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"Bauer, Andreas"
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The Bauer brothers
\"The art of Franz and Ferdinand Bauer was praised by the poet and botanist Johann Goethe as the perfect expression of the aims of botanical illustration. The book examines the contrasting lives of Franz (1758-1840), for 50 years the resident artist at Kew Gardens, and Ferdinand (1760-1826) who led a life of travel and adventure as a natural history artist including participating in the historic voyage to Australia of HMS Investigator in the early nineteenth century. It is illustrated with images from the superb archive of Bauer drawings at the Natural History Museum Library, many of which have never been published before. These include beautiful and finely detailed watercolours of flowering plants collected from across the world, pioneering microscopical drawings of plant anatomy and pictures of the newly discovered animals from the coasts of Australia.\"--Publisher's description.
Book
Symmetry-enforced topological nodal planes at the Fermi surface of a chiral magnet
Despite recent efforts to advance spintronics devices and quantum information technology using materials with non-trivial topological properties, three key challenges are still unresolved
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9
. First, the identification of topological band degeneracies that are generically rather than accidentally located at the Fermi level. Second, the ability to easily control such topological degeneracies. And third, the identification of generic topological degeneracies in large, multisheeted Fermi surfaces. By combining de Haas–van Alphen spectroscopy with density functional theory and band-topology calculations, here we show that the non-symmorphic symmetries
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in chiral, ferromagnetic manganese silicide (MnSi) generate nodal planes (NPs)
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,
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, which enforce topological protectorates (TPs) with substantial Berry curvatures at the intersection of the NPs with the Fermi surface (FS) regardless of the complexity of the FS. We predict that these TPs will be accompanied by sizeable Fermi arcs subject to the direction of the magnetization. Deriving the symmetry conditions underlying topological NPs, we show that the 1,651 magnetic space groups comprise 7 grey groups and 26 black-and-white groups with topological NPs, including the space group of ferromagnetic MnSi. Thus, the identification of symmetry-enforced TPs, which can be controlled with a magnetic field, on the FS of MnSi suggests the existence of similar properties—amenable for technological exploitation—in a large number of materials.
Measurements on a chiral magnet show that non-symmorphic symmetries enforce topological crossings exactly at the Fermi level in certain materials; these crossings can be controlled by an applied magnetic field.
Journal Article
Single dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation
The inverse effects of creatine supplementation and sleep deprivation on high energy phosphates, neural creatine, and cognitive performances suggest that creatine is a suitable candidate for reducing the negative effects of sleep deprivation. With this, the main obstacle is the limited exogenous uptake by the central nervous system (CNS), making creatine only effective over a long-term diet of weeks. Thus far, only repeated dosing of creatine over weeks has been studied, yielding detectable changes in CNS levels. Based on the hypothesis that a high extracellular creatine availability and increased intracellular energy consumption will temporarily increase the central creatine uptake, subjects were orally administered a high single dose of creatinemonohydrate (0.35 g/kg) while performing cognitive tests during sleep deprivation. Two consecutive
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P-MRS scans,
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H-MRS, and cognitive tests were performed each at evening baseline, 3, 5.5, and 7.5 h after single dose creatine (0.35 g/kg) or placebo during sub-total 21 h sleep deprivation (SD). Our results show that creatine induces changes in PCr/Pi, ATP, tCr/tNAA, prevents a drop in pH level, and improves cognitive performance and processing speed. These outcomes suggest that a high single dose of creatine can partially reverse metabolic alterations and fatigue-related cognitive deterioration.
Journal Article
Consistent success in life-supporting porcine cardiac xenotransplantation
Heart transplantation is the only cure for patients with terminal cardiac failure, but the supply of allogeneic donor organs falls far short of the clinical need
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. Xenotransplantation of genetically modified pig hearts has been discussed as a potential alternative
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. Genetically multi-modified pig hearts that lack galactose-α1,3-galactose epitopes (α1,3-galactosyltransferase knockout) and express a human membrane cofactor protein (CD46) and human thrombomodulin have survived for up to 945 days after heterotopic abdominal transplantation in baboons
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. This model demonstrated long-term acceptance of discordant xenografts with safe immunosuppression but did not predict their life-supporting function. Despite 25 years of extensive research, the maximum survival of a baboon after heart replacement with a porcine xenograft was only 57 days and this was achieved, to our knowledge, only once
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. Here we show that α1,3-galactosyltransferase-knockout pig hearts that express human CD46 and thrombomodulin require non-ischaemic preservation with continuous perfusion and control of post-transplantation growth to ensure long-term orthotopic function of the xenograft in baboons, the most stringent preclinical xenotransplantation model. Consistent life-supporting function of xenografted hearts for up to 195 days is a milestone on the way to clinical cardiac xenotransplantation
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α1,3-galactosyltransferase-knockout pig hearts that express human CD46 and human thrombomodulin require non-ischaemic preservation with continuous perfusion and post-transplantation growth control to ensure long-term orthotopic function of the xenograft in baboons.
Journal Article
YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers
YAP1 is a major effector of the Hippo pathway and a well-established oncogene. Elevated YAP1 activity due to mutations in Hippo pathway components or YAP1 amplification is observed in several types of human cancers. Here we investigated its genomic binding landscape in YAP1-activated cancer cells, as well as in non-transformed cells. We demonstrate that TEAD transcription factors mediate YAP1 chromatin-binding genome-wide, further explaining their dominant role as primary mediators of YAP1-transcriptional activity. Moreover, we show that YAP1 largely exerts its transcriptional control via distal enhancers that are marked by H3K27 acetylation and that YAP1 is necessary for this chromatin mark at bound enhancers and the activity of the associated genes. This work establishes YAP1-mediated transcriptional regulation at distal enhancers and provides an expanded set of target genes resulting in a fundamental source to study YAP1 function in a normal and cancer setting.
Journal Article
Comparison of Eddy Current Loss Calculation Techniques for Axial Flux Motors with Printed Circuit Board Windings
In slotless machines, the winding conductors are exposed to the magnetic air gap field, which causes additional eddy current losses, thus decreasing efficiency and affecting thermal utilization. This is the case, inter alia, for axial flux motors equipped with printed circuit board windings, where the winding is made of copper–fiberglass epoxy laminations and located in the air gap. The dominant influencing factors are primarily the width of the conducting tracks and the magnetic air gap flux density and frequency. The evaluation time is a crucial constraint when calculating thousands of different designs for design space exploration or performing multi-objective optimizations. Finite element simulations can achieve very precise results, but unlike semi-analytical approximation functions, they are very time-consuming and therefore not the method of choice for design space exploration. This publication provides a comprehensive overview of a selection of different eddy current loss calculation techniques that are applicable for rectangular tracks and round wire windings. A comparison of the calculated results for a finite element simulation is presented for a slotless axial flux machine with printed circuit board windings and rectangular tracks. The calculation time consumed is also compared. The current density distribution of planar conductors of air gap windings differs from that in electrical steel sheets. In contrast to the methods based on steel sheets, only the adapted methods for conductors in air gaps offer acceptable accuracy. A recommendation is provided for the method that offers the best balance between accuracy and computation time for the early-stage design of slotless axial flux machines.
Journal Article
Techno-economic analysis of a new downstream process for the production of astaxanthin from the microalgae Haematococcus pluvialis
The biotechnological production of the carotenoid astaxanthin is done with the microalgae Haematococcus pluvialis (H. pluvialis). Under nutrient deficiency and light stress, H. pluvialis accumulates astaxanthin intracellularly and forms a resistant cyst cell wall that impedes direct astaxanthin extraction. Therefore, a complex downstream process is required, including centrifugation, mechanical cell wall disruption, drying, and supercritical extraction of astaxanthin with CO2. In this work, an alternative downstream process based on the direct extraction of astaxanthin from the algal broth into ethyl acetate using a centrifugal partition extractor (CPE) was developed. A mechanical cell wall disruption or germination of the cysts was carried out to make astaxanthin accessible to the solvent. Zoospores containing astaxanthin are released when growth conditions are applied to cyst cells, from which astaxanthin can directly be extracted into ethyl acetate. Energy-intensive unit operations such as spray-drying and extraction with supercritical CO2 can be replaced by directly extracting astaxanthin into ethyl acetate. Extraction yields of 85% were reached, and 3.5 g of oleoresin could be extracted from 7.85 g homogenised H. pluvialis biomass using a CPE unit with 244 mL column volume. A techno-economic analysis was done for a hypothetical H. pluvialis production facility with an annual biomass output of 8910 kg. Four downstream scenarios were examined, comparing the novel process of astaxanthin extraction from homogenised cyst cells and germinated zoospores via CPE extraction with the conventional industrial process using in-house or supercritical CO2 extraction via an external service provider. After 10 years of operation, the highest net present value (NPV) was determined for the CPE extraction from germinated zoospores.
Journal Article
Quantum oscillations of the quasiparticle lifetime in a metal
Following nearly a century of research, it remains a puzzle that the low-lying excitations of metals are remarkably well explained by effective single-particle theories of non-interacting bands
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. The abundance of interactions in real materials raises the question of direct spectroscopic signatures of phenomena beyond effective single-particle, single-band behaviour. Here we report the identification of quantum oscillations (QOs) in the three-dimensional topological semimetal CoSi, which defy the standard description in two fundamental aspects. First, the oscillation frequency corresponds to the difference of semiclassical quasiparticle (QP) orbits of two bands, which are forbidden as half of the trajectory would oppose the Lorentz force. Second, the oscillations exist up to above 50 K, in strong contrast to all other oscillatory components, which vanish below a few kelvin. Our findings are in excellent agreement with generic model calculations of QOs of the QP lifetime (QPL). Because the only precondition for their existence is a nonlinear coupling of at least two electronic orbits, for example, owing to QP scattering on defects or collective excitations, such QOs of the QPL are generic for any metal featuring Landau quantization with several orbits. They are consistent with certain frequencies in topological semimetals
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, unconventional superconductors
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,
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, rare-earth compounds
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and Rashba systems
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, and permit to identify and gauge correlation phenomena, for example, in two-dimensional materials
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and multiband metals
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Quantum oscillations in the three-dimensional topological semimetal CoSi are reported, where selected oscillation frequencies have no corresponding extremal Fermi surface cross-sections, representing instead oscillations of the quasiparticle lifetime.
Journal Article
Reciprocal space tomography of 3D skyrmion lattice order in a chiral magnet
It is commonly assumed that surfaces modify the properties of stable materials within the top few atomic layers of a bulk specimen only. Exploiting the polarization dependence of resonant elastic X-ray scattering to go beyond conventional diffraction and imaging techniques, we have determined the depth dependence of the full 3D spin structure of skyrmions—that is, topologically nontrivial whirls of the magnetization—below the surface of a bulk sample of Cu₂OSeO₃. We found that the skyrmions change exponentially from pure Néel- to pure Bloch-twisting over a distance of several hundred nanometers between the surface and the bulk, respectively. Though qualitatively consistent with theory, the strength of the Néel-twisting at the surface and the length scale of the variation observed experimentally exceed material-specific modeling substantially. In view of the exceptionally complete quantitative theoretical account of the magnetic rigidities and associated static and dynamic properties of skyrmions in Cu₂OSeO₃ and related materials, we conclude that subtle changes of the materials properties must exist at distances up to several hundred atomic layers into the bulk, which originate in the presence of the surface. This has far-reaching implications for the creation of skyrmions in surface-dominated systems and identifies, more generally, surface-induced gradual variations deep within a bulk material and their impact on tailored functionalities as an unchartered scientific territory.
Journal Article
pyTFM: A tool for traction force and monolayer stress microscopy
Cellular force generation and force transmission are of fundamental importance for numerous biological processes and can be studied with the methods of Traction Force Microscopy (TFM) and Monolayer Stress Microscopy. Traction Force Microscopy and Monolayer Stress Microscopy solve the inverse problem of reconstructing cell-matrix tractions and inter- and intra-cellular stresses from the measured cell force-induced deformations of an adhesive substrate with known elasticity. Although several laboratories have developed software for Traction Force Microscopy and Monolayer Stress Microscopy computations, there is currently no software package available that allows non-expert users to perform a full evaluation of such experiments. Here we present pyTFM, a tool to perform Traction Force Microscopy and Monolayer Stress Microscopy on cell patches and cell layers grown in a 2-dimensional environment. pyTFM was optimized for ease-of-use; it is open-source and well documented (hosted at https://pytfm.readthedocs.io/ ) including usage examples and explanations of the theoretical background. pyTFM can be used as a standalone Python package or as an add-on to the image annotation tool ClickPoints . In combination with the ClickPoints environment, pyTFM allows the user to set all necessary analysis parameters, select regions of interest, examine the input data and intermediary results, and calculate a wide range of parameters describing forces, stresses, and their distribution. In this work, we also thoroughly analyze the accuracy and performance of the Traction Force Microscopy and Monolayer Stress Microscopy algorithms of pyTFM using synthetic and experimental data from epithelial cell patches.
Journal Article