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The practical application of room-temperature Na-S batteries is hindered by the low sulfur utilization, inadequate rate capability and poor cycling performance. To circumvent these issues, here, we propose an electrocatalyst composite material comprising of N-doped nanocarbon and Fe 3 N. The multilayered porous network of the carbon accommodates large amounts of sulfur, decreases the detrimental effect of volume expansion, and stabilizes the electrodes structure during cycling. Experimental and theoretical results testify the Fe 3 N affinity to sodium polysulfides via Na-N and Fe-S bonds, leading to strong adsorption and fast dissociation of sodium polysulfides. With a sulfur content of 85 wt.%, the positive electrode tested at room-temperature in non-aqueous Na metal coin cell configuration delivers a reversible capacity of about 1165 mA h g −1 at 167.5 mA g −1 , satisfactory rate capability and stable capacity of about 696 mA h g −1 for 2800 cycles at 8375 mA g −1 . Room-temperature sodium-sulfur batteries are promising electrochemical energy storage systems. Here, the authors proposed a Fe3N/carbon composite to regulate the polysulfides chemistry and improve the performances of sodium-sulfur cells.

Room‐temperature Na–S batteries are facing one of the most serious challenges of charge/discharge with long cycling stability due to the severe shuttle effect and volume expansion. Herein, a sodium polysulfides defense system is presented by designing and constructing the cathode‐separator double barriers. In this strategy, the hollow carbon spheres are decorated with MoS2 (HCS/MoS2) as the S carrier (S@HCS/MoS2). Meanwhile, the HCS/MoS2 composite is uniformly coated on the surface of the glass fiber as the separator. During the discharge process, the MoS2 can adsorb soluble polysulfides (NaPSs) intermediates and the hollow carbon spheres can improve the conductivity of S as well as act as the reservoir for electrolyte and NaPSs, inhibiting them from entering the anode to make Na deteriorate. As a result, the cathode‐separator group applied to room‐temperature Na–S battery can enable a capacity of ≈1309 mAh g−1 at 0.1 C and long cycling life up to 1000 cycles at 1 C. This study provides a novel and effective way to develop durable room‐temperature Na–S batteries. An efficient polysulfides defense system in which the cathode‐separator is constructed by HCS/MoS2 composite is proposed and designed. Benefiting from the structural and compositional advantages, the S@HCS/MoS2 composite cathode shows excellent electrochemical performance.

Sodium sulfur batteries require efficient sulfur hosts that can capture soluble polysulfides and enable fast reduction kinetics. Herein, we design hollow, polar and catalytic bipyramid prisms of cobalt sulfide as efficient sulfur host for sodium sulfur batteries. Cobalt sulfide has interwoven surfaces with wide internal spaces that can accommodate sodium polysulfides and withstand volumetric expansion. Furthermore, results from in/ex-situ characterization techniques and density functional theory calculations support the significance of the polar and catalytic properties of cobalt sulfide as hosts for soluble sodium polysulfides that reduce the shuttle effect and display excellent electrochemical performance. The polar catalytic bipyramid prisms sulfur@cobalt sulfide composite exhibits a high capacity of 755 mAh g −1 in the second discharge and 675 mAh g −1 after 800 charge/discharge cycles, with an ultralow capacity decay rate of 0.0126 % at a high current density of 0.5 C. Additionally, at a high mass loading of 9.1 mg cm −2 , sulfur@cobalt sulfide shows high capacity of 545 mAh g −1 at a current density of 0.5 C. This study demonstrates a hollow, polar, and catalytic sulfur host with a unique structure that can capture sodium polysulfides and speed up the reduction reaction of long chain sodium polysulfides to solid small chain polysulfides, which results in excellent electrochemical performance for sodium-sulfur batteries. Sodium sulfur batteries require efficient sulfur hosts that can capture soluble polysulfides and enable fast reduction kinetics. Here, authors report hollow catalytic bipyramid prism CoS 2 /C as efficient sulfur carriers, and investigate the reaction mechanism in the sodium sulfur battery.

Highlights3D “branch-leaf” biomimetic design is proposed for high-performance Na-S batteries.The conductive “branch” can ensure adequate electron and electrolyte supply with the “leaf” can catalyze the conversion of polysulfides.DFT calculation reveals that the Co nanoparticles can enable fast reduction reaction of the polysulfides;The prepared CNF-L@Co/S electrode exhibits a high initial specific capacity of 1201 mAh g−1 at 0.1 C and superior rate performance.Rechargeable room temperature sodium–sulfur (RT Na–S) batteries are seriously limited by low sulfur utilization and sluggish electrochemical reaction activity of polysulfide intermediates. Herein, a 3D “branch-leaf” biomimetic design proposed for high performance Na–S batteries, where the leaves constructed from Co nanoparticles on carbon nanofibers (CNF) are fully to expose the active sites of Co. The CNF network acts as conductive “branches” to ensure adequate electron and electrolyte supply for the Co leaves. As an effective electrocatalytic battery system, the 3D “branch-leaf” conductive network with abundant active sites and voids can effectively trap polysulfides and provide plentiful electron/ions pathways for electrochemical reaction. DFT calculation reveals that the Co nanoparticles can induce the formation of a unique Co–S–Na molecular layer on the Co surface, which can enable a fast reduction reaction of the polysulfides. Therefore, the prepared “branch-leaf” CNF-L@Co/S electrode exhibits a high initial specific capacity of 1201 mAh g−1 at 0.1 C and superior rate performance.

The present study demonstrated for the first time that SNORA70E, which belongs to box H/ACA small nucleolar noncoding RNAs (snoRNAs) who could bind and induce pseudouridylation of RNAs, was significantly elevated in ovarian cancer tissues and was an unfavourable prognostic factor of ovarian cancer. The over‐expression of SNORA70E showed increased cell proliferation, invasion and migration in vitro and induced tumour growth in vivo. Further research found that SNORA70E regulates RAS‐Related Protein 1B (RAP1B) mRNA through pseudouracil modification by combing with the pyrimidine synthase Dyskerin Pseudouridine Synthase 1 (DKC1) and increase RAP1B protein level. What's more, the silencing of DKC1/RAP1B in SNORA70E overexpression cells both inhibited cell proliferation, migration and invasion through reducing β‐catenin, PI3K, AKT1, mTOR, and MMP9 protein levels. Besides, RNA‐Seq results revealed that SNORA70E regulates the alternative splicing of PARP‐1 binding protein (PARPBP), leading to the 4th exon‐skipping in PARPBP‐88, forming a new transcript PARPBP‐15, which promoted cell invasion, migration and proliferation. Finally, ASO‐mediated silencing of SNORA70E could inhibit ovarian cancer cell proliferation, invasion, migration ability in vitro and inhibit tumorigenicity in vivo. In conclusion, SNORA70E promotes the occurrence and development of ovarian cancer through pseudouridylation modification of RAP1B and alternative splicing of PARPBP. Our results demonstrated that SNORA70E may be a new diagnostic and therapeutic target for ovarian cancer.

The high energy density of room temperature (RT) sodium–sulfur batteries (Na‐S) usually rely on the efficient conversion of polysulfide to sodium sulfide during discharging and sulfur recovery during charging, which is the rate‐determining step in the electrochemical reaction process of Na‐S batteries. In this work, a 3D network (Ni‐NCFs) host composed by nitrogen‐doped carbon fibers (NCFs) and Ni hollow spheres is synthesized by electrospinning. In this novel design, each Ni hollow unit not only can buffer the volume fluctuation of S during cycling, but also can improve the conductivity of the cathode along the carbon fibers. Meanwhile, the result reveals that a small amount of Ni is polarized during the sulfur‐loading process forming a polar NiS bond. Furthermore, combining with the nitrogen‐doped carbon fibers, the Ni‐NCFs composite can effectively adsorb soluble polysulfide intermediate, which further facilitates the catalysis of the Ni unit for the redox of sodium polysulfide. In addition, the in situ Raman is employed to supervise the variation of polysulfide during the charging and discharging process. As expected, the freestanding S@Ni‐NCFs cathode exhibits outstanding rate capability and excellent cycle performance. A network‐like Ni‐NCFs composite (nitrogen‐doped carbon fibers implanted with Ni) with excellent conductivity and catalysis is synthesized as host for Na‐S batteries. Among it, the Ni hollow units both can buffer the volume fluctuation of S and accelerate the redox kinetics of Na2Sx. Benefiting from the structural and compositional advantages, as‐assembled batteries show outstanding rate capability and improved cycling ability.

The integration of multi-omics data from diverse high-throughput technologies has revolutionized drug discovery. While various network-based methods have been developed to integrate multi-omics data, systematic evaluation and comparison of these methods remain challenging. This review aims to analyze network-based approaches for multi-omics integration and evaluate their applications in drug discovery. We conducted a comprehensive review of literature (2015–2024) on network-based multi-omics integration methods in drug discovery, and categorized methods into four primary types: network propagation/diffusion, similarity-based approaches, graph neural networks, and network inference models. We also discussed the applications of the methods in three scenario of drug discovery, including drug target identification, drug response prediction, and drug repurposing, and finally evaluated the performance of the methods by highlighting their advantages and limitations in specific applications. While network-based multi-omics integration has shown promise in drug discovery, challenges remain in computational scalability, data integration, and biological interpretation. Future developments should focus on incorporating temporal and spatial dynamics, improving model interpretability, and establishing standardized evaluation frameworks.

Eukaryotic cells possess multiple mechanisms of self‐destruction, including pyroptosis and necroptosis. Pyroptosis is a type of programmed cell death characterized by cellular rupture and linked to inflammation. SnoRNA, a small non‐coding RNA in the nucleolus, can dysregulate specific RNAs through 2'‐O‐methylation, contributing to tumorigenesis. Our StarBase and qRT‐PCR analysis revealed SNORD99 upregulation in endometrial cancer (EC) tissue compared to normal tissue, suggesting its role in pathogenesis. SNORD99 overexpression enhanced migration and proliferation of EC cells, while ASO‐mediated suppression reduced malignant cell spread and division. RNA‐seq and base‐comparing analysis identified GSDMD's differential expression upon SNORD99 overexpression, forming the SNORD99‐FBL RNP complex. RTL‐P experiments showed SNORD99 increased GSDMD's 2'‐O‐methylation. SNORD99 reduced GSDMD, caspase‐1, and NLRP3 protein levels, implicating its role in pyroptosis. Optical and electron microscopy confirmed enhanced pyroptosis features. In summary, SNORD99 modifies GSDMD via 2'‐O‐methylation, suppressing pyroptosis and promoting EC progression. Developing pyroptosis‐inducing drugs may offer new cancer treatment avenues.

Adenosine-to-inosine (A-to-I) editing, a key RNA modification widely found in eukaryotes, is catalyzed by adenosine deaminases acting on RNA (ADARs). Such RNA editing destabilizes endogenous dsRNAs, which are subsequently recognized by the sensors of innate immune and other proteins as autologous dsRNAs. This prevents the activation of innate immunity and type I interferon-mediated responses, thereby reducing the downstream cell death induced by the activation of the innate immune sensing system. ADARs-mediated editing can also occur in mRNAs and non-coding RNAs (ncRNAs) in different species. In mRNAs, A-to-I editing may lead to missense mutations and the selective splicing of coding regions. Meanwhile, in ncRNAs, A-to-I editing may affect targeting and disrupt ncRNAs maturation, leading to anomalous cell proliferation, invasion, and responses to immunotherapy. This review highlights the biological functions of A-to-I editing, its role in regulating innate immunity and cell death, and its potential molecular significance in tumorigenesis and cancer targeted therapy and immunotherapy.

A higher incidence of female infertility has been reported with an unexpectedly early appearance in recent years. The female infertility treatment and application of assisted reproductive technology have recently gained immense interest from scientists. Many studies have discussed the beneficial effects of acupuncture on female infertility. With advancements in science and medical technology, acupuncture-related research has increased in investigating its effectiveness in treating female infertility. This review focuses on a compilation of research in recent years on acupuncture for female infertility treatment and the exploration of the underlying mechanism. For this purpose, literature was searched using various search engines like PubMed, Web of Science, and Google Scholar. The search was refined by only focusing on recent studies on acupuncture effectiveness and mechanism in female infertility and evaluating pregnancy outcomes.