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The aircraft-spotter's film and television companion
\"This first of its kind reference book lists aircraft featured in 350 films and television shows, providing brief individual histories, film locations, serial numbers and registrations. Aircraft are cross-referenced by manufacturer. Appendices provide brief bios on pilots and technicians, information on aircraft collections owned by Tallmantz Aviation and Blue Max Aviation and film credits for U.S. carriers\"-- Provided by publisher.
Book
Predicting falls in older adults: an umbrella review of instruments assessing gait, balance, and functional mobility
Background
To review the validated instruments that assess gait, balance, and functional mobility to predict falls in older adults across different settings.
Methods
Umbrella review of narrative- and systematic reviews with or without meta-analyses of all study types. Reviews that focused on older adults in any settings and included validated instruments assessing gait, balance, and functional mobility were included. Medical and allied health professional databases (MEDLINE, PsychINFO, Embase, and Cochrane) were searched from inception to April 2022. Two reviewers undertook title, abstract, and full text screening independently. Review quality was assessed through the Risk of Bias Assessment Tool for Systematic Reviews (ROBIS). Data extraction was completed in duplicate using a standardised spreadsheet and a narrative synthesis presented for each assessment tool.
Results
Among 2736 articles initially identified, 31 reviews were included; 11 were meta-analyses. Reviews were primarily of low quality, thus at high risk of potential bias. The most frequently reported assessments were: Timed Up and Go, Berg Balance Scale, gait speed, dual task assessments, single leg stance, functional Reach Test, tandem gait and stance and the chair stand test. Findings on the predictive ability of these tests were inconsistent across the reviews.
Conclusions
In conclusion, we found that no single gait, balance or functional mobility assessment in isolation can be used to predict fall risk in older adults with high certainty. Moderate evidence suggests gait speed can be useful in predicting falls and might be included as part of a comprehensive evaluation for older adults.
Journal Article
Highly efficient methane biocatalysis revealed in a methanotrophic bacterium
Methane is an essential component of the global carbon cycle and one of the most powerful greenhouse gases, yet it is also a promising alternative source of carbon for the biological production of value-added chemicals. Aerobic methane-consuming bacteria (methanotrophs) represent a potential biological platform for methane-based biocatalysis. Here we use a multi-pronged systems-level approach to reassess the metabolic functions for methane utilization in a promising bacterial biocatalyst. We demonstrate that methane assimilation is coupled with a highly efficient pyrophosphate-mediated glycolytic pathway, which under oxygen limitation participates in a novel form of fermentation-based methanotrophy. This surprising discovery suggests a novel mode of methane utilization in oxygen-limited environments, and opens new opportunities for a modular approach towards producing a variety of excreted chemical products using methane as a feedstock.
Methane is a promising renewable carbon source for chemical synthesis, yet methane bio-gas is currently underutilised as a feedstock. Here the authors examine the metabolic processes of methanotrophic bacteria to assess their use for conversion of methane to value-added chemical products.
Journal Article
Feeling good : the new mood therapy
\"The clinically proven drug-free treatment for depression.\"--Cover.
Book
mRNA therapeutics in cancer immunotherapy
Synthetic mRNA provides a template for the synthesis of any given protein, protein fragment or peptide and lends itself to a broad range of pharmaceutical applications, including different modalities of cancer immunotherapy. With the ease of rapid, large scale Good Manufacturing Practice-grade mRNA production, mRNA is ideally poised not only for off-the shelf cancer vaccines but also for personalized neoantigen vaccination. The ability to stimulate pattern recognition receptors and thus an anti-viral type of innate immune response equips mRNA-based vaccines with inherent adjuvanticity. Nucleoside modification and elimination of double-stranded RNA can reduce the immunomodulatory activity of mRNA and increase and prolong protein production. In combination with nanoparticle-based formulations that increase transfection efficiency and facilitate lymphatic system targeting, nucleoside-modified mRNA enables efficient delivery of cytokines, costimulatory receptors, or therapeutic antibodies. Steady but transient production of the encoded bioactive molecule from the mRNA template can improve the pharmacokinetic, pharmacodynamic and safety properties as compared to the respective recombinant proteins. This may be harnessed for applications that benefit from a higher level of expression control, such as chimeric antigen receptor (CAR)-modified adoptive T-cell therapies. This review highlights the advancements in the field of mRNA-based cancer therapeutics, providing insights into key preclinical developments and the evolving clinical landscape.
Journal Article
الشعور الجيد : العلاج الجديد للتقلبات المزاجية
في هذا الكتاب، يقدم الدكتور ديفيد دي. بيرنز، الطبيب النفسي المعروف، محتويات الكتاب على أساليب رائعة من شأنها أن ترفع من روحك المعنوية وأن تساعدك على أن تكون صاحب رؤية إيجابية للحياة، ما يمكنك من : - معرفة أسباب تقلباتك المزاجية. - وأد المشاعر السلبية في مهدها. - التعامل مع الشعور بالذنب. - التعامل مع العدوانية والإنتقادات. - التغلب على إدمان الحب وطلب الإستحسان. - تعزيز تقدير الذات. - الشعور بالرضا والسعادة كل يوم.
BOOK
Idiographic Traits
Since its beginnings, personality psychology has focused on both nomothetic and idiographic questions, but nomothetic approaches have captured the majority of attention in the past century. In this article, we demonstrate how recent measurement and modeling techniques provide an avenue for testing idiographic propositions about the dynamic features of a personality system. Findings indicate that people have unique structures of personality and that these structures are sensitive to situations people encounter. At the same time, these unique, mutable systems show longitudinal consistency for some but not all people.
Journal Article
Cobalt-electrocatalytic HAT for functionalization of unsaturated C–C bonds
The study and application of transition metal hydrides (TMHs) has been an active area of chemical research since the early 1960s
1
, for energy storage, through the reduction of protons to generate hydrogen
2
,
3
, and for organic synthesis, for the functionalization of unsaturated C–C, C–O and C–N bonds
4
,
5
. In the former instance, electrochemical means for driving such reactivity has been common place since the 1950s
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but the use of stoichiometric exogenous organic- and metal-based reductants to harness the power of TMHs in synthetic chemistry remains the norm. In particular, cobalt-based TMHs have found widespread use for the derivatization of olefins and alkynes in complex molecule construction, often by a net hydrogen atom transfer (HAT)
7
. Here we show how an electrocatalytic approach inspired by decades of energy storage research can be made use of in the context of modern organic synthesis. This strategy not only offers benefits in terms of sustainability and efficiency but also enables enhanced chemoselectivity and distinct, tunable reactivity. Ten different reaction manifolds across dozens of substrates are exemplified, along with detailed mechanistic insights into this scalable electrochemical entry into Co–H generation that takes place through a low-valent intermediate.
A perspective is given on how an electrocatalytic approach, inspired by decades of energy storage studies, can be used in the context of efficient cobalt-hydride generation with a variety of applications in modern organic synthesis.
Journal Article
Hooked on you: shape of attachment structures in cymothoid isopods reflects parasitic strategy
Background Parasite attachment structures are critical traits that influence effective host exploitation and survival. Morphology of attachment structures can reinforce host specificity and niche specialisation, or even enable host switching. Therefore, it is important to understand the determinants of variation in attachment structures. Cymothoid isopods are striking ectoparasites of fishes that include the infamous ‘tongue-biters.’ They are known to parasitise hosts in one of four qualitatively distinct anatomical regions. Here, we quantify variation in cymothoid attachment structures — hook-like appendages called dactyli — and test whether differences in dactylus shape are correlated with parasite mode (where they attach), allometry, or both, using multivariate ordinary least squares regression. We also assess the influence of shared ancestry on shape using a molecular phylogeny to weight our models using phylogenetic generalised least squares regression. Results We find clear differences in shape between externally-attaching and internally-attaching cymothoids but also between anterior and posterior dactyli across various species with the same attachment mode. Allometric effects are significant for anterior but not posterior dactyli. Mouth-attaching species show greater shape variability than gill- and mouth-attaching species. We find no evidence that there are clade-specific patterns of association between parasite mode and dactylus shape. Conclusions Parasite mode appears to be the main driver of attachment morphology. This likely reflects several components of parasite ecology including feeding and functional demands of attachment in different microhabitats. Geometric morphometric approaches to the quantification of shape variation of simple structures is an effective tool that provides new insights into the evolvability of parasite attachment
Journal Article