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Patients taking various treatments frequently report galactorrhoea as a side effect. Psychotropic drugs, especially neuroleptics, are among the treatments most likely to cause this effect. Conventional tricyclic antidepressants rarely cause galactorrhea. The advent of new selective serotonin reuptake inhibitor (SSRI) antidepressants purported to reduce such side effects. We report the clinical case of a patient with galactorrhoea on Sertraline as well as our therapeutic approach in light of data from recent scientific literature.

Pulmonary embolism is defined as the abrupt obliteration of the trunk or a branch of the pulmonary artery by an embolus most often from a deep vein thrombosis of the lower limbs. It is serious, underdiagnosed, and can be life-threatening. We report the case of a patient who presented with a massive acute pulmonary embolism while taking olanzapine. The interest of our case lies in its rarity, its seriousness but also the possibility of prevention and adequate management in the case of any suggestive clinical symptoms.

 Bipolar disorder is a severe psychiatric disorder. The objective of our study is to describe the epidemiological, clinical, and therapeutic profile of patients followed for bipolar disorder in this hospital. This is a cross-sectional, descriptive study conducted over a period of two years within the mental health and psychiatric diseases department of the Mohammed VI University Hospital in Oujda, Morocco, including 206 patients followed for bipolar disorder on an outpatient basis or hospitalized in one of the departments of the hospital. We included in our study 206 patients with an average age of 37.34+/-12.53 and a male predominance. About 17% of our patients reported a personal medical history and 18.4%, a personal surgical history. Regarding the family history, 40.3% have a medical and surgical history and 63.1%, a psychiatric family history. The consumption of psychoactive substances is present in 49.5% of our patients. About 26.7% reported psychological trauma during childhood. Our patients have reported a history of suicide attempts with a prevalence of 26.6% in several settings: depressive (15%), delusional (5.8%), hallucinatory (3.9%), and anxious (1.9%). Several means were used during these suicide attempts, in particular, defenestration (40%), drug ingestion (36.4%), caustic ingestion (16.4%), strangulation (16.4%), and hanging (10.9%).  It is important to develop a personalized approach to the patient wherever possible and, if necessary, to involve other specialists in diagnosis and treatment.

Introduction: schizophrenic relapse constitutes a formidable challenge in the realm of psychiatric care, often precipitating a cascade of deteriorating symptoms and functional impairment. Addressing this issue necessitates a comprehensive understanding of the factors that contribute to relapse occurrence. Methods: this cross-sectional study, conducted at the Hospital of Mental Health and Psychiatric Diseases in Oujda, sought to explore the intricate interplay between stress, coping mechanisms, and the incidence of relapse among individuals diagnosed with schizophrenia. Over six months, data were collected from three hundred schizophrenia patients, encompassing demographic, clinical, stress, and coping-related variables. Results: analysis of the findings unveiled compelling associations between stress intensity, coping efficacy, and relapse vulnerability. Notably, heightened stress intensity emerged as a significant predictor of relapse occurrence, surpassing the mere exposure to stressors. Furthermore, inadequate coping strategies were found to significantly elevate the risk of relapse, underscoring the pivotal role of adaptive coping skills in mitigating relapse susceptibility. In addition to these associations, the study revealed intriguing insights into the demographic and clinical characteristics of the patient population. Predominantly male and urban-dwelling, the patients exhibited varying levels of education and employment status. A substantial proportion reported a history of substance abuse and psychiatric family history, indicating potential predisposing factors for relapse vulnerability. These findings underscore the imperative of integrating stress management interventions and fostering adaptive coping mechanisms within schizophrenia treatment paradigms. Early identification and targeted interventions aimed at ameliorating stress reactivity and enhancing coping proficiency. Also, it held promise for the reduction of relapse rates and the increase of long-term outcomes for individuals grappling with schizophrenia. Conclusion: by elucidating the nuanced dynamics of stress and coping in relation to relapse, this study contributes valuable insights to the development of tailored interventions and therapeutic strategies in schizophrenia management.

Serotonin syndrome is an iatrogenic disorder induced by serotonergic drug. It is characterised by a symptomatic polymorphism that may create confusion with other clinical conditions, delaying diagnosis and putting the vital prognosis at risk. In light of a case report and a literature review, we here report the clinical case of a patient presenting with confusion, psychomotor agitation, hyperreflexia and spontaneous myoclonus following simultaneous use of paroxetine and amitriptyline. The diagnosis of serotonin syndrome was made after ruling out other possible diagnoses. The patient was admitted to the intensive care unit. This clinical case highlights the importance of thoroughly understanding the clinical manifestations of serotonin syndrome to ensure early and appropriate therapeutic management.