conclusion: Curricular interventions focused on promoting regular exercise, enhancing healthy sleep practices, reducing loneliness, and increasing emotional resilience may improve the mental health of nursing students.

The High Energy Stereoscopic System (H.E.S.S.) is an array of five imaging atmospheric Cherenkov telescopes located in the Khomas Highland in Namibia. Very high energy gamma rays are detected using the Imaging Atmospheric Cherenkov Technique. Using the fifth, larger telescope of the array with a huge mirror area of 600 m2, it was possible to lower the energy threshold down to ≈ 30 GeV. With this unique ability to observe large amounts of gamma rays in the high energy gamma-ray regime (< 100 GeV) by using the large effective area of the fifth telescope at these energies, the H.E.S.S. experiment is ideally suited to observe short time scale transient events like gamma-ray bursts (GRBs). Originally detected by the Vela satellites in 1967, GRBs are among the most energetic processes in the known Universe. Extrapolating the spectrum of long duration GRBs (i.e. a GRB duration of the order of a few seconds or above) measured by current satellite experiments like Fermi, which measured gamma rays up to 95 GeV for GRB 130427A, a detection of these phenomena with the H.E.S.S. array is possible. This paper will give an update on the H.E.S.S. Target of Opportunity (ToO) alert system. It is used for an immediate and fully automatic response to a prompt GRB alert received via the Gamma-Ray Coordinates Network (GCN). The key feature of this system is a fast repointing of the whole array to a new observation position. We will discuss the implementation of the ToO alert system as well as its overall performance. Moreover, we will show that software improvements alone reduced the average response time to a ToO alert to below 60s on average, a decrease by more than 50%.

The High Energy Stereoscopic System (H.E.S.S.) is an array of five Imaging Atmospheric Cherenkov Telescopes located in the Khomas Highland in Namibia. It measures cosmic gamma-rays with very high energies (> 100 GeV) using the Earth's atmosphere as a calorimeter. The H.E.S.S. experiment has entered Phase II in September 2012 with the inauguration of a fifth telescope that is larger and more complex than the other four. The very large mirror area of 600 m2 in comparison to the 100 m2 of the smaller telescopes results in a lower energy threshold as well as an increased overall sensitivity of the system. Moreover, the huge effective area, due to the large mirror size, is crucial in the detection of short time scale low energy transient events. This paper will give a brief overview of the design principles of the current H.E.S.S. data acquisition and array control system. Particular emphasis is given to the new Target of Opportunity alert system that has recently been introduced to the array and allows the instrument to react to such an alert within 60 s.

In this study, the angiogenetic effect of sintered 45S5 Bioglass ® was quantitatively assessed for the first time in the arteriovenous loop (AVL) model. An AVL was created by interposition of a venous graft from the contralateral side between the femoral artery and vein in the medial thigh of eight rats. The loop was placed in a Teflon isolation chamber and was embedded in a sintered 45S5 Bioglass ® granula matrix filled with fibrin gel. Specimens were investigated 3 weeks postoperatively by means of microcomputed tomography, histological, and morphometrical techniques. All animals tolerated the operations well. At 3 weeks, both microcomputed tomography and histology demonstrated a dense network of newly formed vessels originating from the AVL. All constructs were filled with cell-rich, highly vascularized connective tissue around the vascular axis. Analysis of vessel diameter revealed constant small vessel diameters, indicating immature new vessel sprouts. This study shows for the first time axial vascularization of a sintered 45S5 Bioglass ® granula matrix. After 3 weeks, the newly generated vascular network already interfused most parts of the scaffolds and showed signs of immaturity. The intrinsic type of vascularization allows transplantation of the entire construct using the AVL pedicle.

AbstractFemale choice and mate preference have been shown to affect female reproductive effort both prior to copulation (e.g. females seeking extra-pair copulation) and during parental care ('secondary' reproductive effort) in relation to mate quality. Here we show that female zebra finches, Taeniopygia guttata, vary their 'primary' reproductive effort in egg production in relation to the attractiveness of their male partner, for some components of reproduction but not others. Females were allowed to choose 'preferred' and 'non-preferred' males in standard mate choice trials, and were then paired sequentially with each male. Preferred males had significantly higher song duration and song frequency than non-preferred males confirming that females preferred attractive, higher quality males. Male attractiveness had a positive, but weak, effect on clutch size: in breeding experiments individual females laid on average 0.5 eggs more when paired with their preferred male compared to the non-preferred male. However, there was no significant difference in breeding propensity (whether females laid eggs or not), number of days between pairing and laying, mean egg size or egg quality (protein and lipid composition) in relation to male type. These results suggest that components of primary reproductive effort in individual female zebra finches are relatively non-plastic traits.

Expression of the puf and puc operons, which encode proteins of the photosynthetic apparatus of Rhodobacter capsulatus, is regulated by oxygen. A drop in the oxygen tension in the environment leads to an increase in the levels of puf and puc mRNAs. In strains lacking bacteriochlorophyll (Bchl) due to mutations in bch genes, the rise in puf and puc mRNA levels observed on reduction of oxygen tension is much less pronounced than in wild-type cells, indicating co-regulation of the syntheses of pigments and pigment-binding proteins. Here we show that Bchl synthesis also affects the expression of the bchC gene, which codes for a subunit of bacteriochlorophyll synthase, suggesting an autoregulatory mechanism for the Bchl biosynthetic pathway. Furthermore, our data provide evidence that the RegB/RegA two-component system, which is known to play a central role in oxygen-controlled expression of photosynthesis genes, is also involved in the Bchl-dependent regulation. Mutant strains which do not synthesize RegB or RegA show similar oxygen-dependent puf and puc expression in the presence and absence of Bchl. Our results support the view that the RegB/RegA system can directly or indirectly sense whether Bchl synthesis takes place or not.

The author presents the lack of deliverance ministry in the Evangelical church world as being incongruent with biblical, theological and historical underpinnings and, as such, forms a significant hindrance to its effective mission. To demonstrate the efficacy of deliverance, the author surveyed 46 Christian leaders on 98 possible effects of their personal deliverance experience. The author concluded that deliverance renders significant and broad positive effects in the individual leader and makes numerous recommendations pertaining to the inclusion of deliverance in ongoing church ministry, discipleship strategies and global mission.

Observations of astrophysical transients have brought many novel discoveries and provided new insights into physical processes at work under extreme conditions in the Universe. Multi-wavelength and multi-messenger observations of variable objects require dedicated procedures and follow-up systems capable of digesting and reacting to external alerts to execute coordinated follow-up campaigns. The main functions of such follow-up systems are the processing, filtering, and ranking of the incoming alerts, the fully automated rapid execution of the observations according to an observation strategy tailored to the instrument, and real-time data analysis with feedback to the operators and other instruments. H.E.S.S. has been searching for transient phenomena since its inauguration in 2003. In this paper, we describe the transients follow-up system of H.E.S.S. which became operational in 2016. The system allows H.E.S.S. to conduct a more versatile, optimised, and largely autonomous transient follow-up program, combining all major functionalities in one systematic approach. We describe the design, central functionalities, and interfaces of the follow-up system in general and its three main components in detail: the Target of Opportunity (ToO) alert system, the data acquisition and central control system, and the real-time analysis. We highlight architectural decisions and features that enable fully automatic ToO follow-up and indicate key performance metrics of the sub-systems. We discuss the system's capabilities and highlight the need for a fine-tuned interplay of the different sub-systems in order to react quickly and reliably. Lessons learned from the development, integration, and operation of the follow-up system are reviewed in light of new and large science infrastructures and associated challenges in this exciting new era of inter-operable astronomy.

It has been suggested that the efficiency of claim-based utilization review systems could be improved by focusing on providers with very high utilization rates. This strategy assumes that 1) high utilizers are more likely to be overutilizers, 2) labeling claims (e.g., \"high utilizer\") do not bias the review, and 3) the claim review process is sufficiently reliable. These issues were studied in prospective dental utilization review system where dentists submit claims and radiographs to an insurance carrier so that they may obtain treatment authorization. A sample of dentists with very high and moderate utilization rates for amalgams, crowns, and bridges were identified and their pretreatment claims containing these services (N = 553) were collected. Half the services from high and moderate utilizer practices were labeled \"high utilizer,\" and the other half were unlabeled. Seven dental consultants from two large insurance carriers independently assessed the appropriateness of the services (approve or deny) from radiographs. The results indicate that services submitted by dentists with high utilization rates were no more likely to be denied than those with moderate rates, labeling claims did not appear to bias the reviewers, and interconsultant agreement levels for denials seldom exceeded 50 per cent. The study suggests that further development of focused review systems requires a better understanding of the association between utilization rates and overutilization and new methods for improving the reliability of reviewers.

The H.E.S.S. Imaging Air Cherenkov Telescope system is, due to its fast reaction time and its comparably low energy threshold, very well suited to perform follow-up observations of detections at other wavelengths or other messengers like high-energy neutrinos and gravitational waves. These advantages are utilized optimally via a fully automatized system reacting to alerts from various partner observatories covering various wavelengths and astrophysical messengers. In this contribution we'll provide an overview and present recent results from H.E.S.S. programs to follow up on multi-wavelength and multi-messenger alerts. To illustrate the capabilities of the system we present several real-time ToO observations searching for high-energy gamma-ray emission in coincidence with high-energy neutrinos detected by the IceCube and ANTARES neutrino telescopes and outline our program to search for gravitational wave counterparts.