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"Barry, Frank"
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Building structures illustrated : patterns, systems, and design
\"Bestselling reference by reknowned authors of architectural design. One-stop guide to structural design in practice, meant for every designer's desktop. Illustrated throughout with Ching's trademark drawing. Treatment of structural design as part of the entire building design process. Includes overview of the historicial development of architectural materials and structures\"-- Provided by publisher.
Book
Civil service post-war policy debates, Department of Finance orthodoxy and the contours of the modern Irish economy
Many share Michael Mulreany’s interest in the processes associated with the outward reorientation of the Irish economy from the mid-to-late 1950s through to European Economic Community accession in 1973. The Irish case is unusual by international standards in the importance accorded to the policy advice that emanated from within the civil service. While much of the historical focus has been on the Whitaker report of 1958, the contribution of which is celebrated in the 2009 work edited by Mulreany, the Department of Finance did not win all of the crucial debates on outward reorientation in which it was engaged. In particular, it had opposed the introduction in 1956 of export profits tax relief, the origin of the low corporation tax regime that remains in place to this day. This paper revisits the policy positions of the Departments of Finance and Industry and Commerce over the post-war decades and traces the foreign direct investment intensity of the modern Irish economy to the outcome of these debates.
Journal Article
The great influenza : the true story of the deadliest pandemic in history
\"The strongest weapon against pandemic is the truth. Read why in the definitive account of the 1918 Influenza Epidemic, adapted for young readers from the #1 New York Times bestseller. At the height of World War I, history's most lethal influenza virus erupted in an army camp in Kansas, moved east with American troops, and then exploded worldwide, killing as many as 100 million people. It killed more in twenty-four months than AIDS killed in twenty-four years, more in a year than the Black Death killed in a century. It killed many more people than COVID-19, especially those who were young and otherwise healthy. This book, adapted from the #1 New York Times bestseller first published in 2004, shows young readers how this global tragedy came to pass; how science, war, and public policy collided; and how we might be able to prevent it from happening again. Impeccably researched and engrossingly told, The Great Influenza provides young readers with historical and scientific context for epidemics that remains all too relevant today\"-- Provided by publisher.
BOOK
Frank Lloyd Wright : unpacking the archive
Published for a major exhibition at The Museum of Modern Art, this catalog reveals new perspectives on the work of Frank Lloyd Wright. Structured as a series of inquiries into the Frank Lloyd Wright Foundation Archives at Taliesin West, Arizona, the book is a collection of scholarly explorations rather than an attempt to construct a master narrative. Each chapter centers on a key object from the archive that aninvited author has \"unpacked\" -- tracing its meanings and connections, and juxtaposing it with other works from the archive, from MoMA, or from outside collections. The publication aims to open up Wright's work to questions, interrogations and debates, and to highlight interpretations by contemporary scholars, both established Wright experts and others considering this iconic figure from new and illuminating perspectives.
Book
Immunogenicity of allogeneic mesenchymal stem cells
Mesenchymal stem cells (MSCs) inhibit proliferation of allogeneic T cells and express low levels of major histocompatibility complex class I (MHCI), MHCII and vascular adhesion molecule‐1 (VCAM‐1). We investigated whether their immunosuppressive properties and low immunophenotype protect allogeneic rat MSCs against cytotoxic lysis in vitro and result in a reduced immune response in vivo. Rat MSCs were partially protected against alloantigen‐specific cytotoxic T cells in vitro. However, after treatment with IFN‐γ and IL‐1β, MSCs upregulated MHCI, MHCII and VCAM‐1, and cytotoxic lysis was significantly increased. In vivo, allogeneic T cells but not allogeneic MSCs induced upregulation of the activation markers CD25 and CD71 as well as downregulation of CD62L on CD4+ T cells from recipient rats. However, intravenous injection of allo‐MSCs in rats led to the formation of alloantibodies with the capacity to facilitate complement‐mediated lysis, although IgM levels were markedly decreased compared with animals that received T cells. The allo‐MSC induced immune response was sufficient to lead to significantly reduced survival of subsequently injected allo‐MSCs. Interestingly, no increased immunogenicity of IFN‐γ stimulated allo‐MSCs was observed in vivo. Both the loss of protection against cytotoxic lysis under inflammatory conditions and the induction of complement‐activating antibodies will likely impact the utility of allogeneic MSCs for therapeutic applications.
Journal Article
Batgirl, the Bronze Age omnibus
\"Batgirl started her vigilante career when mild-mannered librarian Barbara Gordon, daughter of famed police commissioner Jim Gordon, attended a costume party gone awry. It wasn't long before the teenage genius crime-fighter became a regular feature of Batman's world and an icon to generations of young readers.\"-- Provided by publisher.
Book
Hypoxia Activates the PTHrP –MEF2C Pathway to Attenuate Hypertrophy in Mesenchymal Stem Cell Derived Cartilage
Articular cartilage lacks an intrinsic repair capacity and due to the ability of mesenchymal stem cells (MSCs) to differentiate into chondrocytes, MSCs have been touted as a cellular source to regenerate damaged cartilage. However, a number of prevailing concerns for such a treatment remain. Generally, administration of MSCs into a cartilage defect results in poor regeneration of the damaged cartilage with the repaired cartilage consisting primarily of fibro-cartilage rather than hyaline cartilage. Methods that improve the chondrogenic potential of transplanted MSCs
in vivo
may be advantageous. In addition, the proclivity of MSC-derived cartilage to undergo hypertrophic differentiation or form bone
in vivo
also remains a clinical concern. If MSC-derived cartilage was to undergo hypertrophic differentiation
in vivo
, this would be deleterious in a clinical setting. This study focuses on establishing a mechanism of action by which hypoxia or low oxygen tension can be used to both enhance chondrogenesis and attenuate hypertrophic differentiation of both MSC and ATDC5 derived chondrocytes. Having elucidated a novel mechanism of action, the subsequent goals of this study were to develop an
in vitro
culture regime to mimic the beneficial effects of physiological low oxygen tension in a normoxic environment.
Journal Article
Stan Lee
A collection of comics that celebrates the career of prolific storyteller Stan Lee, Marvel Comics' primary creative leader for two decades and co-creator of numerous iconic superhero characters.
Book
Adipose Mesenchymal Stromal Cell‐Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose‐Escalation Trial
This phase I clinical trial evaluated the safety and clinical efficacy of adipose‐derived stromal cells (ASCs) in osteoarthritis. Eighteen patients with severe knee osteoarthritis were treated with a single intra‐articular injection of autologous ASCs at low (2 × 106 cells), medium (10 × 106), or high (50 × 106) doses (n = 6 each). After 6 months, no serious adverse events were reported, and patients treated with low‐dose ASCs significantly improved in pain and function. Osteoarthritis (OA) is the most widespread musculoskeletal disorder in adults. It leads to cartilage damage associated with subchondral bone changes and synovial inflammation, causing pain and disability. The present study aimed at evaluating the safety of a dose‐escalation protocol of intra‐articular injected adipose‐derived stromal cells (ASCs) in patients with knee OA, as well as clinical efficacy as secondary endpoint. A bicentric, uncontrolled, open phase I clinical trial was conducted in France and Germany with regulatory agency approval for ASC expansion procedure in both countries. From April 2012 to December 2013, 18 consecutive patients with symptomatic and severe knee OA were treated with a single intra‐articular injection of autologous ASCs. The study design consisted of three consecutive cohorts (six patients each) with dose escalation: low dose (2 × 106 cells), medium dose (10 × 106), and high dose (50 × 106). The primary outcome parameter was safety evaluated by recording adverse events throughout the trial, and secondary parameters were pain and function subscales of the Western Ontario and McMaster Universities Arthritis Index. After 6 months of follow‐up, the procedure was found to be safe, and no serious adverse events were reported. Four patients experienced transient knee joint pain and swelling after local injection. Interestingly, patients treated with low‐dose ASCs experienced significant improvements in pain levels and function compared with baseline. Our data suggest that the intra‐articular injection of ASCs is a safe therapeutic alternative to treat severe knee OA patients. A placebo‐controlled double‐blind phase IIb study is being initiated to assess clinical and structural efficacy. Significance Although this phase I study included a limited number of patients without a placebo arm, it showed that local injection of autologous adipose‐derived stem cells was safe and well tolerated in patients with knee osteoarthritis. This study also provides encouraging preliminary evidence of efficacy. Larger and controlled long‐term studies are now mandatory to confirm whether this new strategy of cell therapy can improve pain and induce structural benefit in osteoarthritis.
Journal Article