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"Becker, Daniel"
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What's good : notes on rap and language
\"What's Good is a work of passionate lyrical analysis, a set of freewheeling liner notes, and a love letter to the most vital American art form of the last half century. Over a series of short chapters, each centered on a different lyric, Daniel Levin Becker considers how rap's use of language operates and evolves at levels ranging from the local (slang, rhyme) to the analytical (quotation, transcription) to the philosophical (morality, criticism, irony), celebrating the pleasures and perils of any attempt to decipher its meaning-making technologies. Ranging from Sugarhill Gang to UGK to Young M.A, Rakim to Rick Ross to Rae Sremmurd, Jay-Z to Drake to Snoop Dogg, What's Good reads with the momentum of a deftly curated mixtape, drawing you into the conversation and teaching you to read it as it goes. A book for committed hip-hop heads, curious neophytes, armchair linguists, and everyone in between\"-- Provided by publisher.
BOOK
Longitudinal deep sequencing informs vector selection and future deployment strategies for transmissible vaccines
Vaccination is a powerful tool in combating infectious diseases of humans and companion animals. In most wildlife, including reservoirs of emerging human diseases, achieving sufficient vaccine coverage to mitigate disease burdens remains logistically unattainable. Virally vectored “transmissible” vaccines that deliberately spread among hosts are a potentially transformative, but still theoretical, solution to the challenge of immunising inaccessible wildlife. Progress towards real-world application is frustrated by the absence of frameworks to guide vector selection and vaccine deployment prior to major in vitro and in vivo investments in vaccine engineering and testing. Here, we performed deep sequencing on field-collected samples of Desmodus rotundus betaherpesvirus (DrBHV), a candidate vector for a transmissible vaccine targeting vampire bat–transmitted rabies. We discovered 11 strains of DrBHV that varied in prevalence and geographic distribution across Peru. The phylogeographic structure of DrBHV strains was predictable from both host genetics and landscape topology, informing long-term DrBHV-vectored vaccine deployment strategies and identifying geographic areas for field trials where vaccine spread would be naturally contained. Multistrain infections were observed in 79% of infected bats. Resampling of marked individuals over 4 years showed within-host persistence kinetics characteristic of latency and reactivation, properties that might boost individual immunity and lead to sporadic vaccine transmission over the lifetime of the host. Further, strain acquisitions by already infected individuals implied that preexisting immunity and strain competition are unlikely to inhibit vaccine spread. Our results support the development of a transmissible vaccine targeting a major source of human and animal rabies in Latin America and show how genomics can enlighten vector selection and deployment strategies for transmissible vaccines.
Journal Article
The birthday party
\"Buried deep in rural France, little remains of the isolated hamlet of the Three Lone Girls, save a few houses and a curiously assembled quartet: Patrice Bergogne, inheritor of his family's farm; his wife, Marion; their daughter, Ida; and their neighbor, Christine, an artist. While Patrice plans a surprise for his wife's fortieth birthday, inexplicable events start to disrupt the hamlet's quiet existence: anonymous, menacing letters, an unfamiliar car rolling up the driveway. And as night falls, strangers stalk the houses, unleashing a nightmarish chain of events. Told in rhythmic, propulsive prose that weaves seamlessly from one consciousness to the next over the course of a day, Laurent Mauvignier's The Birthday Party is a deft unraveling of the stories we hide from others and from ourselves, a gripping tale of the violent irruptions of the past into the present, written by a major contemporary French writer.\"-- Provided by publisher.
Book
Prioritizing surveillance of Nipah virus in India
The 2018 outbreak of Nipah virus in Kerala, India, highlights the need for global surveillance of henipaviruses in bats, which are the reservoir hosts for this and other viruses. Nipah virus, an emerging paramyxovirus in the genus Henipavirus, causes severe disease and stuttering chains of transmission in humans and is considered a potential pandemic threat. In May 2018, an outbreak of Nipah virus began in Kerala, > 1800 km from the sites of previous outbreaks in eastern India in 2001 and 2007. Twenty-three people were infected and 21 people died (16 deaths and 18 cases were laboratory confirmed). Initial surveillance focused on insectivorous bats (Megaderma spasma), whereas follow-up surveys within Kerala found evidence of Nipah virus in fruit bats (Pteropus medius). P. medius is the confirmed host in Bangladesh and is now a confirmed host in India. However, other bat species may also serve as reservoir hosts of henipaviruses. To inform surveillance of Nipah virus in bats, we reviewed and analyzed the published records of Nipah virus surveillance globally. We applied a trait-based machine learning approach to a subset of species that occur in Asia, Australia, and Oceana. In addition to seven species in Kerala that were previously identified as Nipah virus seropositive, we identified at least four bat species that, on the basis of trait similarity with known Nipah virus-seropositive species, have a relatively high likelihood of exposure to Nipah or Nipah-like viruses in India. These machine-learning approaches provide the first step in the sequence of studies required to assess the risk of Nipah virus spillover in India. Nipah virus surveillance not only within Kerala but also elsewhere in India would benefit from a research pipeline that included surveys of known and predicted reservoirs for serological evidence of past infection with Nipah virus (or cross reacting henipaviruses). Serosurveys should then be followed by longitudinal spatial and temporal studies to detect shedding and isolate virus from species with evidence of infection. Ecological studies will then be required to understand the dynamics governing prevalence and shedding in bats and the contacts that could pose a risk to public health.
Journal Article
All that is evident is suspect : readings from the Oulipo 1963-2018
\"All That is Evident is Suspect: the first collection in English to offer a life-size picture of the group in its historical and contemporary incarnations, and the first in any language to represent all of its members (numbering 41 as of April 2018 ). Combining fiction, poetry, essays and lectures, and never-published internal correspondence--along with the acrobatically constrained writing and complexly structured narratives that have become synonymous with oulipian practice--this volume shows a unique group of thinkers and artists at work and at play, meditating on and subverting the facts of life, love, and the group itself. It's an unprecedentedly intimate and comprehensive glimpse at the breadth and diversity of one of world literature's most vital, adventurous presences. INSIDE: Sharks as poets and vice versa, the Brisbane pitch drop experiment, novel classifications for real or imaginary libraries, the monumental sadness of difficult loves, the obsolescence of the novel, the symbolic significance of the cup-and-ball game, holiday closures across the Francophone world, what happens at Fahrenheit 452, Warren G. Harding's dark night of the soul, Marcel Duchamp's imperviousness to conventional spacetime laws, bilingual palindromes, cartoon eodermdromes, oscillating poems, mâetro poems, metric poems, literary madness, straw cultivation.\" - From the publisher.
Book
Genetic diversity, infection prevalence, and possible transmission routes of Bartonella spp. in vampire bats
Bartonella spp. are globally distributed bacteria that cause endocarditis in humans and domestic animals. Recent work has suggested bats as zoonotic reservoirs of some human Bartonella infections; however, the ecological and spatiotemporal patterns of infection in bats remain largely unknown. Here we studied the genetic diversity, prevalence of infection across seasons and years, individual risk factors, and possible transmission routes of Bartonella in populations of common vampire bats (Desmodus rotundus) in Peru and Belize, for which high infection prevalence has previously been reported. Phylogenetic analysis of the gltA gene for a subset of PCR-positive blood samples revealed sequences that were related to Bartonella described from vampire bats from Mexico, other Neotropical bat species, and streblid bat flies. Sequences associated with vampire bats clustered significantly by country but commonly spanned Central and South America, implying limited spatial structure. Stable and nonzero Bartonella prevalence between years supported endemic transmission in all sites. The odds of Bartonella infection for individual bats was unrelated to the intensity of bat flies ectoparasitism, but nearly all infected bats were infested, which precluded conclusive assessment of support for vector-borne transmission. While metagenomic sequencing found no strong evidence of Bartonella DNA in pooled bat saliva and fecal samples, we detected PCR positivity in individual saliva and feces, suggesting the potential for bacterial transmission through both direct contact (i.e., biting) and environmental (i.e., fecal) exposures. Further investigating the relative contributions of direct contact, environmental, and vector-borne transmission for bat Bartonella is an important next step to predict infection dynamics within bats and the risks of human and livestock exposures.
Journal Article
On avoiding Ostrogradski instabilities within Asymptotic Safety
A
bstract
We study the renormalization group flow of gravity coupled to scalar matter using functional renormalization group techniques. The novel feature is the inclusion of higher-derivative terms in the scalar propagator. Such terms give rise to Ostrogradski ghosts which signal an instability of the system and are therefore dangerous for the consistency of the theory. Since it is expected that such terms are generated dynamically by the renormalization group flow they provide a potential threat when constructing a theory of quantum gravity based on Asymptotic Safety. Our work then establishes the following picture: upon incorporating higher-derivative terms in the scalar propagator the flow of the gravity-matter system possesses a fixed point structure suitable for Asymptotic Safety. This structure includes an interacting renormalization group fixed point where the Ostrogradski ghosts acquire an infinite mass and decouple from the system. Tracing the flow towards the infrared it is found that there is a subset of complete renormalization group trajectories which lead to stable renormalized propagators. This subset is in one-to-one correspondence to the complete renormalization group trajectories obtained in computations which do not keep track of the higher-derivative terms. Thus our asymptotically safe gravity-matter systems are not haunted by Ostrogradski ghosts.
Journal Article
Sampling to elucidate the dynamics of infections in reservoir hosts
The risk of zoonotic spillover from reservoir hosts, such as wildlife or domestic livestock, to people is shaped by the spatial and temporal distribution of infection in reservoir populations. Quantifying these distributions is a key challenge in epidemiology and disease ecology that requires researchers to make trade-offs between the extent and intensity of spatial versus temporal sampling. We discuss sampling methods that strengthen the reliability and validity of inferences about the dynamics of zoonotic pathogens in wildlife hosts. This article is part of the theme issue ‘Dynamic and integrative approaches to understanding pathogen spillover’.
Journal Article
City sicker? A meta-analysis of wildlife health and urbanization
Urban development can alter resource availability, land use, and community composition, which, in turn, influences wildlife health. Generalizable relationships between wildlife health and urbanization have yet to be quantified and could vary across different measures of health and among species. We present a phylogenetic meta‐analysis of 516 comparisons of the toxicant loads, parasitism, body condition, or stress of urban and non‐urban wildlife populations reported in 106 studies spanning 81 species in 30 countries. We found a small but significant negative relationship between urbanization and wildlife health, driven by considerably higher toxicant loads and greater parasite abundance, greater parasite diversity, and/or greater likelihood of infection by parasites transmitted through close contact. Invertebrates and amphibians were particularly affected, with urban populations having higher toxicant loads and greater physiological stress than their non‐urban counterparts. We also found strong geographic and taxonomic bias in research effort, highlighting future research needs. Our results suggest that some types of health risks are more pronounced for wildlife in urban areas, which could have important implications for conservation.
Journal Article
Using host species traits to understand the consequences of resource provisioning for host-parasite interactions
1. Supplemental food provided to wildlife by human activities can be more abundant and predictable than natural resources, and subsequent changes in wildlife ecology can have profound impacts on host-parasite interactions. Identifying traits of species associated with increases or decreases in infection outcomes with resource provisioning could improve assessments of wildlife most prone to disease risks in changing environments. 2. We conducted a phylogenetic meta-analysis of 342 host-parasite interactions across 56 wildlife species and three broad taxonomic groups of parasites to identify host-level traits that influence whether provisioning is associated with increases or decreases in infection. 3. We predicted dietary generalists that capitalize on novel food would show greater infection in provisioned habitats owing to population growth and food-borne exposure to contaminants and parasite infectious stages. Similarly, species with fast life histories could experience stronger demographic and immunological benefits from provisioning that affect parasite transmission. We also predicted that wide-ranging and migratory behaviours could increase infection risks with provisioning if concentrated and non-seasonal foods promote dense aggregations that increase exposure to parasites. 4. We found that provisioning increased infection with bacteria, viruses, fungi and protozoa (i.e. microparasites) most for wide-ranging, dietary generalist host species. Effect sizes for ectoparasites were also highest for host species with large home ranges but were instead lowest for dietary generalists. In contrast, the type of provisioning was a stronger correlate of infection outcomes for helminths than host species traits. 5. Our analysis highlights host traits related to movement and feeding behaviour as important determinants of whether species experience greater infection with supplemental feeding. These results could help prioritize monitoring wildlife with particular trait profiles in anthropogenic habitats to reduce infectious disease risks in provisioned populations.
Journal Article