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The electricity demand is ever increasing, and the worldwide power generation is largely dependent on the rapidly dwindling fossil fuel resources. It is no different in Bangladesh as well where the prevailing dynamic in the energy sector projects to a certain lack of sustainability. This makes the performance evaluation to determine and improve the efficiency of energy conversion systems an unavoidable requisite. This study investigates the energetic and exergetic performance of a gas engine‐based (4 MW) combined heat and power system situated at Rajshahi District in Bangladesh. Different thermodynamic performance parameters along with the exergo‐environmental effect and the sustainability of the system are also assessed additionally. The overall system and individual components are analyzed based on the actual data measured on site at 48% engine load and a constant engine speed of 1500 rpm. The results reveal that the maximum energy loss and exergy destruction occur in the reciprocating engine with values of 656.54 kW and 1835.04 kW, respectively, followed by the heat recovery steam generator with 465.51 kW energy loss and 671.51 kW exergy destruction. The overall system has energy and exergy efficiency of 29.95% and 23.12%, respectively. The exergetic sustainability index of the system is found to be 1.30. Energy, exergy, exergo‐environmental, and exergetic sustainability analyses have been carried out for a natural gas engine‐driven CHP system in Bangladesh. Detail methodology has been presented, and the results are discussed.

Neospora caninum (NC) is a protozoan infection causing neosporosis, a disease that leads to substantial economic loss in livestock, especially in cattle, sheep, and goats. Unfortunately, there is presently no viable vaccination or authorized therapy available. Our research applied a bioinformatics approach to design a multi-epitope peptide (MEP) vaccine aimed at the pathogenic proteins GRA2 and Nc-p43 of NC, which are critical in parasite-mediated antigenicity and host interactions. Consequently, our research employs an in-silico methodology, including protein sequence retrieval, epitope prediction, vaccine design, structural analysis, molecular docking, molecular dynamics simulations, immunological simulation, and codon optimization using in silico cloning. We conducted analyses of antigenicity, allergenicity, toxicity, topology, and immunogenicity using multiple bioinformatics methods and identified 4 CTL, 4 HTL, and 2 B-cell epitopes. The vaccine design was created by integrating an adjuvant and a PADRE sequence to enhance immunogenicity, along with linkers (AAY, GPGPG, KK) to facilitate appropriate structural assembly, which was then analyzed for optimal complete profiles. Molecular docking with the Bos taurus (cattle) TLR9 receptor demonstrated a robust binding affinity, scoring − 1183.4, while molecular dynamics (MD) simulations over 50 ns validated persistent interactions between the vaccine and immune receptors. Moreover, immunological models forecasted a robust adaptive immune response, marked by an increase in the production of cytokines and the establishment of memory T-lymphocytes. Ultimately, codon optimization and in silico cloning validated the capacity for effective expression in E. coli . The results demonstrate that the developed vaccine has considerable immunogenic potential against NC. Nonetheless, more in vitro and in vivo studies are necessary to confirm its efficiency.

The chlor-alkali industries produce caustic soda (NaOH), chlorine (Cl2), and hydrogen (H2) as primary products. In 2021, the global chlor-alkali market was valued at $63.2 billion. The article evaluates the global aspects of chlor-alkali industries and prospects for Bangladesh. The current production capacity of NaOH from the chlor-alkali industries in Bangladesh is around 282,150 metric tons/year (MT/y). The by-products, chlorine (Cl2) of 250,470 MT/y and hydrogen (H2) of 7055 MT/y, are produced domestically. The local demand of Cl2 is 68,779 MT/y. However, there are no systematic utilizations of the residual Cl2 and vented H2, which threatens the sustainability of the chlor-alkali industries. The article prefigures that a 150,000 MT/y PVC plant can utilize 45.2 % of residual Cl2 of chlor-alkali plants, which would be an economical and environmental milestone for Bangladesh. The residual Cl2 can earn revenue of 908 million USD/y, which can be utilized to import ethylene. For the sustainable utilization of vented H2, production of H2O2, fuel cell electric vehicle (FCEV) and H2 fuel-cell-based power plant are the feasible solutions. Thus, for the long-term growth of the chlor-alkali industry in Bangladesh and other developing countries, systematic utilization of Cl2 and H2 is the only feasible solution.