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As a persistent organic pollutant, methoxychlor has drawn considerable environmental attention. Photocatalysis, recognized for its environmentally friendly characteristics, has been widely utilized for the degradation of contaminants. In this study, the photocatalytic material BiVO4@diatomite was successfully synthesized via the liquid-phase precipitation method. The synthesized material was comprehensively characterized using X-ray diffraction (XRD), energy-dispersive spectroscopy (EDS), scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), UV-vis diffuse reflectance spectroscopy (DRS), and a Brunauer–Emmett–Teller (BET) analysis, providing robust evidence for the material’s stability and biocompatibility. The results confirmed the successful deposition of BiVO4 onto the diatomite surface. Furthermore, the effects of various parameters, including the initial methoxychlor concentration, pH, light exposure duration, and illumination intensity, on the photocatalytic degradation efficiency of methoxychlor by BiVO4@diatomite were systematically investigated to optimize degradation performance. The identification of optimal reaction conditions and the proposed degradation mechanism based on experimental findings will be valuable for guiding future studies and practical applications in environmental pollution control. The integration of BiVO4 with diatomite in this study yields a novel composite system with significantly enhanced photocatalytic degradation performance, offering fresh insights into the design of efficient, stable, and eco-friendly materials for pollutant removal.

In this study, we synthesized Fe3O4 using the co-precipitation method and then prepared magnetic carrier LDHs@Fe3O4 by immobilizing layered double hydroxide on Fe3O4 by in situ growth method. Cellulase was immobilized on this magnetic carrier by using glutaraldehyde as a coupling agent, which can be used for degrading Methoxychlor (MXC). The results demonstrated the maximum MXC removal efficiency of 73.4% at 45 °C and pH = 6.0 with excellent reusability. Through kinetic analysis, it was found that the degradation reaction conforms to the Langmuir–Hinshelwood model and is a first-order reaction. Finally, according to the EPR analysis, the active radicals in the system were found to be OH· and the degradation mechanism was proposed in combination with LC-MS. This study provides a feasible method for degrading organochlorine pesticides, which can be used for groundwater purification.

Methicillin-resistant Staphylococcus aureus (MRSA) is among the leading causes of nosocomial infections and forms biofilms, which are difficult to eradicate because of their increasing resistance to antimicrobial agents. This is especially true for pre-existing biofilms. The current study focused on evaluating the efficacy of three β-lactam drugs, meropenem, piperacillin, and tazobactam, alone and in combination against the MRSA biofilms. When used individually, none of the drugs exhibited significant antibacterial activity against MRSA in a planktonic state. At the same time, the combination of meropenem, piperacillin, and tazobactam showed a 41.7 and 41.3% reduction in planktonic bacterial cell growth, respectively. These drugs were further assessed for biofilm inhibition and removal. The combination of meropenem, piperacillin, and tazobactam caused 44.3% biofilm inhibition, while the rest of the combinations did not show any significant effects. Results also revealed that piperacillin and tazobactam exhibited the best synergy against the pre-formed biofilm of MRSA, with 46% removal. However, adding meropenem to the piperacillin and tazobactam combination showed a slightly reduced activity towards the pre-formed biofilm of MRSA and removed 38.7% of it. Although the mechanism of synergism is not fully understood, our findings suggest that these three β-lactam drugs can be used in combination as very effective therapeutic agents for the treatment of pre-existing MRSA biofilms. The in vivo experiments on the antibiofilm activity of these drugs will pave the way for applying such synergistic combinations to clinics.

This experimental research has been designed to explore the impact of visual cues (visual clips) of school stress on student’s mood and academic performance. It was aimed at investigating the relation between positive guided imagery and negative mood. Participants in the study included 90 boys and 95 girls (N = 185) with the age range of 10-14 years. The sample was randomly selected from different public and private schools of Multan and Bahawalpur. They were randomly assigned to two groups: Group 1 had negative Mood Induction Procedure (MIP) only; group 2 was treated with negative mood induction procedure which was followed by a Positive Guided Imagery (PGI). Students completed demographic sheet and School Situation Survey (Helms & Gablem, 1989) prior to experimentation. The results revealed that academic performance decreases after negative mood induction but not after positive guided imagery. Both groups showed insignificant difference at pre and post-induction 1 level, while a significant difference was found between both groups at post induction phase 2.

In this study, we synthesized Fe O using the co-precipitation method and then prepared magnetic carrier LDHs@Fe O by immobilizing layered double hydroxide on Fe O by in situ growth method. Cellulase was immobilized on this magnetic carrier by using glutaraldehyde as a coupling agent, which can be used for degrading Methoxychlor (MXC). The results demonstrated the maximum MXC removal efficiency of 73.4% at 45 °C and pH = 6.0 with excellent reusability. Through kinetic analysis, it was found that the degradation reaction conforms to the Langmuir-Hinshelwood model and is a first-order reaction. Finally, according to the EPR analysis, the active radicals in the system were found to be OH· and the degradation mechanism was proposed in combination with LC-MS. This study provides a feasible method for degrading organochlorine pesticides, which can be used for groundwater purification.

As a persistent organic pollutant, methoxychlor has drawn considerable environmental attention. Photocatalysis, recognized for its environmentally friendly characteristics, has been widely utilized for the degradation of contaminants. In this study, the photocatalytic material BiVO[sub.4]@diatomite was successfully synthesized via the liquid-phase precipitation method. The synthesized material was comprehensively characterized using X-ray diffraction (XRD), energy-dispersive spectroscopy (EDS), scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), UV-vis diffuse reflectance spectroscopy (DRS), and a Brunauer–Emmett–Teller (BET) analysis, providing robust evidence for the material’s stability and biocompatibility. The results confirmed the successful deposition of BiVO[sub.4] onto the diatomite surface. Furthermore, the effects of various parameters, including the initial methoxychlor concentration, pH, light exposure duration, and illumination intensity, on the photocatalytic degradation efficiency of methoxychlor by BiVO[sub.4]@diatomite were systematically investigated to optimize degradation performance. The identification of optimal reaction conditions and the proposed degradation mechanism based on experimental findings will be valuable for guiding future studies and practical applications in environmental pollution control. The integration of BiVO[sub.4] with diatomite in this study yields a novel composite system with significantly enhanced photocatalytic degradation performance, offering fresh insights into the design of efficient, stable, and eco-friendly materials for pollutant removal.

Methicillin-resistant Staphylococcus aureus (MRSA) is among the leading causes of nosocomial infections and forms biofilms, which are difficult to eradicate because of their increasing resistance to antimicrobial agents. This is especially true for pre-existing biofilms. The current study focused on evaluating the efficacy of three β-lactam drugs, meropenem, piperacillin, and tazobactam, alone and in combination against the MRSA biofilms. When used individually, none of the drugs exhibited significant antibacterial activity against MRSA in a planktonic state. At the same time, the combination of meropenem, piperacillin, and tazobactam showed a 41.7 and 41.3% reduction in planktonic bacterial cell growth, respectively. These drugs were further assessed for biofilm inhibition and removal. The combination of meropenem, piperacillin, and tazobactam caused 44.3% biofilm inhibition, while the rest of the combinations did not show any significant effects. Results also revealed that piperacillin and tazobactam exhibited the best synergy against the pre-formed biofilm of MRSA, with 46% removal. However, adding meropenem to the piperacillin and tazobactam combination showed a slightly reduced activity towards the pre-formed biofilm of MRSA and removed 38.7% of it. Although the mechanism of synergism is not fully understood, our findings suggest that these three β-lactam drugs can be used in combination as very effective therapeutic agents for the treatment of pre-existing MRSA biofilms. The in vivo experiments on the antibiofilm activity of these drugs will pave the way for applying such synergistic combinations to clinics.

This study aimed at examining the role of women's empowerment in antenatal care utilization among married women in Pakistan. The population of the study was based on secondary data from the Pakistan Demographic Health Survey 2017-18. A sample of 6,996 married women was selected, and the women reported their antenatal visits in the last five years. The descriptive, Chi-square, bivariate, and multivariate logistic regression methods were used for data analysis through SPSS. The results of the study showed that only 15% of women had adequate antenatal visits. Bivariate analysis showed that women who had higher income status, higher education, and were working in managerial positions had significantly adequate antenatal health care (P<0.05). Multivariate logistic regression results showed that women who had the power of decision making in their health care alone (OD-1.47; 95% CI- 1.04, 2.10), decided their mobility along with their husbands (OD-1.83; 95% CI-1.46, 2.30), had control over resources, their own mobile (OD-1.31; 95% CI-1.11, 1.55) and bank accounts (OD-1.75; 95% CI-1.37, 2.22), access to information resources–such as internet use (OD-1.84; 95% CI-1.53, 2.21), reading the newspaper (OD-1.18; 95% CI-1.00, 1.39), and watching TV (OD-1.69; 95% CI-1.38, 2.07)–and did not justify wife-beating (OD-1.42; 95% CI-1.20, 1.68) had adequate antenatal care. To enhance the maternal health of women, the government should take initiatives to formulate policies that improve women's status especially among those who had no education, had less decision-making power, lack of economic resources, and faced violence.

Liver fibrosis is a major pathological feature of chronic liver disease and effective therapies are limited at present. The present study focuses on the hepatoprotective potential of L. corymbulosum against carbon tetrachloride (CCl4)-induced liver damage in rats. Analysis of Linum corymbulosum methanol extract (LCM) using high-performance liquid chromatography (HPLC) revealed the presence of rutin, apigenin, catechin, caffeic acid and myricetin. CCl4 administration lowered (p < 0.01) the activities of antioxidant enzymes and reduced glutathione (GSH) content as well as soluble proteins, whereas the concentration of H2O2, nitrite and thiobarbituric acid reactive substances was higher in hepatic samples. In serum, the level of hepatic markers and total bilirubin was elevated followed by CCl4 administration. The expression of glucose-regulated protein (GRP78), x-box binding protein-1 total (XBP-1 t), x-box binding protein-1 spliced (XBP-1 s), x-box binding protein-1 unspliced (XBP-1 u) and glutamate–cysteine ligase catalytic subunit (GCLC) was enhanced in CCl4-administered rats. Similarly, the expression of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and monocyte chemo attractant protein-1 (MCP-1) was strongly increased with CCl4 administration to rats. Co-administration of LCM along with CCl4 to rats lowered (p < 0.05) the expression of the above genes. Histopathology of the liver showed hepatocyte injury, leukocyte infiltration and damaged central lobules in CCl4-treated rats. However, LCM administration to CCl4-intoxicated rats restored the altered parameters towards the levels of control rats. These outcomes indicate the existence of antioxidant and anti-inflammatory constituents in the methanol extract of L. corymbulosum.

Liver fibrosis is a major pathological feature of chronic liver disease and effective therapies are limited at present. The present study focuses on the hepatoprotective potential of L. corymbulosum against carbon tetrachloride (CCl[sub.4] )-induced liver damage in rats. Analysis of Linum corymbulosum methanol extract (LCM) using high-performance liquid chromatography (HPLC) revealed the presence of rutin, apigenin, catechin, caffeic acid and myricetin. CCl[sub.4] administration lowered (p < 0.01) the activities of antioxidant enzymes and reduced glutathione (GSH) content as well as soluble proteins, whereas the concentration of H[sub.2] O[sub.2] , nitrite and thiobarbituric acid reactive substances was higher in hepatic samples. In serum, the level of hepatic markers and total bilirubin was elevated followed by CCl[sub.4] administration. The expression of glucose-regulated protein (GRP78), x-box binding protein-1 total (XBP-1 t), x-box binding protein-1 spliced (XBP-1 s), x-box binding protein-1 unspliced (XBP-1 u) and glutamate–cysteine ligase catalytic subunit (GCLC) was enhanced in CCl[sub.4] -administered rats. Similarly, the expression of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and monocyte chemo attractant protein-1 (MCP-1) was strongly increased with CCl[sub.4] administration to rats. Co-administration of LCM along with CCl[sub.4] to rats lowered (p < 0.05) the expression of the above genes. Histopathology of the liver showed hepatocyte injury, leukocyte infiltration and damaged central lobules in CCl[sub.4] -treated rats. However, LCM administration to CCl[sub.4] -intoxicated rats restored the altered parameters towards the levels of control rats. These outcomes indicate the existence of antioxidant and anti-inflammatory constituents in the methanol extract of L. corymbulosum.